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National Science Review 2024年第6期11卷 93-95页

作者： Vishwanath ganesan Mohammad Jalal Inanlu Nenad Miljkovic Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Materials Research Laboratory University of Illinois Urbana-Champaign International Institute for Carbon Neutral Energy Research (WPI-I2CNER) Kyushu University Institute for Sustainability Energy and Environment (iSEE)University of Illinois Urbana-Champaign

The field of thermal management in highpower electronic devices is a critical area of study, focusing on the efficient dissipation of heat to prevent device overheating and failure [1]. A key aspect of this field is understanding the dynamics of thin liquid film boiling, both on uniform and non-uniform micro-structured wicking surfaces, which can significantly enhance the heat transfer effectiveness[2].

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The Triple Gene Block 1 Movement Protein of the ND18 Strain of Barley Stripe Mosaic Virus is an Avirulence Determinant That Elicits Brachypodium distachyon Bd3-1 resistance

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The Triple Gene Block 1 Movement Protein of the ND18 Strain ...

GFP Expression from A Biologically Active Minireplicon of Sonchus Yellow Net Virus

中国植物病理学会2012年学术年会

作者： LEE Mi-Yeon Florien Gorter Brian Y.T Kim Jessica Grindheim uma ganesan Andrew O.Jackson Department of Plant & Microbial Biology University of California-BerkeleyBerkeleyCA 94720USA

Barley stripe mosaic virus(BSMV) North Dakota 18(ND18),Norwich(NW),Beijing (BJ),Xinjiang(XJ),Type and CV21 strains elicit different phenotypic responses on Brachypodium distachyon, a cereal grass model for ***18 is unable to infect the Brachypodium Bd3-1 inbred line,which contains a recently mapped resistance gene designated Bsr1(Cui et *** ONE,2012, 7(6);e38333).Along with ND18,the BJ,XJ,Type and CV21 strains also failed to produce visible symptoms or virus on Bd3-1,so it is possible that Bsr1 mediates resistance against all five BSMV strains. In contrast,NW overcomes Bd3-1 resistance and is accompanied by an intense mosaic phenotype and large amounts of *** of ND18 and NW genomic RNAs,and a series of chimeric exchanges within RNAβdemonstrate that Bd3-1 phenotypes are mediated by a region within the helicase motif of *** of this region reveals that the ND18 and NW strains contain divergent amino acids at positions 390,392 and 404 within this region,and that the inability of ND18 and the BJ,XJ,Type and CV21 strains to elicit fully virulent BSMV infections on Bd3-1 correlates with a threonine(T) at position 392(T).The virulent NW strain contains K residues at both the 390 and 392 positions and a glutamate (E) residue at position *** substitutions to swap the ND18 and NW 404 residues failed to affect the respective disease ***,R390K and T392K single exchanges and a R390K/ T392K double mutant in ND18 RNA TGB1 resulted in virulent *** contrast,incorporation of single K390R or K392T mutations into the NW TGB1 protein background did not affect the susceptible disease phenotype,suggesting that the NW K and K residues compensate for each *** contrast, a K390R/K392T double mutant in the NW TGB1 background failed to develop fully systemic infections on Bd3-1,or accumulate detectable viral RNA,but prominent necrotic streaks radiating from the secondary leaf veins were *** experiments in toto

关键词： Barley stripe mosaic virus Brachypodium distachyon resistance ND18 strain avirulence determinants Triple Gene Block 1(TGB1)

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GFP Expression from A Biologically Active Minireplicon of So...

