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RACI责任矩阵中，首席营销官角色的变迁

国际品牌观察 2022年第10期 34-36页

作者： umme sutarwala 岳璐

从负责的角色，到执行的角色，首席营销官的身份在发生微妙的变化，但其最重要的使命依然是推动建立以客户为中心的秩序，推动以满足客户需求为解决方案的品牌增长。长期以来，营销预算一直是企业最先被削减最后被恢复的预算。在新冠疫... 详细信息

从负责的角色，到执行的角色，首席营销官的身份在发生微妙的变化，但其最重要的使命依然是推动建立以客户为中心的秩序，推动以满足客户需求为解决方案的品牌增长。长期以来，营销预算一直是企业最先被削减最后被恢复的预算。在新冠疫情这样的“黑天鹅”面前，全球各地的企业都遭遇了不同程度的预算削减。高德纳咨询公司（Gartner）的年度CMO《2021-2022年营销支出调查》显示，自2021年以来，所有被追踪的九个行业——日用消费品、金融服务、健康、零售、

关键词：首席营销官

The synergistic effects of green tea polyphenols and antibiotics against potential pathogens

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Advances in Bioscience and Biotechnology 2013年第11期4卷 959-967页

作者： Bobak Haghjoo Lee H. Lee umme Habiba Hassan Tahir Moe Olabi Tin-Chun Chu Department of Biological Sciences Seton Hall University South Orange USA Department of Biology & Molecular Biology Montclair State University Montclair USA

Green tea leaves contain many polyphenolic compounds such as (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)epigallocatechin-3-gallate (EGCG). These polyphenol compounds have been implicated to have distinct properties that combat the harmful effects of cell proliferation. They contain certain anti-viral and antibacterial properties that inhibit growth. In this study, 1% green tea and modified lipophilic green tea polyphenols (GTP and LTP) were used in combination with the most commonly prescribed antibiotics to study their effects on gram-positive, gram-negative, and acid-fast bacteria. The results indicated that 1% GTP and 1% LTP provided different synergistic effects on several antibiotics in various bacteria. It was found that 1% GTP works the best synergistically against Enterobacter aerogenes, making the resistant strain susceptible to 8 out of 12 antibiotics used. 1% LTP worked the best on Escherichia coli and was able to convert 7 antibiotic resistant categories to susceptible. In addition, 1% LTP was also able to inhibit the growth of Serratia marcescens synergistically with 3 antibiotics. These results suggest that 1% GTP and 1% LTP provide beneficial effects on selected antibiotics against microbial growth and are able to reverse the antibiotic resistance to susceptible. Green tea polyphenols could serve as natural alternatives to combat against antibiotic resistance pathogens.

关键词： GTP LTP Green Tea Polyphenols Pathogenic Microorganisms Kirby-Bauer Disk Diffusion Method Antibiotic Resistance

Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264.7 macrophages

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Advances in Bioscience and Biotechnology 2013年第8期4卷 30-37页

作者： Hui Tang umme Amara Dora Tang Mark A. Barnes Christine McDonald Laura E. nagy Departments of Pathobiology Cleveland Clinic Cleveland USA

The innate immune response is a complex process involving multiple pathogen-recognition receptors, including toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors. Complement is also a critical component of innate immunity. While complement is known to interact with TLR-mediated signals, the interactions between NOD-like receptors and complement are not well understood. Here we report a synergistic interaction between C5a and Nod2 signaling in RAW 264.7 marophages. Long-term treatment with muramyl dipeptide (MDP), a NOD2 ligand, enhanced C5a-mediated expression of chemokine mRnas in RAW 264.7 cells. This response was dependent on NOD2 expression and was associated with a decrease in expression of C5L2, a receptor for C5a which acts as a negative modulator of C5a receptor (C5aR) activity. MDP amplified C5a-mediated phosphorylation of p38 MAPK. Treatment of RAW264.7 cells with an inhibitor of p38 attenuated the synergistic effects of C5aon MDP-primed cells on MIP-2, but not MCP-1, mRna. In contrast, inhibition of AKT prevented C5a stimulation of MCP-1, but not MIP-2, mRna, in MDP-primed cells. Taken together, these data demonstrated a synergistic interaction between C5a and NOD2 in the regulation of chemokine expression in macrophages, associated with a down-regulation of C5L2, a negative regulator of C5a receptor activity.

