Intrahepatic cholestasis of pregnancy is associated with increased risk of hepatobiliary disease and adverse fetal outcomes: A systematic review and meta-analysis

作     者：Peter Olujimi Odutola Peter Oluwatobi Olorunyomi Olanrewaju Olamide Olatawura Ifeoluwapo Olorunyomi Olukayode Madojutimi Ayomide O.Fatunsin Uju Okeke Peter Olujimi Odutola;Peter Oluwatobi Olorunyomi;Olanrewaju Olamide Olatawura;Ifeoluwapo Olorunyomi;Olukayode Madojutimi;Ayomide O.Fatunsin;Uju Okeke

作者机构：Harvard UniversityCambridgeMassachusetts 02138USA The Robert Gordon UniversityGarthdeeAberdeenScotlandAB107QBUK College of MedicineOlabisi Onabanjo UniversitySagamuOgun State 120107Nigeria College of Health ProfessionsChamberlain UniversityDowners GroveIllinois 60515-5683USA College of Public HealthNortheastern Illinois UniversityChicagoIllinois 60625USA SSM HealthcareSaint LouisMissouri 63104USA Texas A&M UniversityCollege StationTexas 77843USA 

出 版 物：《iLIVER》 (国际肝胆健康（英文）)

年 卷 期：2023年第2卷第4期

页      面：219-226页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Intrahepatic Cholestasis Hepatobiliary Fetal 

摘      要：Background and aims:The aim of this study was to review the literature and perform a meta-analysis to clarify the association between intrahepatic cholestasis of pregnancy and risks of long-term maternal hepatobiliary disease as well as adverse fetal outcomes including preterm birth,meconium-stained amniotic fluid,and ***:This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.A comprehensive literature search was performed using Cochrane,Embase,and PubMed databases to identify observational or cohort studies comparing pregnant women with intrahepatic cholestasis of pregnancy(ICP)to pregnant women without *** from the included studies were analyzed using the Review Manager 5.4.1 ***:The meta-analysis showed a significant association between ICP and the risk of hepatobiliary diseases(pooled risk ratio[RR]:2.81,95%confidence interval[CI]:2.66–2.97,p0.00001),hepatitis C(HC):a significant association between ICP and risk of HC(pooled RR:4.02,95%CI:3.12–5.19,p0.00001),meconium-stained amniotic fluid(MSAF):ICP was significantly associated with an increased risk of MSAF(pooled RR:1.91,95%CI:1.65–2.21,p0.00001),and preterm birth:the meta-analysis demonstrated a significant association between ICP and preterm birth(pooled RR:2.11,95%CI:2.01–2.21,p0.00001).Conclusion:ICP demonstrated statistically significant associations with increased risks of hepatobiliary disease,HC,MSAF,and preterm birth.