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Effects of Sleep Disorders on Hemoglobin Alc Levels in Type 2 Diabetic Patients

Chinese Medical Journal 2015年第24期128卷 3292-3297页

作者： Ahmet Keskin Murat Unalacak ugur bilge Pinar Yildiz Seda Guler Engin Burak Selcuk Muzaffer Bilgin Department of Family Medicine Yildrinm Beyazit University Faculty of Medicine Ankara Turkey Department of Family Medicine Hacettepe University Faculty of Medicine Ankara Turkey Department of Family Medicine Faculty of Medicine Eskisehir Osmangazi University Eskisehir 9026100 Turkey Department of internal Medicine Faculty of Medicine Eski~ehir Osmangazi University Eskisehir 9026100 Turkey Department of Family Medicine Faculty of Medicine Inonu University Malatya Turkey Department of Biostatistics and Medical Informatics Faculty of Medicine Eskisehir Osmangazi University Fskisehir 9026100 Turkey

Background： Studies have reported the presence of sleep disorders in approximately 50-70% of diabetic patients, and these may contribute to poor glycemic control, diabetic neuropathy, and overnight hypoglycemia. The aim of this study was to determine the frequency of sleep disorders in diabetic patients, and to investigate possible relationships between scores of these sleep disorders and obstructive sleep apnea syndrome （OSAS） and diabetic parameters （fasting blood glucose, glycated hemoglobin Alc [HbA lc], and lipid levels）. Methods： We used the Berlin questionnaire （BQ） for OSAS, the Epworth Sleepiness Scale （ESS）, and the Pittsburgh Sleep Quality Index （PSQI） to determine the frequency of sleep disorders and their possible relationships with fasting blood glucose, HbA I c, and lipid levels. Results： The study included 585 type 2 diabetic patients admitted to family medicine clinics between October and December 2014. Sleep, sleep quality, and sleep scores were used as the dependent variables in the analysis. The ESS scores showed that 54.40% of patients experienced excessive daytime sleepiness, and according to the PSQI, 64.30% experienced poor-quality sleep. The BQ results indicated that 50.20% of patients were at high-risk of OSAS. HbAlc levels correlated significantly with the ESS and PSQI results （r = 0.23, P 〈 0.001 and r = 0.14, P = 0.001, respectively）, and were significantly higher in those with high-risk of OSAS as defined by the BQ （P 〈 0.001 ）. These results showed that HbAlc levels were related to sleep disorders. Conclusions： Sleep disorders are common in diabetic patients and negatively affect the control of diabetes. Conversely, poor diabetes control is an important factor disturbing sleep quality. Addressing sleep disturbances in patients who have difficulty controlling their blood glucose has dual benefits： Preventing diabetic cornplications caused by sleep disturbance and improving diabetes control.

关键词： Hemoglobin A1c Obstructive Sleep Apnea Syndrome Sleep Disorders Type 2 Diabetes Mellitus

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Physical and mechanical properties of some hybrid corn varieties

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International Journal of Agricultural and Biological Engineering 2013年第1期6卷 111-116页

作者： TurgutÖztürk bilge Esen Department of Agricultural Structure and Irrigation Faculty of AgricultureUniversity of Ondokuz Mayıs55139 SamsunTurkey

The aim of this study was to determine the structural designing parameters of silo and bins used for storage of some hybrid corn varieties(Zea mays L.).In the research,three corn varieties-dentcorn(Zea mays indentata Sturt.),popcorn(Zea mays everta Sturt.),sweetcorn(Zea mays sacharata Sturt.)-widespread cultivated in Turkey were ***-mechanical parameters(bulk density,true density,angle of internal friction,static coefficient of friction)were considered as the dependent variables,and moisture content(8%,10%,12%,and 14%)as the independent *** bulk density,true density and angle of internal friction varied from 608.46 to 856.46 kg/m^(3),950.88 to 1110.89 kg/m^(3),and 25.2°to 34.2°,respectively,with the increase in moisture content from 8% to 14%.According to results of the research,the highest average value for bulk density,true density,angle of internal friction were found in popcorn variety(839.17 kg/m^(3)),popcorn variety(1074.40 kg/m^(3)),sweetcorn variety(30.50°),*** highest average value for static coefficient of friction at concrete surface(C30)was recorded in dentcorn variety(0.662).

关键词： corn varieties physical properties angle of internal friction coefficient of friction

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An adaptive Markov chain algorithm applied over map-matching of vehicle trip GPS data

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Geo-Spatial Information Science 2021年第3期24卷 484-497页

作者： bilge Kaan Karamete Louai Adhami Eli Glaser Engineering GeospatialKinetica DB IncArlingtonVAUSA

Markov chains have frequently been applied to match the probable routes with a set of GPS trip data that a pilot vehicle is emitting over a specific graph road network. This class of mapmatching (MM) algorithms presently demonstrates and involve statistical and ad-hoc measures to drive the Markov chain transitional probabilities in picking the best route combinations constrained over the graph road network. In this study, we have devised an adaptive scheme to modify the Markov Chain (MC) kernel window as we move along the GPS samples to reduce the mistakes that can happen by the use of narrower MC widths. The measure for temporarily increasing the MC window width is chosen to be the ratio between the geodesic distance of current route to the actual geodesic distance between each pair of GPS samples. This adaptive use of MC has shown to have hardened the results significantly with tolerable computational cost increase. The details of the overall algorithm are depicted by the example routes extracted from various vehicle trips and the results are shown to validate the usefulness of the algorithm in practice.

