HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site
作者机构：Beijing Advanced Innovation Centre for Biomedical EngineeringKey Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina SCG Cell Therapy Pte.LtdSingapore Institute of VirologyTechnical University of Munich/Helmholtz Zentrum MünchenMunichGermany German Center for Infection Research(DZIF)MunichGermany Key Laboratory of Genomic and Precision MedicineBeijing Institute of GenomicsChinese Academy of SciencesBeijingChina University of Chinese Academy of SciencesBeijingChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2021年第9卷第3期
页 面：399-408页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the 111Project(Project No.:B13003) Innovation Promotion Association CAS(2016098) National Natural Science Foundation of China(81201700)to D.Z
主 题：Double-strand break Chimeric reads Junction reads Fusion transcript Virus cellular junction Virus cell junction Virus host junction
摘 要：Hepatitis B virus(HBV),one of the well-known DNA oncogenic viruses,is the leading cause of hepatocellular carcinoma(HCC).In infected hepatocytes,HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing *** of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying ***,the quantity and biological activity of integration sites may reflect the DNA damage within affected cells or the potential survival benefits they may *** wellknown human genomic features include repeat elements,particular regions(such as telomeres),and frequently interrupted genes(e.g.,telomerase reverse transcriptase[***],lysine methyltransferase 2B[***2B],cyclin E1[CCNE1],and cyclin A2[CCNA2]).Consequently,distinct genomic features within diverse integrations differentiate their biological ***,accumulating evidence has shown that viral proteins produced by integrants may cause cell damage even after the suppression of HBV *** integration-derived gene products can also serve as tumor markers,promoting the development of novel therapeutic strategies for *** integrants can be single copy or multiple copies of different fragments with complicated rearrangement,which warrants elucidation of the whole viral integrant arrangement in future *** of these considerations underlie an urgent need to develop novel methodology and technology for sequence characterization and function evaluation of integration events in chronic hepatitis B-associated disease progression by monitoring both host genomic features and viral *** endeavor may also serve as a promising solution for evaluating the risk of tumorigenesis and as a companion diagnostic for designing therapeutic strategies targeting integration-related disease complications.
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