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Acetylation of PPARγin macrophages promotes visceral fat degeneration in obesity

Life Metabolism 2022年第3期1卷 258-269页

作者： Nicole Aaron Tarik Zahr Ying He Lexiang Yu Brent Mayfield utpal bpajvani Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNYUSA Department of Pharmacology Columbia UniversityNew YorkNYUSA Department of Pathology and Cell Biology Columbia UniversityNew YorkNYUSA Department of Genetics and Development Columbia UniversityNew YorkNYUSA Department of Medicine Columbia UniversityNew YorkNYUSA

Obesity is characterized by chronic,low-grade inflammation,which is driven by macrophage infiltration of adipose ***γ is well established to have an anti-inflammatory function in macrophages,but the mechanism that regulates its function in these cells remains to be fully ***γundergoes post-translational modifications(PTMs),including acetylation,to mediate ligand responses,including on metabolic ***,we report that PPARγacetylation in macrophages promotes their infiltration into adipose tissue,exacerbating metabolic *** generated a mouse line that expresses a macrophage-specific,constitutive acetylation-mimetic form of PPARγ(K293Q^(flox/flox):LysM-cre,mK293Q)to dissect the role of PPARγacetylation in *** highfat diet feeding to stimulate macrophage infiltration into adipose tissue,we assessed the overall metabolic profile and tissue-specific phenotype of the mutant mice,including responses to the PPARγagonist ***-specific PPARγK293Q expression promotes proinflammatory macrophage infiltration and fibrosis in epididymal white adipose tissue,but not in subcutaneous or brown adipose tissue,leading to decreased energy expenditure,insulin sensitivity,glucose tolerance,and adipose tissue ***,mK293Q mice are resistant to Rosiglitazone-induced improvements in adipose tissue *** study reveals that acetylation is a new layer of PPARγregulation in macrophage activation,and highlights the importance and potential therapeutic implications of such PTMs in regulating metabolism.

关键词： PPARγacetylation adipose tissue remodeling macrophage inflammation fibrosis

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Amebic liver abscess: An update

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World Journal of Hepatology 2024年第3期16卷 316-330页

作者： Ramesh Kumar Rishabh Patel Rajeev Nayan Priyadarshi Ruchika Narayan Tanmoy Maji utpal Anand Jinit R Soni Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India Department of Surgical Gastroenterology All India Institute of Medical SciencesPatna 801507India

Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver *** is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily colonises the *** is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular *** of the male gender,during their reproductive years,are most prone to ALA,and this appears to be due to a poorly mounted immune response linked to serum testosterone *** is more common in the right lobe of the liver,is strongly associated with alcohol consumption,and can heal without the need for *** majority of ALA patients have an uncomplicated course,a number of complications have been described,including rupture into abdomino-thoracic structures,biliary fistula,vascular thrombosis,bilio-vascular compression,and secondary bacterial *** on clinico-radiological findings,a classification system for ALA has emerged recently,which can assist clinicians in making treatment *** research has revealed the role of venous thrombosis-related ischemia in the severity of *** years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited *** has been the drug of choice for ALA patients for many ***,concerns over the resistance and adverse effects necessitate the creation of new,safe,and potent antiamebic *** the indication of the drainage of uncomplicated ALA has become more clear,high-quality randomised trials are still necessary for robust *** drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis,for whom surgery represents a significant risk of *** regard to all of the aforementioned issues,this article intends to present an u

关键词： Amebic liver abscess Amebiasis Ruptured liver abscess Percutaneous drainage Metronidazole

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Vascular complications of liver abscess: A literature review

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World Journal of Meta-Analysis 2024年第3期12卷 17-29页

作者： Rahul Arya Ramesh Kumar Rajeev N Priyadarshi Ruchika Narayan utpal Anand Department of Gastroenterology All India Institute of Medical SciencesPatna 801507BiharIndia Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507BiharIndia Department of Surgical Gastroenterology All India Institute of Medical SciencesPatna 801507India

