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Evaluation of the anti-inflammatory activity of extract of Vernonia Amygdalina

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 150-151页

作者： Georgewill oa Georgewill UO Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesUniversity of Port Harcourt

Objective:To investigate the anti-inflammatory activity of the extract of Vernonia amygdalina (V.A).Methods:Inflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat *** 6 hrs,cutting out the ear quantitated the *** cut ear was weighed and the increase in weight relative to control group was ***:When co-applied with croton oil to the rat ear extract of *** a reduction in the inflammatory response when croton oil alone was applied to the rat *** extract produced(69.1 +2.0)%reduction of the inflammatory response produced by croton oil alone,lower than the reduction of the inflammatory response produced by acetyl salicylic acid[(71.1±2.0)%].Conclusions:This finding suggests that extract of *** antiinflammatory activity and may explain the usefulness of the leaves of this plant in the treatment of inflammatory disease conditions by traditional healers.

关键词： Inflammatory response Groton oil Acetyl salicylic acid Vernonia amygdalina

Pattern of intestinal helminth infections among school children in an urban community in Ibadan,Nigeria

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Asian Pacific Journal of Tropical Medicine 2008年第3期1卷 42-47页

作者： Fatiregun AA Oluwatoba oa Department of Epidemiology Medical Statistics and Environmental HealthFaculty of Public HealthCollege of MedicineUniversity of IbadanIbadanNigeria

Despite a substantial reduction in the incidence and prevalence of parasitic diseases in the industrialized world, they continue to be an important public health problem in many developing African countries,including Nigeria. However,estimates of the prevalence of such infections among school age children,who bear the greatest health burden due to these diseases,are hard to come *** objective of this study was therefore to determine the prevalence and type of intestinal helminth infections among primary school *** study was cross-sectional in *** participants included 266 pupils recruited from three government primary schools in the Mokola area of Ibadan,*** pupils were interviewed and their stool samples examined for eggs of common *** mean age of the pupils was 9.8±2.6 years,and 128(48.1%) were *** pupils(7.1%) had intestinal helminth *** lumbricoides was found in 17 pupils(6. 4%) and was the most prevalent helminth among the children,while Trichuris trichiura was found in only two subjects(0.8%).Previous infestations and the use of public toilets were found to be significantly associated with current infections(P<0.05).This study demonstrated that the prevalence of intestinal infections was low among the pupils studied,and that Ascaris infection was the commonest infestation.

关键词： prevalence intestinal helminths school children

The extract of Mucuna pruriens possesses histamine activity

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 29-31页

作者： Reginald NP Nwankwoala Georgewill oa Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesUniversity of Port Harcourt

Objective:To investigate the activity of the active principle in the spines of the seed pods of Mucuna pruriens using contraction of guinea pig ileum as index of pharmacological activity. Methods:The active principle was extracted with 0.0015 M *** strips of guinea pig ileum were prepared and contractile responses were measured using a *** sets of experiment were conducted:（1）.The contraction of the ileum in presence of different concentrations of histamine,2-methylhistamine and the extract of Mucuna pruriens.（2）.The contractile response of the ileum in presence of different concentrations of the extract and antagonists including diphenhydramine,atropine and ***:（1） The extract of Mucuna pruriens hair, 2- methylhistamine and histamine produced dose dependent contraction of guinea pig ileum (Extract ED50 = 13.0μg/mL,2-methylhistamine ED50=8.5μg/mL and histamine ED50=10.0μg/ mL).（2） Diphenhydramine,an H,antagonist competitively blocked the contractile response of the Mucuna pruriens extract（3） Coadminstration of the Mucuna pruriens extract either with different doses of antimuscarinic agent atropine or 5-hydroxytryptamine blocking agent methysergide did not alter the extract induced contractile response of the guinea pig ***:These results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects.

关键词： Mucuna pruriens Histamine activity Itching Irritation

Antiarthritic activity of Vernonia amygdalina in albino rats

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Asian Pacific Journal of Tropical Medicine 2009年第5期2卷 58-60页

作者： Georgewill oa Georgewill UO Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesCollege of Health SciencesUniversity of Port HarcourtChobaNigeria

Objective:To evaluate the antiarthritic activity of water extract of leaves of Vernonia amygdalina(V.A.) on arthritis induced model of ***:Arthritis was induced in male albino Wister rats by injection of croton oil(0.1 mL) into the left foot pad of the *** with *** 200 and 400 mg/kg and standard Indomethacin(0.3 mg/kg) was started on the same day and continued up to the 12th *** paw volume was measured on the 1st,5th,12th and 21st day,respectively for both the paws and anti-arthritic activity was ***:The extract of *** reduction in the inflammation of the paw due to croton *** antiarthritic action started on the 5th day and continued till the 12th day and the activity was comparable to that of the standard on both *** inhibited adjuvant induced arthritis and had significant ant-inflammatory effect(P<0.05).Conclusion:This report therefore clearly showed that *** inhibited adjuvant induced arthritis in rats as it significantly reduced the paw volume on the 12th day and may explain the effectiveness of this plant when used in the tropics for the treatment of arthritis.

