Non-alcoholic Fatty Liver Disease:Growing Burden, Adverse Outcomes and Associations

作     者：Ramesh Kumar Rajeev Nayan Priyadarshi Utpal Anand Ramesh Kumar;Rajeev Nayan Priyadarshi;Utpal Anand

作者机构：Department of GastroenterologyAll India Institute of Medical SciencesPatnaIndia Department of RadiodiagnosisAll India Institute of Medical SciencesPatnaIndia Department of Surgical GastroenterologyAll India Institute of Medical SciencesPatnaIndia 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2020年第8卷第1期

页      面：76-86页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：NAFLD NASH Metabolic Outcome Association 

摘      要：Nonalcoholic fatty liver disease(NAFLD)is a systemic disor-der with a complex multifactorial pathogenesis and hetero-genous clinical ***,once believed to be an innocuous condition,has now become the most common cause of chronic liver disease in many countries *** is already highly prevalent in the general population,and owing to a rising incidence of obesity and diabetes mellitus,the incidence of NAFLD and its impact on global healthcare are expected to increase in the future.A subset of patients with NAFLD develops progressive liver disease lead-ing to cirrhosis,hepatocellular carcinoma,and liver *** has emerged as one of the leading causes of cirrhosis and hepatocellular carcinoma in recent ***,HCC can occur in NAFLD even in absence of *** with the general population,NAFLD increases the risk of liver-related,cardiovascular and all-cause *** is bidirectionally associated with metabolic *** increases the risk and contributes to aggravation of the pathophysiology of atherosclerosis,cardiovascular diseases,diabetes mellitus,and chronic kidney *** addition,NAFLD is linked to colorectal polyps,polycystic ovarian syndrome,osteoporosis,obstructive sleep apnea,stroke,and various extrahepatic *** resection of steatotic liver is associated with increased risk of liver failure and *** is an increasing trend of NAFLD-related cirrhosis requiring liver transplantation,and the recurrence of NAFLD in such patients is almost *** review discusses the growing burden of NAFLD,its outcomes,and adverse associations with various diseases.