Prediction of significant hyperbilirubinemia in term neonates by early non-invasive bilirubin measurement

作     者：Manish Jain Akash Bang Anju Tiwari Shuchi Jain 

作者机构：Department of PediatricsMGIMSSevagramWardha MaharashtraIndia Department of Obstetrics&GynecologyMGIMSSevagramWardha MaharashtraIndia 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2017年第13卷第3期

页      面：222-227页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：hyperbilirubinemia neonate transcutaneous bilirubin 

摘      要：Background:Neonatal jaundice is a common *** evaluated the utility and best cut-off values of 24-and 48-hour transcutaneous bilirubin indices (TcBI) in predicting subsequent significant hyperbilirubinemia and evaluated various associated maternal and fetal risk ***:TcBI at 24 and 48 hours and serum bilirubin levels at 72 hours of age were obtained for healthy,term,appropriate for gestational age *** with prematurity,birth weight 17 mg/dL after 72 hours of life and various cut-offs,and were evaluated by calculating sensitivity,specificity and predictive ***:Of 500 newborns,4.6% had significant hyperbilirubinemia,27% had TcBI (mg/dL) 5 at 24 hours,and 27.4% had TeBI 8 at 48 *** of them had subsequent hyperbilirubinemia (100% negative predictive value).The percentage of newborns with subsequent hyperbilirubinemia increased from 3.4% to 13.2% as their 24-hour TcBI increased from 6 to above 9 mg/dL and from 4.2% to 7.4% as their 48-hour TcBI increased from 8 to above 11 mg/*** best cut-off value was TcBI (mg/dL) 7 (odd ratio=4.86,95% confidence interval:1.66-15.22) at 24 hours and 10 (odd ratio=2.87,95% confidence interval:1.04-8.29) at 48 *** under the receiver operating characteristic curve for 24-and 48-hour measurements was 0.750 and 0.715,*** premature rupture of membranes,deep transverse arrest,post-date pregnancy,and fetal distress were significant risk factors for ***:Twenty-four and 48-hour TcB indices are good predictors of subsequent ***-four-hour TcBI had better predictive abili