Development,characterization and solubility enhancement of comparative dissolution study of second generation of solid dispersions and microspheres for poorly water soluble drug

作     者：Poovi Ganesan Rajpriyadarsini Soundararajan Uma Shanmugam Vinothini Ramu 

作者机构：Department of PharmaceuticsCollege of PharmacyMother Theresa Post Graduate and Research Institute of Health Sciences(A Government of Puducherry Institution)Puducherry 605006India 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2015年第10卷第5期

页      面：433-441页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

主　　题：Hydrochlorothiazide Ethyl cellulose Hydroxypropyl methylcellulose Second generation solid dispersion Microsphere Solvent evaporation method 

摘      要：The poor dissolution characteristics of water-insoluble drugs are a major challenge for pharmaceutical *** of the particle size/increase in the surface area of the drug is a widely used and relatively simple method for increasing dissolution *** objective of this study was to improve solubility,release and comparability of dissolution of a poorly soluble drug using two different types of formulations(solid dispersions and microspheres).Hydrochlorothiazide was used as a model *** solid dispersions and microspheres were prepared by solvent evaporation method using ethyl cellulose,hydroxypropyl methylcellulose in different drug-to-carrier ratios(1:1,1:2 w:w).The prepared formulations were evaluated for interaction study by Fourier transform infrared spectroscopy,differential scanning calorimetry,percentage of practical yield,drug loading,surface morphology by scanning electron microscopy,optical microscopy and in-vitro release *** results showed no interaction between the drug and polymer,amorphous state of solid dispersions and microspheres,percentage yield of 42.53%to 78.10%,drug content of 99.60%to 99.64%,good spherical appearance in formulation VI and significant increase in the dissolution rate.