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Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin

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Journal of Biomaterials and Nanobiotechnology 2011年第4期2卷 414-425页

作者： umesh kumar parida Ashok kumar Nayak Birendra kumar Binhani P. L. Nayak KIIT School of Biotechnology KIIT University Bhubaneswar India. P. L. Nayak Research Foundation Neelachal Bhavan Bidyadharpur Cuttack India P. L. Nayak Research Foundation Neelachal Bhavan Cuttack India P. L. Nayak Research Foundation Neelachal Bhavan Cuttack India

In the present research program, polymer nanocomposites have been used as the drug carrier for delivery systems of anticancer drug. Chitosan (Cs) and Polyvinyl Alcohol (PVA) with different ratios were blended with different wt% of Cloisite 30B solution by solvent casting method. Glutaraldehyde with different wt% was added to the blended solution as a crosslinking agent. Cloisite 30B was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Curcumin with different concentrations were loaded with CS-PVA/ C 30B nanocomposites for studying the in-vitro drug delivery systems. Morphology and structure characterization of nanocomposites were investigated by fourier transmission infra red spectroscopy (FTIR), scanning electron microscope (SEM), tensile strength and water uptake capacity. The drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.

关键词： Chitosan PVA C 30B Glutaraldehyde Curcumin Drug Delivery

Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy

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World Journal of Radiology 2024年第7期16卷 265-273页

作者： Parneet Singh Kanhaiyalal Agrawal Ashique Rahman Tejasvini Singhal Girish kumar parida Gopinath Gnanasegaran Department of Nuclear Medicine All India Institute of Medical SciencesBhubaneshwar 751019OdishaIndia Department of Nuclear Medicine Royal Free HospitalLondon NW32QGUnited Kingdom

BACKGROUND Bone is one of the common sites of metastasis from prostate *** scintigraphy(BS)is one of the most sensitive imaging modalities currently used for bone metastatic *** metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal *** To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate *** This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging *** with abnormal BS were evaluated for the pattern of skeletal involvement and data were pre-sented in descriptive format in the form of *** A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the *** of 150 patients(8.67%)had no abnormal uptake on planar images,ruling out metastatic ***-four patients(16%)had heterogeneous uptake in the spine with distribution charac-teristic of degenerative disease and no scan pattern of metastatic *** patients(20%)had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered ***-three out of 150 patients(55.3%)had increased tracer uptake,which was indeterminate,thus,single photon emission computed tomography-computed tomography(SPECT-CT)was acquired,which showed 51 with metastatic disease,31 benign lesions,and one indeterminate *** of 150 patients had exclusive pelvic bone uptake,which was found to be metastatic in 4/7 patients in *** six out of 150 patients showed exclusive extrapelvic tracer uptake,of which only 3 had vertebral metastatic *** of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was *** The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinom

关键词： Pelvic Prostate cancer Bone scan Single photon emission computed tomography-computed tomography Skeletal metastasis

Environmental fate and health exposures of the geogenic and anthropogenic contaminants in potable groundwater of Lower Ganga Basin,India

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Geoscience Frontiers 2022年第3期13卷 115-129页

作者： Indrani Mukherjee umesh kumar Singh Integrated Science Education and Research Centre(ISERC) Institute of ScienceVisva-Bharati UniversitySantiniketanBirbhum 731235West BengalIndia Department of Environmental Science School of EarthBiological and Environmental SciencesCentral University of South BiharGaya 824236BiharIndia

The study evaluated the sources and controlling factors of the groundwater contaminants in an agroeconomic region of Lower Ganga Basin using principal component analysis(PCA),multivariable linear regressions(MLR),correlation analysis,and hierarchical cluster analysis,and evaluated the public health risks using the Latin Hypercube Sampling,goodness-of-fit statistics,Monte Carlo simulation and Sobol sensitivity analysis based on the 1000 samples collected in two sampling cycles(N=1000).The study reveals that the dissolution of fluoride-bearing minerals and semi-arid climate regulate the fluoride concentrations(0.10–18.25 mg/L)in *** application of inorganic nitrogenous fertilizers and livestock manure mainly contributed to elevated nitrate levels(up to 435.0 mg/L)in *** health risks analysis indicates that fluoride exposure is more prevalent in the residents of each age group than the nitrate and both contaminants exhibited higher non-carcinogenic health risks on the infant and child(minor)age groups compared to adolescents and *** on the cokriging interpolation mapping,the minor residents of 17.88%–23.15%of the total area(4545.0 km^(2))are vulnerable to methemoglobinemia whereas the residents of all age-groups in 38.47%–44.45%of the total area are susceptible to mild to severe dental/skeletal fluorosis owing to consumption of untreated nitrate and fluoride enriched *** Sobol sensitivity indices revealed contaminant levels,groundwater intake rate and their collective effects are the most influential factors to pose potential health risks on the *** recharge and rainwater harvesting practices should be adopted to improve the groundwater quality and the residents are advised to drink purified groundwater.

