Antiarthritic activity of Vernonia amygdalina in albino rats

作     者：Georgewill OA Georgewill UO 

作者机构：Department of Pharmacology and ToxicologyFaculty of Basic Medical SciencesCollege of Health SciencesUniversity of Port HarcourtChobaNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2009年第2卷第5期

页      面：58-60页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Vernonia amygdalina Antiarthritic effect Croton oil 

摘      要：Objective:To evaluate the antiarthritic activity of water extract of leaves of Vernonia amygdalina(V.A.) on arthritis induced model of ***:Arthritis was induced in male albino Wister rats by injection of croton oil(0.1 mL) into the left foot pad of the *** with *** 200 and 400 mg/kg and standard Indomethacin(0.3 mg/kg) was started on the same day and continued up to the 12th *** paw volume was measured on the 1st,5th,12th and 21st day,respectively for both the paws and anti-arthritic activity was ***:The extract of *** reduction in the inflammation of the paw due to croton *** antiarthritic action started on the 5th day and continued till the 12th day and the activity was comparable to that of the standard on both *** inhibited adjuvant induced arthritis and had significant ant-inflammatory effect(P0.05).Conclusion:This report therefore clearly showed that *** inhibited adjuvant induced arthritis in rats as it significantly reduced the paw volume on the 12th day and may explain the effectiveness of this plant when used in the tropics for the treatment of arthritis.