检索结果-南通市图书馆

COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1402-1428页

作者： Sunny kumar Malini Basu Pratyasha Ghosh uttam Pal Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of Economics Bethune CollegeUniversity of CalcuttaKolkata 700006India

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.

关键词： Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2

Elemental variations in glacier cryoconites of Indian Himalaya and Spitsbergen,Arctic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第6期8卷 1339-1347页

作者： Shiv Mohan Singh kumar Avinash Parmanand Sharma Ravindra uttam Mulik Ajay kumar Upadhyay Rasik Ravindra Earth System Science Organisation National Centre for Antarctic and Ocean ResearchHeadland SadaGoa403804India National Research Centre for Grapes Pune412307India Ministry of Earth Sciences Prithvi BhavanIMD CampusOpp.India Habitat CentreLodi RoadNew Delhi110003India

Cryoconite samples were collected from two different climatic domains i.e.,the Sutri Dhaka glacier,western Himalaya India and Svalbard glaciers,the Spitsbergen,Arctic,to understand the elemental source and elemental deposition *** data of geochemical analysis suggest that the Himalayan cryoconite samples accumulate higher concentrations as compared to the cryoconite samples of the Arctic *** concentration of lithophile elements(Cs,Li,Rb and U)was recorded higher in the cryoconite holes of the Himalayas,especially,in the lower to the higher parts of the glacier,whereas,lower concentrations were recorded in the Arctic *** elements in the Himalayan cryoconites are enriched in As and Bi while the Arctic cryoconite samples show a higher concentration of Bi,Pb and *** higher concentrations are responsible for influencing the ecosystem and in human health related *** elements(Co,Fe,Mn and Ni)show high concentrations in the Himalayan samples,whereas,the Arctic samples show minor variations and low elemental concentration in these elements,*** addition,a few elements,such as Ag,Mg,and Ca show higher concentration in the Himalayan glacier *** also occurs in high concentrations in Arctic glacier samples.R-mode factor analysis of the Himalayas(Arctic)samples indicate that the elements are distributed in four(three)factors,explaining 89%(90%)of the variance in their elemental *** Factor 1 suggests statistically significant positive loadings for most of the lithophile,chalcophile and siderophile elements of the "Himalayan" and the Arctic cryoconite *** sample-wise factor score distribution shows a considerable variation in the sampling locations along the glaciers of both the *** 2 and 3,demonstrate insignificant loading for most of the elements,except statistically significant positive loading in some of the elements of the both,Himalayan and Arctic "cryoconites".The higher el

关键词： Cryoconite Elemental concentration Factor analyses Himalaya Spitsbergen

Applications of phototheranostic nanoagents in photodynamic therapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2015年第5期8卷 1373-1394页

作者： Jayeeta Bhaumik Amit kumar Mittal Avik Banedee Yusuf Chisti uttam Chand Banerjee Department of Pharmaceutical Technology (Biotechnology) National Institute of Pharmaceutical Education and Research Sector 67 S.A.S. Nagar 160062 India Department of Radiology Dayanand Medical College and Hospital Ludhiana 141001 India School of Engineering Massey University Private Bag 11 222 Palmerston North New Zealand

Nanotherapeutics has an increasing role in the treatment of diseases such as cancer. In photodynamic therapy （PDT） a therapeutically inactive photosensitizer compound is selectively activated by light to produce molecules capable of killing diseased cells and pathogens. A phototheranostic agent can be defined as a single nanoentity with the capabilities for targeted delivery, optical imaging and photodynamic treatment of a disease. Malignant cells, tissue and microbial etiologic agents can be effectively targeted by PDT. Photodynamic therapy is noninvasive, or minimally invasive, and has few side effects as damage to healthy tissue is minimized and the killing effect is localized. Various forms of cancer, acne and other diseases may be treated. The in vivo efficacy of photosensitizers is further improved by attaching them to nanostructures capable of targeting the diseased site. Such photosensitizer-functionalized nanostructures, or nano- therapeutics, allow site-specific delivery of imaging and therapeutic agents for improved phototheranostic performance. This review explores the potential applications of phototheranostic nanostructures in diagnosis and therapy.

关键词： phototheranostics photodynamic therapy photosensitizers theranostics nanomedicine

Formulation optimization and characterization of transdermal film of curcumin by response surface methodology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2021年第2期13卷 274-285页

作者： Priyanka Kriplani kumar Guarve uttam Singh Baghel Guru Gobind Singh College of Pharmacy Yamuna Nagar135001India I.K.Gujral Punjab Technical University Jalandhar 144603India Department of Pharmacy University of KotaKota 324005India