Extensive vascular network and proximity to the gastrointestinal tract make the liver susceptible to abscess *** pyogenic liver abscesses account for the majority of liver abscesses in the Western world,amebic liver abscesses are more prevalent in tropical and developing *** liver abscesses heal without ***,various vascular complications can occur in these patients,including compression of the inferior vena cava,thrombosis of the portal vein and/or hepatic veins,hepatic artery pseudoaneurysm,direct rupture into major vessels or the pericardium,and biliovascular *** compli-cations can present significant clinical challenges due to the potential for hae-morrhage,ischemia,and systemic embolism,thereby increasing the risk of morbidity and *** compression,flow stasis,inflammation,endothelial injury,and direct invasion are some of the proposed mechanisms that can cause vascular complications in the setting of a liver *** the diag-nosis,thorough assessment,and therapeutic planning of vascular complications,more sophisticated imaging techniques such as multidetector computed tomo-graphy angiography or magnetic resonance angiography may be *** most vascular complications resolve with abscess treatment alone,additional interventions may be required based on the nature,severity,and course of the *** article aims to provide a systematic update on the spectrum of vascular complications of liver abscesses,offering insights into their pathogenesis,diagnosis,and management strategies.

关键词： Liver abscess Pylephlebitis Venous thrombosis Pseudoaneurysm Portal cavernoma Inferior vena cava obstruction

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Analysis and design of open trench barriers in screening steady-state surface vibrations

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Earthquake Engineering and Engineering Vibration 2014年第3期13卷 545-554页

作者： Ankurjyoti Saikia utpal Kumar Das Department of Civil Engineering Tezpur University

The problem of vibration isolation by rectangular open trenches in a plane strain context is numerically studied using a finite element code, PLAXIS. The soil media is assumed to be linear elastic, isotropic, and homogeneous subjected to a vertical harmonic load producing steady-state vibration. The present model is validated by comparing it with previously published works. The key geometrical features of a trench, i.e., its depth, width, and distance from the source of excitation, are normalized with respect to the Rayleigh wavelength. The attenuation of vertical and horizontal components of vibration is studied for various trench dimensions against trench locations varied from an active to a passive case. Results are depicted in non-dimensional forms and conclusions are drawn regarding the effects of geometrical parameters in attenuating vertical and horizontal vibration components. The screening efficiency is primarily governed by the normalized depth of the barrier. The effect of width has little significance except in some specific cases. Simplified regression models are developed to estimate average amplitude reduction factors. The models applicable to vertical vibration cases are found to be in excellent agreement with previously published results.

关键词： finite element open trench vibration isolation wave barrier non-dimensional

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Adsorption of Hydrazoic Acid on Pristine Graphyne Sheet： A Computational Study

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物理化学学报 2018年第5期34卷 537-542页

作者： DEB Jyotirmoy PAUL Debolina PEGU David SARKAR utpal Department of Physics Assam University Silchar-788011 India.

Herein we have investigated the interaction between hydrazoic acid(HN3) and a pristine graphyne system based on density functional theory(DFT) method using generalized gradient approximation. The van der Waals dispersion correction is also considered for predicting the possibility of using the graphyne system for detection of hydrazoic acid. Pristine graphyne has a band gap of 0.453 eV, which decreases to 0.424 eV when HN3 is adsorbed on graphyne. The electrical conductivity of HN3-adsorbed graphyne is greater than that of its pristine counterpart. Charge transfer analysis reveals that the HN3-adsorbed graphyne system behaves as an n-type semiconductor; however, its pristine analogue acts as an intrinsic semiconductor. Pristine graphyne has zero dipole moment; however, its interaction with HN3 increases its dipole moment. The electronic properties of graphyne is significantly influenced by the presence of HN3, leading to the possibility of designing graphyne-based sensors for HN3 detection.

关键词：密度泛函理论纯石墨体系电导率半导体

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A Wide Learning Approach for Interpretable Feature Recommendation for 1-D Sensor Data in IoT Analytics

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International Journal of Automation and computing 2019年第6期16卷 800-811页

作者： Snehasis Banerjee Tanushyam Chattopadhyay utpal Garain TCS Research&Innovation Tata Consultancy ServicesEcospaceKolkata 700160India Computer Vision&Pattern Recognition Unit Indian Statistical Institute203 B.T.RoadKolkata 700108India

This paper presents a state of the art machine learning-based approach for automation of a varied class of Internet of things(Io T) analytics problems targeted on 1-dimensional(1-D) sensor data. As feature recommendation is a major bottleneck for general Io Tbased applications, this paper shows how this step can be successfully automated based on a Wide Learning architecture without sacrificing the decision-making accuracy, and thereby reducing the development time and the cost of hiring expensive resources for specific problems. Interpretation of meaningful features is another contribution of this research. Several data sets from different real-world applications are considered to realize the proof-of-concept. Results show that the interpretable feature recommendation techniques are quite effective for the problems at hand in terms of performance and drastic reduction in development time.

