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Anomalous phenomena in DC–ulf geomagnetic daily variation registered three days before the 12 May 2008 Wenchuan M_S 8.0 earthquake

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Earth and Planetary Physics 2019年第4期3卷 330-341页

作者： mei Li Li Yao YaLi Wang Michel Parrot Masashi Hayakawa Jun Lu HanDong Tan Tao Xie China Earthquake Networks Center China Earthquake Administration Beijing 100045 China Laboratoire de Physique et Chimie de l’Environnement et de l’Espace Université d’Orléans CNRS Orléans France Hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro–Communications (UEC) Chofu Japan UEC Advanced Wireless Communications Research Center Chofu Japan School of geophysics and Information Technology China University of Geosciences Beijing 100083 China

The hourly data of the vertical Z and the horizontal H components of 37 ground-based DC-ulf geomagnetic stations are examined during 20 April-12 May 2008. On 9 May 2008, three days before the Wenchuan MS 8.0 shock, anomalies-a double low-point and a decreased amplitude-are registered on the curves of the Z component at 25 stations in a large-scale area surrounding the Wenchuan epicentral area. The H component shows none of the double low-point phenomenon but does exhibit a reduced magnitude at the same time. The geomagnetic index Kp is also examined and indicates that the anomalies appear at a solar quiet period. The appearing time shift(Tzs) between the first low-point on May 9 and the minimum point occurring time of May 1-5, 2008 is also *** results show that Tzs is on the order of 1-2 hours earlier or later than usual and there is a 2-6 hours’ gap between these two lowpoints. However, there is still a transition area which includes the epicenter where Tzs=0. Variation amplitude examined on vertical Z increases as the distance from the epicenter decreases. An Earth-air-ionosphere model has been employed to investigate a possible mechanism of this phenomenon and positive results have been unexpectedly attained. All these above-related results tend to prove that the variations of the Z and H on May 9, 2008 during the solar quiet period are probably associated with the forthcoming Wenchuan MS 8.0 earthquake.

关键词： Wenchuan MS 8.0 earthquake geomagnetic abnormity spatial variations Earth-air-ionosphere model

The phenotype and activation status of regulatory T cells during Friend retrovirus infection

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Virologica Sinica 2014年第1期29卷 48-60页

作者： Jara J.Joedicke Kirsten K.Dietze gennadiy Zelinskyy ulf Dittmer Institute for Virology University Hospital EssenUniversity of Duisburg-Essen

The suppressive capacity of regulatory T cells(Tregs) has been extensively studied and is well established for many *** expansion,accumulation,and activation of Tregs in viral infections are of major interest in order to find ways to alter Treg functions for therapeutic *** are able to dampen effector T cell responses to viral infections and thereby contribute to the establishment of a chronic *** the Friend retrovirus(FV) mouse model,Tregs are known to expand in all infected *** better understand the characteristics of these Treg populations,their phenotype was analyzed in *** acute FV-infection,Tregs became activated in the spleen and bone marrow,as indicated by various T cell activation markers,such as CD43 and ***,Tregs in the bone marrow,which contains the highest viral loads during acute infection,displayed greater levels of activation than Tregs from the *** expansion was driven by proliferation but no FV-specific Tregs could be *** Tregs in FV-infection did not produce granzyme B(gzmB) or tumor necrosis factor a(TNFa),which are thought to be a potential mechanism for their suppressive ***,Tregs expressed inhibitory markers,such as TIM3,PD-1 and *** TIM3 and PD-L1 with antibodies during chronic FV-infection increased the numbers of activated *** data may have important implications for the understanding of Treg functions during chronic viral infections.

关键词：调节性T细胞病毒感染逆转录病毒激活表现型 T细胞活化状态慢性感染

Phylogenetic definitions for 25 higher-level clade names of birds

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Avian Research 2022年第2期13卷 109-126页

作者： george Sangster Edward L.Braun ulf S.Johansson Rebecca T.Kimball gerald Mayr Alexander Suh Naturalis Biodiversity Center Darwinweg 2PO Box 95172300RALeidenthe Netherlands Department of Biology University of FloridaGainesvilleFL32607USA Department of Zoology Swedish Museum of Natural HistoryP.O.Box 50007SE–10405StockholmSweden Senckenberg Research Institute and Natural History Museum Frankfurt Ornithological SectionSenckenberganlage 2560325Frankfurt am MainGermany School of Biological Sciences University of East AngliaNorwichNR47TUUK

Knowledge of the higher-level phylogenetic relationships of birds has grown substantially during the past two decades due to the application of genomic ***,the nomenclature of higher-level taxa has not become more stable,due to the lack of regulation of taxon names above the level of superfamily by the ICZN,and the usage of rank-based nomenclature,which is not tied to clades in a *** of regulation and the instability of rank-based nomenclature impede effective communication among *** review support for higher-level avian clades using a set of 10 phylogenomic data sets,and identify clades that are supported by congruency of at least four of *** provide formal definitions of the names of these clades based on the rules of the recently published *** names of 25 clades are here defined using minimum-crown-clade(n=23),minimum-clade(n=1)and maximum-crown-clade(n=1)*** new names are introduced here:Dinocrypturi,Pteroclimesites,Musophagotides,Phaethoquornithes and *** also review diagnostic apomorphies of the relevant clades,and identify known synonyms and *** establishing a formal link between higher-level taxon names and well-supported phylogenetic hypotheses,our phylogenetic definitions will provide a solid basis for the stabilization of avian higher-level nomenclature.

