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Ecto-GPR37:a potential biomarker for Parkinson’s disease

Translational Neurodegeneration 2021年第1期10卷 77-90页

作者： Xavier Morato Paula Garcia-Esparcia Josep Argerich Franc Llorens Inga Zerr Wojciech Paslawski Eva Borras Eduard Sabido ulla epetaja-repo Victor Fernandez-Duenas Isidro Ferrer Per Svenningsson Francisco Ciruela Pharm acology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaUHospitalet de LlobregatSpain Neuroscience Program Bellvitge Biomedical Research InstituteIDIBELLL'Hospitalet de LlobregatSpain Section of Neurology Department of Clinical NeuroscienceDepartm ent of NeuroscienceKarolinska InstituteStockholmSweden Neuropathology Unit Departm ent of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaL'Hospitalet de LlobregatSpain CIBERNED Centro de Investigacion Biomedica en Red de Enfermedades NeurodegenerativasInstituto CarlosⅢMadridSpain Department of Neurology Clinical Dementia Center and National Reference Center for CID SurveillanceUniversity Medical SchoolGottingenGermany German Center for Neurodegenerative Diseases GottingenGermany Proteomics Unit Center for Genomic RegulationBarcelonaSpain Proteomics Unit Universitat Pompeu FabraBarcelonaSpain Research Unit of Biomedicine Medical Research Center OuluUniversity of OuluOuluFinland

Objective:a-Synuclein has been studied as a potential biomarker for Parkinson's disease(PD)with no concluding ***,there is an urgent need to find out reliable specific biomarkers for ***37 is an orphan G protein-coupled receptor that toxically accumulates in autosomal recessive juvenile ***,we investigated whether GPR37 is upregulated in sporadic PD,and thus a suitable potential biomarker for ***:GPR37 protein density and mRNA expression in postmortem substantia nigra(SN)from PD patients were analysed by immunoblot and RT-qPCR,*** presence of peptides from the N-terminus-cleaved domain of GPR37(***-GPR37)in human cerebrospinal fluid(CSF)was determined by liquid chromatography-mass spectrometric *** engineered in-house nanoluciferase-based immunoassay was used to quantify ecto-GPR37 in CSF samples from neurological control(NC)subjects,PD patients and Alzheimer's disease(AD)***:GPR37 protein density and mRNA expression were significantly augmented in sporadic *** amounts of ecto-GPR37 peptides in the CSF samples from PD patients were identified by mass spectrometry and quantified by the in-house ELISA ***,the CSF total a-synuclein level in PD patients did not differ from that in NC ***,the cortical GPR37 mRNA expression and CSF ecto-GPR37 levels in AD patients were also ***:GPR37 expression is increased in SN of sporadic PD *** ecto-GPR37 peptides are significantly increased in the CSF of PD patients,but not in AD *** results open perspectives and encourage further clinical studies to confirm the validity and utility of ecto-GPR37 as a potential PD biomarker.

关键词： GPR37 Pael-R Parkinson's disease Cerebrospinal fluid Biomarker Alzheimer's disease a-5ynuclein Orphan receptor

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Applying Frameworks for Cognitive Services in IIoT

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Journal of Systems Science and Systems Engineering 2021年第1期30卷 59-84页

作者： ulla Gain School of Computing University of Eastern FinlandFI-70211KuopioFinland

The technology,which enables creating new types of products,processes and services(i.e.,things),which outcomes alter traditional competition and industry boundaries and create new lasting *** digitalization process uses digital technologies to provide the possibilities of new revenue and value-producing,i.e.,it changes business models and offers new value *** change is *** most important ten strategic technology trends in 2019 include Edge computing,Blockchain,event and data-driven strategies,Digital Twins,and the maintenance of transparency(i.e.,traceability),Intelligent Apps and Analytics(Gartner 2018).In this paper,we experiment with the capabilities of intelligent applications to match the industrial business *** paper aims to bring insights closer to business ***’s technological advantages can be achieved through data-driven strategies and wherein cognitive services are integrated into IoT(Internet of Things)and big *** experiment with the Industrial IoT(IIoT)business models and value propositions to match the intelligent insights of cognitive solutions to business *** IIoTs support and demand transparency and thus also data-driven objective insights,and because cognitive solutions can enhance insights on a product,a process or service and therefore provide measurable business *** indicators enable interconnected smart things to collaborate.