关键词： Anaphylatoxin C5L2 C5a Receptor Complement NOD2

Effect of Missing Nutrient Elements on Grain Yield of Wet Season Rice in Bangladesh

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American Journal of Plant Sciences 2019年第4期10卷 631-639页

作者： Md Mozammel Haque Abdul Latif Sha Jatish Chandra Biswas Md Rafiqul Islam Aminul Islam umme Aminun naher Soil Science Division Bangladesh Rice Research Institute Gazipur Bangladesh Soil Science Division Bangladesh Rice Research Institute Gazipur Bangladesh

Background and objective: Long-term fertility study is one of the important factors to monitor changes in yield because of different nutrient management options and cropping systems involved in Asian regions. Many short-term and long-term fertilizer trials were conducted for intensive irrigated rice cropping patterns mostly to provide fertilizer rate, but did not considered sustainable soil management for soil health. The objective of the present study was to examine the effect of missing nutrient elements for a long time on rice yield, photosynthetic rate and residual soil fertility. Materials and Methods: The experiment was initiated on a permanent layout at the Bangladesh Rice Research Institute (BRRI) farm, Gazipur during 2000 to 2008 in wet season. Seven treatments in randomized complete block design with four replications were imposed. Grain yield was determined at physiological maturity from three 5 m2 areas within each plot followed by bagging and threshing. Photosynthetic was measure by Li Cor 6400 (USA) machine during study period. Soil sample was analyzed for following standard methods. Results: It was found that grain yield was in decreasing trends for the missing elements that were similar with BR 11 and BRRI dhan 31. On an average, grain yield reductions were 11.6, 7.0, 10.6, 1.1 and 3.4 percent for -N, -P, -K, -S and -Zn, than complete fertilizer treatment (NPKSZn) respectively. Under no fertilization, the ability of soil was to produce 2.9 t·ha-1 of BR11 and 3.1 t·ha-1 of BRRI dhan 31 respectively. Photosynthetic rate of rice plant was always higher in complete fertilizer treatment (NPKSZn) than missing of any nutrient element. The decrease in photosynthetic rate was more pronounced with N missing than others for both the rice varieties. Conclusion: It is concluded that balance chemical fertilizers (NPKSZn) are to be used for sustained and/or increased rice production and to maintain soil fertility.

关键词： Long-Term Fertilizer Soil Nutrient Status Photosynthetic Rate Variety Yield Pattern

CAR T Cell Immunotherapy That Revolutionary Breakthrough in Human Oncology Treatment: A Review

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Pharmacology & Pharmacy 2022年第11期13卷 483-515页

作者： Shammi Binte Bashar Zannat Akhter Bidhan Chandro Saha Md. Mushfiqul Islam Himaloy umme Kulsum Md. Rashedur Rahman Department of Pharmacy Primeasia University Banani Dhaka Bangladesh Department of Pharmacy Jahangirnagar University Savar Dhaka Bangladesh

The discovery of CAR T cell immunotherapy, also known as chimeric antigen receptor (CAR) T cell immunotherapy, has added a new dimension to the world of cancer treatment. This is a gene-based treatment in which T cells from the patient’s body are taken and genetically engineered in the lab to grow receptors. T cells containing this receptor are then injected into the patient’s body to bind to the antigen on the surface area of the cancer cell and kill the cancer cell. Structurally, the co-stimulatory domain added to CAR T cells has now reached the 5th GEN of chimeric antigen receptor T cells. Chimeric antigen T cell immunotherapy is the first FDA-approved treatment for hematological malignancies that is both safe and effective. However, due to some challenges such as a lack of safety control, an immunosuppressive tumor microenvironment, ineffective T cell trafficking, and so on, CAR-T immunotherapy treatment for solid malignancy is still in the clinical phase. In the result and discussion, we have presented a survey of CAR T cell therapy with a combination of pharmacological drugs. The things we mentioned are that CAR T cell immunotherapy is innovative, suitable, elegant, and also controls synergistic anti-cancer effects. A better understanding of combinatory CAR T cell therapies provides fundamental information for improvement of those therapies, in addition to the article highlighting future opportunities, commercial advancements, and various applications of CAR T cell therapy in different cancer cells. In the entire review article, we have highlighted the neck and crop of CAR T cell therapy, from which it is easy to understand the therapy and the need for this therapy in cancer prevention and its progress.

