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Adverse effects of tyrosine kinase inhibitors in cancer therapy:pathophysiology, mechanisms and clinical management

Signal Transduction and Targeted Therapy 2023年第8期8卷 3622-3648页

作者： Sunitha Shyam Sunder umesh C.Sharma Saraswati Pokharel Cardio-Oncology Research Group Department of Pathology and Laboratory MedicineRoswell Park Comprehensive Cancer CenterBuffaloNYUSA Division of Cardiovascular Medicine Jacob’s School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA

Since their invention in the early 2000s,tyrosine kinase inhibitors(TKIs)have gained prominence as the most effective pathwaydirected anti-cancer *** have shown significant utility in the treatment of multiple hematological malignancies and solid tumors,including chronic myelogenous leukemia,non-small cell lung cancers,gastrointestinal stromal tumors,and HER2-positive breast *** their widespread applications,an increasing frequency of TKI-induced adverse effects has been *** TKIs are known to affect multiple organs in the body including the lungs,liver,gastrointestinal tract,kidneys,thyroid,blood,and skin,cardiac involvement accounts for some of the most serious *** most frequently reported cardiovascular side effects range from hypertension,atrial fibrillation,reduced cardiac function,and heart failure to sudden *** potential mechanisms of these side effects are unclear,leading to critical knowledge gaps in the development of effective therapy and treatment *** are limited data to infer the best clinical approaches for the early detection and therapeutic modulation of TKI-induced side effects,and universal consensus regarding various management guidelines is yet to be *** this state-of-the-art review,we examine multiple pre-clinical and clinical studies and curate evidence on the pathophysiology,mechanisms,and clinical management of these adverse *** expect that this review will provide researchers and allied healthcare providers with the most up-to-date information on the pathophysiology,natural history,risk stratification,and management of emerging TKI-induced side effects in cancer patients.

关键词： clinical involvement organs

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A New High Performance Realization of Hyperchaotic Modified Canonical Chua Circuit Using JFETs

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Chinese Physics Letters 2008年第8期25卷 2803-2805页

作者： Prem Bhushan Mital umesh Kumar R.S. Prasad IEC College of Engineering and Technology GB Nagar Pin-201 306 India Indian Institute of Technology Delhi Pin-110016 India Inderprastha Eng. College Sahibabad Ghaziabad (UP) India

A new implementation of hyperchaotic modified canonical Chua circuit using junction field-effect transistors （JFETs） is proposed. The design is based on a source coupled JFET circuit to approximate a smooth cubic nonlinearity and a two-terminal negative resistance element containing a p-n-p silicon transistor and an n-channel JFET. The realization is supported by Orcad Pspice simulation and numerical MATLAB results. The hyperchaotic nature is confirmed by two positive Lyapunov exponents associated with the attractor which is a fractal with a Lyapunov dimension between 3 and 4.

关键词： OSCILLATOR

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Sliding Mode Control of Coupled Tank Systems Using Conditional Integrators

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 118-125页

作者： Sankata Bhanjan Prusty Sridhar Seshagiri umesh Chandra Pati Kamala Kanta Mahapatra Department of Electronics and Communication Engineering Madanapalle Institute of Technology and ScienceMadanapalleAndhra Pradesh 517325India Department of Electrical and Computer Engineering San Diego State UniversitySan DiegoCA 92182 USA Department of Electronics and Communication Engineering National Institute of TechnologyRourkelaOdisha 769008India

For the problem of set point regulation of the liquid level in coupled tank systems, we present a continuous sliding mode control(SMC) with a "conditional integrator", which only provides integral action inside the boundary layer. For a special choice of the controller parameters, our design can be viewed as a PID controller with anti-windup and achieves robust *** proposed controller recovers the transient response performance without control chattering. Both full-state feedback as well as output-feedback designs are presented in this work. Our output-feedback design uses a high-gain observer(HGO) which recovers the performance of a state-feedback design where plant parameters are assumed to be known. We consider both interacting as well as non-interacting tanks and analytical results for stability and transient performance are presented in both the cases. The proposed controller continuous SMC with conditional integrators(CSMCCI) provides superior results in terms of the performance measures as well as performance indices than ideal SMC, continuous SMC(CSMC) and continuous SMC with conventional integrator(CSMCI). Experimental results demonstrate good tracking performance in spite of unmodeled dynamics and disturbances.

