Strategies to treat neurodegeneration in neuronal ceroid lipofuscinosis:a view onto the retina

作     者：Udo Bartsch Udo Bartsch

作者机构：Department of OphthalmologyUniversity Medical Center Hamburg-EppendorfHamburgGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第3期

页      面：558-559页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100212[医学-眼科学] 10[医学] 

基　　金：supported by the“Stiftung zur F?rderung der Universit?tsmedizin Hamburg” the“Ernst and Berta Grimmke Stiftung”(to UB) 

主　　题：degenerative childhood encoding 

摘      要：Neuronal ceroid lipofuscinosis(NCL),also known as Batten disease,is the umbrella term for a group of neurodegenerative lysosomal storage disorders with onset mainly in *** total 13 genetically distinct NCLs are caused by mutations in genes encoding soluble or transmembrane proteins,and have been classified according to the affected gene into CLN1 to CLN8 and CLN10 to *** accumulation of autofluorescent storage material due to lysosomal dysfunction is a hallmark of all NCLs.