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Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel Prashant Sharma Vamsi Krishna Uppalapati umesh Kumar Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

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Exploring nitrogen reduction reaction mechanisms in electrocatalytic ammonia synthesis:A comprehensive review

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Journal of Energy Chemistry 2024年第5期92卷 681-697页

作者： Abhishek umesh Shetty Ravi Sankannavar School of Chemical and Materials Science Indian Institute of Technology GoaFarmagudiPonda 403401GoaIndia Department of Chemical Engineering M.S.Ramaiah Institute of TechnologyMSR NagarMSRIT PostBengaluru 560054KarnatakaIndia

The electrochemical nitrogen reduction reaction(eNRR)holds significant promise as a sustainable alternative to the conventional large-scale Haber Bosch process,offering a carbon footprint-free approach for ammonia *** the process is thermodynamically feasible at ambient temperature and pressure,challenges such as the competing hydrogen evolution reaction,low nitrogen solubility in electrolytes,and the activation of inert dinitrogen(N_(2))gas adversely affect the performance of ammonia *** hurdles result in low Faradaic efficiency and low ammonia production rate,which pose obstacles to the commercialisation of the *** have been actively designing and proposing various electrocatalysts to address these issues,but challenges still need to be resolved.A key strategy in electrocatalyst design lies in understanding the underlying mechanisms that govern the success or failure of the electrocatalyst in driving the electrochemical *** mechanistic studies,we gain valuable insights into the factors affecting the reaction,enabling us to propose optimised designs to overcome the *** review aims to provide a comprehensive understanding of the various mechanisms involved in eNRR on the electrocatalyst *** delves into the various mechanisms such as dissociative,associative,Mars-van Krevelen,lithium-mediated nitrogen reduction and surface hydrogenation mechanisms of nitrogen *** unravelling the intricacies of eNRR mechanisms and exploring promising avenues,we can pave the way for more efficient and commercially viable ammonia synthesis through this sustainable electrochemical process by designing an efficient electrocatalyst.

关键词： Green ammonia synthesis Electrolysis Electrocatalysis Nitrogen reductionreaction Electrochemical reaction pathways Reactionmechanism

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Environmental fate and health exposures of the geogenic and anthropogenic contaminants in potable groundwater of Lower Ganga Basin,India

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Geoscience Frontiers 2022年第3期13卷 115-129页

作者： Indrani Mukherjee umesh Kumar Singh Integrated Science Education and Research Centre(ISERC) Institute of ScienceVisva-Bharati UniversitySantiniketanBirbhum 731235West BengalIndia Department of Environmental Science School of EarthBiological and Environmental SciencesCentral University of South BiharGaya 824236BiharIndia

The study evaluated the sources and controlling factors of the groundwater contaminants in an agroeconomic region of Lower Ganga Basin using principal component analysis(PCA),multivariable linear regressions(MLR),correlation analysis,and hierarchical cluster analysis,and evaluated the public health risks using the Latin Hypercube Sampling,goodness-of-fit statistics,Monte Carlo simulation and Sobol sensitivity analysis based on the 1000 samples collected in two sampling cycles(N=1000).The study reveals that the dissolution of fluoride-bearing minerals and semi-arid climate regulate the fluoride concentrations(0.10–18.25 mg/L)in *** application of inorganic nitrogenous fertilizers and livestock manure mainly contributed to elevated nitrate levels(up to 435.0 mg/L)in *** health risks analysis indicates that fluoride exposure is more prevalent in the residents of each age group than the nitrate and both contaminants exhibited higher non-carcinogenic health risks on the infant and child(minor)age groups compared to adolescents and *** on the cokriging interpolation mapping,the minor residents of 17.88%–23.15%of the total area(4545.0 km^(2))are vulnerable to methemoglobinemia whereas the residents of all age-groups in 38.47%–44.45%of the total area are susceptible to mild to severe dental/skeletal fluorosis owing to consumption of untreated nitrate and fluoride enriched *** Sobol sensitivity indices revealed contaminant levels,groundwater intake rate and their collective effects are the most influential factors to pose potential health risks on the *** recharge and rainwater harvesting practices should be adopted to improve the groundwater quality and the residents are advised to drink purified groundwater.