关键词： Digitalization industrial internet of things cognitive services digital twin blockchain

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Inflammation and immunosuppression in severe acute pancreatitis

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World Journal of Gastroenterology 2010年第23期16卷 2867-2872页

作者： Marja-Leena Kylnp Heikki repo Pauli Antero Puolakkainen Department of Surgery University of Helsinki Department of Bacteriology and Immunology Haartman InstituteUniversity of Helsinki

Acute pancreatitis(AP) is a common disease,which usually exists in its mild ***,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or *** the development of organ failure is the major cause of death in AP,early identification of patients likely to develop organ failure is *** is initiated by intracellular activation of pancreatic proenzymes and autodigestion of the *** of the pancreatic parenchyma first induces an inflammatory reaction locally,but may lead to overwhelming systemic production of inflammatory mediators and early organ ***,anti-inflammatory cytokines and specific cytokine inhibitors are *** anti-inflammatory reaction may overcompensate and inhibit the immune response,rendering the host at risk of systemic *** present,there is no specific treatment for *** understanding of the pathogenesis of systemic inflammation and development of organ dysfunction may provide us with drugs to ameliorate physiological disturbances.

关键词： Acute pancreatitis Organ failure Inflammatory response Immunosuppression Coagulation

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Functionalization of nitrogen-doped graphene quantum dot:A sustainable carbon-based catalyst for the production of cyclic carbonate from epoxide and CO_(2)

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Journal of Environmental Sciences 2023年第4期126卷 408-422页

作者： Zahra Eshaghi Gorji Abbas Ali Khodadadi Siavash Riahi Timo repo Yadollah Mortazavi Marianna Kemell Catalysis and Nanostructured Materials Research Laboratory School of Chemical EngineeringCollege of EngineeringUniversity of TehranTehran ***Iran Department of Chemistry University of HelsinkiHelsinki 00014Finland Institute of Petroleum Engineering School of Chemical EngineeringCollege of EngineeringUniversity of TehranTehran ***Iran

A series of organic compounds were successfully immobilized on an N-doped graphene quantum dot (N-GQD) to prepare a multifunctional organocatalyst for coupling reaction between CO_(2)and propylene oxide (PO).The simultaneous presence of halide ions in conjunction with acidic-and basic-functional groups on the surface of the nanoparticles makes them highly active for the production of propylene carbonate (PC).The effects of variables such as catalyst loading,reaction temperature,and structure of substituents are *** proposed catalysts were characterized by different techniques,including Fourier transform infrared spectroscopy (FTIR),field emission scanning electron microscopy/energy dispersive X-ray microanalysis (FESEM/EDX),thermogravimetric analysis (TGA),elemental analysis,atomic force microscopy (AFM),and ultraviolet–visible (UV-Vis) *** optimal reaction conditions,3-bromopropionic acid (BPA) immobilized on N-GQD showed a remarkable activity,affording the highest yield of 98%at 140℃ and 106Pa without any co-catalyst or *** new metal-free catalysts have the advantage of easy separation and reuse several *** on the experimental data,a plausible reaction mechanism is suggested,where the hydrogen bonding donors and halogen ion can activate the epoxide,and amine functional groups play a vital role in CO_(2)adsorption.

关键词： Heterogeneous organocatalyst CO_(2) Propylene carbonate N-doped graphene quantum dot Nanomaterials

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MicroProteins:Expanding functions and novel modes of regulation

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Molecular Plant 2021年第5期14卷 705-707页

作者： Kaushal Kumar Bhati ulla Dolde Stephan Wenkel Louvain Institute of Biomolecular Sciences Catholic University of LouvainLouvain la Neuve 1348Belgium Plant Science Research Laboratory(LRSV) UMR5546 CNRS/Universite Toulouse 331320 Castanet-TolosanFrance Copenhagen Plant Science Centre Department of Plant&Environmental SciencesUniversity of CopenhagenThorvaldsensvej 401871 Frederiksberg CDenmark

MicroProteins are small,5-15-kDa single-domain proteins that are evolutionarily related to multi-domain proteins with sequence homology(Eguen et al.,2015).The single domain of microProteins is often a protein-protein interaction(PPI)-domain,through which they can interact with their multi-domain protein targets(Figure 1).The first experimental insight that microProteins exist and how they act came from the identification of the regulatory feedback mechanism of class III homeodomain-leucine zipper(HD-ZIPIII)transcription factors by LITTLE ZIPPER(ZPR)microProteins(Wenkel et al.,2007;Kim et al.,2008).In Arabidopsis,the LITTLE ZIPPER microProtein family consists of four members(ZPR1-4)containing only a leucine zipper *** HD-ZIPIII transcription factor REVOLUTA directly transcriptionally upregu-lates multiple ZPR *** proteins physically interact with their HD-ZIPIII targets and suppress their DNA binding ability.

