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A randomized,controlled,open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China

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Frontiers of Medicine 2024年第1期18卷 98-108页

作者： Jie Jin Zhihua Ran Emanuele Noseda Bernard Roubert Matthieu Marty Anna Mezzacasa udo Michael Göring The First Affiliated Hospital Zhejiang University College of MedicineHangzhou310058China Renji Hospital Shanghai Jiao Tong University School of MedicineShanghai200025China Vifor Pharma Glattbrugg8152Switzerland

Iron deficiency(ID)and ID anemia(IDA)pose significant public health concerns in *** iron sucrose(IS)treatment is well-established in the country,ferric carboxymaltose(FCM)offers the advantage of higher doses and fewer *** open label,randomized,controlled,non-inferiority trial was conducted at multiple sites in China to compare the outcomes of FCM(maximum of 2 doses,500 or 1000 mg iron)and IS(up to 11 infusions,200 mg iron)treatments in subjects with *** primary endpoint was the achievement of hemoglobin(Hb)response(an increase of⩾2 g/dL from baseline)within 8 weeks,whereas secondary endpoints included changes in Hb,transferrin saturation,and serum ferritin *** the 371 randomized subjects,a similar percentage of subjects treated with FCM and IS achieved Hb-response(FCM 99.4%,IS 98.3%),thereby confirming the non-inferiority of FCM compared with IS(difference 1.12(−2.15,4.71;95%confidence interval(CI))).Furthermore,a significantly higher proportion of FCM-treated subjects achieved early Hb-response at Week 2(FCM 85.2%,IS 73.2%;difference 12.1(3.31,20.65;95%CI)).Additionally,the increase in TSAT and serum ferritin levels from baseline was significantly greater at all time points for FCM-treated *** safety profiles of FCM and IS were comparable,with the exception of transient hypophosphatemia and pyrexia,which are consistent with FCM’s known safety *** conclusion,FCM proves to be an efficacious treatment for IDA,providing faster Hb-response and correction of ID with fewer administrations than IS.

关键词： iron deficiency anemia intravenous iron ferric carboxymaltose iron sucrose Hb response early response

基于干细胞的胶质细胞源性神经营养因子和睫状神经营养因子对CLN7型神经元蜡样脂褐质沉积症小鼠模型视网膜退行性病变的治疗研究

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中华眼底病杂志 2024年第7期40卷 526-537页

作者：魏莹莹 udo Bartsch 汉堡-埃彭多夫大学医学中心眼科德国汉堡100731 长沙湘江爱尔眼科医院长沙410011

目的观察CLN7型神经元蜡样脂褐质沉积症小鼠模型视网膜变性的形态学和功能学改变,以及基于神经干细胞(NSC)的胶质细胞源性神经营养因子(GDNF)和(或)睫状神经营养因子(CNTF)对小鼠光感受器细胞的治疗效果。方法鼠龄14 d的CLN7型小鼠100... 详细信息

目的观察CLN7型神经元蜡样脂褐质沉积症小鼠模型视网膜变性的形态学和功能学改变,以及基于神经干细胞(NSC)的胶质细胞源性神经营养因子(GDNF)和(或)睫状神经营养因子(CNTF)对小鼠光感受器细胞的治疗效果。方法鼠龄14 d的CLN7型小鼠100只随机分为实验组、对照组,分别为80、20只。鼠龄14 d的C57BL/6J小鼠20只设定为野生型组(WT组)。对照组、WT组小鼠不作任何处理,于2、4、6月龄时,采用免疫组织化学染色观察视网膜视锥细胞、视杆-双极细胞、视锥-双极细胞分布和数量变化;采用视网膜电图(ERG)检查记录暗视a、b波及明视b波振幅。实验组小鼠随机选取单侧眼为实验眼,玻璃体腔分别注射2μl CNTF-NSC、GDNF-NSC、CNTF-NSC和GDNF-NSC 1:1细胞混合物(GDNF/CNTFNSC),并据此再分为CNTF-NSC组、GDNF-NSC组、GDNF/CNTF-NSC组;对侧眼玻璃体腔注射不含神经营养因子(NTF)的NSC 2μl作为自身对照组。实验组不同治疗亚组于小鼠2、4月龄时,采用免疫组织化学染色观察光感受器细胞的数量;采用ERG检查记录暗视a、b波及明视b波振幅;小鼠4月龄时,观察移植的NSC分化情况和NTF表达。两组间比较采用双因素方差分析。结果与WT组比较,小鼠2、4、6月龄时,对照组小鼠周边区视网膜视锥细胞密度(F=285.10),中央区、周边区视网膜视杆-双极细胞密度(F=823.20、346.20)、视锥-双极细胞密度(F=356.30、210.60)以及暗视a、b波振幅(F=1911.00、387.10)均显著降低,差异有统计学意义(P0.05)。结论随年龄增长,CLN7型小鼠表现出渐进性加重的退行性变化,这种变化在光感受器细胞和双极细胞的形态结构及功能上是一致的。基于NSC玻璃体内递送的CNTF和GDNF/CNTF均对光感受器细胞有保护作用,但联合使用GDNF/CNTF并未展现出比各自单独使用时更显著的协同保护效果。GDNF对CLN7型小鼠视网膜的形态和功能均没有治疗效果。