关键词： Aves Congruence PhyloCode Phylogenetic nomenclature Phylogenomics Rankless taxonomy

Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 506-511页

作者： Tom Florian Ulmer Anne Weiland georg Lurje Christian Klink Anne Andert Hamid Alizai Christoph Heidenhain ulf Neumann Department of general Visceral and Transplantation Surgery RWTH Aachen University Hospital Aachen Germany Department of Urology Helios Hospital Berlin-Buch Germany

BACKgROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery. Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70%partial hepatectomy. METHODS: Seventy-two male Wistar rats were randomly assigned into three groups(n=24 in each group): 70% partial hepatectomy as control(PHC), 70% partial hepatectomy with splenectomy(PHS) or 70% partial hepatectomy with a micropump for terlipressin administration(PHT). Eight rats in each group were sacrificed on postoperative day(POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine(BrdU) and Ki-67 labeling was performed. Portal venous pressure, serum concentrations of creatinine, urea, albumin, bilirubin and prothrombin time as well as liver-, body-weight and their ratio were determined on POD 1, 3 and ***: The liver-, body-weight and their ratio were not statistically different among the groups. On POD 1, 3 and 7 portal venous pressure in the intervention groups(PHT:8.13 ±1.55, 10.38±1.30, 6.25±0.89 cm H2O and PHS: 7.50±0.93,8.88 ±2.42, 5.75±1.04 cm H2O) was lower compared to the control group(PHC: 8.63±2.06, 10.50±2.45, 6.50±2.67 cmH2O). Hepatocyte proliferation in the intervention groups was delayed, especially after splenectomy on POD 1(Brd U: PHS vs PHC, 20.85% ±13.05% vs 28.11%±10.10%; Ki-67, 20.14%±14.10% vs 23.96% ±11.69%). However, none of the differences were statistically ***: Neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. Further studies assessing the regulation of portal venous pressure as well as extended hepatectomy animal models and liver function tests will help to further investigate mechanisms of live

关键词： liver regeneration liver failure terlipressin splenectomy hepatectomy

Quality of life after curative liver resection: A single center analysis

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World Journal of gastroenterology 2010年第19期16卷 2388-2395页

作者： Helge Bruns Kirsten Krtschmer ulf Hinz Anette Brechtel Monika Keller Markus W Büchler Peter Schemmer Department of general Surgery Ruprecht-Karls-University 69120 Heidelberg Germany Psychosomatic Medicine Section Psychooncology Ruprecht-Karls-University 69120 Heidelberg Germany

AIM: To evaluate quality of life (QoL) after curative liver resection and identify variables associated with decreased QoL. METHODS: From October 2001 to July 2004, 323 patients underwent liver resection. At 3-36 mo after discharge, 188 patients were disease free. QoL was assessed using the Short Form (SF)-12 Health Survey with mental and physical component scales (SF-12 MCS and PCS), supplemented with generic questions concerning pain and liver-specific items. RESULTS: Sixty-eight percent (128/188) returned the questionnaire, which was completed in 75% (96/128) of cases. Median SF-12 PCS and MCS were 46.7 (inter- quartile range: 34.2-53.9) and 54.1 (42.8-58.2). Fifty percent were pain free with a median symptom score of 1.75 (1.38-2.13). PCS was higher after major hepatec-tomy [57% (55/96)] compared to minor resection (P = 0.0049), which represented an improved QoL. QoL was not affected by sex but by age compared to the general german population. MCS was higher after liver surgery for metastatic disease [55.9 (47.5-58.8)] compared to primary carcinoma [49.6 (36.5-55.1)] and benign disease [49.2 (37.7-56.3)] (P = 0.0317). There was no correlation between length of postoperative period and QoL. Pain, def iciencies in everyday life and a high symptom score significantly decreased MCS and PCS. CONCLUSION: Most patients were only marginally affected even after major liver resection; however, minor complications were associated with decreased SF-12 MCS and PCS and need careful attention.