关键词： domain. Figure insight

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Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia:a systematic review and meta‑analysis

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World Journal of Pediatrics 2022年第9期18卷 589-597页

作者： Ilari Kuitunen Panu Kiviranta ulla Sankilampi Marjo Renko Institute of Clinical Medicine Department of PediatricsUniversity of Eastern FinlandKuopioFinland Department of Pediatrics Mikkeli Central HospitalPorrassalmenkatu 35-3750100 MikkeliFinland Department of Pediatrics Kuopio University HospitalKuopioFinland

Background Neonatal hyperbilirubinemia is observed in most newborns,and 5–15%of neonates require *** is efective but often prolongs hospitalization and has both short-term and potential long-term *** aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid(UDCA)combined with phototherapy in neonatal *** A literature search was conducted on September 1,2021;590 studies were screened,and 17 full texts were assessed by two *** included randomized controlled trials with or without placebo *** outcomes were changes in total bilirubin levels at 24 hours and phototherapy *** calculated mean diferences with 95%confdence intervals(CI).Results Six studies with 880 neonates were *** these studies,only two used a placebo-controlled double-blinded *** overall risk of bias was high in one and moderate in four of the included *** mean decrease in the total bilirubin level during the frst 24 hours was 2.06 mg/dL(95%CI 0.82–3.30;six studies)greater in the UDCA treatment *** phototherapy duration was 19.7 hours(95%CI 10.4–29.1;fve studies)shorter in the UDCA treatment *** We found low-quality evidence that UDCA as an adjuvant to phototherapy seems to decrease total bilirubin faster and shorten phototherapy duration compared to standard *** studies are needed to confrm the efcacy,acute and long-term outcomes,and safety before implementing UDCA as an adjuvant to phototherapy in neonatal hyperbilirubinemia.

关键词： Jaundice Phototherapy Unconjugated hyperbilirubinemia Ursodeoxycholic acid

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Bridging mapping and simulation modelling in the ecosystem service assessments of boreal forests:effects of bioenergy production on carbon dynamics

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Forest Ecosystems 2021年第1期8卷 35-49页

作者： Anu Akujärvi Anna repo Altti M.Akujärvi Jari Liski Finnish Environment Institute SYKE Biodiversity CentreLatokartanonkaari 11FI-00790 HelsinkiFinland University of Helsinki Department of Geosciences and GeographyP.O.Box 64FI-00014 HelsinkiFinland Natural Resources Institute Finland(Luke) P.O.Box 2FI-00791 HelsinkiFinland VTT Technical Research Centre of Finland LTD P.O.Box 1000FI-02044 VTT EspooFinland Finnish Meteorological Institute Climate System Research UnitP.O.Box 503FI-00101 HelsinkiFinland

Background:Increasing the use of forest harvest residues for bioenergy production reduces greenhouse emissions from the use of fossil ***,it may also reduce carbon stocks and habitats for deadwood dependent ***,simple tools for assessing the trade-offs of alternative management practices on forest dynamics and their services to people are *** objectives of this study were to combine mapping and simulation modelling to investigate the effects of forest management on ecosystem services related to carbon cycle in the case of bioenergy production;and to evaluate the suitability of this approach for assessing ecosystem services at the landscape *** level simulations of forest growth and carbon budget were combined with extensive multi-source forest inventory data across a southern boreal landscape in *** changes in the stand age class distribution over the study region were simulated to mimic variation in management ***:The mapping framework produced reasonable estimates of the effects of forest management on a set of key ecosystem service indicators:the annual carbon stocks and fluxes of forest biomass and soil,timber and energy-wood production and the coarse woody litter production over a simulation period 2012–*** harvesting,affecting the stand age class distribution,was a key driver of the carbon stock changes at a landscape *** forest harvest residues in the final felling caused carbon loss from litter and soil,particularly with combined aboveground residue and stump *** also reduced the annual coarse woody litter production,demonstrating negative impacts on deadwood abundance and,consequently,forest ***:The refined mapping framework was suitable for assessing ecosystem services at the landscape *** procedure contributes to bridging the gap between ecosystem service mapping and detailed simulation modelling in boreal *** allows for v

关键词： Carbon budget Ecosystem services Forest management Forest bioenergy Landscape level Mapping Modelling

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Compression curve analysis and compressive strength measurement of brittle granule beds in lieu of individual granule measurements

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Particuology 2016年第6期14卷 60-68页