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

中国植物病理学会2011年学术年会

作者： Andrew O.Jackson uma ganesan Manling Shi Jennifer N.Bragg Mi-Yeon Lee Justin Kappel Cole Peters Sharon Marr University of California BerkeleyCA 94720

＜正＞Sonchus yellow net virus（SYNV） is an extensively characterized plant rhabdovirus that replicates in the nucleus and undergoes morphogenesis at the inner nuclear *** minimum infectious unit of SYNV is a ribonucleoprotein core complex,consisting of the nucleocapsid（N） protein,the phosphoprotein（P） and the polymerase（L） protein complexed with the negative-strand genomic（g） *** genetic analysis of plant negative strand viruses,in contrast to animal negative strand

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Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar ganesan Cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song Jinhui Zhang Hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

An Imperative Role of Fetal Autopsy in Previable Fetuses-Amniotic Deformity Adhesions,Mutilations Complex

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Maternal-Fetal Medicine 2024年第3期6卷 134-140页

作者： Harini Devi JKA Nidhya ganesan umamaheswari Gurusamy Department of Pathology PSG Institute of Medical Sciences and ResearchPeelameduCoimbatore 641004India

Objective:To identify the occurrence of the amniotic deformity adhesions,mutilation(ADAM)complex and imperative role of fetal autopsy in diagnosing this ***:A retrospective descriptive study spanning nine years,from January 2014 to January 2022,was conducted at the Department of Pathology within a tertiary care hospital in South *** study focused on analyzing the clinical presentation,prenatal ultrasonogram,and morphological features of fetuses with the ADAM complex,limb body wall complex,or amniotic ***:Among the 438 fetuses assessed during the study period,five fetuses showed features of the ADAM complex(0.01%).The most frequent gestational age observed was 12–18 weeks andmost fetuseswere *** common anomaly encountered was limb defects,followed by abdominal and cranial ***:The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk *** pathologist plays a crucial role in understanding the complexities of the ADAM *** antenatal imaging and therapies offer potential for prevention through improved counseling.

关键词： Amniotic band syndrome ADAM complex Previable fetus Fetal autopsy

Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients

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World Journal of Diabetes 2024年第1期15卷 24-33页

作者： Rupak Desai Nishanth Katukuri Sumaja Reddy Goguri Azra Kothawala Naga Ruthvika Alle Meena Kumari Bellamkonda Debankur Dey Sharmila ganesan Minakshi Biswas Kuheli Sarkar Pramoda Prattipati Shaylika Chauhan Independent Researcher Independent ResearcherAtlantaGA 30079United States Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Medicine Chalmeda Anand Rao Institute of Medical SciencesTelangana 505001India Department of Medicine Jawaharlal Nehru Medical CollegeBelgaum 590010India Department of Medicine Narayana Medical CollegeAndhra PradeshNellore 524003India Department of Medicine Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research FoundationVijaywada 521286India Department of Medicine Medical College KolkataKolkata 700073India Department of Medicine P.E.S.Institute of Medical Sciences and ResearchAndhra Pradesh 517425India Department of Medicine Shaheed Ziaur Rahman Medical CollegeBogra 5800Bangladesh Department of Medicine College of Medicine and J.N.M HospitalKalyani 741235India Department of Medicine Jawaharlal Nehru Medical College IndiaKarnatakaBelagavi 590010India Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States

BACKGROUND Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events(MACCE).However,the relationship between prediabetes and MACCE in atrial fibrillation(AF)patients has not been extensively ***,this study aimed to establish a link between prediabetes and MACCE in AF *** To investigate a link between prediabetes and MACCE in AF *** We used the National Inpatient Sample(2019)and relevant ICD-10 CM codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes,excluding *** primary outcome was MACCE(all-cause inpatient mortality,cardiac arrest including ventricular fibrillation,and stroke)in AF-related *** Of the 2965875 AF-related hospitalizations for MACCE,47505(1.6%)were among patients with *** prediabetes cohort was relatively younger(median 75 vs 78 years),and often consisted of males(56.3%vs 51.4%),blacks(9.8%vs 7.9%),Hispanics(7.3%vs 4.3%),and Asians(4.7%vs 1.6%)than the non-prediabetic cohort(P<0.001).The prediabetes group had significantly higher rates of hypertension,hyperlipidemia,smoking,obesity,drug abuse,prior myocardial infarction,peripheral vascular disease,and hyperthyroidism(all P<0.05).The prediabetes cohort was often discharged routinely(51.1%vs 41.1%),but more frequently required home health care(23.6%vs 21.0%)and had higher *** adjusting for baseline characteristics or comorbidities,the prediabetes cohort with AF admissions showed a higher rate and significantly higher odds of MACCE compared to the non-prediabetic cohort[18.6%vs 14.7%,odds ratio(OR)1.34,95%confidence interval 1.26-1.42,P<0.001].On subgroup analyses,males had a stronger association(aOR 1.43)compared to females(aOR 1.22),whereas on the race-wise comparison,Hispanics(aOR 1.43)and Asians(aOR 1.36)had a stronger association with MACCE with prediabetes vs whites(aOR 1.33)and blacks(aOR 1.21).CONCLUSION This population-