Objective:India is referred as goldmine of herbal drugs but still lack of optimization of herbal drugs,which has kept us on the back *** rationale of the study is to prepare optimized transdermal drug delivery system of curcumin employing response surface methodology to study the collective effect of independent variables like concentration of ethyl cellulose,hydroxyl propyl methyl cellulose and dibutyl phthalate which significantly influenced characteristics like percentage elongation and in vitro drug ***:Twenty formulations containing varying concentrations of polymers and permeation enhancer were prepared using solvent casting ***:The study revealed that the effect of dibutyl phthalate(DBP) concentration was the highest on percentage elongation(P <0.0001),while hydroxy propyl methyl cellulose(HPMC) concentration exhibited pronounced effect on drug release(P <0.0001) through dialysis *** model fitted the best for curcumin release and elongation for all *** to Derringer's desirability prediction tool,the composition of optimized film was found to be 242.14% of HPMC,109.59% of ethyl cellulose(EC),and 1.03% of *** these conditions,the optimized patch exhibited a predicted value of%elongation and in vitro drug release of 94.35% and 80.0306%,respectively,which was comparable to the actual values of percent elongation and in vitro drug release i.e.95.02% and 81.03% *** and thermal studies were also performed which revealed no interaction or complexation between drug and *** ex vivo study performed using rat skin showed that the cumulative drug release from the optimized patch showed flux of(30.68±18) μg/cm~2/***:It can be concluded that in future if proper optimization of herbal formulations is carried out,they can become the first choice for patients as compare to synthetic drugs.

关键词： Curcumin herbal drugs osteoarthritis formulation optimization transdermal film

Mathematical model of zika virus dynamics with vector control and sensitivity analysis

在线全文

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2020年第1期5卷 23-41页

作者： Sudhanshu kumar Biswas uttam Ghosh Susmita Sarkar Department of Mathematics Sripat Singh CollegeMurshidabadWest BengalIndia Department of Applied Mathematics University of CalcuttaKolkataIndia

In this paper,we have developed and analyzed a deterministic Zika model considering both vector and sexual transmission route with the effect of human awareness and vector control in the absence of disease induce *** formulate the model,we assume that the Zika virus is being first transmitted to human by mosquito bite,and then it is being transmitted to his or her sexual *** system contains at most three equilibrium points among them one is the disease free and other two are endemic equilibrium points,exists under certain *** theoretical analysis shows that the diseases-free equilibrium is locally and globally asymptotically stable if the basic reproduction number is less than *** we have established that endemic equilibrium point which is locally asymptotically stable if the basic reproduction number is greater than *** system exhibits backward bifurcation when the transmission probability per biting of susceptible mosquito with infected humans crosses the critical *** estimate the model parameters and validate the model by fitting the model with the reported Zika infected human data from 1 to 36 week of 2016 Zika outbreak in ***,using the normalised forward sensitivity index method we have established that the model parameter mosquito biting rate,recruitment rate of mosquito,transmission probability per biting of Susceptible(infected)humans with infected(susceptible)mosquito,rate of awareness in host population,recovery rates of infected human are most sensitive parameters of the considered Zika ***,some conclusions are given to control the spreading of the Zika disease.

关键词： Zika virus Vector transmission Sexual transmission Basic reproduction number Stability analysis Backward bifurcation Sensitivity analysis

Evaluating active leprosy case identifcation methods in six districts of Nepal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2023年第6期12卷 105-106页

作者： Ram kumar Mahato uttam Ghimire Madhav Lamsal Bijay Bajracharya Mukesh Poudel Prashnna Napit Krishna Lama Gokarna Dahal David T.S.Hayman Ajit kumar Karna Basu Dev Pandey Chuman Lal das Krishna Prasad Paudel Epidemiology and Disease Control Division Department of Health Services Ministry of Health and Population Kathmandu Nepal Epidemiology and Disease Control Division-Malaria Program Management Unit- SCI-GF Kathmandu Nepal Leprosy Control & Disability Management Section EPidemiology and Disease Control Division DoHS Kathmandu Nepal Lalgadh Leprosy Hospital & Service Center Nepal Leprosy Trust Lalgadh Nepal Molecular Epidemiology and Public Health Laboratory Infectious Disease Research Centre Hopkirk Research Institute Massey University Palmerston North New Zealand Center for Health and Disease Studies-Nepal Kathmandu Nepal DEJIMA Infectious Disease Research Alliance Nagasaki University Nagasaki Japan

Background Nepal has achieved and sustained the elimination of leprosy as a public health problem since 2009,but 17 districts and 3 provinces with 41%(10,907,128)of Nepal’s population have yet to eliminate the *** cases and grade-2 disabilities(G2D)indicate recent transmission and late diagnosis,respectively,which necessitate active and early case *** operational research was performed to identify approaches best suited for early case detection,determine community-based leprosy epidemiology,and identify hidden leprosy cases early and respond with prompt *** Active case detection was undertaken in two Nepali provinces with the greatest burden of leprosy,Madhesh Province(40%national cases)and Lumbini Province(18%)and at-risk prison populations in Madhesh,Lumbini and Bagmati *** detection was performed by(1)house-to-house visits among vulnerable populations(n=26,469);(2)contact examination and tracing(n=7608);in Madhesh and Lumbini Provinces and,(3)screening prison populations(n=4428)in Madhesh,Lumbini and Bagmati Provinces of *** case direct medical and nonmedical costs for each approach were *** New case detection rates were highest for contact tracing(250),followed by house-to-house visits(102)and prison screening(45)per 100,000 population ***,the cost per case identifed was cheapest for house-to-house visits[Nepalese rupee(NPR)76,500/case],followed by contact tracing(NPR 90,286/case)and prison screening(NPR 298,300/case).House-to-house and contact tracing case paucibacillary/multibacillary(PB:MB)ratios were 59:41 and 68:32;female/male ratios 63:37 and 57:43;pediatric cases 11%in both approaches;and grade-2 disabilities(G2D)11%and 5%,*** leprosy was not signifcantly diferent among household and neighbor contacts[odds ratios(OR)=1.4,95%confdence interval(CI):0.24-5.85]and for contacts of MB versus PB cases(OR=0.7,95%CI 0.26-2.0).Attack rates were not signifcantly d