关键词： Cokriging Health risks Principal component analysis Cluster analysis Nitrate contamination Fluoride contamination

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Analytical techniques for serratiopeptidase: A review

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Journal of Pharmaceutical Analysis 2017年第4期7卷 203-207页

作者： Vandana Gupte umesh Luthra Ipca Laboratories Ltd. Biotech R & DKandivali (W)Mumbai 400067MaharashtraIndia

A review is presented on different analytical techniques used for qualitative and quantitative analysis of serratiopeptidase, a proteolytic enzyme, which has recently gained importance as an anti-inflammatory *** have been made to collate all the relevant references to the extent possible. The review discusses the advantages and disadvantages of the cited analytical techniques, which will help to give insights into the methods used for estimation of serratiopeptidase as such, from clinical isolates and from its dosage *** review highlights the basic as well as advanced techniques performed for estimating serratiopeptidase. The techniques illustrated here have been demonstrated to be useful for qualitative and quantitative determination of serratiopeptidase and may find application in analyzing other related proteases.

关键词： Serratiopeptidase Anti-inflammatorydrug Analyticalmethod Qualitativeanalysis Quantitativeanalysis

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A review of cooling technologies for high temperature rotating components in gas turbine

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Propulsion and Power Research 2022年第3期11卷 293-310页

作者： umesh Unnikrishnan Vigor Yang Georgia Institute of Technology AtlantaGAUSA

Modern gas turbines work under demanding high temperatures, high pressures, andhigh rotational speeds. In order to ensure durable and reliable operation, effective cooling mea-sures must be applied to the high-temperature rotating components, including turbine bladesand turbine disks. Cooling technology, however, is one of the most challenging problems inthis field. The present work reviews the current state of cooling technology research, at boththe fundamental science and engineering implementation levels, including modeling and simu-lation, experiments and diagnostics, and cooling technologies for blades and disks. In numericalsimulation, the RANS approach remains the most commonly used technique for flow-dynamicsand heat-transfer simulations. Much attention has been given to the development of improvedturbulence modeling for flows under rotation. For measurement and diagnostics, advancedinstrumentation and rotating-flow test facilities have been developed and valuable experimentaldata obtained. Detailed velocity and temperature distributions in rotating boundary layers havebeen obtained at scales sufficient to resolve various underlying mechanisms. Both isothermaland non-isothermal conditions have been considered, and the effects of Coriolis and buoyancyforces on flow evolution and heat transfer quantitatively identified. Cooling technologies havebeen improved by optimizing cooling passage dsigns, especially for curved configurations un-der rotation. Novel methods such as lamellar cooling and micro-scale cooling were proposed,and their effectiveness evaluated. For disk/cavity cooling, efforts were mainly focused on rotor-stator systems, with special attention given to the position of air injection into disks.

关键词： Gas turbine Rotating components Turbine blade Turbine disk Cooling technology

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Bianchi .Type-I Massive String Magnetized Barotropic Perfect Fluid Cosmological Model in General Relativity

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Chinese Physics Letters 2007年第8期24卷 2455-2458页

作者： BALI Raj PAREEK umesh Kumar PRADHAN Anirudh Department of Mathematics University of Rajasthan Jaipur-302 004 India Department of Mathematics Jaipur Engineering College and Research Centre Jaipur-303 905 India Department of Mathematics Hindu Post-graduate College Zamania-232 331 Chazipur India

Bianchi type-I massive string cosmological model with magnetic field of barotropic perfect fluid distribution through the techniques used by Latelier and Stachel is investigated. To obtain the deterministic model of the universe, it is assumed that the universe is filled with barotropic perfect fluid distribution. The magnetic field is due to electric current produced Mong the x-axis with infinite electrical conduictivity. The behaviour of the model in the presence and absence of magnetic field together with other physical aspects is further discussed.

关键词： coated conductor buffer layer self-epitaxy CeO2

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Performance assessment of aged binder rejuvenated with Polanga oil

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 608-620页

作者： Sujit Kumar Pradhan umesh Chandra Sahoo School of Infrastructure Indian Institute of Technology BhubaneswarOdisha 752050India

Presently,there is a necessity of increasing the reclaimed asphalt pavement(RAP)content in recycling of asphalt pavements to save material cost,preserve energy and protect the environment and efforts are being made to utilize 100%RAP in the *** binder is usually stiff due to oxidation and loss of *** addition of high amount of RAP to the asphalt mix,may make it prone to fatigue *** to this reason,rejuvenators are added to restore some of the physical and chemical properties for desired performance of the *** this study,a locally available non-edible oil known as Polanga oil(biological name:Calophyllum inophyllum)has been explored as rejuvenator to study its effect on performance of the aged *** binder prepared in the laboratory using the Pressure Aging Vessel(PAV)and binder extracted from the RAP collected from a nearby source were used in this study for *** binder and RAP binder mixed with the rejuvenator at varying *** rheological characterizations in terms of flow,rutting,fatigue and creep recovery of rejuvenated PAV aged&RAP binders were carried out using a dynamic shear rheometer(DSR)to determine the optimum dosage of the *** was observed that,5 percent of Polanga oil is able to divulge the desirable rheological properties of the rejuvenated binder.

