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Anti-voltage-gated potassium channel complex antibody-mediated limbic encephalitis:a case report of a 53-yearold man admitted to intensive care psychiatric unit with psychotic mania

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General Psychiatry 2020年第4期33卷 241-244页

作者： Homayun Shahpesandy Rosemary Mohammed-Ali Ahmed Oladosu Tarik AI-Kubaisy Moses Anene umesh sira ramaiah The Hartsholme Centre Lincolnshire Partnership NHS Foundation TrustLincolnUK Spalding Community Mental Health Team Lincolnshire Partnership NHS Foundation TrustSpaldingUK Early Intervention Psychosis Team Consultant Psychiatrist North Lincolnshire Community Mental HealthRotherham Doncaster NHS Foundation TrustScunthorpeUK Peter Hodgkinson Centre Lincolnshire Partnership NHS Foundation TrustLincolnUK Psychiatric Liaison Team Lincolnshire Partnership NHS Foundation TrustLincolnUK

Limbic encephalitis represents a cluster of autoimmune disorders,with inflammation in the medial temporal lobe characterised by subacute onset of neuropsychiatric symptoms such as anxiety,affective symptoms,psychosis,short-term memory impairment as well as faciobrachial and grand mal *** aim to present a case of a 53-year-old man with positive anti-voltage-gated potassium channel(VGKC)complex antibodies who initially presented with symptoms of psychotic *** weeks post-psychiatric symptomatology,he presented with neurological symptoms such as faciobrachial jerking and tonic-clonic *** patient had no previous psychiatric history and was initially treated with psychotropic *** experience emphasises the fact that limbic encephalitis is not easy to identify as most patients initially present with psychiatric symptomatology than neurological ***,immunological and laboratory testing takes a rather long time to determine the *** is more,few psychiatrists consider autoimmune nature of the neuropsychiatric ***,it is important to consider autoimmune encephalitis in patients with new-onset psychosis or mania who also present with neurological symptoms at some stage of their *** indicators of autoimmune encephalitis include neurological symptoms such as facial twitching,seizures,confusion and cognitive decline.

关键词： initially potassium admitted

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Exploring nitrogen reduction reaction mechanisms in electrocatalytic ammonia synthesis:A comprehensive review

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Journal of Energy Chemistry 2024年第5期92卷 681-697页

作者： Abhishek umesh Shetty Ravi Sankannavar School of Chemical and Materials Science Indian Institute of Technology GoaFarmagudiPonda 403401GoaIndia Department of Chemical Engineering M.S.Ramaiah Institute of TechnologyMSR NagarMSRIT PostBengaluru 560054KarnatakaIndia

The electrochemical nitrogen reduction reaction(eNRR)holds significant promise as a sustainable alternative to the conventional large-scale Haber Bosch process,offering a carbon footprint-free approach for ammonia *** the process is thermodynamically feasible at ambient temperature and pressure,challenges such as the competing hydrogen evolution reaction,low nitrogen solubility in electrolytes,and the activation of inert dinitrogen(N_(2))gas adversely affect the performance of ammonia *** hurdles result in low Faradaic efficiency and low ammonia production rate,which pose obstacles to the commercialisation of the *** have been actively designing and proposing various electrocatalysts to address these issues,but challenges still need to be resolved.A key strategy in electrocatalyst design lies in understanding the underlying mechanisms that govern the success or failure of the electrocatalyst in driving the electrochemical *** mechanistic studies,we gain valuable insights into the factors affecting the reaction,enabling us to propose optimised designs to overcome the *** review aims to provide a comprehensive understanding of the various mechanisms involved in eNRR on the electrocatalyst *** delves into the various mechanisms such as dissociative,associative,Mars-van Krevelen,lithium-mediated nitrogen reduction and surface hydrogenation mechanisms of nitrogen *** unravelling the intricacies of eNRR mechanisms and exploring promising avenues,we can pave the way for more efficient and commercially viable ammonia synthesis through this sustainable electrochemical process by designing an efficient electrocatalyst.

关键词： Green ammonia synthesis Electrolysis Electrocatalysis Nitrogen reductionreaction Electrochemical reaction pathways Reactionmechanism

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Thermoregulation,incubator humidity,and skincare practices in appropriate for gestational age ultra-low birth weight infants:need for more evidence

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World Journal of Pediatrics 2024年第7期20卷 643-652页

作者： umesh Mishra Deanne August Karen Walker Pranav R.Jani Mark Tracy Faculty of Medicine and Health University of SydneySydneyAustralia Department of Neonatology Westmead HospitalWestmeadNSWAustralia Grantley Stable Neonatal Unit Royal Brisbane and Women’s HospitalBrisbaneAustralia School of Nursing Midwifery and Social WorkUniversity of QueenslandBrisbaneAustralia Department of Newborn Care Royal Prince Alfred HospitalCamperdownAustralia