关键词： Quality of life Liver resection

Loco-regional hepatocellular carcinoma treatment services as a bridge to liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 228-236页

作者： Sophia Schmitz georg Lurje Florian Ulmer Anne Andert Philipp Bruners Maximilian Schulze-Hagen ulf Neumann Wenzel Schoening Department of general- Visceral- and Transplantation Surgery University Hospital of RWTH Aachen Aachen Germany Department of Diagnostic and Interventional Radiology University Hospital of RWTH Aachen Aachen Germany Department of Surgery Maastricht University Medical Center (MUMC) Maastricht Netherlands Department of Surgery Charité– University Medicine at Berlin Germany

Background: Liver transplantation remains the main curative treatment option for hepatocellular carcinoma(HCC) patients. In the Eurotransplant area Milan criteria are used to assign priority extra points(exceptional MELD, ex MELD) for patients on the waiting list. To prevent patients from tumor progression, loco-regional(neoadjuvant) treatment(LRT) is used. For patients unlikely to timely receive an organ via primary allocation,“extended critera donor(ECD) organs” are used. The present study aimed to investigate the survival after LT with a strategy of minimizing waiting list dropouts by using LRT for bridging and transplanting ECD organs if possible and necessary. Methods: Between October 2010 and May 2015, 50 liver transplants for HCC were included in this retrospective study. Of those, 42(84%) met the Milan criteria according to the preoperative radiological examination. Forty-one patients(82%) received LRT. The waiting time was analyzed according to LRT. Kaplan-meier curves with log-rank statistics were used for survival analyses. Results: One-and five-year overall survival within Milan criteria was 94.3% and 83.7% compared with 91.7% and 67.9% beyond Milan criteria, though statistical significance was not reached( P = 0.487). LRT had no impact on overall survival( P = 0.629). Median waiting time was shorter if no LRT was performed(4.6 months vs. 1.5 months, P = 0.006) and there were no cases of waiting list dropouts. Using ECD organs had no impact on overall survival( P = 0.663). Conclusions: Patients with an expected waiting time to transplantation of > 6 months could be successfully treated with LRT as a bridge to transplant. Overall and disease-free survival for patients within and beyond Milan criteria was comparable and the use of ECD organs in this cohort of HCC patients proved to be a safe option.

关键词： Hepatocellular carcinoma Liver transplantation Therapeutic embolization Liver neoplasms Organ transplantation

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高强度不锈钢绞索在桥梁工程中的应用

腐蚀科学与防护技术 2008年第6期20卷 454-457页

作者：吴媛 ulf Nürnberger Otto-graf-Institute斯图加特大学斯图加特德国70569

检测了冷拉高强Cr-Ni-Mo不锈钢绞索的力学和物理性能;并从实验室研究和项目跟踪观察两方面介绍高强度不锈钢绞索的抗腐蚀性能;最后,展望了高强度不锈钢绞索在桥梁工程方面的应用.

关键词：高强度不锈钢绞索桥梁腐蚀

Transplanting embryonic stem cells onto damaged human corneal endothelium

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World Journal of Stem Cells 2017年第8期9卷 127-132页

作者： Charles Hanson Arsaell Arnarsson Thorir Hardarson Ann Lindgard Mandana Daneshvarnaeini Catarina Ellerstrom Anita Bruun ulf Stenevi Unit of Reproductive Medicine Sahlgrenska University Hospital Neuroscience Laboratory University of Akureyri Fertility Centre Scandinavia Carlanderska Hospital Department of Ophthalmology Gothenburg University Takara Bio Europe AB Arvid Wallgrens Backe 2041346 GothenburgSweden Department of Ophthalmology Lund University Hospital

AIM To investigate whether human embryonic stem cells(hESCs) could be made to attach, grow and differentiate on a human Descemet's membrane(DM).METHODS Spontaneously differentiated hESCs were transferred onto a human corneal button with the endothelial layer removed using ocular sticks. The cells were cultured on a DM for up to 15 d. The genetically engineered hESC line expressed green fluorescent protein, which facilitated identification during the culture experiments, tissue preparation, and analysis. To detect any differentiation into human corneal endothelial-like cells, we analysed the transplanted cells by immunohistochemistry using specific *** We found transplanted cells form a single layer of cells with a hexagonal shape in the periphery of the DM. The majority of the cells were negative for octamer-binding transcription factor 4 but positive for paired box 6 protein, sodium potassium adenosine triphosphatase(NaKATPase), and Zona Occludens protein 1. In four of the 18 trials, the transplanted cells were found to express CK3, which indicates that the stem cells differentiated into corneal epithelial cells in these cases. CONCLUSION It is possible to get cells originating from hESCs to become established on a human DM, where they grow and differentiate into corneal endothelial-like cells in vitro.

关键词： Embryonic stem cells Cornea Descemet’s membrane Endothelium Immunohistochemistry

NON-DESTRUCTIVE MEASUREMENTS OF LEAD AND BARIUM IN ARCHAEOLOgICAL BONE SAMPLES USINg XRF

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Nuclear Science and Techniques 1991年第1期2卷 48-52页

作者：黄士斌 ulf Nilsson Sren Mattsson Institute of Nuclear Medicine Shanghai Medical University Shanghai 200032 China Department of Radiation Physics University of LundMalmo General HospitalS-214 01 MalmoSweden

The lead and barium contents in sixteen archaeological bone samples from 10 persons buried in Dalsby, Sweden, were determined by means of X- ray fluorescence analysis using two "Co sources for excitation and a planar ge detector for registration of the X- rays. The lead concentrations were found to be less than 168μ g/g, and the barium concentrations were in the range of 15- 97μg/g.

关键词： X- ray fluorescence analysis Lead Barium Archaeological bone