关键词： Hidden Markov chain(HMC) map-matching(MM) graph networks

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Mode of delivery, birth weight and the incidence of congenital nasolacrimal duct obstruction

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1134-1138页

作者： Ayse Dolar bilge Department of Ophthalmology Emsey Hospital

AIM: To study any possible association of congenital nasolacrimal duct obstruction(CNLDO) with mode of delivery, birth weight and gestational age. METHODS: We retrospectively reviewed charts of all patients(n=2591) under the age of 3 y who were born between April 2015 and May 2017 and were examined at the Ophthalmology Clinic of Emsey Hospital Istanbul, Turkey. We identified patients(n=105) who were diagnosed as CNLDO. The mode of delivery, birth weight and gestational age along with any adverse event during or after delivery or any other health history were determined. Birth statistical data were obtained from the hospital’s medical records database. RESULTS: Gestational age of babies who were born via cesarean section(CS) was lower than gestational age of babies who were born via normal spontaneous vaginal delivery(NSVD;P=0.002). Babies who were born via CS were found to have 3.75 times higher risk of developing NLDO when compared to babies who were born via NSVD(OR=3.754). CONCLUSION: There is a possible association between CS and CNLDO.

关键词： congenital nasolacrimal duct obstruction cesarian section normal spontaneous vaginal delivery

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Microstructure,mechanical properties,and corrosion resistance of an explosively welded Mg-Al composite

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Journal of Magnesium and Alloys 2022年第4期10卷 1086-1095页

作者： Mustafa Acarer bilge Demir Burak Dikici Emin Salur Department of Metallurgical and Materials Engineering Technology FacultySelcuk UniversityKonya 42075Turkey Department of Mechanical Engineering Karabuk UniversityKarabuk 78100Turkey Department of Metallurgical and Materials Engineering Atatürk UniversityErzurum 25240Turkey

In this study,an attempt was made to manufacture an AZ31–Al5005 laminated composite by explosive welding.A mixture of ammonium nitrate(90%),fuel oil(5%),and TNT(5%)was used as the *** detonation velocity of the explosive material was approximately 3100 m•s^(−1).The microstructure and mechanical and corrosion properties of the joint were comparatively *** characterisation of the joint was conducted by optical microscopy(OM),scanning electron microscopy with energy-dispersive spectroscopy(SEM-EDS),high-resolution transmission electron microscopy(HR-TEM),and X-ray diffraction(XRD).The mechanical properties were determined using micro-Vickers hardness,tensile,and Charpy impact *** addition,electrochemical tests were conducted on the AZ31–Al5005 laminated composite and the individual components to determine their corrosion *** corrosion behaviours of the structures were determined in a 3.5%NaCl solution at room temperature using potentiodynamic scanning(PDS).The metallurgical structure and mechanical properties of the joints were within the acceptable limits.

关键词： corrosion welded Microstructure

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Interaction of microglia and T cells: a deadly duo behind Taumediated neurodegeneration

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3894-3895页

作者： bilge Askin Susanne Wegmann German Center for Neurodegenerative Diseases Charitéplatz 110117 BerlinGermany Einstein Center for Neurosciences Berlin Charité-Universitätsmedizin BerlinBerlinGermany

A recent study by Chen et *** in Nature reported the presence of activated T cells in the brains of transgenic mice with frontotemporal dementia(FTD)-like Tau protein pathology and in postmortem Alzheimer’s disease(AD)brains.1 The infiltration of T cells correlated with the degree of Tau pathology and microglia activation,and appeared to promote *** progressive aggregation of amyloid-β in extracellular amyloid plaques and of Tau in neurofibrillary tangles are the two main protein pathological hallmarks of *** are accompanied by synaptic loss,neuroinflammation,and neuronal death,and com-promise the blood-brain barrier,allowing immune cells to infiltrate the brain parenchyma and interact with glial cells and neurons;all of these factors contribute to disease progression.2 Activated T cells can be found in postmortem brains of different neurological disorders,in AD,particularly in areas with neuronal loss and Tau pathology,i.e.,the hippocampus and limbic structures.

