COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
作者机构：Cancer Biology and Inflammatory Disorder DivisionCouncil of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of MicrobiologyDhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of EconomicsBethune CollegeUniversity of CalcuttaKolkata 700006India
出 版 物：《Genes & Diseases》 (基因与疾病(英文))
年 卷 期：2023年第10卷第4期
页 面：1402-1428页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Department of Science and Technology India[NanoMission:DST/NM/NT/2018/105(G) SERB:EMR/2017/000992]and Focused Basic Research(FBR)(No.MLP-142),HCP-40(Pan-Cancer Mission),Council of Scientific and Industrial Research(CSIR),Govt.of India
主 题：Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2
摘 要：Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.
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