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Performance analysis of cow dung as an eco-friendly additive material for sustainable moulding and casting

China Foundry 2019年第6期16卷 423-429页

作者： manjunath Patel G C Kapil Gupta Ganesh Chate mahesh B Parappagoudar Sandeep m Jayashankar umesh m daivagna Dept.of mechanical Engineering PES Institute of Technology and ManagementShivamoggaAffiliated to Visvesvaraya Technological UniversityBelagaviIndia Dept.of mechanical and Industrial Engineering Technology University of JohannesburgSouth Africa Dept.of mechanical Engineering KLS Gogte Institute of TechnologyBelgaumAffiliated to Visvesvaraya Technological UniversityBelagaviIndia Dept.of mechanical Engineering Padre Conceicao College of EngineeringVernaIndia Dept.of mechanical Engineering Ballari Institute of Technology and ManagementBellaryAffiliated to Visvesvaraya Technological UniversityBelagaviIndia

In the present work,an attempt is made to partially replace high cost silica sand with sustainable eco-friendly *** practical utility of cow dung as an additive material that facilitates binding in sand moulds has been *** Taguchi method is used to plan and conduct nine experiments with three replicates *** analysis of variance study is performed to understand the practical significance of moulding sand variables,that is,percentage of cow dung,clay,water,and degree of ramming on sand mould *** conflicting multiple objective functions(maximize mould hardness,and minimize collapsibility and gas evolution)are optimized by utilizing the Data Envelopment Analysis Ranking(DEAR)*** optimal parameters i.e.6%of clay,4%of water,5%of cow-dung and 4 numbers of ramming strokes are obtained by applying a hybrid Taguchi-DEAR *** parameters show the best moulding properties are:mould hardness 55,gas evolution 5.9 ml·g-1,and collapsibility 470 g·***,a Lovejoy coupling made of aluminium is cast in the sand mould prepared with cow dung and without cow dung,with the optimum set of *** mechanical properties,surface finish,and microstructure of the casting cast with cow-dung are better than that without cowdung.

关键词： casting cow-dung optimization sand mould sustainability

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Exploring nitrogen reduction reaction mechanisms in electrocatalytic ammonia synthesis:A comprehensive review

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Journal of Energy Chemistry 2024年第5期92卷 681-697页

作者： Abhishek umesh Shetty Ravi Sankannavar School of Chemical and materials Science Indian Institute of Technology GoaFarmagudiPonda 403401GoaIndia Department of Chemical Engineering M.S.Ramaiah Institute of TechnologyMSR NagarMSRIT PostBengaluru 560054KarnatakaIndia

The electrochemical nitrogen reduction reaction(eNRR)holds significant promise as a sustainable alternative to the conventional large-scale Haber Bosch process,offering a carbon footprint-free approach for ammonia *** the process is thermodynamically feasible at ambient temperature and pressure,challenges such as the competing hydrogen evolution reaction,low nitrogen solubility in electrolytes,and the activation of inert dinitrogen(N_(2))gas adversely affect the performance of ammonia *** hurdles result in low Faradaic efficiency and low ammonia production rate,which pose obstacles to the commercialisation of the *** have been actively designing and proposing various electrocatalysts to address these issues,but challenges still need to be resolved.A key strategy in electrocatalyst design lies in understanding the underlying mechanisms that govern the success or failure of the electrocatalyst in driving the electrochemical *** mechanistic studies,we gain valuable insights into the factors affecting the reaction,enabling us to propose optimised designs to overcome the *** review aims to provide a comprehensive understanding of the various mechanisms involved in eNRR on the electrocatalyst *** delves into the various mechanisms such as dissociative,associative,mars-van Krevelen,lithium-mediated nitrogen reduction and surface hydrogenation mechanisms of nitrogen *** unravelling the intricacies of eNRR mechanisms and exploring promising avenues,we can pave the way for more efficient and commercially viable ammonia synthesis through this sustainable electrochemical process by designing an efficient electrocatalyst.

关键词： Green ammonia synthesis Electrolysis Electrocatalysis Nitrogen reductionreaction Electrochemical reaction pathways Reactionmechanism

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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through mYC degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.mello metamia Ciampricotti umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm morrsey Sanjoy mehta Jesse Barnes michael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia molina-Pinelo Sohrab Salehi Helena A.Yu Joseph m.Chan Charles m.Rudin Department of medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the mYC Proto-Oncogen(mYC),implicated in stemness and histological *** overexpression of a degradation-resistant mYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

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Pulsed light processing of foods for microbial safety

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Food Quality and Safety 2017年第3期1卷 187-201页

作者： m.L.Bhavya H.umesh Hebbar Department of Technology Scale-up CSIR-Central Food Technological Research InstituteMysoreIndia.