关键词： Leprosy Early case detection Community-based epidemiology Hidden case New case detection rate Attack rate Cost per case identifed Nepal

An Assessment of Yarsagumba(Ophiocordyceps sinensis) Collection in Dhorpatan Hunting Reserve, Nepal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2014年第2期11卷 555-562页

作者： Barna Bahadur THAPA Saroj PANTHI Rajesh kumar RAI uttam Babu SHRESTHA Achyut ARYAL Sabina SHRESTHA Bhushan SHRESTHA Department of National Parks and Wildlife Conservation Babar Mahal Dhorpatan Hunting Reserve Baglung Station Green Governance Nepal Department of Biology University of Massachusetts Institute of Natural and Mathematical Sciences Massey University Graduate School of Biotechnology Institute of Life Sciences and Resources Kyung Hee University Green Energy Mission/Nepal Ghatte Kulo Anam Nagar Mushroom Research Division National Institute of Horticultural and Herbal Science Rural Development Administration

Yarsagumba(Ophiocordyceps sinensis), an endemic species to the Himalayas and Tibetan Plateau, is one of the most valuable medicinal mushrooms in the world. In Nepal, it is distributed largely in isolated patches of alpine grasslands of 3,000-5,000 m elevation. Although it is reported from 27 northernmost districts of Nepal, the local distribution pattern of this species is largely ***, the collection system and local management regime of this species are not well documented. We conducted a field survey at Dhorpatan Hunting Reserve(DHR) among the different stakeholders in January-June 2012 to assess collection sites, patterns and trends and to understand the management regime. We estimated that about 75 kg of Yarsagumba is collected every year from DHR and the amount has been declining since 2008. To manage the resource, locals have initiated regulating the collection by issuing permits, taxing to the collectors, and monitoring the activities of harvesters with the help of park authorities. The revenue generated at local level from the permits has been used for community developmental activities.

关键词： Chinese caterpillar fungus Medicinal fungus Himalayan gold Conservation Yartsagunbu

Stability of Zn-EDTA over That of Zinc Sulphate in Soils

在线全文

学校读者我要写书评

暂无评论

Stability of Zn-EDTA over That of Zinc Sulphate in Soils

Minimization of Phenols and Phenolic Compounds in Pulp and Paper Industries： Biological Approaches

国际农业工程大会

作者： Tanmoy Karak uttam kumar Singh D.K.das Visiting Scientist Department of Soil and Water Sciences College of Resources and Environmental Sciences China Agricultural University No.2 West Yuanmingyuan Road Beijing-100094 P.R.China. Visiting Scientist Department of Soil and Water Sciences College of Resources and Environmental Sciences China Agricultural University No.2 West Yuanmingyuan Road Beijing-100094 P.R.China. Professor Department of Agricultural Chemistry and Soil Science Faculty of Agriculture Bidhan Chandra Krishi Viswavidyalaya Mohanpur-741252 Nadia West Bengal India

＜正＞ Zinc （Zn） is one of the essential micronutrients required for growth and development of crops. It plays an important role in different plant metabolism process like development of cell wall, respiration, photosynthesis and other bio-chemical functions etc. As much as around 40% of soil samples analyzed throughout all districts of West Bengal have been found to be deficient in Zn. The problem seems to be more acute for rice as around half of the total rice areas found

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Chemistry and Chemical Engineering 2011年第7期5卷 595-607页

作者： Manoj kumar Ghosh uttam kumar Ghosh Samit kumar Department of Paper Technology Indian Institute of Technology Roorkee Saharanpur Campus Saharanpur 247001 U.P. India

The liquid effluents released from several industries including the pulp and paper industries contain phenol and phenolic compounds. The hazardous phenols and their chlorinated phenolic derivatives from pulp and paper industries bear the potential to exert deleterious effects on the human health and aquatic ecosystems, if they are released untreated in the environment. Biodegradation of phenolic compounds in the effluent streams from pulp and paper industries is an important eco-friendly method for the removal of toxicity in industrial waste water, while the minimization of formation of these toxic compounds require several in-plant biotechnological techniques such as biopulping and biobleaching. Present paper reviews, the biochemical pathways involved in degradation of phenols and chlorophenols through microorganisms. Various biotechnological strategies involved in minimization and biodegradation of phenol and phenolic compounds and their related environmental engineering aspects such as utility of different bioreactor configurations have been discussed for the treatment of pulp and paper mill effluents.

关键词： Biodegradation biobleaching biopulping chlorophenol.