Background Although not universal,active care is being offered to infants weighing<500 g at birth,referred to as ultra-low birth weight(ULBW)infants appropriate for gestational *** infants have the greatest risk of dying or developing major *** infants face challenges related to fluid and heat loss as well as skin injury in the initial days of life from extreme anatomical and physiological immaturity of the *** there is an emerging literature on the outcomes of ULBW infants,there is a paucity of evidence to inform practice guidelines for delivering optimal care to this cohort of *** sources A comprehensive review of the literature was performed using the PubMed and Embase *** keywords included“thermoregulation or body temperature regulation”,“incubator humidity”,“skin care”,“infant,extremely low birth weight”and“ultra-low birth weight infants”.Results Evidences for thermoregulation,incubator humidity,and skincare practices are available for preterm infants weighing<1500 g at birth but not specifically for ULBW *** on thermoregulation,incubator humidity,or skincare practices had a small sample size and did not include a sub-group analysis for ULBW *** practice recommendations in ULBW infants are adopted from research in very and/or extremely low birth weight *** This narrative review focuses on challenges in thermoregulation,incubator humidity,and skincare practices in ULBW infants,highlights current research gaps and suggests potential developments for informing practices for improving health outcomes in ULBW infants.

关键词： Incubator humidity Neonatal intensive care unit Skincare Thermoregulation Ultra-low birth weight

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Fish Gelatin-Based Film Containing Maillard Reaction Products:Properties and Its Use as Bag for Packing Chicken Skin Oil

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Journal of Renewable Materials 2024年第6期12卷 1125-1143页

作者： Krisana Nilsuwan Yolanda Victoria Rajagukguk umesh Patil Thummanoon Prodpran Soottawat Benjakul International Center of Excellence in Seafood Science and Innovation Faculty of Agro-IndustryPrince of Songkla UniversitySongkhla90110Thailand Department of Food Safety and Quality Management PoznańUniversity of Life SciencesPoznań60-637Poland Center of Excellence in Bio-Based Materials and Packaging Innovation Faculty of Agro-IndustryPrince of Songkla UniversityHat YaiSongkhla90110Thailand Department of Food and Nutrition Kyung Hee UniversitySeoul02447Republic of Korea

Maillard reaction is a non-enzymatic browning reaction and its products(MRPs)have been proven to possess antioxidant *** research aimed to produce a fish gelatin-based packaging incorporated with MRPs to retard lipid oxidation in chicken skin oil(CSO)during storage at ambient temperature(28℃–30℃).MRPs produced from fish gelatin and fructose(1:1,90℃,pH 11)showed the highest antioxidant properties compared to those prepared under other *** glycerol/MRPs ratios(30:0,25:5,20:10,15:15,10:20,5:25,0:30)were incorporated into the film and resulting films were ***/MRPs at 10:20 ratio was chosen to add into the film prior to bag preparation via heat sealing *** packed in the bag was monitored for lipid hydrolysis and oxidation during 15 days of storage(30℃±0.5℃,RH 52%±5%).After 15 days,quality deterioration was lower in CSO packed in the prepared gelatin bag as evidenced by lower FFA,TBARS,and volatile compounds in comparison with CSO packed in LDPE *** gelatin film added with MRPs possessed an excellent water vapor barrier property(WV-BP).This finding indicated that MRPs could be used to substitute glycerol and simultaneously could serve as antioxidants for the developed active *** novel packaging can be a potential alternative packaging for retarding lipid oxidation of lipid or fatty foods.

关键词： Active film antioxidant shelf-life extension Maillard reaction products fish gelatin

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尼泊尔巴迪亚国家公园缓冲区的人象冲突

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Journal of Resources and Ecology 2024年第2期15卷 412-421页

作者： PAHARI Sagar JOSHI Rajeev PAUDEL umesh 南十字星大学澳大利亚利斯莫尔2480 尼泊尔农林大学自然资源管理学院林学系尼泊尔卡塔里56310 尼泊尔巴迪亚自然保护国家信托基金会尼泊尔巴迪亚21800

亚洲象(Elephasmaximus)是尼泊尔特莱(Terai)低地保护区重要的大型动物之一,它们经常在保护区森林边界附近遇到人类及其生计支持活动。人象冲突一直是保护区附近人类居住区的主要问题之一,每年都会造成经济损失,甚至威胁人类的生命安全... 详细信息