关键词： Conditional integrator coupled tank system LabVIEW sliding mode control

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Vision-based tip position tracking control of two-link flexible manipulator

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IET Cyber-Systems and Robotics 2020年第2期2卷 53-66页

作者： umesh Kumar Sahu Dipti Patra Bidyadhar Subudhi Department of Electrical Engineering National Institute of TechnologyRourkela 769008India Department of Electronics and Telecommunication G H Raisoni College of EngineeringNagpurMaharashtra-440016India School of Electrical Sciences Indian Institute of Technology GoaPondaGoa-401403India

Owing to the non-collocation of actuators and sensors in a flexible-link manipulator(FLM)it becomes difficult to achieve accurate tip position *** resolve this issue,a vision sensor is used for direct measurement of the tip position instead of employing the traditional mechanical *** the different visual servoing(VS)control schemes,image-based VS(IBVS)is more ***,there are many challenges in the IBVS scheme such as singularities in the interaction matrix and local minima in trajectories that affect the system performance in real-time *** this study,the moment-based new visual feature is selected to address the aforesaid issues that arise in the IBVS ***,a new two-time scale IBVS controller is developed for addressing the tip-tracking control problem of the two-link flexible manipulator(TLFM).In the proposed control scheme,the dynamics of the FLM is decomposed into two-time scale models,namely a slow subsystem and a fast *** performance and robustness of the proposed new two-time scale IBVS controller for TLFM are verified by pursuing simulation *** is observed from the obtained results that the proposed controller effectively stabilises the oscillatory dynamics and tracks the reference trajectory accurately.

关键词： subsystem scheme manipulator

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Stability of LRS Bianchi type-I cosmological models in f(R,T)-gravity

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Research in Astronomy and Astrophysics 2019年第4期19卷 63-76页

作者： umesh Kumar Sharma Rashid Zia Anirudh Pradhan Aroon Beesham Department of Mathematics Institute of Applied Sciences & Humanities GLA University Department of Mathematical Sciences University of Zululand

This paper examines the stability of the transition from the early decelerating stage of the Universe to the recent accelerating stage for the perfect fluid cosmological locally rotationally symmetric(LRS) Bianchi-I model in f(R, T) theory. To determine the solution of field equations, the idea of a timevarying deceleration parameter(DP) which yields a scale factor, for which the Universe attains a phase transition scenario and is consistent with recent cosmological observations, is used. The time-dependent DP yields a scale factor a=exp■, where β and k are respectively arbitrary and integration constants. By using the recent cons_traints(H_0 _= 73.8, and q_0 =-0.54) from Type Ia Supernova(SN Ia) data in combination with Baryonic Acoustic Oscillations(BAO) and Cosmic Microwave Background(CMB) observations(Giostri et al.), we obtain the values of β = 0.0062 and k = 0.000016 for which we have derived a cosmological model from the early decelerated phase to the present accelerating phase. By applying_ other r_ecent constraints(H_0 = 73.8, q_0 =-0.73) from SNe Ia Union data(Cunha), we obtain the values of β = 0.0036 and k = 0.000084 for which we have derived a cosmological model in the accelerating phase only. We have compared both models with experimental data. The stability of the background solution has been examined also for the metric perturbations alongside the properties of future singularities in a Universe ruled by dark energy with phantom type fluid. We demonstrate the presence of a stable fixed point with a condition of state ω <-1 and numerically affirm this is really a late-time attractor in the ghost overwhelmed Universe. Some physical and geometric properties of the model are found and examined.

关键词： LRS Bianchi-I Universe Time-dependent deceleration parameter f(R,T) gravity theory Transit universe

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FedRec:Trusted rank-based recommender scheme for service provisioning in federated cloud environment

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Digital Communications and Networks 2023年第1期9卷 33-46页

作者： Ashwin Verma Pronaya Bhattacharya umesh Bodkhe Deepti Saraswat Sudeep Tanwar Kapal Dev Department of Computer Science and Engineering Institute of TechnologyNirma UniversityAhmedabadGujarat382481India Department of Institute of Intelligent Systems University of JohannesburgPO Box 524South Africa

