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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Synthesis and Crystal Structure of Trans-bis(acesulfamato-O)tetraaquazinc(Ⅱ)

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1047-1050页

作者： SAHIN Onur ICBuDAK Hasan B(u|¨)y(u|¨)KG(u|¨)NG(O|¨)R Orhan Department of Physics Faculty of Arts and SciencesOndokuz Mayis UniversitySamsunTurkey Department of Chemistry Faculty of Arts and SciencesOndokuz Mayis UniversitySamsunTurkey

The title compound, trans-bis（acesulfamato-O）tetraaquazinc（Ⅱ）（I, C8H16N2O12S2Zn）, crystallizes in the triclinic system, space group P1 with a = 5.1638（5）, b = 8.5338（9）, c = 9.9583（9）A, α = 74.325（8）, β = 81.112（7）, γ = 75.800（8）°, V= 407.77（7） A3, Z = 1, F（000） = 236, Rint = 0.085, T= 296 K, the final R = 0.029 and wR = 0.078 for 1832 observed reflections with I〉 2σ（0. The ZnⅡcentre resides on a centre of symmetry and has a distorted octahedral geometry. The basal plane is defined by two carbonyl O atoms of two monodentate trans-oriented acesulfamato ligands and two trans-aqua ligands. The axial positions in the octahedron are occupied by two trans-aqua ligands. Intermolecular O-H…O hydrogen bonds produce R22（8） and R22（16） rings, which lead to two- dimensional polymeric chains.

关键词： crystal structure zinc(Ⅱ) octahedral complex hydrogen bonds

Study of K^(*)(892)^(0)andФ(1020)meson production in proton–proton and Pb–Pb collisions at√S_(NN)=2.76 TeV

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Communications in Theoretical Physics 2021年第2期73卷 89-95页

作者： y Ali M Ahmed A Arif Q Ali u Tabassam u Rubab M Suleymanov Department of Physics COMSATS UniversityPark RoadIslamabad44000Pakistan Institute for Physical Problems Baku Suate UniversityBakuAZ 1000Azrbajan

In this paper,we describe a study of charged particle yield as a function of pT for K^(*)(892)0 and phgr(1020)mesons in proton–proton(pp)and Pb–Pb collisions at√S_(NN)=2.76 TeV in the central rapidity region of|y|y important ratio,the nuclear modification factor,to study the effects of the medium in the most central region,i.e.0%–5%*** data simulation,we used the EPOS-LHC and EPOS-1.99 *** check the validity of these models'simulations,we compared the data obtained from these Monte Carlo simulation programs with ALICE experimental data for√S_(NN)=2.76 *** was concluded that the models'predictions for the phgr-meson in pp and for the most central Pb-Pb collisions disagreed with the ALICE data,and that the difference increased with *** may be connected with the essential role of collective parton behaviors which could not have been taken into account by the *** K^(*)0 mesons,both programs gave almost the same predictions,and with pT in the interval pT>3 GeV c^(−1),the predictions were very close to the experimental *** models gave higher predictions for the soft pT interval and lower predictions for the hard *** values of the RAA distributions were lower than unity and both models were very close to the ALICE *** is very interesting that the models were not able to describe the pT distributions,but they gave good predictions for their *** may possibly be due to parton collective *** observed some additional suppression of K^(*)0 at low values of pT with respect to phgr-mesons,which may be related to the role of the masses of the particles in soft *** rising trend for R_(AA)in the region from pT=10 GeV c^(−1)to 20 GeV c^(−1) observed by the ALICE experiment was absent for theФ-mesons.

关键词： Quark Gluon Plasma EPOS-LHC nuclear modification factor

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Experimental and finite element analysis for fracture of coating layer of galvannealed steel sheet

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 111-116页

作者： S.I.KIM J.u.HER y.C.JANG y.LEE Sheet Products and Process Research Group POSCO Techology Research Laboratory Department of Mechanical Engineering Chung-Ang University

Mechanical properties of galvannealed (GA) steel sheet used for automotive exposed panel and predicted failure phenomenon of its coating layer were evaluated using finite element method. V-bending test was performed to understand better the fracture of coating layer of GA steel sheet during plastic deformation. yield strength of the coating layer was calculated by using a relative difference between hardness of coating layer measured from the nano-indentation test and that of substrate. To measure shearing strength at the interface between substrate and coating layer, shearing test with two specimens attached by an adhesive was carried out. using the mechanical properties measured, a series of finite element analyses coupled with a failure model was performed. Results reveal that the fracture of coating layer occurs in an irregular manner at the region where compressive deformation is dominant. Meanwhile, a series of vertical cracks perpendicular to material surface are observed at the tensile stressed-region. It is found that 0.26-0.28 of local equivalent plastic strain exists at the coating and substrate at the beginning of failure. The fracture of coating layer depends on ductility of the coating layer considerably as well.

