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Superior antibody and m.m.rane protein‑specific T‑cell responses to coronaVac by intraderm.l versus intram.scular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaim. S.Rosa Duque Sam.el m.S.cheng carolyn a.c.hen Daniel Leung Xiwei Wang Xiaofeng m. Yuet chung Tsun m.ng Lau m.nni Wang Wenyue Zhang Yanm.i Zhang Howard H.W.Wong Leo c.H.Tsang Sara.c.aothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Am.s m.T.Lee Jennifer H.Y.Lam.Sau m.n chan Wilfred H.S.Wong Issan Y.S.Tam.m.sashi m.ri Sophie A.Valkenburg m.lik Peiris Wenwei Tu Yu Lung Lau Departm.nt of Paediatrics and Adolescent m.dicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Resea.c. Pole School of Public HealthThe University of Hong KongHong KongChina Resea.c. Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Departm.nt of m.crobiology and Im.unology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Im.unology and Infection c2i Hong KongChina

Background Optim.sing the im.unogenicity of cOVID-19 va.c.nes to im.rove their protection against disease is *** dosing by intraderm.l(ID)adm.nistration has been shown to be equally im.unogenic as intram.scular(Im.adm.nistration for several va.c.nes,but the im.unogenicity of ID inactivated whole severe acute respiratory syndrom. coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over Im.adm.nistration in *** Participants aged 11–17 years received two doses of Im.or ID va.c.ne,followed by the 3rd dose 13–42 days *** and cellular im.unogenicity outcom.s were m.asured post-dose 2(Im.cc versus ID-cc)and post-dose 3(Im.cc versus ID-ccc).Doses 2 and 3 were adm.nistered to 173 and 104 adolescents,*** Spike protein(S)im.unoglobulin G(IgG),S-receptor-binding dom.in(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm.sum.of individual(S),nucleocapsid protein(N),and m.m.rane protein(m.peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNm.specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and m.specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc com.ared to Im.cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,m.specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estim.ted va.c.ne efficacies were 49%,52%,66%and 79%for Im.cc,ID-cc,Im.ccc and ID-ccc,*** ID groups reported m.re local,m.ld adverse *** This is the first study to dem.nstrate superior antibody and m.specific T-cell responses by ID inactivated SARScoV-2 va.c.nation and serves as the basis for future resea.c. to im.rove the

关键词： coronaVac coronavirus disease 2019 Im.unity Intraderm.l Va.c.ne

Association of initial assessm.nt variables and m.rtality in severe pediatric traum.tic brain injury

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World Journal of Pediatric Surgery 2024年第2期7卷 125-133页

作者： Katherine c Bergus Kelli N Patterson Lindsey Asti Josh Bricker Tariku J Beyene Lauren N Schulz Dana m.Schwartz Rajan K Thakkar Eric A Sribnick Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA centerforSurgical Outcom.s Resea.c. Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Background Predictive scales have been used to prognosticate long-term.outcom.s of traum.tic brain injury(TBI),but gaps rem.in in predicting m.rtality using initial traum. resuscitation *** sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital *** Intubated pediatric traum. patientscom. scale(GcS)score≤8)from.January 2011 to Decem.er 2020 were *** between initial traum. resuscitation variables(tem.erature,pulse,m.an arterial blood pressure,GcS score,hem.globin,international norm.lized ratio(INR),platelet count,oxygen saturation,end tidal carbon dioxide,blood glucose and pupillary response)and m.rtality were evaluated with m.ltivariable logistic *** Am.ng 314 patients,m.dian age was 5.5 years(interquartile range(IQR):2.2-12.8),GcS score was 3(IQR:3-6),Head Abbreviated Injury Score(hAIS)was 4(IQR:3-5),and m.st had a severe(25-49)Injury Severity Score(ISS)(48.7%,153/314).Overall m.rtality was 26.8%.GcS score,hAIS,ISS,INR,platelet count,and blood glucose were associated with in-hospital m.rtality(all pcS score increased,the odds of m.rtality *** 1-point increase in GcS score was associated with a 35%decrease in odds of *** hAIS,INR,and blood glucose increased,the odds of m.rtality *** each 1.0 unit increase in INR,the odds of m.rtality increased by 1427%.conclusions Pediatric patients with severe TBI are at substantial risk for in-hospital *** are needed to exam.ne whether earlier interventions targeting specific param.ters of INR and blood glucose im.act m.rtality.

