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Transjugular intrahepatic porto-systemic shunt in the elderly:Palliation for complications of portal hypertension

World Journal of Hepatology 2012年第2期4卷 35-42页

作者： Mubin I Syed Hetal Karsan Hector Ferral Azim Shaikh uzma waheed Talal Akhter Alan Gabbard Kamal Morar Robert Tyrrell Dayton Interventional Radiology DaytonOH 45409United States Department of Radiological Sciences Wright State University School of Medicine Department of Hepatology Emory University Department of Interventional Radiology Rush University Medical Center Department of the College of Medicine Northeast Ohio Medical University Department of Gastroenterology Springfield Regional Medical Center

AIM:To present a dedicated series of transjugular intrahepatic porto-systemic shunts(TIPS) in the elderly since data is sparse on this population ***:A retrospective review was performed of patients at least 65 years of age who underwent TIPS at our institutions between 1997 and *** patients were referred for *** deemed that 2 patients were not considered appropriate candidates due to their markedly advanced liver *** the 23 patients suitable for TIPS,the indications for TIPS placement was portal hypertension complicated by refractory ascites alone(n = 9),hepatic hydrothorax alone(n = 2),refractory ascites and hydrothorax(n = 1),gastrointestinal bleeding alone(n = 8),gastrointestinal bleeding and ascites(n = 3).RESULTS:Of these 23 attempted TIPS procedure patients,21 patients had technically successful TIPS procedures.A total of 29 out of 32 TIPS procedures including revisions were successful in 21 patients with a mean age of 72.1 years(range 65-82 years).Three of the procedures were unsuccessful attempts at TIPS and 8 procedures were successful revisions of our existing *** of 21 patients who underwent successful TIPS(excluding 5 patients lost to follow-up) were followed for a mean of 14.7 *** and/or hydrothorax was controlled following technically successful procedures in 12 of 13 *** was controlled following technically successful procedures in 10 out of 11 ***:We have demonstrated that TIPS is an effective procedure to control refractory complications of portal hypertension in elderly patients.

关键词： Transjugular intrahepatic porto-systemic shunt Portal hypertension Elderly Ascites Cirrhosis

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Dielectric behavior of Cu-Zn ferrites with Si additive

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Chinese Physics B 2014年第5期23卷 553-555页

作者： uzma G Department of Physics University of Wah

Since ferrites are highly sensitive to the additives present in or added to them, extensive work, to improve the properties of basic ferrites, has been carded out on these aspects. The present paper reports the effects of composition, frequency, and temperature on the dielectric behavior of a series of CuxZn1-xFe2O4 ferdte samples prepared by the usual ceramic technique. In order to improve the properties of the samples, low cost Fe2O3 having 0.5 wt.% Si as an additive is selected to introduce into the system. The dielectric constant increases by increasing the Cu content, as the electron exchange of Cu^2＋〈=〉 Cu^＋ is responsible for the conduction and the polarization. However, the addition of Si could decrease the dielectric constant as it suppresses the ceramic grain growth and promotes the quality factor at higher frequencies. Dielectric constant ε′ and loss tangent tan δ of the mixed Cu-Zn ferrite decrease with increasing frequency, attributed to the Maxwell-Wagner polarization, which increases as the temperature increases.

关键词： Cu-Zn ferrite dielectric behavior Si additive

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Evaluation of Darwin＇s fecundity advantage hypothesis in Parthenium beetle, Zygogramma bicolorata

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Insect Science 2013年第4期20卷 531-540页

作者： Omkar and uzma Afaq Ladybird Research Laboratory Department of Zoology University of Lucknow Lucknow 226007 India

In the Parthenium beetle, Zygogramma bicolorata Pallister （Coleoptera： Chrysomelidae）, variation in body size exists between and within the sexes. The females are larger than the males. Darwin （1874） proposed the fecundity advantage hypothesis, that is, large-sized females produce more progeny, with subsequent studies supporting, as well as, refuting the hypothesis. Thus, in order to evaluate whether this hypothesis stands in Z. bicolorata we performed experiments to investigate the role of body size in influencing：（i） assortative mating; （ii） reproductive attributes; and （iii） growth, development and survival of offspring. It is the first attempt in this beetle. We found that size influenced assortative mating, reproductive output and offspring fitness. Larger males and females were preferred as mates over smaller ones. The pairs, having larger adults as mates, had higher fecundity, while the egg viability was influenced by the male size only. The offspring of larger parents had fast development and higher survival, indicating thereby possible better nutrient allotment by the female and supply of accessory gland proteins by the male in addition to better quality of genes.

