Development,characterization and solubility enhancement of comparative dissolution study of second generation of solid dispersions and microspheres for poorly water soluble drug
发展，表征和水难溶药物的第二代固体分散体和微球的比较溶出研究的增溶作者机构：Department of PharmaceuticsCollege of PharmacyMother Theresa Post Graduate and Research Institute of Health Sciences(A Government of Puducherry Institution)Puducherry 605006India
出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)
年 卷 期：2015年第10卷第5期
页 面：433-441页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学]
主 题：Hydrochlorothiazide Ethyl cellulose Hydroxypropyl methylcellulose Second generation solid dispersion Microsphere Solvent evaporation method
摘 要：The poor dissolution characteristics of water-insoluble drugs are a major challenge for pharmaceutical *** of the particle size/increase in the surface area of the drug is a widely used and relatively simple method for increasing dissolution *** objective of this study was to improve solubility,release and comparability of dissolution of a poorly soluble drug using two different types of formulations(solid dispersions and microspheres).Hydrochlorothiazide was used as a model *** solid dispersions and microspheres were prepared by solvent evaporation method using ethyl cellulose,hydroxypropyl methylcellulose in different drug-to-carrier ratios(1:1,1:2 w:w).The prepared formulations were evaluated for interaction study by Fourier transform infrared spectroscopy,differential scanning calorimetry,percentage of practical yield,drug loading,surface morphology by scanning electron microscopy,optical microscopy and in-vitro release *** results showed no interaction between the drug and polymer,amorphous state of solid dispersions and microspheres,percentage yield of 42.53%to 78.10%,drug content of 99.60%to 99.64%,good spherical appearance in formulation VI and significant increase in the dissolution rate.
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