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A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles:Overview and Future Perspectives

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Infectious microbes & Diseases 2022年第4期4卷 139-148页

作者： Christian K.ezeh Chibuzor N.eze uju m.e.dibua Stephen C.emencheta Department of microbiology University of NigeriaNsukkaEnugu StateNigeria Department of Pharmaceutical microbiology University of NigeriaNsukkaEnugu StateNigeria

Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health ***/biological nanotechnologies constitute an interesting area of research for discovering antimycobacterial *** review focused on the biological(green)synthesis of silver nanoparticles(AgNPs)as an alternative source of antimycobacterial *** for this study were searched and screened from three electronic databases(Google Scholar,Pubmed and ScienceDirect)following the Preferred Reporting Items for Systematic Reviews and meta-analyses *** from in total 17 eligible studieswere reported in this systematic *** of the 17 studies used plants to fabricate AgNPs,whereas the remaining five studies used microorganisms(bacteria and/or fungi).Silver as part of silver nitrate(AgNO3)was themetal precursor reported for the synthesis of AgNPs in these *** nanoparticles were mostly spherical,with sizes ranging from12 *** minimum inhibitory concentrations varied between studies and were divided into three groups:(i)those more effective than the antibiotic(controls),(ii)those more effective than plant extracts,and(iii)those less effective than the antibiotic *** addition,little or no cytotoxicity effects were *** nanoparticles were also shown to be highly specific or selective toward mycobacterial *** systematic review highlights the antimycobacterial potential of biologically synthesized AgNPs,underscoring the possibility of discovering/developing new antimycobacterial agents using biological synthesis approaches with less toxicity and high selectivity.

关键词： antimycobacterial activity silver nanoparticles cytotoxicity biological synthesis tuberculosis mycobacterial

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Anticariogenic potentials of clove,tobacco and bitter kola

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Asian Pacific Journal of Tropical medicine 2011年第10期4卷 814-818页

作者： dibua esther uju Nnamani Petra Obioma Department of microbiology Faculty of Biological SciencesUniversity of NigeriaNsukka 410001Enugu StateNigeria Drug Delivery Research Unit Department of PharmaceuticsFaculty of Pharmaceutical SciencesUniversity of NigeriaNsukka 410001Enugu StateNigeria

Objective:To investigate three tropical plant materials - clove seeds[Syzygium aromalicum(S. aromaticum)],bitter kola fruits[Garcinia kola(***)]and tobacco leaves(Nicotiana species) as potential targeted killers of Streptococcus mutans(***),a cavity-causing bacterium(gram-positive, facultative anaerobe) that resides in a multispecies microbial community(dental plaque) for the treatment of dental caries(tooth decay).methods:Thirty one(31) teeth samples were collected from patients with obvious signs of tooth decay(swollen gum,weak or fallen tooth,etc.) using sterile swab *** samples were collected from two major denial clinics in Nsukka, enugu State,Nigeria and investigated by spread inoculation onto sterile blood agar and mueller Hinton agar(mHA) respectively and incubated at 37℃for 24 *** discrete colonies obtained were further re-inoculated onto sterile mitis salivarius agar(mSA) plates and incubated as above. The isolates were characterized by gram staining and calalase *** leaves,clove seeds and bitter kola fruits were ground into powder,extracted with three different solvents(n-hexane, hot water and ethanol),filtered,dried and stored in clean containers,corked and kept until used. The plant extracts were investigated for phytochemistry,minimum inhibitory concentration(mIC), minimum cidal concentration(mCC)and compared with some conventional antibiotics commonly used against tooth *** sensitivity test was also carried *** results were statistically ***:The extracts showed varied phytochemical composition but most abundantly the *** result also shows that females(16) have more tooth decay than males(15) and that 16 samples were very bloody while 15 were slightly *** microbial characterization showed that 18 samples were catalase-positive indicating the presence of S. mutans while 13 were catalase-negative suspected to be Staphylococcus *** Gram reaction confirmed 13 Gram-negative and

关键词： Tooth decay Clove Tobacco Bitter kola extracts Antimicrobial property

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Is pass‑through of the exchange rate to restaurant and hotel prices asymmetric in the US?Role of monetary policy uncertainty

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Financial Innovation 2023年第1期9卷 539-557页

作者： uju Violet Alola Ojonugwa Usman Andrew Adewale Alola Department of Tourism Guidance Istanbul Gelisim UniversitIstanbulTurkey economics and Finance Application and Research Center Department of EconomicsIstanbul Ticaret UniversityIstanbulTurkey Centre for Research on Digitalization and Sustainability Inland Norway University of Applied Sciences2418 ElverumNorway Faculty of economics Administrative and Social SciencesNisantasi UniversityIstanbulTurke