关键词： Vernonia amygdalina Antiarthritic effect Croton oil

Effect of extract of Abrus precatorius on blood glucose concentration of alloxan induced diabetic Albino Wistar Rats

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 16-17页

作者： Georgewill oa Georgewill UO Department of Pharmacology and Toxicology

Objective:To evaluate the effect of extract of Abrus precatorius on blood glucose of alloxan induced albino wistar ***:Experimental animals received daily oral administration of extract of Abrus precatorius for 14 *** effect of 200 mg/kg dose was studied during the treatment ***:There was a significant reduction in blood glucose concentration(P < 0.05) with the mean blood glucose of the different groups as 5.0±0.3 for normal control,7.0±0.4 for diabetic control group and 4.0±0.2 for diabetic treated group. Conclusion:The findings of this study suggest that extract of Abrus precatorius has hypoglycemic effect.

关键词： Abrus precatorius Hypoglycemia Diabetes Hyperglycemia

Anti-inflammatory effects of Morninga oleifera lam extract in rats

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 133-135页

作者： Georgewill oa Georgewill UO Nwankwoala RNP Department of Pharmacology College of Health SciencesUniversity of Port Harcourt

Objective:To investigate the acute and delayed anti-inflammatory effects of Morning oleifera lam（MOL） crude methanolic ***:Compared the anti-inflammatory effects of MOL with that of standard anti-inflammatory agents like indomethacin and hydrocortisone using Air Pouch ***:In both acute and delayed inflammation,the MOL extract produced dose dependent anti-inflammatory effect[acute IC50=（399.30±5.43） mg/kg;delayed IC50=（510.26±4.53） mg/kg].The order of anti-inflammatory potency for the three drugs was hydrocortisone> indomethacin > ***:These observations indicate that MOL possesses potential anti-inflammatory property.

关键词： Extract Moringa oleifera lam Anti-nflammatory,indomethacin Hydrocortisone

Aspergillus gaarensis,a new addition to section Circumdati from soil of Lake El-Gaar in Wadi-El-Natron,Egypt

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Studies in Fungi 2020年第1期5卷 59-65页

作者： Al-Bedak oa Moubasher AH Assiut University Mycological Centre(AUMC) Assiut UniversityAssiut 71511Egypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

In the present study,a novel fungus belonging to the genus Aspergillus section Circumdati was isolated from a cultivated soil sample close to El-Gaar lake in Wadi-El-Natron region,*** of the internal transcribed spacer(ITS)gene of its DNA showed that the isolate differs from all known Aspergillus species in section *** novel Aspergillus species is described here as Aspergillus *** characteristics and molecular data were applied to determine its novel taxonomic *** macro and micro characteristics of the novel species are presented in the current study.

关键词： ITS new taxon phylogeny saline

Paracremonium moubasheri,a new species from an alkaline sediment of Lake Hamra in Wadi-El-Natron,Egypt with a key to the accepted species

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Studies in Fungi 2019年第1期4卷 216-222页

作者： Al-Bedak oa Ismail MA Mohamed RA Assiut University Mycological Centre(AUMC) Assiut UniversityAssiutEgypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

During surveys of extremophilic fungi in hypersaline,alkaline lakes of Wadi-El-Natron,Egypt,an interesting fungus was recovered from a mud sample collected from Lake Hamra in Wadi-El-Natron,*** likelihood analysis of Internal Transcribed Spacer(ITS)gene along with morphological comparisons of related taxa revealed a novel taxon,Paracremonium moubasheri which is described and illustrated in the current *** moubasheri can be distinguished from the known species of the genus by its large conidia,in addition to the presence of chlamydospores.

关键词： Acremonium-like Hypersaline Hypocreales new taxon Phylogeny

The use of Phanerochaete chrysosporium,Trichoderma harzianum and Trichoderma viride for biogas production

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Studies in Fungi 2020年第1期5卷 368-380页

作者： Mahmoud YA-G Awadalla oa Estafanous AN Etawy WA Tanta University Faculty of ScienceBotany and Microbiology DepartmentMycology Research Lab.Tanta 31527Egypt Agriculture Microbiology Department SoilWater and Environment Research InstituteAgriculture Research CenterCairoEgypt

The expanding cost of ordinary fuel in urban zones requires the investigation of other vitality *** exploitation of agricultural wastes for biogas production could protect our environment and can also solve emerging energy crises *** chrysosporium,Trichoderma virdie and Trichoderma harzianum were used to ferment rice straw and cattle dung for production of compost and *** yield was determined using displacement technique,using acidified water(1 N H_(2)SO_(4))to prevent solubilization of carbon dioxide contained in the *** results showed that the highest rate of biogas and methane were recorded with treated rice straw mixed with cattle dung where the amount of production from the total gas was 51.84 of biogas and 37.86 of methane per Liter(L)/Kilogram(Kg)of fermented ***,the results showed that the consumed biogas and methane related to volatile solids gave the highest amount with untreated rice straw(86.32 and 56.72 L/Kg respectively)followed by treated rice straw and untreated and treated mixtures of rice straw and cattle dung *** results also showed that the highest bacterial count was obtained from fungi treated rice straw mixed with cattle dung(125×10^(3)cells/g)followed by treated rice straw(32×10^(3)cells/g).This study confirms that ***,*** and *** significantly speed up the process of aerobic and anaerobic fermentation of rice straw in respect to biogas and methane production.

关键词： Aerobic fermentation Anaerobic fermentation Methane Rice straw