关键词： pathology amyloid inflammation

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Determination of epidemic parameters from early phase fatality data： A case study of the 2009 A（H1N1） pandemic in Europe

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International Journal of Biomathematics 2018年第2期11卷 135-146页

作者： Ayse Humeyra bilge Funda Samanlioglu Faculty of Engineering and Natural Sciences Kadir Has University Istanbul Turkey

This paper demonstrates that the susceptible-infected-removed （SIR） model applied to the early phase of an epidemic can be used to determine epidemic parameters reliably. As a case study, the SIR model is applied to the fatality data of the 2009 fall wave cycle of the A（H1N1） pandemic in 12 European countries. It is observed that the best estimates of the basic reproduction number R0 and the mean duration of the infection period l/r/ lie on a curve in the scatterplots, indicating the existence of a nearly-invariant quantity which corresponds to the duration of the epidemic. Spline interpolation applied to the early phase of the epidemic, an approximately 10-week period, together with a future control point in the stabilization region, is sufficient to estimate model parameters. The SIR model is run over a wide range of parameters and estimates of R0 in the range 1.2- 2.0 match the values in the literature. The duration of the infection period, 1/η is estimated to be in the range 2.0-7.0 days. Longer infection periods are tied to spatial characteristics of the spread of the epidemic.

关键词： Differential equations epidemic model influenza epidemiology A(H1N1) basic reproduction number,

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Functional,chemical,and sensorial properties of gluten-free fermented instant soup powders developed by use of mung bean and drum drying process

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Food Bioscience 2022年第3期47卷 1070-1081页

作者： bilge Taşkın NazlıSavlak Department of Food Engineering Faculty of EngineeringManisa Celal Bayar University45140YunusemreManisaTurkey

There is a potent demand to develop novel gluten-free food alternatives that are nutritious and ***-free instant fermented soup powder was developed by partial substitution of rice flour with mung bean *** of drum drying conditions;feed moisture(45–65%),drum rotating speed(0.6–2.2 rpm),and steam pressure(75–95 psi)on functional,chemical,sensorial,and morphological properties of soup powders were *** powders exhibited high protein content(20.52–22.62%)and remarkable amounts of dietary fibers(2.63–3.94%),total phenolics(2.23–3.64μg GAE/g),and antioxidant capacities(DPPH:6.28–9.96μmol TEAC/g,FRAP:26.02–42.88μmol/g).The instant structure of the soup powder was provided by water solubility(17.93–23.14%),water absorption(3.20–4.20 g/g),and gelatinization degree(82.92–97.60%)analyses,as well as SEM appearances and DSC *** conditions were determined as 57.55%feed moisture,1.00 rpm rotating speed,and 91.27 psi steam *** instant soup powders had enhanced chemical,functional and bioactive properties,and can be used practically in daily and social life by celiac patients or gluten sensitive *** bean was proven to be a valid option for novel application opportunities in gluten-free systems.

关键词： Gluten-free Antioxidant activity Mung bean Optimization Instant soup Drum drying Quality characteristics

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Application of ultrasonic waves in measurement of hardness of welded carbon steels

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Defence Technology（防务技术） 2015年第3期11卷 255-261页

作者： Fatih UZUN Ali Nezihi bilge Department of Chemical Engineering Yeditepe University Department of Energy Systems Engineering Bilgi University

The ultrasonic contact impedance technique and ultrasonic wave velocities have been widely used for non-destructive hardness *** wave velocity shift provides through the thickness average hardness, however, the correlations are performed according to surface hardness. In order to accept this technique as a particular non-destructive method for determination of hardness, it is necessary to test it with industrial applications. A widely used joining(welding) technique is selected for this purpose. Samples of carbon steels with three different carbon contents, but similar composition, are annealed in order to obtain the softened samples with different hardness values. Rockwell B scale hardness of heat treated samples, which are assumed to be isotropic, are determined and correlated with ultrasonic wave velocity shifts. Effect of welding process on hardness is investigated using ultrasonic wave velocity shifts, and the results are verified with destructive hardness measurements.

关键词：超声波速度硬度测量焊接工艺工业应用碳钢非破坏性硬度测试接触阻抗

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Antiprotozoal assessment and phenolic acid profiling of five Fumaria(fumitory) species

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 283-286页

作者： Ilkay Erdogan Orhan Nilgun Ozturk bilge Sener Department of Pharmacognosy Faculty of PharmacyGazi University Department of Pharmacognosy Faculty of PharmacyAnadolu University

Objective:To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal ***:Consequently,in the current study,antiprotozoal effect of the ethanol extracts obtained from five Fumaria species(Fumaria densiflora,Fumaria cilicica,Fumaria rostellata,Fumaria kralikii,and Fumaria parviflora)was investigated against the parasites;Plasmodium falciparum(malaria)and Trypanosoma bruceirhodesiense(human African trypanosomiasis)at 0.81 and 4.85μg/mL ***:Among them,Fumaria densiflora extract exerted the highest antiplasmodial(93.80%)and antitrypanasomal effect(55.40%),while the ethanol extracts of Fumaria kralikii(43.45%)and Fumaria rostellata(41.65%)showed moderate activity against Plasmodium ***,phenolic acid contents of the extracts were analyzed using high performance liquid chromatography(HPLC)and trans-cinnamic(4.32 mg/g)and caffeic(3.71 mg/g)acids were found to be the dominant phenolic acids in Fumaria ***:According to our results,Fumaria densiflora deserve further study for its promising antiprotozoal activity.

关键词： Fumaria Fumitory Antiprotozoal Malaria Trypanosomiasis Phenolic acid

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