The demand for processed foods and the awareness about food quality and safety are increasing *** consumers’demand for minimally processed foods and growing competition in the market have made the processors to adopt newer non-thermal technologies that preserve nutrients and sensory properties of the ***,heat processing of foods is carried out to convert raw material into value-added product,reduce or eliminate microbial load to improve safety,and extend shelf *** of the limitations of thermal processing techniques can be overcome by employing non-thermal *** hydrostatic pressure,pulsed electric field,ultrasound,cold plasma,dense phase carbon dioxide,ozone,and pulsed light(PL)processing are gaining popularity in food *** technology is a non-thermal technology,where sterilization and decontamination are achieved by impinging high-intensity light pulses of short durations on surfaces of foods and high-transmission *** a few reports on the PL technology are available,in-depth studies on this are needed to adopt at a commercial *** present review provides an overview of light-based processing of foods and covers important aspects such as different PL systems used for processing of foods,mode of action of PL on microbes,the effect of PL on liquid foods,surface decontamination of foods and parameters that affect PL efficacy,combination processing with *** the growing demand in non-thermal processing for the technological advancement in the area of generation of light,light-based processing will be a promising technology for microbial load reduction.

关键词： Pulsed light Food safety Non-thermal processing minimally processed microbial load.

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Identification of EST–SSRs and molecular diversity analysis in mentha piperita

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The Crop Journal 2015年第4期3卷 335-342页

作者： Birendra Kumar umesh Kumar Hemant Kumar Yadav CSIR-Central Institute of medicinal and Aromatic Plant Sciences P.O.CIMAP Near Kukrail Picnic Spot CSIR-National Botanical Research Institute Rana Pratap Marg Academy of Scientific and Innovative Research (AcSIR)

EST sequences of mentha piperita available in the public domain(NCBI) were exploited to develop SSR markers. A total of 1316 ESTs were assembled into 155 contigs and 653 singletons and of these, 110 sequences were found to contain 130 SSRs, with a frequency of1 SSR/3.4 kb. Dinucleotide repeat SSRs were most frequent(72.3%) with the AG/CT(43.8%)repeat motif followed by AT/AT(16.2%). Primers were successfully designed for 68SSR-containing sequences(62.0%). The 68 primers amplified 13 accessions of m. piperita and 54 produced clear amplicons of the expected size. Of these 54, 33(61%) were found to be polymorphic among m. piperita accessions, showing from 2 to 4 alleles with an average of2.33 alleles/SSR, and the polymorphic information content(PIC) value varied between 0.13 and 0.51(average 0.25). All the amplified SSRs showed transferability among four different species of mentha, with a highest in mentha arvensis(87.0%) and minimum in mentha citrata(37.0%). The newly developed SSRs markers were found to be useful for diversity analysis, as they successfully differentiated among species and accessions of mentha.

关键词： EST–SSRs Genetic diversity mentha piperita Polymorphic information content Transferability

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Development of image motion compensation system for 1.3 m telescope at Vainu Bappu Observatory

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Research in Astronomy and Astrophysics 2020年第1期20卷 93-106页

作者： Sreekanth Reddy Vallapureddy Ravinder Kumar Banyal Sridharan Rengaswamy P umesh Kamath Aishwarya Selvaraj Indian Institute of Astrophysics

We developed a tip-tilt system to compensate the turbulence induced image motion for the 1.3 m telescope at Vainu Bappu Observatory,at *** instrument is designed to operate at the visible wavelength band(480-700 nm)with a field of view of 1′×1′.The tilt corrected images have demonstrated up to ≈57% improvement in image resolution and a corresponding peak intensity increase by a factor of ≈2.8.A closed-loop correction bandwidth of ≈26 Hz has been achieved with on-sky tests and the root mean square motion of the star image has been reduced by a factor of ~*** results are consistent with theoretical and numerical predictions of wave-front aberrations caused by atmospheric turbulence and image quality improvement expected from a real-time control *** this paper,we present details of the instrument design,laboratory calibration studies and quantify its performance on the telescope.

关键词： adaptive optics atmospheric effects high angular resolution

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Poly(amaranth) film based sensor for resolution of dopamine in the presence of uric acid:A voltammetric study

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Chinese Chemical Letters 2010年第12期21卷 1490-1492页

作者： umesh Chandra B.E.Kumara Swamy Ongera Gilbert m.Pandurangachar Sathish Reddy S.Sharath Shankar B.S.Sherigara Department of P.G.Studies and Research in Industrial Chemistry Kuvempu UniversityJnana SahyadriShankaraghattaShimoga 577 451KarnatakaIndia Department of Chemistry SSMRV Degree CollegeJayanagara 4T BlockBanglore 41KarnatakaIndia

The electropolymerized film of amaranth was prepared on the surface of graphite pencil electrode（GPE） using cyclic voltammetric *** poly（amaranth） film coated electrode exhibited an excellent electrocatalytic activity towards the detection of dopamine（DA） in the presence of uric acid（UA） in 0.2 mol/L phosphate buffer solution at pH *** effect of interference study was carried out using differential pulse voltammetric *** poly（amaranth） modified GPE was applied for the detection of DA in dopamine injection with satisfactory results.