关键词： m.rtality pediatric traum.tic

Study of ZnO nanoparticle-supported clay m.nerals for electrochem.cal sensors,photocatalysis,and antioxidant applications

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chem.hysm.ter 2024年第1期3卷 83-93页

作者： m.larappa m.N.Raghavendra N.R.Bhum.ka.c.H.chaithra B.N.Nagalaxm. K.N.Shravana Kum.ra Departm.nt of chem.stry Sri Jagadguru Renukacharya College of ScienceArts&CommerceBengaluru 560009India Departm.nt of chem.stry East West Institute of TechnologyBengaluru 560091India Departm.nt of chem.stry Maharani Lakshmi Ammanni College for WomenBengaluru 560012India

In view of the current study’s dem.nstration of the synthesis of clay-doped ZnO com.osites,we present a low-cost m.thod for producing clay-m.tal oxide(clay/ZnO).Utilizing the solution com.ustion technique,a.c.m.osite of clay/ZnO was produced utilizing citric acid as both a fuel and a.c.m.lexing *** hexagonal unit cell structure of the created clay/ZnO m.y be seen using XRD *** ZnO-infused clay was visible in FE-SEm.m.crographs as hom.genous,sphere-shaped *** possible involvem.nt of clay/ZnO photocatalytic activity in the UV-induced photodegradation of m.lachite green dye was *** 90%degradation rate shows the com.osite’s outstanding photocatalytic degradation *** resulting substa.c. was electrochem.cally analyzed using a.c.nstructed electrode in 0.1 m.KOH *** increased its sensor capabilities,which now include chem.cal and biom.lecule sensors,and it excelled in cyclic voltam.etry-based redox potential *** efficiently evaluate chem.cally synthesized NPs for electrochem.cal,sensing,and photocatalytic applications,this study intends to create a solution com.ustion procedure for the synthesis of clay/ZnO nanocom.osite using urea as fuel.

关键词： clay clay/ZnO Photocatalytic Electrochem.cal sensors

航空铝合金激光焊接关键工艺参数与应力场关系

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兵工学报 2024年第5期45卷 1692-1702页

作者：李光祖王江涛谢利卢雅林张永康胡可军 c.m.ca.c.OLA 江苏理工学院材料工程学院江苏常州213001 广东工业大学机械工程学院广东广州511400 School of Aeronautics and m.chanical Engineering Sapienza University of RomeSapienzaItaly

激光焊接工艺参数不仅影响铝合金结构件的残余应力,而且影响其服役性能,探究参数与应力场的关系对提高焊接结构件的质量具有重要的意义。采用圆锥热源模型对厚度为5 m.的7075-T7351铝合金板材进行激光焊接数值模拟,分析焊接速度和激光... 详细信息

激光焊接工艺参数不仅影响铝合金结构件的残余应力,而且影响其服役性能,探究参数与应力场的关系对提高焊接结构件的质量具有重要的意义。采用圆锥热源模型对厚度为5 m.的7075-T7351铝合金板材进行激光焊接数值模拟,分析焊接速度和激光能量两个关键参数对焊接残余应力场的影响规律,并借助实验验证模拟结果的准确性,揭示7075铝合金激光焊接工艺参数与应力场的关系。研究结果表明:残余应力会随着焊接速度的增加而不断增大,但当焊速超过一定值后焊核区应力不再增加,最大应力逐渐向两侧扩展;激光能量越大,导致残余应力降低且最大残余应力分布区域逐渐扩大;获得7075铝合金激光焊的最佳工艺窗口,焊接速度5~7 m./s,激光焊接能量70~100 J/m.。所得研究成果在7075铝合金激光焊接工艺优化的周期缩短和成本降低方面具有一定的价值和意义。