亚洲象(Elephasmaximus)是尼泊尔特莱(Terai)低地保护区重要的大型动物之一,它们经常在保护区森林边界附近遇到人类及其生计支持活动。人象冲突一直是保护区附近人类居住区的主要问题之一,每年都会造成经济损失,甚至威胁人类的生命安全,这一问题阻碍了保护区的可持续管理。本研究的目的是分析巴迪亚国家公园缓冲区人象冲突的原因,并评估人们对这种大型动物的感知。为此,在巴迪亚国家公园缓冲区内的三个市镇进行了结构化问卷调查。此外,作为问卷调查的补充,还对关键知情人士进行了访谈。结果显示,93%的受访者在过去三年中曾遭遇大象的袭击。由于大象袭击,去年每个家庭平均损失了大约9690尼泊尔卢比。大象的攻击行为大多数发生在7月至9月,其次是10月至12月。这表明大象对作物的偏好是研究区大象发起攻击/袭击行为的主要原因。大象袭击的第二个重要原因是由于农田向森林的扩张而导致大象食物不足。90%的受访者对大象攻击的反应是驱赶它们(使用火或噪音);51%的受访者接受人象共存,他们认为大象具有生物学和经济价值;然而,还有41%的人拒绝与大象共存,因为大象对当地居民及其生计构成了威胁。人象冲突已对保护区管理活动产生了负面影响,因此,必须通过保护区、当地居民和行政利益相关者的合作来解决相关问题。建议以后开展更多的研究,以了解大象在森林边界和邻近定居点附近人们的居住和迁徙模式。

关键词：攻击补偿作物的损害感知偏好

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Environmental fate and health exposures of the geogenic and anthropogenic contaminants in potable groundwater of Lower Ganga Basin,India

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Geoscience Frontiers 2022年第3期13卷 115-129页

作者： Indrani Mukherjee umesh Kumar Singh Integrated Science Education and Research Centre(ISERC) Institute of ScienceVisva-Bharati UniversitySantiniketanBirbhum 731235West BengalIndia Department of Environmental Science School of EarthBiological and Environmental SciencesCentral University of South BiharGaya 824236BiharIndia

The study evaluated the sources and controlling factors of the groundwater contaminants in an agroeconomic region of Lower Ganga Basin using principal component analysis(PCA),multivariable linear regressions(MLR),correlation analysis,and hierarchical cluster analysis,and evaluated the public health risks using the Latin Hypercube Sampling,goodness-of-fit statistics,Monte Carlo simulation and Sobol sensitivity analysis based on the 1000 samples collected in two sampling cycles(N=1000).The study reveals that the dissolution of fluoride-bearing minerals and semi-arid climate regulate the fluoride concentrations(0.10–18.25 mg/L)in *** application of inorganic nitrogenous fertilizers and livestock manure mainly contributed to elevated nitrate levels(up to 435.0 mg/L)in *** health risks analysis indicates that fluoride exposure is more prevalent in the residents of each age group than the nitrate and both contaminants exhibited higher non-carcinogenic health risks on the infant and child(minor)age groups compared to adolescents and *** on the cokriging interpolation mapping,the minor residents of 17.88%–23.15%of the total area(4545.0 km^(2))are vulnerable to methemoglobinemia whereas the residents of all age-groups in 38.47%–44.45%of the total area are susceptible to mild to severe dental/skeletal fluorosis owing to consumption of untreated nitrate and fluoride enriched *** Sobol sensitivity indices revealed contaminant levels,groundwater intake rate and their collective effects are the most influential factors to pose potential health risks on the *** recharge and rainwater harvesting practices should be adopted to improve the groundwater quality and the residents are advised to drink purified groundwater.

关键词： Cokriging Health risks Principal component analysis Cluster analysis Nitrate contamination Fluoride contamination

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Analytical techniques for serratiopeptidase: A review

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Journal of Pharmaceutical Analysis 2017年第4期7卷 203-207页

作者： Vandana Gupte umesh Luthra Ipca Laboratories Ltd. Biotech R & DKandivali (W)Mumbai 400067MaharashtraIndia

A review is presented on different analytical techniques used for qualitative and quantitative analysis of serratiopeptidase, a proteolytic enzyme, which has recently gained importance as an anti-inflammatory *** have been made to collate all the relevant references to the extent possible. The review discusses the advantages and disadvantages of the cited analytical techniques, which will help to give insights into the methods used for estimation of serratiopeptidase as such, from clinical isolates and from its dosage *** review highlights the basic as well as advanced techniques performed for estimating serratiopeptidase. The techniques illustrated here have been demonstrated to be useful for qualitative and quantitative determination of serratiopeptidase and may find application in analyzing other related proteases.

关键词： Serratiopeptidase Anti-inflammatorydrug Analyticalmethod Qualitativeanalysis Quantitativeanalysis

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Bianchi .Type-I Massive String Magnetized Barotropic Perfect Fluid Cosmological Model in General Relativity

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Chinese Physics Letters 2007年第8期24卷 2455-2458页

作者： BALI Raj PAREEK umesh Kumar PRADHAN Anirudh Department of Mathematics University of Rajasthan Jaipur-302 004 India Department of Mathematics Jaipur Engineering College and Research Centre Jaipur-303 905 India Department of Mathematics Hindu Post-graduate College Zamania-232 331 Chazipur India

Bianchi type-I massive string cosmological model with magnetic field of barotropic perfect fluid distribution through the techniques used by Latelier and Stachel is investigated. To obtain the deterministic model of the universe, it is assumed that the universe is filled with barotropic perfect fluid distribution. The magnetic field is due to electric current produced Mong the x-axis with infinite electrical conduictivity. The behaviour of the model in the presence and absence of magnetic field together with other physical aspects is further discussed.

