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Link between irritable bowel syndrome,depression,and colorectal cancer risk in young patients:Age-matched nationwide populationbased study

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World Journal of Gastrointestinal Pathophysiology 2024年第3期15卷 1-8页

作者： Sai Priyanka Mellacheruvu Sai Prasanna Lekkala Sukhjinder Chauhan Adil Sarvar Mohammed Sravya R Mundla Ankita Shenoy Bilal Khan Mohammed Jerrin Bawa Shantha Nallapothula Priyatham Gurram Akhil jain Rupak Desai Mohammed Mustafa Nayeem Department of Public Health University of MassachusettsLowellMA 01854United States Department of Internal Medicine Mamata Medical CollegeTelanganaKhammam 507002India Department of Internal Medicine Mountainview HospitalLas VegasNV 89128United States Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48602United States Department of Public Health Apollo Institute of Medical Sciences and ResearchTelanganaHyderabad 500090India Department of Medicine Dr D.Y.Patil University School of MedicineMaharashtraNavi Mumbai 400706India Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Internal Medicine Flushing Hospital Medical CenterQueensNY 11355United States Department of Internal Medicine PES Institute of Medical Sciences and ResearchAndhra PradeshKuppam 517425India Department of Gastroenterology Mayo ClinicScottsdaleAZ 85259United States Division of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77079United States Independent Researcher AtlantaGA 30079United States Department of Internal Medicine Parkview Medical CenterPuebloCO 81003United States

BACKGROUND There exists a link between irritable bowel syndrome(IBS)and ***,chronic depression is known to increase the risk of cancer in *** this population-based analysis,we investigated the prevalence and the odds of colorectal cancer(CRC)in young-depressed patients with *** To investigate the relationship between IBS and CRC in young,depressed patients using a nationally representative United States inpatient *** The 2019 National Inpatient Sample was used to identify young(18-44 years)patients admitted with comorbid depression in the presence vs absence of IBS using relevant International Classification of Diseases,Tenth Revision,Clinical Modification *** endpoint was the prevalence and odds of CRC in age matched(1:1)youngdepressed cohort hospitalized with IBS(IBS+)vs without IBS(IBS-).Multivariable regression analysis was performed adjusting for potential *** Age-matched(1:1)young-depressed IBS+(83.9%females,median age 36 years)and IBS-(65.8%females,median age 36 years)cohorts consisted of 14370 patients in each ***+cohort had higher rates of hypertension,uncomplicated diabetes,hyperlipidemia,obesity,peripheral vascular disease,chronic obstructive pulmonary disease,hypothyroidism,prior stroke,prior venous thromboembolism,anxiety,bipolar disorder,and borderline personality disorder(P<0.005)vs the ***,prior myocardial infarction,acquired immunodeficiency syndrome,dementia,smoking,alcohol abuse,and drug abuse(P<0.005)are high in *** rate of CRC was comparable in both cohorts[IBS+n=25(0.17%)vs IBS-n=35(0.24%)].Compared to the IBS-cohort,the odds ratio(OR)of developing CRC was not significantly higher[OR 0.71,95% confidence interval(CI)0.23-2.25]in IBS+***,adjusting for baseline sociodemographic and hospital characteristics and relevant comorbidities,the OR was found to be non-significant(OR 0.89,95%CI 0.21-3.83).CONCLUSION This nationwide propensity-matched ana

关键词： Colorectal cancer Depression Irritable bowel syndrome Young patients National inpatient sample Comorbidities

Ten mg dexrabeprazole daily is as effective as 20 mg dexrabeprazole daily

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World Journal of Gastroenterology 2008年第28期14卷 4586-4587页

作者： Rajendra Kanakia Suresh jain Gastroenterologist & Hepatologist Kanakia Healthcare & Digestive Health CentreMumbai-400014India Digestive Endoscopy Clinic & A Day Care Center Pune 411001India

Ten mg dexrabeprazole daily has been shown to be more effective than 20 mg rabeprazole daily against gastroesophageal reflux disease (GERD). This report shows that the efficacy of 10 mg dexrabeprazole daily is equivalent to that of 20 mg dexrabeprazole daily against GERD. This implies that a dose of 10 mg dexra- beprazole is sufficient to block the maximum amount of proton pumps without any need to double the dose as suggested with rabeprazole.