关键词： Cokriging Health risks Principal component analysis Cluster analysis Nitrate contamination Fluoride contamination

Medical Data Clustering and Classification Using TLBO and Machine Learning Algorithms

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Computers, Materials & Continua 2022年第3期70卷 4523-4543页

作者： Ashutosh kumar Dubey umesh Gupta Sonal Jain Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Institute of Engineering and Technology JK Lakshmipat UniversityJaipurIndia

This study aims to empirically analyze teaching-learning-based optimization(TLBO)and machine learning algorithms using k-means and fuzzy c-means(FCM)algorithms for their individual performance evaluation in terms of clustering and *** the first phase,the clustering(k-means and FCM)algorithms were employed independently and the clustering accuracy was evaluated using different *** the second phase,the non-clustered data obtained from the first phase were preprocessed with *** was performed using k-means(TLBO-KM)and FCM(TLBO-FCM)(TLBO-KM/FCM)*** objective function was determined by considering both minimization and maximization ***-clustered data obtained from the first phase were further utilized and fed as input for threshold *** benchmark datasets were considered from theUniversity of California,Irvine(UCI)Machine Learning Repository for comparative study and *** are breast cancer Wisconsin(BCW),Pima Indians Diabetes,Heart-Statlog,Hepatitis,and Cleveland Heart Disease *** combined average accuracy obtained collectively is approximately 99.4%in case of TLBO-KM and 98.6%in case of *** approach is also capable of finding the dominating *** findings indicate that TLBO-KM/FCM,considering different computational measures,perform well on the non-clustered data where k-means and FCM,if employed independently,fail to provide significant *** different feature sets,the TLBO-KM/FCM and SVM(GS)clearly outperformed all other classifiers in terms of sensitivity,specificity and ***/FCM attained the highest average sensitivity(98.7%),highest average specificity(98.4%)and highest average accuracy(99.4%)for 10-fold cross validation with different test data.

关键词： K-means FCM TLBO TLBO-KM TLBO-FCM TLBO-KM/FCM machine learning algorithms

An efficient algorithm to clip a 2D-polygon against a rectangular clip window

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Applied Mathematics(A Journal of Chinese Universities) 2022年第1期37卷 147-158页

作者： Sushil Chandra Dimri umesh kumar Tiwari Mangey Ram Department of Computer Science and Engineering Graphic Era(Deemed to be University)DehradunUttarakhandIndia

Polygon clipping is of great importance in computer *** of the popular algorithms to clip a polygon is Cohan–Sutherland Hodgeman algorithm which is based on line ***–Sutherland Hodgeman algorithm clips the polygon against the given rectangular clip window with the help of line clipping ***–Sutherland algorithm requires traversing the polygon in anti clockwise direction(positive orientation).In this work we propose an efficient polygon clipping algorithm against a rectangular clip *** algorithm uses parametric representation of polygon *** the concept of point clipping,we can find required intersection points of edges of polygon with clip window *** suited numerical illustrations are used to explain the proposed polygon clipping *** proposed algorithm is computationally less expensive and comprehensive.

关键词： point clipping polygon clipping clip window line segment computational complexity

Ball Convergence Theorems for Chebyshev-Halley Method in B-Space

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Journal of Mathematical Research with Applications 2023年第6期43卷 723-736页

作者： Chandni kumarI Pradip kumar parida Department of Mathematics Central University of Jharkhand

A local convergence analysis of Chebyshev-Halley method having third order of convergence for approximating zero of non-linear operator f(v) = 0 by using convex majorant function and their condition in B-space(Banach space), is presented in this article. We give the error estimate to show the efficiency of our study. Besides, we established the relation between majorant function and Kantorovich or Smale-type result as special cases of our general theory.

