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HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site

Journal of Clinical and Translational Hepatology 2021年第3期9卷 399-408页

作者： Dake Zhang Ke Zhang urlike protzer Changqing Zeng Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina SCG Cell Therapy Pte.Ltd Singapore Institute of Virology Technical University of Munich/Helmholtz Zentrum MünchenMunichGermany German Center for Infection Research(DZIF) MunichGermany Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina

Hepatitis B virus(HBV),one of the well-known DNA oncogenic viruses,is the leading cause of hepatocellular carcinoma(HCC).In infected hepatocytes,HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing *** of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying ***,the quantity and biological activity of integration sites may reflect the DNA damage within affected cells or the potential survival benefits they may *** wellknown human genomic features include repeat elements,particular regions(such as telomeres),and frequently interrupted genes(e.g.,telomerase reverse transcriptase[***],lysine methyltransferase 2B[***2B],cyclin E1[CCNE1],and cyclin A2[CCNA2]).Consequently,distinct genomic features within diverse integrations differentiate their biological ***,accumulating evidence has shown that viral proteins produced by integrants may cause cell damage even after the suppression of HBV *** integration-derived gene products can also serve as tumor markers,promoting the development of novel therapeutic strategies for *** integrants can be single copy or multiple copies of different fragments with complicated rearrangement,which warrants elucidation of the whole viral integrant arrangement in future *** of these considerations underlie an urgent need to develop novel methodology and technology for sequence characterization and function evaluation of integration events in chronic hepatitis B-associated disease progression by monitoring both host genomic features and viral *** endeavor may also serve as a promising solution for evaluating the risk of tumorigenesis and as a companion diagnostic for designing therapeutic strategies targeting integration-related disease complications.

关键词： Double-strand break Chimeric reads Junction reads Fusion transcript Virus cellular junction Virus cell junction Virus host junction

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Innate immune recognition and modulation in hepatitis D virus infection

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World Journal of Gastroenterology 2020年第21期26卷 2781-2791页

作者： Stephanie Jung Sebastian Maximilian Altstetter Ulrike protzer Institute of Virology Technical University of Munich/Helmholtz Zentrum MünchenMunich D-81675Germany German Center for Infection Research(DZIF) Munich Partner SiteMunich D-81675Germany

Hepatitis D virus(HDV)is a global health threat with more than 15 million humans *** treatment options are largely unsatisfactory leaving chronically infected humans at high risk to develop liver cirrhosis and hepatocellular *** is the only human satellite virus *** encodes only two proteins,and requires Hepatitis B virus(HBV)envelope protein expression for productive virion release and spread of the *** HDV could evolve and why HBV was selected as a helper virus remains *** the discovery of Na+-taurocholate co-transporting polypeptide as the essential uptake receptor for HBV and HDV,we are beginning to understand the interactions of HDV and the immune *** HBV is mostly regarded a stealth virus,that escapes innate immune recognition,HBV-HDV coinfection is characterized by a strong innate immune *** RNA sensor melanoma differentiation antigen 5 has been reported to recognize HDV RNA replication and activate innate *** immunity,however,seems not to impair HDV replication while it inhibits *** this review,we describe what is known up-to-date about the interplay between HBV as a helper and HDV’s immune evasion strategy and identify where additional research is required.

关键词： Hepatitis D virus Hepatitis B virus Innate immunity Pathogen-associated molecular pattern molecules Immune evasion Immunosuppression

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