关键词： Dexrabeprazole Rabeprazole Gastroesophageal reflux disease

The effect of side walls on particles mixing in rotating drums

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Particuology 2023年第1期72卷 112-121页

作者： Aman jain Fabien Evrard Berend van Wachem Chair of Mechanical Process Engineering Otto-von-Guericke-University MagdeburgUniversitaetsplatz 2Magdeburg 39106Germany

In this paper, we study the effects of the presence and shape of side walls and of the overall length of rotating cylindrical drums on the mixing of particles with differing sizes by application of the discrete element method (DEM). By varying the semi-axis of the spheroidally shaped side walls and the length of the overall drum, we observe the formation of circulation patterns near the side walls. Although there is a vast amount of literature studying mixing regimes in rotating drums, little is known about the effect of the side walls of the drum on particle mixing. The results of our study demonstrate that introducing curved side walls induces a strong circulation pattern near these side walls, but has, paradoxically, a negative impact on mixing and actually promotes segregation. The cause for this segregation is the difference in velocity of differently sized particles near the curved side walls. Large particles accumulate at the curved side walls, whereas small particles move away from the curved side walls. When the length of the drum is increased, the overall effect of the side walls is decreased, although it does remain observable, even in very large drums.

关键词： Discrete element method Rotating drums Particle mixing Side walls of rotating drums

Occult hepatitis C virus infection is more common than hepatitis B infection in maintenance hemodialysis patients

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World Journal of Gastroenterology 2008年第14期14卷 2288-2289页

作者： Pankaj jain Sandeep Nijhawan Department of Gastroenterology SMS Medical College Jaipur 302004 India

Patients of end stage renal disease on maintenance hemodialysis were enrolled to study the prevalence of occult and dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and non-occult hepatitis B and C virus infection. One hundred and two patients were enrolled. Thirty patients had HCV infection, three of them were positive in anti-HCV. So, 27 (90%) of HCV-positive patients had occult HCV infection. Eleven (11%) patients had HBV infection. Five patients were positive in anti-HBc or HBV-DNA, but negative in HBsAg (occult HBV infection). Three (3%) patients had dual HBV and HCV infection. None of the patients showed changes in viral markers during the follow-up of 8 mo on average (1-12 mo).

关键词： Occult hepatitis C Hepatitis B Maintenance hemodialysis

Parameters influencing the optical properties of SnS thin films

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Journal of Semiconductors 2013年第9期34卷 26-31页

作者： Priyal jain P.Arun Department of Electronic Science University of Delhi-South CampusBenito Juarez MargDelhi 110021India Material Science Research Lab S.G.T.B.Khalsa College University of DelhiDelhi 110007 India

Tin sulphide （SnS） thin films have been recognized as a potential candidate for solar cells. Many fab- rication techniques have been used to grow SnS thin films. The band-gap, Eg of SnS films as reported in litera ture, were found to vary from 1.2-2.5 eV depending on the film fabrication technique. The present work reports the structural, compositional, morphological and optical characterization of SnS thin films fabricated by thermal evaporation at room temperature. Results show that for the given fabrication technique/condition, the band-gap functionally depends on the lattice parameter and grain size. The well-defined variation allows for tailoring SnS film as per requirements.

关键词： nano-composites nanostructures photoluminescence oxides

Full-Duplex Cooperative Relaying with Non-Linear Energy Harvesting for Vehicular Communication

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Journal of Communications and Information Networks 2023年第4期8卷 369-377页

作者： Vaijayanti Panse Tapan Kumar jain Indian Institute of Information Technology Nagpur441108India

This paper analyses the performance of fullduplex(FD)dual-hop vehicular cooperative network with decode-and-forward(DF)*** FD relay nodes,we examine the effects of non-linear hybrid power time splitting(PTS)based energy harvesting(EH).All three nodes—source(S),relay(R),and destination(D)are assumed to be moving *** expressions for the system's outage probability(OP)over double(cascaded)Rayleigh fading channels are *** also analyse the impact of residual self-interference(RSI)caused at FD relay on system's *** compare the performance of system with two relay selection techniques,namely,maximum channel gain-based(Max-G)relay selection and minimum RSI-based(Min-SI)relay *** paper considers the joint effect of time splitting ratio and self-interference cancellation(SIC)level to find the optimum EH ***,the effect of time splitting ratio and average signal-to-noise ratio(SNR)on outage and throughput performance of the system are also investigated in this *** derived expressions are validated through Monte Carlo simulations.