关键词： galvannealed steel sheet fracture simulation coating layer finite element analysis, failure model

A Study on the Estimation of Prefabricated Glass Fiber Reinforced Concrete Panel Strength Values with an Artificial Neural Network Model

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Computers, Materials & Continua 2016年第4期52卷 41-52页

作者： S.A.yıldızel A.u.Öztürk Manisa Celal Bayar university Engineering FacultyTurkey

In this study,artificial neural networks trained with swarm based artificial bee colony optimization algorithm was implemented for prediction of the modulus of rapture values of the fabricated glass fiber reinforced concrete *** the application of the ANN models,143 different four-point bending test results of glass fiber reinforced concrete mixes with the varied parameters of temperature,fiber content and slump values were introduced the artificial bee colony optimization and conventional back propagation *** and the testing results of the corresponding models showed that artificial neural networks trained with the artificial bee colony optimization algorithm have remarkable potential for the prediction of modulus of rupture values and this method can be used as a preliminary decision criterion for quality check of the fabricated products.

关键词： Neural network glass fiber reinforced concrete glass fiber

Effectiveness of heat and mass transfer on mixed convective peristaltic motion of nanofluid with irreversibility rate

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Communications in Theoretical Physics 2021年第10期73卷 36-46页

作者： y Akbar F M Abbasi u M Zahid S A Shehzad Department of Mathematics COMSATS University IslamabadIslamabadPakistan Department of Mathematics COMSATS University IslamabadSahiwalPakistan

Entropy generation is one of the key features in analysis as it exhibits irreversibility of the system. Therefore, the present study investigates the entropy generation rate in a mixed convective peristaltic motion of a reactive nanofluid through an asymmetrical divergent channel with heat and mass transfer characteristics. The endorsed nanofluid model holds thermophoresis and Brownian diffusions. Mathematical modeling is configured under the effects of mixed convection, heat generation/absorption and viscous dissipation. A chemical reaction is also introduced for the description of mass transportation. The resulting system of differential equations is numerically tackled by employing the Shooting method. The findings reveal that entropy generation rises by improving the Brownian motion and thermophoresis parameters. The temperature of the nanofluid decreases due to rising buoyancy forces caused by the concentration gradient. The concentration profile increases by increasing the chemical reaction parameter. The velocity increases by enhancing the Brownian motion parameter.

关键词： peristaltic flow thermophoresis and Brownian motion mixed convection chemical reaction irreversibility nanofluid

Resonant production of color octet muons at Future Circular Collider-based muon-proton colliders

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Chinese Physics C 2018年第8期42卷 99-107页

作者： y.C.Acar u.Kaya B.B.Oner Department of Material Science and Nanotechnology TOBB University of Economics and Technology Department of Physics Ankara University

We investigate the resonant production of color octet muons in order to explore the discovery potential of Future Circular Collider（FCC）-based μp *** is shown that the search potentials of μp colliders essentially... 详细信息

关键词： leptogluons lepton-hadron interactions composite models muon-proton colliders color octet muon,beyond the standard model

FuRTHER INVESTIGATION INTO APPROXIMATION OF A COMMON SOLuTION OF FIXED POINT PROBLEMS AND SPLIT FEASIBILITy PROBLEMS

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Acta Mathematica Scientia 2016年第3期36卷 913-930页

作者： y.SHEHu O.T.MEWOMO F.u.OGBuISI Department of Mathematics University of Nigeria School of Mathematics Statistics and Computer ScienceUniversity of Kwazulu-Natal

The purpose of this paper is to study and analyze an iterative method for finding a common element of the solution set ~ of the split feasibility problem and the set F（T） of fixed points of a right Bregman strongly nonexpansive mapping T in the setting of p- uniformly convex Banach spaces which are also uniformly smooth. By combining Mann＇s iterative method and the Halpern＇s approximation method, we propose an iterative algorithm for finding an element of the set F（T）∩Ω moreover, we derive the strong convergence of the proposed algorithm under appropriate conditions and give numerical results to verify the efficiency and implementation of our method. Our results extend and complement many known related results in the literature.

关键词： strong convergence split feasibility problem uniformly convex uniformly smooth fixed point problem right Bregman strongly nonexpansive mappings