作者： Matti Jairvelainen Aaretti Kaleva Annikka Kaitajairvi ,Jarmo Laakso ulla Kanerva Erkki Levanen Department of Materials Science Tampere University of Technology PO Box 589 FIN-33101 Tampere Finland VTT Technical Research Centre of Finland Sinitaival 6 PO Box 1300 FI33101 Tampere Finland

Powders in granulated form are used in various processes to facilitate convenient usage. The durability of the formed granules is a crucial parameter, typically evaluated by the compressive strength of the gran- ules. However, especially for granules with a diameter in the order of tens of microns, statistically relevant testing of individual granules is not a feasible alternative, and in such cases uniaxial bed compression is required. There has not been consensus on whether uniaxial compression of a granule bed can be used to study the fracture of micron size or brittle granules. In our case study of a bed of sintered kaolinite granules with diameters under 100 μm, we show how the compressive strength of individual granules can be obtained from the compressive measurement of the entire bed by plotting the relative density versus the logarithmic pressure scale. We compressed the kaolinite powder with different loads; microscopy confirmed that below the ana- lyzed strength the granules are intact, though the granules start to fracture in the curved region on the compression curve. We found that angle-fitting can be used to locate the average compressive strength on the compression curve and to follow the evolution of strength with sintering temperature. The experi- ments in unison demonstrate that compression curve analysis is applicable for strength analysis of brittle granules.

关键词： GranuleMechanical characterization Pressing Compressive strength Sintering Compression curves

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Recent applications of ionic liquids in quasi-solid-state lithium metal batteries

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Green Chemical Engineering 2021年第3期2卷 253-265页

作者： Jiajia Li Fangfang Li Lan Zhang Haitao Zhang ulla Lassi Xiaoyan Ji Energy Engineering Division of Energy ScienceLuleåUniversity of TechnologyLuleå97187Sweden Beijing Key Laboratory of Ionic Liquids Clean Process Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Sustainable Chemistry Faculty of TechnologyUniversity of OuluOulu90570Finland

Quasi-solid-state lithium metal batteries are considered as one of the most promising energy storage devices,and the application of ionic liquids(ILs)as a new generation of functionalized electrolyte components in lithium metal batteries has become one of the research *** this review,the very recent research work related to using ILs to develop quasi-solid-state electrolytes and their influences on the performances of quasi-solid-state lithium metal batteries were surveyed and summarized,suggesting that the introduction of ILs can improve the ionic conductivity,broaden the electrochemical stability window,and enhance the electrochemical stability of the selected ***,using ILs to prepare high-performance electrodes with unique microstructures and uniform distribution of fillers were also *** composite quasi-solid-state electrolytes were suggested as the mainstream of electrolytes in the future due to the combination of the advantages of inorganic and polymer quasi-solid-state electrolytes,and their development challenges in high energy and high safety quasisolid-state lithium metal batteries were also discussed.

关键词： Ionic liquids Quasi-solid-state electrolytes Lithium metal batteries Energy storage

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Effect of weld microstructure on brittle fracture initiation in the thermallyaged boiling water reactor pressure vessel head weld metal

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 867-876页

作者： Noora Hytönen Zai-qing Que Pentti Arffman Jari Lydman Pekka Nevasmaa ulla Ehrnstén Pål Efsing Nuclear Reactor Materials VTT Technical Research Centre of Finland Ltd.Kivimiehentie 3P.O.Box 1000FI-02044 VTTFinland Department of Solid Mechanics Royal Institute of Technology(KTH)SE-10044 StockholmSweden

Effects of the weld microstructure and inclusions on brittle fracture initiation are investigated in a thermally aged ferritic high-nickel weld of a reactor pressure vessel head from a decommissioned nuclear power ***-welded and reheated regions mainly consist of acicular and polygonal ferrite,*** examination of Charpy V-notch impact toughness specimens reveals large inclusions(0.5-2.5μm)at the brittle fracture primary initiation *** impact energies were measured for the specimens in which brittle fracture was initiated from a small inclusion or an inclusion away from the *** density,geometry,and chemical composition of the primary initiation inclusions were investigated.A brittle fracture crack initiates as a microcrack either within the multiphase oxide inclusions or from the debonded interfaces between the uncracked inclusions and weld metal *** fracture sites can be determined in all the specimens tested in the lower part of the transition curve at and below the 41-J reference impact toughness energy but not above the mentioned value because of the changes in the fracture mechanism and resulting changes in the fracture appearance.

关键词： reactor pressure vessel brittle fracture weld microstructure thermal aging

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