This study examines the exchange rate pass-through to the United States(US)restaurant and hotel prices by incorporating the effect of monetary policy uncertainty over the period 2001:m12 to 2019:*** the nonlinear autoregressive distributed lag(NARDL)model,empirical evidence indicates asymmetric pass-through of exchange rate and monetary policy ***,a stronger pass-through effect is observed during depreciation and a negative shock in monetary policy uncertainty,corroborating asymmetric pass-through *** results further show that a positive shock in energy prices leads to an increase in restaurant and hotel ***,asymmetric causality indicates that a positive shock in the exchange rate causes a positive shock to restaurant and hotel *** found feedback causal effects between positive and negative shocks in monetary policy uncertainty and positive and negative shocks in the exchange ***,we detected a one-way asymmetric causality,flowing from a positive(negative)shock to a positive(negative)shock in energy ***,these findings provide insights for policymakers to achieve low and stable prices in the US restaurant and hotel industry through sound monetary policy *** drivers of restaurant and hotel business in tourism destinations are *** is asymmetric pass-through of exchange rate and monetary policy uncertainty.A stronger pass-through is observed during appreciation and a negative shock to monetary policy *** is asymmetric causality from positive shock in exchange rate to postive shock in restaurant and hotel prices.

关键词： Restaurant and hotel prices exchange rate monetary policy uncertainty energy price index US economy

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Intrahepatic cholestasis of pregnancy is associated with increased risk of hepatobiliary disease and adverse fetal outcomes: A systematic review and meta-analysis

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iLIVeR 2023年第4期2卷 219-226页

作者： Peter Olujimi Odutola Peter Oluwatobi Olorunyomi Olanrewaju Olamide Olatawura Ifeoluwapo Olorunyomi Olukayode madojutimi Ayomide O.Fatunsin uju Okeke Harvard University CambridgeMassachusetts 02138USA The Robert Gordon University GarthdeeAberdeenScotlandAB107QBUK College of medicine Olabisi Onabanjo UniversitySagamuOgun State 120107Nigeria College of Health Professions Chamberlain UniversityDowners GroveIllinois 60515-5683USA College of Public Health Northeastern Illinois UniversityChicagoIllinois 60625USA SSm Healthcare Saint LouisMissouri 63104USA Texas A&m University College StationTexas 77843USA

Background and aims:The aim of this study was to review the literature and perform a meta-analysis to clarify the association between intrahepatic cholestasis of pregnancy and risks of long-term maternal hepatobiliary disease as well as adverse fetal outcomes including preterm birth,meconium-stained amniotic fluid,and ***:This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and meta-Analyses guidelines.A comprehensive literature search was performed using Cochrane,embase,and Pubmed databases to identify observational or cohort studies comparing pregnant women with intrahepatic cholestasis of pregnancy(ICP)to pregnant women without *** from the included studies were analyzed using the Review manager 5.4.1 ***:The meta-analysis showed a significant association between ICP and the risk of hepatobiliary diseases(pooled risk ratio[RR]:2.81,95%confidence interval[CI]:2.66–2.97,pepatitis C(HC):a significant association between ICP and risk of HC(pooled RR:4.02,95%CI:3.12–5.19,pmeconium-stained amniotic fluid(mSAF):ICP was significantly associated with an increased risk of mSAF(pooled RR:1.91,95%CI:1.65–2.21,peterm birth:the meta-analysis demonstrated a significant association between ICP and preterm birth(pooled RR:2.11,95%CI:2.01–2.21,pemonstrated statistically significant associations with increased risks of hepatobiliary disease,HC,mSAF,and preterm birth.

关键词： Intrahepatic Cholestasis Hepatobiliary Fetal

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effect of methanolic extract of Tetrapleura tetraptera(Schum and Thonn)Taub leaves on hyperglycemia and indices of diabetic complications in alloxan-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 272-278页

作者： Sunday ene-Ojo Atawodi Ojochenemi ejeh Yakubu mubarak Labaran Liman Dorothy uju iliemene Department of Biochemistry Ahmadu Bello University