关键词：神经元蜡样质脂褐质沉积症7型胶质细胞源性神经营养因子睫状神经营养因子慢病毒神经干细胞眼内干细胞移植神经保护

Analysis of Secured Cloud Data Storage Model for Information

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Journal of Software Engineering and Applications 2024年第5期17卷 297-320页

作者： Emmanuel Nwabueze Ekwonwune udo Chukwuebuka Chigozie Duroha Austin Ekekwe Georgina Chekwube Nwankwo Department of Computer Science Imo State University Owerri Nigeria Department of Computer Science Gregory University Abia Nigeria Department of Computer Science Anambra State University Awka Nigeria

This paper was motivated by the existing problems of Cloud Data storage in Imo State University, Nigeria such as outsourced data causing the loss of data and misuse of customer information by unauthorized users or hackers, thereby making customer/client data visible and unprotected. Also, this led to enormous risk of the clients/customers due to defective equipment, bugs, faulty servers, and specious actions. The aim if this paper therefore is to analyze a secure model using Unicode Transformation Format (UTF) base 64 algorithms for storage of data in cloud securely. The methodology used was Object Orientated Hypermedia Analysis and Design Methodology (OOHADM) was adopted. Python was used to develop the security model;the role-based access control (RBAC) and multi-factor authentication (MFA) to enhance security Algorithm were integrated into the Information System developed with HTML 5, JavaScript, Cascading Style Sheet (CSS) version 3 and PHP7. This paper also discussed some of the following concepts;Development of Computing in Cloud, Characteristics of computing, Cloud deployment Model, Cloud Service Models, etc. The results showed that the proposed enhanced security model for information systems of cooperate platform handled multiple authorization and authentication menace, that only one login page will direct all login requests of the different modules to one Single Sign On Server (SSOS). This will in turn redirect users to their requested resources/module when authenticated, leveraging on the Geo-location integration for physical location validation. The emergence of this newly developed system will solve the shortcomings of the existing systems and reduce time and resources incurred while using the existing system.

关键词： Cloud Data Information Model Data Storage Cloud Computing Security System Data Encryption

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河内博物馆

中国建筑装饰装修 2012年第4期 238-239页

作者： Meinhard von Gerkan Nikolaus Goetze Klaus Lenz Nicole Flores Martin Friedrich Jessica Last udo meyer Duc Tran Cong Marcus Bredt

穿过园林景观来访者可从四个方向进入博物馆。在正方形的建筑体中庭内,一座圆形的挑空大厅将入口层面于其上的三层展览空间连接起来。如同倒置的金字塔般,中庭向上呈阶梯状展开。来访者向外望去,仿佛"漂浮"于主题公园景观之上。盘旋上... 详细信息

穿过园林景观来访者可从四个方向进入博物馆。在正方形的建筑体中庭内,一座圆形的挑空大厅将入口层面于其上的三层展览空间连接起来。如同倒置的金字塔般,中庭向上呈阶梯状展开。来访者向外望去,仿佛"漂浮"于主题公园景观之上。盘旋上升的坡道作为极富表现力的空间元素,将人们吸引至建筑顶部,并且实现了展览空间与中庭的视线交流。由于展览空间全部安排在建筑的首层至三层,会议、科研中心,办公空间以

关键词：博物馆博物院文化机构建筑体中庭

Evaluation of Ear and Facial Indices of Ibibio and Efik Female Children of Akwa Ibom and Cross River States, Nigeria

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Journal of Biosciences and Medicines 2024年第7期12卷 1-8页

作者： Nsikak Michael Umoh Kelechi Chinkata Uruakpa Eru Eru Mba Michael Effiong Oku Theresa Isamoh Nnenna Williams Eric Agim Agaba Samson Omini Paulinus John Emah Gabriel udo-Affah Department of Anatomical Sciences Faculty of Basic Medical Sciences College of Medical Sciences University of Calabar Calabar Nigeria

Background: The ear and face are indispensable and distinctive features for hearing and identification. Objectives: This study was designed to generate anthropometric data of the ear and facial indices of females of Efik and Ibibio children in Cross River and Akwa Ibom States, show morphological and aesthetic differences and ethnicity. Methods: A total of 600 female children (300 Efiks and 300 Ibibios) aged 2 to 10 years that met the inclusion criteria were chosen from selected primary schools in Calabar Municipality, Calabar South of Cross River State and from Uyo, Itu of Akwa Ibom State, Nigeria. Standardized measurements of face length, face width, ear length, and ear width were taken with a spreading caliper;the facial (proscopic) and ear (auricular) indices were determined. Results: Efik subjects presented a mean face length of 8.36 ± 0.06 cm, face width of 11.04 ± 0.04 cm, ear length of 4.92 ± 0.02 cm, and ear width of 3.06 ± 0.01 cm. Ibibio subjects had mean values for face length, face width, ear length, and ear width as 8.17 ± 0.05 cm, 10.75 ± 0.05 cm, 4.77 ± 0.03 cm, and 2.94 ± 0.02 cm respectively. The mean facial index and ear index for Efik subjects were 75.68 ± 0.31 and 62.16 ± 0.27 respectively;while the mean facial and ear indices for Ibibio subjects were 74.79 ± 0.36 and 61.80 ± 0.34 respectively. Statistical analysis demonstrated significant differences in face length, ear length, ear width and facial index, with the Efik subjects having higher values than Ibibio subjects (p Conclusion: The results showed hypereuryproscopic face as the prevalent face type among females of both ethnic groups, therefore can be of importance in sex, ethnic, and racial differentiation, and in clinical practice, aesthetics and forensic medicine.