关键词： body size development fecundity offspring fitness reproductive success

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A new tool for monitoring brain function: eye tracking goes beyond assessing attention to measuring central nervous system physiology

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Neural Regeneration Research 2015年第8期10卷 1231-1233页

作者： uzma Samadani Steven and Alexandra Cohen Veterans Center for Post-Traumatic Stress and Traumatic Brain Injury at NYU Langone Medical Center Departments of Neurosurgery Psychiatry Physiology and Neuroscience New York University School of Medicine New York New York Harbor Health Care System USA

Concussion and other forms of brain injury are not always detectable with conventional means such as radiographic *** lack of accurate diagnostics,biomarkers,and outcome measures has a devastating *** patients may suffer in obscurity,self-medicate into an addictive spiral,have impaired professional activity,and develop failed interpersonal relationships.

关键词： interpersonal suffer impaired devastating diagnostics professional assessing spatially calibration tracked

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One-dimensional quantum walks with a position-dependent coin

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Communications in Theoretical Physics 2020年第6期72卷 18-28页

作者： Rashid Ahmad uzma Sajjad Muhammad Sajid Department of Physics Kohat University of Science and TechnologyKohat 26000Khyber-PakhtunkhwaPakistan

We investigate the evolution of a discrete-time one-dimensional quantum walk driven by a position-dependent *** rotation angle,which depends upon the position of a quantum particle,parameterizes the coin *** different values of the rotation angle,we observe that such a coin leads to a variety of probability distributions,***,periodic,classicallike,semi-classical-like,and ***,we study the Shannon entropy associated with position and the coin space of a quantum particle,and compare them with the case of the position-independent *** results show that the entropy is smaller for most values of the rotation angle as compared to the case of the position-independent *** also study the effect of entanglement on the behavior of probability distribution and Shannon entropy by considering a quantum walk with two identical position-dependent entangled *** observe that in general,a wave function becomes more localized as compared to the case of the positionindependent coin and hence the corresponding Shannon entropy is *** results show that a position-dependent coin can be used as a controlling tool of quantum walks.

关键词： quantum walk position-dependent coin Shannon entropy

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Effect of interferon plus ribavirin therapy on hepatitis C virus genotype 3 patients from Pakistan:Treatment response,side effects and future prospective

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Asian Pacific Journal of Tropical Medicine 2015年第2期8卷 85-89页

作者： Yasir waheed Atta ur Rahman School of Applied Biosciences National University of Sciences & Technology(NUST)Islamabad 44000Pakistan

More than 10 million people are suffering from hepatitis C virus(HCV) in Pakistan,The available treatment option is a combination of interferon and *** response is linked with several factors and also induces a number of side *** searched in *** Medi Net and Coogle Scholar for the articles presenting the effect of interferon plus ribavirin therapy on HCV patients from Pakistan,their side effects and future *** major prevalent HCV genotype in Pakistan is *** interferon alpha plus ribavirin showed sustained virological response of 54%-64%while pegylaled interferon alpha plus ribavirin showed sustained virological response of 58%-75%.IL-28 B CC genotype is linked with better sustained virological *** on patients with HCV genotype 3 infections showed no correlation between treatment response and interferon sensitivity determining region *** therapy is linked with a number of side effects like thyroid *** disorders,weight loss,gastrointestinal tract side effects and neuropsychiatric side *** side effects of clubbing of fingers and seizures were also observed in a couple of *** alpha plus ribavirin therapy showed better response rate in HCV genotype 3 patients from Pakistan with number of side effects.A couple of interferon free therapies are light of hope for the patients living with HCV.

关键词： Hepatitis C virus Interferon therapy Genotype 3

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Progress on global hepatitis elimination targets

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World Journal of Gastroenterology 2021年第47期27卷 8199-8200页

作者： Yasir waheed Multidisciplinary Laboratory Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan

In 2016,the World Health Assembly adopted a Global Health Sector Strategy on viral hepatitis,with targets set for the years 2020 and 2030 to achieve hepatitis *** main target of hepatitis elimination strategy is to reduce the incidence of hepatitis B virus(HBV)and hepatitis C virus(HCV)by 90%and mortality by 65%in *** last 5 years,the number of people receiving HCV treatment has increased from 1 million to 9.4 million;however,this number is far from the 2030 target of 40 million people receiving HCV *** and HCV incidence rates are down from 1.4 million to 1.1 million annual deaths but this is far from the 2030 target of<0.5 million *** coronavirus disease 2019 pandemic has severely affected the efforts in the fight against *** major donor has committed to investing in the fight against *** is running *** is a need to speed up efforts in the fight against hepatitis to achieve hepatitis elimination by 2030.