关键词： Cancer Immunotherapy Chimeric Antigen Receptor Co-Stimulatory Domain Cell Trafficking Hematological Malignancy

苯巴比妥和卡马西平应用于儿童期癫痫的副作用:随机对照研究

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英国医学杂志中文版 2007年第5期10卷 272-275页

作者： Selina H Banu Moshrat Jahan umme Kulsum Koli Saadia Ferdousi naila Z khan Brian Neville 魏研萍 clinical neurophysiologist and paediatric neurologist primary care physician trained in childhood epilepsy child psychologist professor of child development and neurology Prince of Wales's professor of childhood epilepsy

目的比较两种最常用的抗癫痫药物——苯巴比妥和卡马西平在孟加拉儿童癫痫患者中应用时的行为学副作用。设计前瞻性随机对照单中心研究。地点孟加拉 Dhaka 儿童专科医院。对象 108例2～15岁全身性强直-阵挛发作(51例)或局限性继发全身... 详细信息

目的比较两种最常用的抗癫痫药物——苯巴比妥和卡马西平在孟加拉儿童癫痫患者中应用时的行为学副作用。设计前瞻性随机对照单中心研究。地点孟加拉 Dhaka 儿童专科医院。对象 108例2～15岁全身性强直-阵挛发作(51例)或局限性继发全身性发作(57例)的患儿。主要结局评估指标癫痫控制和行为学副作用。结果 91例患儿随访12个月。6例需改用其他抗癫痫药物。比较了85例患儿的药物副作用。药物治疗和随访1年,在随访中的后1/4时间,71例患儿未再癫痫发作。随机分组后,苯巴比妥组32例102天、卡马西平组39例74天未再癫痫发作。10例患儿行为学问题增多,其中4例不能接受(苯巴比妥组1例,卡马西平组3例)。但独立 t 检验显示,两组试验药物间没有显著性差异。结论在资源缺乏的国家,苯巴比妥不引起癫痫儿童过多的行为学副作用。临床试验注册号 NCT00381537[***]。

关键词：药物副作用随机对照研究儿童期癫痫苯巴比妥卡马西平强直一阵挛发作抗癫痫药物全身性发作

Nutritional, Phytochemicals and Antioxidant Properties of Some Popular Pulse Varieties of Bangladesh

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Journal of Agricultural Chemistry and Environment 2020年第4期9卷 343-368页

作者： Tanvir Ahmmed Asma Rahman umme Salma Zakia Akter Md. Mesbah Uddin Ansary Md. Ibrahim Khalil Nurul Karim Latiful Bari Laboratory of Preventive and Integrative Biomedicine (PIB) Department of Biochemistry and Molecular Biology Jahangirnagar University Savar Dhaka Bangladesh Food Nutrition & Agricultural Research Unit Center for Advanced Research in Sciences (CARS) University of Dhaka Dhaka Bangladesh Department of Biochemistry and Molecular Biology Gono Bishwabidyalay Savar Dhaka Bangladesh

In this study, we estimate the proximate compositions, phytochemicals (polyphenol, flavonoids, flavonol, tannin, protein, carbohydrate, reducing sugar, and β carotene), antioxidant activities, vitamins, minerals, and heavy metals of the four pulses (mung, anchor, chickpea, lentils) and compare among them to find out more nutritious pulse samples. Mung was found to contain the highest amount of polyphenol (98.02 ± 1.74 mg GAE/100 g) and tannin (447.98 ± 9.96 mg TE/100 g) and anchor (771.35 ± 3.76 mg CE/100 g) was rich in flavonoids as compared to other two pulse samples. Mung was also rich in ash, carbohydrate, vitamin B1, copper and anchor was rich in crude fiber, protein, reducing sugar, and vitamin B2 content. The highest amount of phytochemicals contained in mung and anchor corresponded to its highest antioxidant activity in analyzed antioxidant assays respectively. Other two pulses included in this study were found to contain good source of vitamins, minerals and other nutrients.