关键词： Anthropometry Ear Facial Indices Identification Nigeria

Strategies to treat neurodegeneration in neuronal ceroid lipofuscinosis:a view onto the retina

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Neural Regeneration Research 2023年第3期18卷 558-559页

作者： udo Bartsch Department of Ophthalmology University Medical Center Hamburg-EppendorfHamburgGermany

Neuronal ceroid lipofuscinosis(NCL),also known as Batten disease,is the umbrella term for a group of neurodegenerative lysosomal storage disorders with onset mainly in *** total 13 genetically distinct NCLs are caused by mutations in genes encoding soluble or transmembrane proteins,and have been classified according to the affected gene into CLN1 to CLN8 and CLN10 to *** accumulation of autofluorescent storage material due to lysosomal dysfunction is a hallmark of all NCLs.

关键词： degenerative childhood encoding

A comparative study of using two numerical strategies to simulate the biochemical processes in microbially induced calcite precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 592-602页

作者： Dianlei Feng Xuerui Wang udo Nackenhorst Xuming Zhang Pengzhi Pan Department of Hydraulic Engineering Tongji UniversityShanghai200092China Institute of Fluid Mechanics and Environmental Physics in Civil Engineering Leibniz University HannoverHannover30167Germany Institute of Mechanics and Computational Mechanics Leibniz University HannoverHannover30167Germany State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

In this study,we carried out a comparative study of two different numerical strategies for the modeling of the biogeochemical processes in microbially induced calcite precipitation(MICP)process.A simplified MICP model was used,which is based on the mass transport *** numerical strategies,namely the operator splitting(OS)and the global implicit(GI)strategies,were adopted to solve the coupled reactive mass transport *** two strategies were compared in the aspects of numerical accuracy,convergence property and computational efficiency by solving the presented MICP *** look more into the details of the model,sensitivity analysis of some important modeling parameters was also carried out in this paper.

关键词： Microbially induced calcite precipitation(MICP) Advection-diffusion-reaction(ADR)equation Time discontinuous Galerkin(TDG)method Open Geo Sys-PHREEQC

Conversion of twisted light to twisted excitons using carbon nanotubes

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npj Computational Materials 2022年第1期8卷 392-402页

作者： Xiaoning Zang Nirpendra Singh Mark T.Lusk udo Schwingenschlögl Applied Physics Program Physical Sciences and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Department of Physics Khalifa University of Science and TechnologyAbu Dhabi127788United Arab Emirates Department of Physics Colorado School of MinesGoldenCO80401USA

Carbon nanotubes are explored as a means of coherently converting the orbital angular momentum of light to an excitonic form that is more amenable to quantum information *** analytical analysis,based on dynamical conductivity,is used to show that orbital angular momentum is conserved,modulo N,for a carbon nanotube illuminated by radially polarized,twisted *** result is numerically demonstrated using real-time time-dependent density functional theory which captures the absorption of twisted light and the subsequent transfer of twisted *** results suggest that carbon nanotubes are promising candidates for constructing optoelectronic circuits in which quantum information is more readily processed while manifested in excitonic form.

关键词： twisted carbon light

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越南河内国家会议中心(NCC)

建筑技艺 2010年第7期16卷 40-47页

作者：曼哈德.冯.格康 Susi Winter Tuyen Tran Viet Robert Wildegger Hito Ueda Marcus Tanzen udo meyer Birgit Fllmer Jens Reichert Uli Rsler Frederik Heisel Annika Schrder Elena Melnikova Markus Carlsen Nicole Flores Schlotfeldt Licht Müller BBM Breimann Bruun Christian Gahl 德国gmp建筑师事务所越南国家建设咨询公司

会议中心、酒店和博物馆镶嵌在一片以越南文化和传统作为特色主题和象征的开阔的景观园林内。会议中心作为主导建筑坐落于南北轴线上,几乎占据了以大湖、小池和假山为特色的整个景观公园的中心地带。与园林景观的有机形状形成鲜明对比... 详细信息

会议中心、酒店和博物馆镶嵌在一片以越南文化和传统作为特色主题和象征的开阔的景观园林内。会议中心作为主导建筑坐落于南北轴线上,几乎占据了以大湖、小池和假山为特色的整个景观公园的中心地带。与园林景观的有机形状形成鲜明对比的是：道路和步道系统规划为一个严密的线性网格。

关键词：南河景观园林中心地带园林景观博物馆酒店建筑公园