The emergence of on-demand service provisioning by Federated Cloud Providers(FCPs)to Cloud Users(CU)has fuelled significant innovations in cloud provisioning *** to the massive traffic,massive CU resource requests are sent to FCPs,and appropriate service recommendations are sent by ***,the FourthGeneration(4G)-Long Term Evolution(LTE)network faces bottlenecks that affect end-user throughput and ***,the data is exchanged among heterogeneous stakeholders,and thus trust is a prime *** address these limitations,the paper proposes a Blockchain(BC)-leveraged rank-based recommender scheme,FedRec,to expedite secure and trusted Cloud Service Provisioning(CSP)to the CU through the FCP at the backdrop of base 5G communication *** scheme operates in three *** the first phase,a BCintegrated request-response broker model is formulated between the CU,Cloud Brokers(BR),and the FCP,where a CU service request is forwarded through the BR to different *** service requests,Anything-as-aService(XaaS)is supported by 5G-enhanced Mobile Broadband(eMBB)*** the next phase,a weighted matching recommender model is proposed at the FCP sites based on a novel Ranking-Based Recommender(RBR)model based on the CU *** the final phase,based on the matching recommendations between the CU and the FCP,Smart Contracts(SC)are executed,and resource provisioning data is stored in the Interplanetary File Systems(IPFS)that expedite the block *** proposed scheme FedRec is compared in terms of SC evaluation and formal *** simulation,FedRec achieves a reduction of 27.55%in chain storage and a transaction throughput of 43.5074 Mbps at 150 *** the IPFS,we have achieved a bandwidth improvement of 17.91%.In the RBR models,the maximum obtained hit ratio is 0.9314 at 200 million CU requests,showing an improvement of 1.2%in average servicing latency over non-RBR models and a maximization trade-off of QoE index of 2.76

关键词： Blockchain 5G-enhanced mobile broadband Federated clouds Rank-based recommender model Smart contracts

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Pulsed light processing of foods for microbial safety

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Food Quality and Safety 2017年第3期1卷 187-201页

作者： M.L.Bhavya H.umesh Hebbar Department of Technology Scale-up CSIR-Central Food Technological Research InstituteMysoreIndia.

The demand for processed foods and the awareness about food quality and safety are increasing *** consumers’demand for minimally processed foods and growing competition in the market have made the processors to adopt newer non-thermal technologies that preserve nutrients and sensory properties of the ***,heat processing of foods is carried out to convert raw material into value-added product,reduce or eliminate microbial load to improve safety,and extend shelf *** of the limitations of thermal processing techniques can be overcome by employing non-thermal *** hydrostatic pressure,pulsed electric field,ultrasound,cold plasma,dense phase carbon dioxide,ozone,and pulsed light(PL)processing are gaining popularity in food *** technology is a non-thermal technology,where sterilization and decontamination are achieved by impinging high-intensity light pulses of short durations on surfaces of foods and high-transmission *** a few reports on the PL technology are available,in-depth studies on this are needed to adopt at a commercial *** present review provides an overview of light-based processing of foods and covers important aspects such as different PL systems used for processing of foods,mode of action of PL on microbes,the effect of PL on liquid foods,surface decontamination of foods and parameters that affect PL efficacy,combination processing with *** the growing demand in non-thermal processing for the technological advancement in the area of generation of light,light-based processing will be a promising technology for microbial load reduction.

关键词： Pulsed light Food safety Non-thermal processing Minimally processed Microbial load.

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Multi-role Remotely Operated Marine Surface Vehicle

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Journal of Marine Science and Application 2022年第3期21卷 219-227页

作者： Nishan B Shetty Pruthviraj umesh KV Gangadharan Former National Institute of Technology Karnataka Mangaluru 575025India National Institute of Technology Karnataka Mangaluru 575025India

Development of man-packable,versatile marine surface vehicle with ability to rescue a drowning victim and also capable of carrying mission specific sensor is *** thinking methodology is implemented by using existing equipment/platform with the addition of external attachment to make it a functional *** prototyping process with extensive testing to achieve user-centric *** prototypes and their possible sub-configurations with their integration and characteristics are studied and compared with numerical model,inferences obtained are utilised to improve for the next iteration.A novel hinge-clamp assembly enables this marine surface vehicle to operate in the event of an overturn,this phenomenon is further studied with the aid of a mathematical model(Pendulum in a fluid).This research project aims to demonstrate a multi-role unmanned surface vehicle.