关键词： Feature engineering sensor data analysis Internet of things(IoT)analytics interpretable learning automation

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Groundwater solute chemistry,hydrogeochemical processes and fluoride contamination in phreatic aquifer of Odisha,India

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Geoscience Frontiers 2021年第3期12卷 234-248页

作者： Sudarsan Sahu utpal Gogoi N.C.Nayak Central Ground Water Board SERBhujal BhawanBhubaneswarOdishaIndia

The work investigates the major solute chemistry of groundwater and fluoride enrichment(F^(-))in the shallow phreatic aquifer of *** study also interprets the hydrogeochemical processes of solute acquisition and the genetic behavior of groundwater F^(-)contamination.A total of 1105 groundwater samples collected from across the state from different hydro-geomorphic settings have been analyzed for the major solutes and F^(-) *** is alkaline in nature(range of pH:6.6-8.7;ave.:7.9)predominated by moderately hard to very hard *** cation and anion chemistry stand in the orders of Ca^(2+)>Na^(+)>Mg^(2+)>K^(+) and HCO_(3)^(-)>Cl^(-)>SO_(4)^(2-)>CO_(3)^(2-) *** average mineralization is low(319 mg/L).The primary water types are Ca-Mg-HCO_(3) and Ca-Mg-Cl^(-)HCO_(3),followed by Na-Cl,Ca-Mg-Cl,and Na-Ca-Mg-HCO_(3)^(-)***-halite dissolution and reverse ion exchange are the significant processes of solute *** the geogenic as well as the anthropogenic sources contribute to the groundwater fluoride contamination,*** ratio of Na^(+)/Ca^(2+)>1.0 comprises Na-HCO_(3)(Cl)water types with F^(-)>1.0 mg/L(range 1.0-3.5 mg/L)where the F^(-)bears geogenic *** relations exist between F^(-)and pH,Na^(+),TDS,and HCO_(3)^(-).It also reflects a perfect Na-TDS correlation(0.85).The ratio of Na^(+)/Ca^(2+)<1.0 segregates the sample population(F^(-)range:1.0-4.0 mg/L)with the F derived from anthropogenic *** water types include Ca-Mg-HCO_(3)(Cl)varieties which are recently recharged meteoritic water *** F^(-) levels exhibit poor and negative correlations with the solutes in *** Na-TDS relation remains poor(0.12).In contrast,the TDS levels show strong correlations with Ca^(2+)(0.91),Mg^(2+)(0.80)and even Cl^(-)(0.91).The majority of the monitoring points with the anthropogenic sources of groundwater F^(-) are clustered in the Hirakud Canal Command area in the western parts of the state,indi

关键词： Groundwater Phreatic Aquifer Quality Odisha India

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Soil texture classification using multi class support vector machine

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Information Processing in Agriculture 2020年第2期7卷 318-332页

作者： utpal Barman Ridip Dev Choudhury Department of IT Gauhati UniversityGuwahatiAssamIndia Department of Computer Science IDOLGauhati UniversityGuwahatiAssamIndia

The objective of this study is to process the soil images to generate a digital soil classification system for rural farmers at low *** texture is the main factor to be considered before doing *** affects the crop selection and regulates the water transmission *** conventional hydrometer method determines the percentage of sand,silt,and clay present in a soil *** method is very cost and time-consuming *** this approach,we collect 50 soil samples from the different region of west Guwahati,Assam,*** samples are photographed under a constant light condition using an Android mobile of 13 MP *** fraction of sand,silt,and clay of the soil samples are determined using the hydrometer *** result of the hydrometer test is processed with the United State Department of Agriculture soil classification triangle for the final soil *** images are processed through the different stages like pre-processing of soil images for image enhancement,extracting the region of interest for segmentation and the texture analysis for feature *** feature vector is calculated from the Hue,Saturation,and Value(HSV)histogram,color moments,color auto Correlogram,Gabor wavelets,and discrete wavelet ***,Support Vector Machine classifier is used to classify the soil images using linear *** proposed method gives an average of 91.37%accuracy for all the soil samples and the result is nearly the same with the United State Department of Agriculture soil classification.