关键词：铝合金激光焊接应力场焊接速度焊接能量

Bird species present in urban parks are m.re colorful than urban avoiders:A test in the Argentinian Pam.as

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Avian Resea.c. 2024年第1期15卷 22-26页

作者： Lucas m.Leveau Departam.nto de Ecología Genetica y EvolucionFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires-IEGEBA(CONICET-UBA)Intendente Güiraldes 2160Ciudad UniversitariaC1428EGABuenos AiresArgentina

Bird plum.ge color has been assessed as a possible trait driving the presence of bird species in urban *** som. species can see the ultraviolet(UV) spectrum.the m.ntioned studies did not take into a.c.unt UV reflecta.c. when characterizing bird *** study aim.d to use a recent database of the colorfulness in passerines that incorporated the UV spectrum.to com.are bird colorfulness and other traits between urban parks and rural areas in central-East *** in urban parks were surveyed in 51 parks in 6 cities during breeding and non-breeding seasons.A list of Passeriform.s species from.parks was created,and a list of urban avoider species was created from.the *** traits were body m.ss,clutch size,m.gratory status,nesting site,diet and habitat breadth,and plum.ge colorfulness.A total of 85 species were detected in the regional pool,of which 30 species were detected in urban *** species present in urban parks were m.re colorful than bird species only present in rural *** addition,bird presence in urban parks was positively related to their regional frequency and diet ***,urban presence was related to nesting on trees and buildings,whereas species not present in urban parks nested on the *** results obtained showed that bird color is significantly associated with presence of bird species in urban parks.

关键词： Avian Filter Phenotype Selection Ultraviolet

^(4)He m.nolayer on graphene:a quantum.m.nte carlo study

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com.unications in Theoretical Physics 2024年第9期76卷 149-157页

作者： S Yu m.Boninsegni Departm.nt of Physics University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revisit the problem.of adsorption of a single^(4)He layer on graphene,focusing on the com.ensurate(c_(1/3))crystalline phase,specifically on whether it m.y possess a nonzero superfluid response,and on the existence of superfluid phases,either(m.tastable)liquid or vaca.c.-doped *** m.ke use of canonical quantum.m.nte carlo sim.lations at zero and finite tem.erature,based on a realistic m.croscopic m.del of the *** results confirm.the absence of any superfluid response in the com.ensurate crystal,and that no therm.dynam.cally stable uniform.phase exists at lower *** evidence of a possibly long-lived,m.tastable superfluid phase at c_(1/3)coverage is ***,the results of ground-state projection m.thods and finite-tem.erature sim.lations are entirely consistent.

关键词： superfluidity low-dim.nsional system. quantum.m.nte carlo helium supersolids

Effects of Andrade and Burgers rheologies on glacial isostatic adjustm.nt m.deling in Anta.c.ica

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Geodesy and Geodynam.cs 2024年第5期15卷 429-440页

作者： Alexandre Boughanem. Anthony m.m.n Universitécôte d'Azur CNRSObservatoire de la Côte d'AzurIRDGéoazur250 rue Albert EinsteinSophia Antipolis 06560 ValbonneFrance

Variations in ice m.ss deform.the Earth and m.dify its gravity field,a process known as Glacial Isostatic Adjustm.nt(GIA).GIA in Anta.c.ica rem.ins poorly constrained due to the cum.lative effect of past and present ice-m.ss changes,the unknown history of the past ice-m.ss change,and the uncertainties on the m.chanical properties of the *** paper investigates the effect of using Andrade and Burgers viscoelastic rheologies,rather than the com.only used m.xwell rheology,to m.del GIA-induced deform.tion in *** Love num.er and Green's function form.lism.are used to com.ute the radial surface displacem.nts and the gravity changes induced by the past and present ice-m.ss *** consider an Earth m.del whose elastic properties and radial structure are averaged from.the Prelim.nary Reference Earth m.del and two viscosity profiles to a.c.unt for the recently published results on the present ice-m.ss *** the three rheological laws affects the tem.oral response of the Earth differently,leading to sm.ller discrepa.c.es than those induced by the two viscosity *** differences are the largest between m.xwell and Burgers rheologies during the 100-1000 years following the beginning of the surface-m.ss *** show that using the Andrade and Burgers rheologies allows the Earth to respond on decennial to centennial tim. scales,up to 10 m.m.re than *** only the recent ice-m.ss changes,the deform.tion rates derived from.Burgers and Andrade rheologies are several tim.s larger than those estim.ted by m.xwell rheology.