关键词： Multi-role platform Remotely operated ring buoy surface vehicle Unmanned marine surface vehicle Novel Hinge-Clamp Assembly Lifesaving equipment

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Traditional and emerging Fusarium mycotoxins disrupt homeostasis of bovine mammary cells by altering cell permeability and innate immune function

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Animal Nutrition 2023年第1期12卷 388-397页

作者： Ran Xu umesh K.Shandilya Alexandros Yiannikouris Niel A.Karrow Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada Alltech Inc. Center for Animal Nutrigenomics and Applied Animal NutritionNicholasvilleKY 40356USA

High incidence of traditional and emerging Fusarium mycotoxins in cereal grains and silages can be a potential threat to feed safety and *** biodegradation of Fusarium mycotoxins by rumen microflora following ingestion of mycotoxin-contaminated feeds can lead to their circulatory transport to target tissues such as mammary *** bovine udder plays a pivotal role in maintaining milk yield and composition,thus,human ***,toxic effects of Fusarium mycotoxins on bovine mammary gland are rarely *** this study,the bovine mammary epithelial cell line was used as an in-vitro model of bovine mammary epithelium to investigate effects of deoxynivalenol(DON),enniatin B(ENB)and beauvericin(BEA)on bovine mammary gland *** indicated that exposure to DON,ENB and BEA for 48 h significantly decreased cell viability in a concentration-dependent manner(P<0.001).Exposure to DON at 0.39μmol/L and BEA at 2.5μmol/L for 48 h also decreased paracellular flux of FITC-40 kDa dextran(P<0.05),whereas none of the mycotoxins affected transepithelial electrical resistance after 48 h *** qPCR was performed for assessment of expression of gene coding tight junction(TJ)proteins,toll-like receptor 4(TLR4)and cytokines after 4,24 and 48 h of ***,ENB and BEA significantly upregulated the TJ protein zonula occludens-1,whereas markedly downregulated claudin 3(P<0.05).Exposure to DON at 1.35μmol/L for 4 h significantly increased expression of occludin(P<0.01).DON,ENB and BEA significant downregulated TLR4(P<0.05).In contrast,ENB markedly increased expression of cytokines interleukin-6(IL-6)(P<0.001),tumor necrosis factorα(TNF-a)(P<0.05)and transforming growth factor-β(TGF-β)(P<0.01).BEA significantly upregulated IL-6(P<0.001)and TGF-β(P=0.01),but downregulated TNF-α(P<0.001).These results suggest that DON,ENB and BEA can disrupt mammary gland homeostasis by inducing cell death as well as altering its paracellular permeability and expres

关键词： Fusarium mycotoxin Invitro cell culture Bovine mammary epithelial cells Epithelial paracellular permeability Innate immunity

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Risk assessment framework for power control systems with PMU-based intrusion response system

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Journal of Modern Power Systems and Clean Energy 2015年第3期3卷 321-331页

作者： Jie YAN Manimaran GOVINDARASU Chen-Ching LIU Ming NI umesh VAIDYA Department of Electrical and Computer Engineering Iowa State UniversityAmesIA 50011USA Market Engineering MISOCarmelIN 46032USA School of Electrical Engineering and Computer Science Washington State UniversityPullmanWA 99165USA NARI Technology Co.Ltd. Nanjing 211106China

Cyber threats are serious concerns for power *** example,hackers may attack power control systems via interconnected enterprise *** paper proposes a risk assessment framework to enhance the resilience of power systems against cyber *** duality element relative fuzzy evaluation method is employed to evaluate identified security vulnerabilities within cyber systems of power systems *** attack graph is used to identify possible intrusion scenarios that exploit multiple *** intrusion response system(IRS)is developed to monitor the impact of intrusion scenarios on power system dynamics in real *** calculates the conditional Lyapunov exponents(CLEs)on line based on the phasor measurement unit *** system stability is predicted through the values of *** actions based on CLEs will be suggested if power system instability is likely to happen.A generic wind farm control system is used for case *** effectiveness of IRS is illustrated with the IEEE 39 bus system model.

关键词： Cyber security Supervisory control and data acquisition(SCADA) Risk assessment Intrusion response system(IRS) Conditional Lyapunov exponents(CLEs) Phasor measurement unit(PMU) Voltage instability

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