关键词： Virgin bitumen Reclaimed asphalt pavement Rejuvenator Polanga oil Aged bitumen Rheology

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Medical Data Clustering and Classification Using TLBO and Machine Learning Algorithms

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Computers, Materials & Continua 2022年第3期70卷 4523-4543页

作者： Ashutosh Kumar Dubey umesh Gupta Sonal Jain Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Institute of Engineering and Technology JK Lakshmipat UniversityJaipurIndia

This study aims to empirically analyze teaching-learning-based optimization(TLBO)and machine learning algorithms using k-means and fuzzy c-means(FCM)algorithms for their individual performance evaluation in terms of clustering and *** the first phase,the clustering(k-means and FCM)algorithms were employed independently and the clustering accuracy was evaluated using different *** the second phase,the non-clustered data obtained from the first phase were preprocessed with *** was performed using k-means(TLBO-KM)and FCM(TLBO-FCM)(TLBO-KM/FCM)*** objective function was determined by considering both minimization and maximization ***-clustered data obtained from the first phase were further utilized and fed as input for threshold *** benchmark datasets were considered from theUniversity of California,Irvine(UCI)Machine Learning Repository for comparative study and *** are breast cancer Wisconsin(BCW),Pima Indians Diabetes,Heart-Statlog,Hepatitis,and Cleveland Heart Disease *** combined average accuracy obtained collectively is approximately 99.4%in case of TLBO-KM and 98.6%in case of *** approach is also capable of finding the dominating *** findings indicate that TLBO-KM/FCM,considering different computational measures,perform well on the non-clustered data where k-means and FCM,if employed independently,fail to provide significant *** different feature sets,the TLBO-KM/FCM and SVM(GS)clearly outperformed all other classifiers in terms of sensitivity,specificity and ***/FCM attained the highest average sensitivity(98.7%),highest average specificity(98.4%)and highest average accuracy(99.4%)for 10-fold cross validation with different test data.

关键词： K-means FCM TLBO TLBO-KM TLBO-FCM TLBO-KM/FCM machine learning algorithms

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Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 106-107页

作者： umesh K Bhanot Department of Pathology University of Ulm89081 UlmGermanyMD

To the Editor:I read the report of Krishnasamy et al1 with great *** authors make a valid point about management issues associated with pancreatic ductal intraepithelial neoplasia (PanIN) in their ***,a few clarificat... 详细信息

关键词： Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia

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Identification of EST–SSRs and molecular diversity analysis in Mentha piperita

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The Crop Journal 2015年第4期3卷 335-342页

作者： Birendra Kumar umesh Kumar Hemant Kumar Yadav CSIR-Central Institute of Medicinal and Aromatic Plant Sciences P.O.CIMAP Near Kukrail Picnic Spot CSIR-National Botanical Research Institute Rana Pratap Marg Academy of Scientific and Innovative Research (AcSIR)

EST sequences of Mentha piperita available in the public domain(NCBI) were exploited to develop SSR markers. A total of 1316 ESTs were assembled into 155 contigs and 653 singletons and of these, 110 sequences were found to contain 130 SSRs, with a frequency of1 SSR/3.4 kb. Dinucleotide repeat SSRs were most frequent(72.3%) with the AG/CT(43.8%)repeat motif followed by AT/AT(16.2%). Primers were successfully designed for 68SSR-containing sequences(62.0%). The 68 primers amplified 13 accessions of M. piperita and 54 produced clear amplicons of the expected size. Of these 54, 33(61%) were found to be polymorphic among M. piperita accessions, showing from 2 to 4 alleles with an average of2.33 alleles/SSR, and the polymorphic information content(PIC) value varied between 0.13 and 0.51(average 0.25). All the amplified SSRs showed transferability among four different species of Mentha, with a highest in Mentha arvensis(87.0%) and minimum in Mentha citrata(37.0%). The newly developed SSRs markers were found to be useful for diversity analysis, as they successfully differentiated among species and accessions of Mentha.

关键词： EST–SSRs Genetic diversity Mentha piperita Polymorphic information content Transferability

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