关键词： Prediabetes Atrial fibrillation Cardiovascular disease risk Major adverse cardiovascular and cerebrovascular events Stroke Mortality

Seaweed nutraceuticals and their therapeutic role in disease prevention

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Food Science and Human Wellness 2019年第3期8卷 252-263页

作者： Abirami R.ganesan uma Tiwari Gaurav Rajauria School of Applied Sciences College of EngineeringScience and TechnologyFiji National UniversityFiji School of Science Institute of Technology SligoBallinodeCo.SligoIreland School of Agriculture and Food Science University College DublinLyons Research FarmCelbridgeCo.KildareIreland

There is a growing interest that bioactive compounds from seaweed can play a major therapeutic role in disease prevention in *** bioactives including polysaccharides,pigments,fatty acids,polyphenols and peptides have been proven to possess various beneficial biological properties that could potentially contribute to functional food and nutraceutical *** bioactive are explored for functional properties such as antioxidant,antibacterial,anticancer,antidiabetic,antitumor,antiviral,anti-inflammatory and anticoagulant properties,both in an in-vitro and in-vivo model *** review critically examines the existing scientific knowledge on primary and secondary metabolites from seaweed and their functional properties for health-related *** presents an update on the most recent evidence relating to their effect on health-related conditions and their action on cellular *** advancement and challenges for seaweed bioactive as a nutraceutical in relation to their biocompatibility and bioavailability to understand their therapeutic development is discussed.

关键词： Functional ingredients Glucose metabolism Lipid metabolism Macroalgae Bioavailability

In Vitro Free Radical Scavenging Activity of Ethanolic Extract of the Whole Plant of Evolvulus Alsinoides(L.) L.

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Chinese Journal of Integrative Medicine 2015年第6期21卷 453-458页

作者： Duraisamy Gomathi ganesan Ravikumar Manokaran Kalaiselvi Balasubramaniam Vidya Chandrasekar uma Department of Biochemistry Karpagam University

Objective： To identify the free radical scavenging activity of ethanolic extract of Evolvulus alsinoides. Methods： The free radical scavenging activity was evaluated by in vitro methods like reducing power assay, total antioxidant activity, 2,2-diphenyl-l-picrylhydrazyl （DPPH） reduction, superoxide radical scavenging activity, 2,2＇-azinobis-（3-ethylbenzothiazoline-6-sulfonic acid）（ABTS＊） scavenging activity, hydroxyl radical scavenging assay, and nitric oxide radical scavenging assay, which were studied by using ascorbic acid as standard. Results： The extract showed significant activities in all antioxidant assays compared with the reference antioxidant ascorbic acid. The total antioxidant activity as well as the reducing power was also found to increase in a dose-dependent manner. Conclusion： Evolvulus alsinoides may act as a chemopreventive agent, providing antioxidant properties and offering effective protection from free radicals.