Objective:To investigate the ameliorative role of Tetrapleura tetraplera(Schum and Thonn)Taub(***)leaf in hyperglycemia with associated conditions like oxidative stress,kidney damage and disorders in lipid ***:Five groups of five rats each intraperitoneally received the following treatment schedules for 7 d:untreated normal control,untreated alloxan-diabetic control,diabetic treated with glibenclamide,normal rats treated with extract(50 mg/kg)and diabetic rats treated with the *** were made for fasting blood sugar,body weight changes,malondialdehyde,aspartate aminotransferase,alanine aminotransferase,bilirubin,superoxide dismutase,catalase,lipid profile,packed cell volume,hemoglobin,urea and creatinine in all the ***:Whereas the untreated diabetic rats showed a significant decrease(Ped cell volume,superoxide dismutase,catalase and high-density lipoprotein-cholesterol with a concomitant increase in the levels of malondialdehyde,fasting blood sugar,aspartate aminotransferase,alanine aminotransferase,bilirubin,urea and creatinine,administration of methanolic extract of *** leaf or glibenclamide alleviated these altered parameters in the treated ***:methanolic extract of *** leaves possesses a potent capacity for treatment of diabetes and the accompanying complications,including oxidative stress and hyperlipidemia.

关键词： Antidiabetic Tetrapleura tetraptera Alloxan-induced diabetes Antioxidant Hepatoprotection Disease chemoprevention

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Rheological modeling of the effects of Adulteration on Nigerian Honey

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Open Journal of Fluid Dynamics 2018年第3期8卷 249-263页

作者： John uju Nwalor Faith Uchenna Babalola Vincent Okechukwu Anidiobu Department of Chemical engineering University of Lagos Lagos Nigeria Food Process engineering Section Department of Food Technology The Federal Polytechnic Ado-Ekiti Nigeria

Honey was serially diluted with different percentages of glucose, fructose and water and each was analysed rheologically at room temperature of 27°C. Pure honey exhibits thixotropic time-dependent rheological behaviour, the behaviour of glucose and fructose solutions in water (a Newtonian solvent) tends towards near Newtonian. The rheological profiles of pure and adulterated honey samples were determined using RV DV-III Ultra Programmable Rheometer at low rates of share. A Structural Kinetic model was developed which provided good correlations with the rheological data. The new model was used to classify samples using their average molecular weights as one of the distinguishing parameters. Also the order of the kinetics in the new model suggests the number of active components in the “honey” undergoing deformation as 3. Carreau-Yasuda model was also improved upon to provide an independent assessment of average molecular weight of samples.

关键词： Honey Rheology Structural Kinetic model Amended Carreau-Yasuda model Honey Adulteration

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Igbo Language and Identity

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Journal of Literature and Art Studies 2013年第9期3卷 576-588页

作者： Umo uju Clara Department of Arts education University of Nigeria

This paper sought to identify the position of Igbo language in relation to its identity both in Nigeria and world wide. Specifically, it expounded the problems hindering the study of Igbo language. A study of Igbo language and identity is pertinent because language and culture are attached to man"s identity and human interaction. Unfortunately, most of the Igbos do not want to be identified with this language called Igbo. The paper reviewed available literature on Igbo language and highlighted some strategies for increasing the interest of people in learning Igbo language. It was discovered from the study that pedagogical problems, tone problems, orthography, and diacritic problems, are some of the issues that inhibit the repositioning of Igbo language as Igbo man"s identity. In view of this, it was recommended among others that Igbo linguist should try and document all the slight phonological and word differences existing in the dialects and absorb them in central Igbo.

关键词：语言学尼日利亚人际交往教学问题学习

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When Prior Knowledge Helps： Self-Report of First-Year University Undergraduates on Academic Writing

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Sino-US english Teaching 2015年第11期12卷 861-868页

作者： uju C. Ukwuoma Botswana International University of Science and Technology (BIUST) Palapye Botswana

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Comparative Analysis of the Determinants of Residential Land Values

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Chinese Business Review 2012年第2期11卷 187-192页

作者： Ilechukwu Victor uju Salau Taofik Iyanda University of Lagos LagosNigeria

City development is a result of many factors, of which land value is one of the major determinants. The past urban economics studies have shown that land value is largely determined by location factors such as distance from Central Business District (CBD) ignoring the non-location factors like time of purchase and neighbourhood infrastructures. Therefore, this paper attempts to establish the relative importance of location and non-location factors in the determination of residential land value by positing Onitsha, Nigeria as a case study. eight hundred and fifty residential housing units were selected and questionnaire administered to the landlords through multi-stage sampling technique. The stepwise regression analysis results showed that non-location factors, especially, time of land purchase, contribute more to the variation in residential land values. The paper suggests the revision of the classical economic theories to represent the conditions of urban areas in developing countries.

关键词：土地价值住宅用地逐步回归分析城市经济学中央商务区发展中国家城市发展基础设施

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