关键词： Chebyshev-Halley method Majorizing function Majorant condition Local convergence Kantorovich-type condition Smale-type condition

Analysis of some critical aspects in hot machining of Ti-5553 superalloy: Experimental and FE analysis

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Defence Technology（防务技术） 2019年第3期15卷 344-352页

作者： Asit kumar parida Kalipada Maity Mechanical Engineering Department Indian Institute of Technology Delhi India National Institute of Technology Rourkela Mechanical Engineering Department India

In this study, a newly developed titanium superalloy, i.e., the Ti-5553 alloy has used for hot machining. This material replaced Ti-grade-5 alloy in the application of aerospace, automobile, and biomedical sector. However, similar to Ti-grade-5 alloy, the Ti-5553 alloy has a low thermal conductivity which makes it difficult-to-cut material categories hence, high tool wear, cutting force and bad surface finish. Hot machining of Ti-5553 has been studied at different machining condition (room and hot) using Deform-2D finite element analysis. The result from the simulation test was compared with the experimental value and reduction of cutting and thrust forces was observed. The experiment was carried out with the same input parameters as simulation, and good coherence between them observed. Additionally, cutting zone temperature, effective stress, etc. for both room and elevated the temperature are also discussed.

关键词： Ti-5553 Hot machining Cutting force Flank wear Finite element analysis

FEM analysis and experimental investigation of force and chip formation on hot turning of Inconel 625

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Defence Technology（防务技术） 2019年第6期15卷 853-860页

作者： Asit kumar parida Kalipada Maity Indian Institute of Technology Delhi Department of Mechanical EngineeringIndia National Institute of Technology Rourkela Department of Mechanical EngineeringIndia

This study investigates the hot machining of Inconel 625 alloy by using flame heating under different machining conditions using finite element analysis(FEM).Turning tests are performed at different cutting speeds and heating temperatures using uncoated carbide insert by DEFORM *** reduction in cutting force and tool wear has achieved at heating conditions compared to room *** tool life is achieved at the highest cutting speed and higher heating temperature *** heating conditions of the 600℃ continuous chip is formed whereas at room temperature saw-tooth chip formation is observed.A significant agreement is achieved between simulated and experimental cutting forces and chip *** effect of feed rates and depth of cuts are also studied experimentally during turning of Inconel 625 in a systematic manner.

关键词： Hot machining Force Inconel 625 Surface roughness Chip morphology

Identification of EST–SSRs and molecular diversity analysis in Mentha piperita

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The Crop Journal 2015年第4期3卷 335-342页

作者： Birendra kumar umesh kumar Hemant kumar Yadav CSIR-Central Institute of Medicinal and Aromatic Plant Sciences P.O.CIMAP Near Kukrail Picnic Spot CSIR-National Botanical Research Institute Rana Pratap Marg Academy of Scientific and Innovative Research (AcSIR)

EST sequences of Mentha piperita available in the public domain(NCBI) were exploited to develop SSR markers. A total of 1316 ESTs were assembled into 155 contigs and 653 singletons and of these, 110 sequences were found to contain 130 SSRs, with a frequency of1 SSR/3.4 kb. Dinucleotide repeat SSRs were most frequent(72.3%) with the AG/CT(43.8%)repeat motif followed by AT/AT(16.2%). Primers were successfully designed for 68SSR-containing sequences(62.0%). The 68 primers amplified 13 accessions of M. piperita and 54 produced clear amplicons of the expected size. Of these 54, 33(61%) were found to be polymorphic among M. piperita accessions, showing from 2 to 4 alleles with an average of2.33 alleles/SSR, and the polymorphic information content(PIC) value varied between 0.13 and 0.51(average 0.25). All the amplified SSRs showed transferability among four different species of Mentha, with a highest in Mentha arvensis(87.0%) and minimum in Mentha citrata(37.0%). The newly developed SSRs markers were found to be useful for diversity analysis, as they successfully differentiated among species and accessions of Mentha.

关键词： EST–SSRs Genetic diversity Mentha piperita Polymorphic information content Transferability