关键词： Cooperative communication vehicular networks energy harvesting full-duplex outage probability

Inhibition and attenuation of pathogenicity of Porphyromonas gingivalis by leupeptin： A review

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Frontiers in Biology 2017年第3期12卷 192-198页

作者： Hansa jain Harsarn Dass Dental College India

BACKGROUND： Porphyromonas gingivalis is a periodontal pathogen, which is considered to be a keystone pathogen for periodontitis. A diverse conglomerate of P. gingivalis virulence factors including lipopolysaccharide, fimbriae, capsular polysaccharide, haemagglutinin and cysteine proteases （Arg-gingipains and Lys-gingipain） are considered to be involved in the pathogenesis ofperiodontitis. Leupeptin is a cysteine protease inhibitor which is specific for Arg gingipains. The present review focuses on action of leupeptin on Arg gingipains. METHOD： A search was carried out systematically from the start till September, 2016. The search was made in Medline database via PubMed. The keywords enlisted were ＂leupeptin＂; ＂gingipains＂; ＂periodontitis＂ using Boolean operator ＂and.＂ RESULTS： The result was selection of 58 articles which linked leupeptin to periodontitis and gingipains; pathogenesis of periodontitis, pathogenicity of gingipains and role of leupeptin. CONCLUSION： It was concluded that leupeptin inhibits and attenuates a number of destructive activities of Arg gingipains including inhibition ofplatelet aggregation; inhibit degradation of LL-37, which is an antimicrobial peptide; blocking inhibition ofmonocyte chemoattractant protein; restoring level ofinterleukin-2; inhibiting degradation of collagen type I and IV to name a few.

关键词： Porphyromonas gingivalis gingipains leupeptin cysteine protease inhibitor periodontitis

Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents

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Journal of Pharmaceutical Analysis 2020年第1期10卷 1-12页

作者： Swati Chauhan Neha jain Upendra Nagaich Department of Pharmaceutics Amity Institute of PharmacyAmity UniversityNoidaU.P.India

Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical *** are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical ***,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with *** modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface *** take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological *** review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of *** the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces.

关键词： Nanomedicine Biochemical application Diamondoids Surface functionalization Drug targeting

Cationic antimicrobial peptide： LL-37 and its role in periodontitis

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Frontiers in Biology 2017年第2期12卷 116-123页

作者： Hansa jain Department of Pedodontics Harsarn Dass Dental College India

BACKGROUND： Periodomitis i.e. inflammation of the periodontium is a multifactorial disease. Antimicrobial peptides （AMPs） which demonstrate a broad-spectrum of activity against varied number of bacteria, fungi, viruses, and parasites, and cancerous cells have been linked to periodontitis. The AMPs even possess the caliber of immunomodulation, and are significantly responsive to innate immuno-stimulation and infections. LL-37 plays a salubrious role by preventing and in treatment of chronic forms of periodontitis. OBJECTIVE： In the present work we will review the role of antimicrobial peptide LL-37 in periodontitis. METHODS： A systematic search was carried out from the beginning till August, 2016 using the Pubmed search engine. The keywords included ＂LL-37,＂＂periodontitis,＂＂Papillon-Lefevre syndrome,＂＂Morbus Kostmann,＂＂Haim-Munk syndrome＂ along with use of Boolean operator ＂and.＂ RESULTS： The search resulted in identifying 67 articles which included articles linking LL-37 with periodontitis, articles on Papillon-Lefevre syndrome, Morbus Kostmann, Haim-Munk syndrome, LL-37 and periodontitis and articles on pathogenicity of periodontitis. CONCLUSION： The literature search concluded that LL-37 plays a pivotal role in preventing and treatment of severe form of periodontitis.

关键词： LL-37 antimicrobial peptides cathelicidin periodontitis