关键词： coated conductor buffer layer self-epitaxy CeO2

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A review of cooling technologies for high temperature rotating components in gas turbine

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Propulsion and Power Research 2022年第3期11卷 293-310页

作者： umesh Unnikrishnan Vigor Yang Georgia Institute of Technology AtlantaGAUSA

Modern gas turbines work under demanding high temperatures, high pressures, andhigh rotational speeds. In order to ensure durable and reliable operation, effective cooling mea-sures must be applied to the high-temperature rotating components, including turbine bladesand turbine disks. Cooling technology, however, is one of the most challenging problems inthis field. The present work reviews the current state of cooling technology research, at boththe fundamental science and engineering implementation levels, including modeling and simu-lation, experiments and diagnostics, and cooling technologies for blades and disks. In numericalsimulation, the RANS approach remains the most commonly used technique for flow-dynamicsand heat-transfer simulations. Much attention has been given to the development of improvedturbulence modeling for flows under rotation. For measurement and diagnostics, advancedinstrumentation and rotating-flow test facilities have been developed and valuable experimentaldata obtained. Detailed velocity and temperature distributions in rotating boundary layers havebeen obtained at scales sufficient to resolve various underlying mechanisms. Both isothermaland non-isothermal conditions have been considered, and the effects of Coriolis and buoyancyforces on flow evolution and heat transfer quantitatively identified. Cooling technologies havebeen improved by optimizing cooling passage dsigns, especially for curved configurations un-der rotation. Novel methods such as lamellar cooling and micro-scale cooling were proposed,and their effectiveness evaluated. For disk/cavity cooling, efforts were mainly focused on rotor-stator systems, with special attention given to the position of air injection into disks.

关键词： Gas turbine Rotating components Turbine blade Turbine disk Cooling technology

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In vitro antioxidant assessment and a rapid HPTLC bioautographic method for the detection of anticholinesterase inhibitory activity of Geophila repens

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Journal of Integrative Medicine 2017年第3期15卷 231-241页

作者： umesh Chandra Dash Atish Kumar Sahoo Regional Plant Resource Centre Medicinal & Aromatic Plant Division Forest & Environment DepartmentGovt. of Odisha Nayapalli Bhubaneswar 751015 India

OBJECTIVE： Geophila repens （L.） I. M. Johnst. （Rubiaceae）, a small, creeping, perennial herb, is claimed to have memory-enhancing property. The goal of this study was to assess its antioxidant and anticholinesterase activity and conduct a rapid bioautographic enzyme assay for screening acetylcholinesterase （ACHE） and butyrylcholinesterase （BChE） inhibition of G. repens extracts. METHODS： Antioxidant activity of G. repens extracts was assessed by performing 1,1-diphenyl-2- picrylhydrazyl （DPPH）, nitric oxide （NO）, superoxide （SOD）, hydroxyl （OH） and total antioxidant capacity （TAC） assays. Anticholinesterase activity was investigated by quantifying the AChE and BChE inhibitory activities of chloroform （CGR）, ethyl acetate （EGR） and methanol （MGR） extract fractions from G. repens leaves. A rapid high-performance thin-layer chromatography （HPTLC） bioautographic method for the detection of AChE and BChE inhibition was performed. RESULTS： Among all extract fractions, EGR exhibited the highest half maximal inhibitory concentration （IC50） in DPPH, SOD, NO, OH and TAC assays, with IC50 of （38.33 ± 3.21）, （45.14 ±1.78）, （59.81± 1.32）, （39.45 ± 0.79） and （43.76 ± 0.81 ） μg/mL respectively. EGR displayed competitive, reversible inhibition of AChE and BChE activities with IC50 of （68.63±0.45） and （59.45 ±0.45）μg/mL, respectively. Total phenolic and flavonoids contents of EGR were found to be 360.42 mg gallic acid equivalents and 257.31 mg quercetin equivalents per gram of extract. Phytoconstituents of the EGR extract that were inhibitors of cholinesterase produced white spots on the yellow background of HPTLC plates in the bioautographic test. CONCLUSION： The results of this study revealed that phenols and flavonoids could be responsible for the antioxidant, anticholinesterase activities of G. repens.

关键词： Geophila repens Alzheimer disease acetylcholinesterase butyrylcholinesterase fingerprint bioautographic phenolic, antioxidant

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