关键词： Evolvulus alsinoides ethanolic extract total antioxidant reducing power ascorbic acid convolvulaceae

Development,characterization and solubility enhancement of comparative dissolution study of second generation of solid dispersions and microspheres for poorly water soluble drug

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Asian Journal of Pharmaceutical Sciences 2015年第5期10卷 433-441页

作者： Poovi ganesan Rajpriyadarsini Soundararajan uma Shanmugam Vinothini Ramu Department of Pharmaceutics College of PharmacyMother Theresa Post Graduate and Research Institute of Health Sciences(A Government of Puducherry Institution)Puducherry 605006India

The poor dissolution characteristics of water-insoluble drugs are a major challenge for pharmaceutical *** of the particle size/increase in the surface area of the drug is a widely used and relatively simple method for increasing dissolution *** objective of this study was to improve solubility,release and comparability of dissolution of a poorly soluble drug using two different types of formulations(solid dispersions and microspheres).Hydrochlorothiazide was used as a model *** solid dispersions and microspheres were prepared by solvent evaporation method using ethyl cellulose,hydroxypropyl methylcellulose in different drug-to-carrier ratios(1:1,1:2 w:w).The prepared formulations were evaluated for interaction study by Fourier transform infrared spectroscopy,differential scanning calorimetry,percentage of practical yield,drug loading,surface morphology by scanning electron microscopy,optical microscopy and in-vitro release *** results showed no interaction between the drug and polymer,amorphous state of solid dispersions and microspheres,percentage yield of 42.53%to 78.10%,drug content of 99.60%to 99.64%,good spherical appearance in formulation VI and significant increase in the dissolution rate.

关键词： Hydrochlorothiazide Ethyl cellulose Hydroxypropyl methylcellulose Second generation solid dispersion Microsphere Solvent evaporation method

Antioxidant activity and functional group analysis of Evolvulus alsinoides

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Chinese Journal of Natural Medicines 2014年第11期12卷 827-832页

作者： Duraisamy Gomathi ganesan Ravikumar Manokaran Kalaiselvi Kanakasabapathi Devaki Chandrasekar uma Food Analyst Post Harvest Technology Centre Tamil Nadu Agricultural University Coimbatore Research Associate Dalmia Centre for Research and Development Coimbatore Assistant Professor Departments of Biotechnology Kongunadu Arts and Science College Coimbatore Department of Biochemistry Karpagam University Coimbatore 641021 Department of Biochemistry College of Medicine & Health Science Hawassa University Hawassa Ethiopia

AIM: Many oxidative stress-related diseases occur as a result of the accumulation of free radicals in the body. Free radicals are generated by various endogenous systems, exposure to different physiochemical conditions, or pathological states. A balance between free radicals and antioxidants is necessary for appropriate physiological function. A lot of studies are going on worldwide directed towards finding natural antioxidants of plant origin. FTIR spectroscopy is used to develop a rapid and effective analytical method for studying the main constituents in medicinal plants. The chemical constituents in the plants were identified and monitored for their medicinal properties. The aim of this study was to evaluate the in vitro antioxidant activities and FTIR spectroscopic analysis of the ethanolic extract of Evolvulus alsinoides. METHOD: Free radical scavenging activity of ethanolic extract of the whole plant of E. alsinoides was evaluated by in vitro methods, including total antioxidant assay(FRAP method) and hydrogen peroxide scavenging activity using ascorbic acid as a standard. The degree of lipid peroxidation was examined by estimating the thiobarbituric acid reactive substances(TBARS) using standard methods and the functional groups were analyzed using FTIR spectroscopy. The IR spectrum in the mid-infrared region 4 000–400 cm–1 was used for discriminatio and to identify various functional groups present in E. alsinoides. RESULTS: The findings indicated the presence of amino acids, amides, amines, carboxylic acids, carbonyl compounds, organic hydrocarbons, and halogens in the ethanolic extract of E. alsinoides, and the antioxidant activities were significantly increased, when compared with the standard antioxidant ascorbic acid, in a dose-dependent manner. CONCLUSION: The findings indicated promising antioxidant activity of the crude extract of E. alsinoides, and needs further exploration for their potential effective use.

关键词： Evolvulus alsinoides Convolvulaceae Ethanolic extract FT-IR Free radicals Ascorbic acid