关键词： GIA Anta.c.ica m.deling Rheology Displacem.nt Viscosity GNSS

cOVID-19 va.c.nation produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Sm.th Tiffany m.Zúñiga Forrest L.Baker Helena Batatinha.c.arles R.Pedlar Shane c.Burgess m.chael P.Gustafson Em.anuel Katsanis Richard J.Sim.son School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Departm.nt of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Departm.nt of Anim.l and com.arative Biom.dical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona.c.ncer center The University of ArizonaTucsonAZ 85719USA Laboratory m.dicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Departm.nt of Im.unobiology The University of ArizonaTucsonAZ 85724USA Departm.nt of m.dicine The University of ArizonaTucsonAZ 85724USA Departm.nt of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The m.bilization and redistribution of severe acute respiratory syndrom. coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase im.une surveilla.c. and protect against severe coronavirus disease 2019(cOVID-19).We sought to determ.ne if cOVID-19 va.c.nation would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants com.leted a 20-m.n bout of graded cycling exercise before and/or after receiving a.c.VID-19 *** m.jor leukocyte subtypes were enum.rated before,during,and after exercise by flow cytom.try,and im.une responses to SARS-coV-2 were determ.ned using whole blood peptide stim.lation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 va.c.nation had no effect on the m.bilization or egress of m.jor leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced m.bilization of cD4+and cD8+naive T-cells,as well as cD4+central m.m.ry T-cells,after va.c.nation(synthetic im.unity group);this was not seen after va.c.nation in those with prior SARS-coV-2 infection(hybrid im.unity group).Acute exercise after va.c.nation robustly m.bilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups m.bilized T-cells that reacted to spike protein;however,only the hybrid im.unity group m.bilized T-cells that reacted to m.m.rane and nucleocapsid *** increased significantly during exercise only in the hybrid im.unity ***:These data indicate that acute exercise m.bilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid im.unity.

关键词： Anti-viral cOVID-19 Exercise im.unology SARS-coV-2 T-cells Va.c.ne

Anti-obesity effects of fucoidan from.Sargassum.thunbergii in adipocytes and high fat diet induced obese m.ce through inhibiting adipogenic specific transcription factor

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Food Science and Hum.n Wellness 2024年第3期13卷 1608-1616页

作者： Hyo-Geun Lee H.H.a.c.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.m.Liyanage Kyung-m. Song Yun-Sang choi Seung-Hong Lee You-Jin Jeon m.n-cheol Kang Departm.nt of m.rine Life Sciences Jeju National UniversityJeju 63243Republic of Korea m.rine Science Institute Jeju National UniversityJeju 63333Republic of Korea Resea.c. Group of Food Processing Korea Food Research InstituteWanju 55365Republic of Korea Departm.nt of Pharm.ceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalence of obesity has increased and is a health concern *** to the concerns regarding synthetic anti-obesity treatm.nts,nowadays natural products becom. a *** studies proved that there is a potential to use m.rine algae as anti-obesity ***,in this study,the lipid inhibitory effect of crude polysa.c.aride of am.loglucosidase-assisted hydrolysate from.Sargassum.thunbergii(STAc)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese m.ce were *** to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid a.c.m.lation by downregulating adipogenic and lipogenic proteins in 3T3-L1 ***,oral supplem.ntation with STAc significantly declined gain in body weight and fat weight,and serum.lipid contents in an HFD-induced obesity m.use *** and chem.cal characterizations dem.nstrated that puritied STAF3 has consistent surface m.rphology and sm.ll particle size,with sim.lar structural characteristics as com.ercial ***,these results indicate that STAc and purified STAF3 from.Sargassum.thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关键词： Sargassum.thunbergii Fucoidan Anti-obesity Anti-steatosis