关键词： Pulses Phytochemicals Antioxidant Activity Nutrients Bangladesh

Investigation of Antibacterial, Cytotoxic and Antioxidant Properties of the Mangrove Plant Xylocarpus mekongensis

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Advances in Bioscience and Biotechnology 2016年第4期7卷 205-213页

作者： Mahmuda Akter Sadia Afrin Sk. nazmus Sakib Rana Biswas Md. Morsaline Billah Mohammad Shahedur Rahman umme Salma Zohora Biotechnology and Genetic Engineering Discipline Khulna University Khulna Bangladesh Department of Biotechnology and Genetic Engineering Jahangirnagar University Dhaka Bangladesh

The plant (Xylocarpus mekongensis) of the Sundarbans mangrove origin was evaluated for its antibacterial, cytotoxic and antioxidant properties using methanolic and chloroformic leaf, stem and bark extracts, respectively. The methanolic extracts contained higher amount of total phenolics, flavonoids, tannins than the chloroformic extracts and the result was in correlation with their ferric reducing power ability as well. However, the chloroformic bark extract contained more potent DPPH free radical scavenging activity than others. Antibacterial activity of the extracts was determined against both Gram-positive (Micrococcus and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhimurium and Salmonella paratyphi) by disc diffusion assay and their zone of inhibitions (ZOI) were measured. Moreover, their minimum inhibitory concentrations (MIC) were determined by tube dilution method. Chloroformic bark and stem extracts showed strong inhibition to growth of P. aeruginosa (ZOI = 19 mm and MIC = 150 μg/ml) and S. aureus (ZOI = 19.5 mm and MIC = 250 μg/ml), respectively. All six extracts were subjected to brine shrimp lethality bioassay for possible measure of cytotoxicity. Concentration dependent increment in percentage mortality of brine Shrimp nauplii produced by the extracts indicated the presence of cytotoxic principles in these extractives. Therefore, Xylocarpus mekongensis showed antioxidant, antibacterial and cytotoxic activities.

关键词： Xylocarpus mekongensis Antioxidant Antibacterial and Cytotoxicity

Costing Principles of a Denim Pant

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Journal of Textile Science and Technology 2019年第2期5卷 48-60页

作者： A T M Mohibullah umme Magreba Takebira Mustafijur Rahman Md. Saiful Alam A. S. M. Sayem Sarker Shadman Quamar Mahir Department of Apparel Manufacturing & Technology BGMEA University of Fashion & Technology Dhaka Bangladesh

Denim pant is a significant prospect for the RMG sector of Bangladesh with an enormous future. The pricing is the most important factor obtainable in the global competitive market without having any suspicion. It is difficult to exist in the apparel market without providing lowest costing of garment. The study focuses on the entire factor that is directly related to the FOB cost of a basic denim pant where includes fabric cost, trims & accessories cost, storing, cost of making charge, washing cost, testing cost, commercial cost and profit is shown chronologically. All the calculations of the study were done on the basis of an industrial frame work and both primary and secondary data were collected from six different denim pant manufactures and exporters. The study provided convinced principle of fabric consumption, thread consumption, CM calculation, required poly;cartoons calculations and costing were done very carefully. The study also provides potential wash and testing, so that the total price ranges can be contained as well as demonstrating total FOB cost. The manufacturers, exporters, retailer and consumers of denim pant will get the apparent method of costing and its parameter.

关键词： Denim Jeanswear Costing Consumption Measurement