关键词： Image processing Soil SVM Classification

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Non-alcoholic Fatty Liver Disease:Growing Burden, Adverse Outcomes and Associations

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 76-86页

作者： Ramesh Kumar Rajeev Nayan Priyadarshi utpal Anand Department of Gastroenterology All India Institute of Medical SciencesPatnaIndia Department of Radiodiagnosis All India Institute of Medical SciencesPatnaIndia Department of Surgical Gastroenterology All India Institute of Medical SciencesPatnaIndia

Nonalcoholic fatty liver disease(NAFLD)is a systemic disor-der with a complex multifactorial pathogenesis and hetero-genous clinical ***,once believed to be an innocuous condition,has now become the most common cause of chronic liver disease in many countries *** is already highly prevalent in the general population,and owing to a rising incidence of obesity and diabetes mellitus,the incidence of NAFLD and its impact on global healthcare are expected to increase in the future.A subset of patients with NAFLD develops progressive liver disease lead-ing to cirrhosis,hepatocellular carcinoma,and liver *** has emerged as one of the leading causes of cirrhosis and hepatocellular carcinoma in recent ***,HCC can occur in NAFLD even in absence of *** with the general population,NAFLD increases the risk of liver-related,cardiovascular and all-cause *** is bidirectionally associated with metabolic *** increases the risk and contributes to aggravation of the pathophysiology of atherosclerosis,cardiovascular diseases,diabetes mellitus,and chronic kidney *** addition,NAFLD is linked to colorectal polyps,polycystic ovarian syndrome,osteoporosis,obstructive sleep apnea,stroke,and various extrahepatic *** resection of steatotic liver is associated with increased risk of liver failure and *** is an increasing trend of NAFLD-related cirrhosis requiring liver transplantation,and the recurrence of NAFLD in such patients is almost *** review discusses the growing burden of NAFLD,its outcomes,and adverse associations with various diseases.

关键词： NAFLD NASH Metabolic Outcome Association

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Chronic renal dysfunction in cirrhosis:A new frontier in hepatology

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World Journal of Gastroenterology 2021年第11期27卷 990-1005页

作者： Ramesh Kumar Rajeev Nayan Priyadarshi utpal Anand Department of Gastroenterology All India Institute of Medical SciencesPatna 801507BiharIndia Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507BiharIndia Department of Surgical Gastroenterology All India Institute of Medical SciencesPatna 801507BiharIndia

Chronic kidney disease(CKD)in patients with liver cirrhosis has become a new frontier in *** recent years,a sharp increase in the diagnosis of CKD has been observed among patients with *** rising prevalence of risk factors,such as diabetes,hypertension and nonalcoholic fatty liver disease,appears to have contributed significantly to the high prevalence of ***,the diagnosis of CKD in cirrhosis is now based on a reduction in the estimated glomerular filtration rate of<60 mL/min over more than 3 *** definition has resulted in a better differentiation of CKD from acute kidney injury(AKI),leading to its greater *** has also been noted that a significant proportion of AKI transforms into CKD in patients with decompensated *** in cirrhosis can be structural CKD due to kidney injury or functional CKD secondary to circulatory and neurohormonal *** available literature on combined cirrhosis-CKD is extremely limited,as most attempts to assess renal dysfunction in cirrhosis have so far concentrated on *** to problems related to glomerular filtration rate estimation in cirrhosis,the absence of reliable biomarkers of CKD and technical difficulties in performing renal biopsy in advanced cirrhosis,CKD in cirrhosis can present many challenges for *** combined hepatorenal dysfunctions,fluid mobilization becomes problematic,and there may be difficulties with drug tolerance,hemodialysis and decision-making regarding the need for liver vs simultaneous liver and kidney *** paper offers a thorough overview of the increasingly known CKD in patients with cirrhosis,with clinical consequences and difficulties occurring in the diagnosis and treatment of such patients.

关键词： Acute kidney injury Cirrhosis Chronic kidney disease Renal failure Hepatorenal syndrome Renal function

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