关键词： Hepatitis elimination Blood donations Safe injections Hepatitis B vaccination Harm reduction

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Hepatitis C eradication: A long way to go

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World Journal of Gastroenterology 2015年第43期21卷 12510-12512页

作者： Yasir waheed Foundation University Medical College Foundation University Islamabad

Hepatitis C virus(HCV) is a major global health problem with high morbidity and mortality. About 185 million people are living with HCV,of which 80% are living in low and middle income countries. With the development of new highly effective treatments for HCV,it is considered that the eradication of HCV may only be one step away. The major problem with new treatment options is its high price. The price of sofosbuvir-based treatment for one patient in the United States is US$85000-110000,while the actual production cost of a 12 wk direct-acting antiviral regimen is less than US$250. Another major hindrance in HCV eradication is the lack of quality management of blood transfusion screens. Due to the lack of HCV screening,75% of people in the United States with HCV infection are unaware of their positive HCV status. The control of massive HCV pandemic will require a significant financial investment,political will,and support from medical,pharmaceutical,and civil organizations around the globe.

关键词： Hepatitis C virus Treatment Diagnostics Screening

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Performance analysis of machine learning models for intrusion detection system using Gini Impurity-based Weighted Random Forest (GIWRF) feature selection technique

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Cybersecurity 2022年第2期5卷 119-140页

作者： Raisa Abedin Disha Sajjad waheed Department of Information and Communication Technology Bangladesh University of ProfessionalsMirpur CantonmentDhaka1216Bangladesh Department of Information and Communication Technology Mawlana Bhashani Science and Technology UniversitySantoshTangail1902Bangladesh

To protect the network, resources, and sensitive data, the intrusion detection system (IDS) has become a fundamental component of organizations that prevents cybercriminal activities. Several approaches have been introduced and implemented to thwart malicious activities so far. Due to the effectiveness of machine learning (ML) methods, the proposed approach applied several ML models for the intrusion detection system. In order to evaluate the performance of models, UNSW-NB 15 and Network TON_IoT datasets were used for offline analysis. Both datasets are comparatively newer than the NSL-KDD dataset to represent modern-day attacks. However, the performance analysis was carried out by training and testing the Decision Tree (DT), Gradient Boosting Tree (GBT), Multilayer Perceptron (MLP), AdaBoost, Long-Short Term Memory (LSTM), and Gated Recurrent Unit (GRU) for the binary classification task. As the performance of IDS deteriorates with a high dimensional feature vector, an optimum set of features was selected through a Gini Impurity-based Weighted Random Forest (GIWRF) model as the embedded feature selection technique. This technique employed Gini impurity as the splitting criterion of trees and adjusted the weights for two different classes of the imbalanced data to make the learning algorithm understand the class distribution. Based upon the importance score, 20 features were selected from UNSW-NB 15 and 10 features from the Network TON_IoT dataset. The experimental result revealed that DT performed well with the feature selection technique than other trained models of this experiment. Moreover, the proposed GIWRF-DT outperformed other existing methods surveyed in the literature in terms of the F1 score.

关键词： Cyber security Feature selection Intrusion Detection System Machine learning Network security

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Influence of thyroid volume reduction on absorbed dose in ^(131)I therapy studied by using Geant4 Monte Carlo simulation

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Chinese Physics C 2014年第5期38卷 62-68页

作者： Ziaur Rahman Sikander M Mirza waheed Arshed Nasir M Mirza waheed Ahmed Health Physics Division Pakistan Institute of Nuclear Science and Technology Department of Physics and Applied Mathematics Pakistan Institute of Engineering and Applied Sciences

A simulation study has been performed to quantify the effect of volume reduction on the thyroid absorbed dose per decay and to investigate the variation of energy deposition per decay due to β- and γ-activity of 131I with volume/mass of thyroid, for water, ICRP- and ICRU-soft tissue taken as thyroid material. A Monte Carlo model of the thyroid, in the Geant4 radiation transport simulation toolkit was constructed to compute the β- and γ-absorbed dose in the simulated thyroid phantom for various values of its volume. The effect of the size and shape of the thyroid on energy deposition per decay has also been studied by using spherical, ellipsoidal and cylindrical models for the thyroid and varying its volume in 1-25 cm3 range. The relative differences of Geant4 results for different models with each other and MCNP results lie well below 1.870%. The maximum relative difference among the Geant4 estimated results for water with ICRP and ICRU soft tissues is not more than 0.225%. S-values for ellipsoidal, spherical and cylindrical thyroid models were estimated and the relative difference with published results lies within 3.095%. The absorbed fraction values for beta particles show a good agreement with published values within 2.105% deviation. The Geant4 based simulation results of absorbed fractions for gammas again show a good agreement with the corresponding MCNP and EGS4 results （±6.667%） but have 29.032% higher values than that of MIRD calculated values. Consistent with previous studies, the reduction of the thyroid volume is found to have a substantial effect on the absorbed dose. Geant4 simulations confirm dose dependence on the volume/mass of thyroid in agreement with MCNP and EGS4 computed values but are substantially different from MIRD8 data. Therefore, inclusion of size/mass dependence is indicated for 131I radiotherapy of the thyroid.

关键词： mean absorbed dose rate Geant4 Monte Carlo simulation and 131I therapy

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