关键词： Poly(amaranth) Graphite pencil electrode Dopamine Uric acid Sensor

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Silica chloride catalyzed one-pot synthesis of fully substituted pyrazoles

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Chinese Chemical Letters 2011年第10期22卷 1187-1190页

作者： Dhanaji V.Jawale umesh R.Pratap Jyotirling R.mali Ramrao A.mane Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad(M.S.) 431 004India

Silica chloride catalysted one pot cyclocondensation of aldehydes,ethyl acetoacetate and phenyl hydrazine leading to substituted pyrazoles has been reported.

关键词： One-pot synthesis Silica chloride Solvent free Fully substituted pyrazoles

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In vitro antioxidant assessment and a rapid HPTLC bioautographic method for the detection of anticholinesterase inhibitory activity of Geophila repens

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Journal of Integrative medicine 2017年第3期15卷 231-241页

作者： umesh Chandra Dash Atish Kumar Sahoo Regional Plant Resource Centre Medicinal & Aromatic Plant Division Forest & Environment DepartmentGovt. of Odisha Nayapalli Bhubaneswar 751015 India

OBJECTIVE： Geophila repens （L.） I. m. Johnst. （Rubiaceae）, a small, creeping, perennial herb, is claimed to have memory-enhancing property. The goal of this study was to assess its antioxidant and anticholinesterase activity and conduct a rapid bioautographic enzyme assay for screening acetylcholinesterase （ACHE） and butyrylcholinesterase （BChE） inhibition of G. repens extracts. mETHODS： Antioxidant activity of G. repens extracts was assessed by performing 1,1-diphenyl-2- picrylhydrazyl （DPPH）, nitric oxide （NO）, superoxide （SOD）, hydroxyl （OH） and total antioxidant capacity （TAC） assays. Anticholinesterase activity was investigated by quantifying the AChE and BChE inhibitory activities of chloroform （CGR）, ethyl acetate （EGR） and methanol （mGR） extract fractions from G. repens leaves. A rapid high-performance thin-layer chromatography （HPTLC） bioautographic method for the detection of AChE and BChE inhibition was performed. RESULTS： Among all extract fractions, EGR exhibited the highest half maximal inhibitory concentration （IC50） in DPPH, SOD, NO, OH and TAC assays, with IC50 of （38.33 ± 3.21）, （45.14 ±1.78）, （59.81± 1.32）, （39.45 ± 0.79） and （43.76 ± 0.81 ） μg/mL respectively. EGR displayed competitive, reversible inhibition of AChE and BChE activities with IC50 of （68.63±0.45） and （59.45 ±0.45）μg/mL, respectively. Total phenolic and flavonoids contents of EGR were found to be 360.42 mg gallic acid equivalents and 257.31 mg quercetin equivalents per gram of extract. Phytoconstituents of the EGR extract that were inhibitors of cholinesterase produced white spots on the yellow background of HPTLC plates in the bioautographic test. CONCLUSION： The results of this study revealed that phenols and flavonoids could be responsible for the antioxidant, anticholinesterase activities of G. repens.

关键词： Geophila repens Alzheimer disease acetylcholinesterase butyrylcholinesterase fingerprint bioautographic phenolic, antioxidant

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Conservation and management of Forest Resources in India: Ancient and Current Perspectives

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Natural Resources 2015年第4期6卷 256-272页

作者： m. S. umesh Babu Sunil Nautiyal Centre for Ecological Economics and Natural Resources Institute for Social and Economic Change Bangalore India

This paper brings out the issues related to natural resource exists, management and erosion right from the ancient to modern era. The natural resource such as forests and forest products were found as a basic source of survival for living organisms during the initial period. Later, the natural resources started degrading slowly and steadily due to increased human activities. In the beginning, natural resources were the primary assets for the growth of agriculture, industry, urbanization etc. Subsequently, increased anthropogenic activities started degrading the forest cover on a large scale through extending the agricultural land scape and other developmental activities in the country. The importance of traditional knowledge regarding resource conservation, protection of sacred grooves, endangered species etc. started declining in modern India. Innovativeness and policy framework for resource conservation and utilization became unfriendly in addition to gradual decline of community management. The key findings of the study point to major gaps existing such as between line departments and institutions in the promotion and management of forests, human welfare, agriculture, animal husbandry etc. moreover, people tend to be more inclined towards the utilization of natural resources rather than conservation. From an observational and practical point of view, the natural resource has been declining rapidly in India. Therefore, this study strongly suggests that a due attention be directed towards developing people-friendly and environment friendly conservation strategies.

关键词： Theory Practice Natural Resources Approaches management

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