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High Voltage 2020年第6期5卷 731-738页

作者： L.Loiselle u.mohan rao I.Fofana Research Chair on the Aging of Power Network Infrastructure(ViAHT) Universitédu QuébecàChicoutimiChicoutimiQCG7H 2B1Canada

In this work, mineral oil and synthetic esters were selected at different ageing factors (based on acidity values). Fresh and aged oils have been subjected to high-energy discharges (repeated 100 breakdowns) to simulate electric faults of highly vulnerable intensity. The intent of this work is to understand the influence of high-energy electric faults on oil degradation and gassing tendency at different ageing conditions. In this study, the influence of the high-energy discharges on degradation and gassing tendency at different ageing factors is reported for mineral oil and synthetic esters. Oil degradation is reported by adopting ultraviolet spectroscopy, turbidity and particle counter as per american society for testing and materials (ASTM) standard test methods. Gassing tendencies and fault gas analysis are understood by dissolved the gas analysis using Duval's triangle and Duval's pentagon methods for mineral and non-mineral oils. It is found that the influence of high-energy discharges on oil degradation is higher in mineral oils to that of the synthetic esters. The intensity of the gassing tendency is higher for ester fluids;however, as per the Duval methods, the faulty conditions are at lower levels as compared to mineral oils.

关键词： synthetic energy high

Ground-layer Adaptive Optics for the 2.5 m Wide-field and High-resolution Solar Telescope

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Research in Astronomy and Astrophysics 2024年第3期24卷 224-236页

作者： Ying Yang Lan-Qiang Zhang Nan-Fei Yan Jin-Sheng Yang Zhen Li Teng-Fei Song Xue-Jun rao Chang-Hui rao Key Laboratory on Adaptive Optics Chinese Academy of SciencesChengdu 610209China Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China School of Electronic Electrical and Communication Engineering of the University of Chinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Beijing 100049China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern A&A Ministry of EducationNanjing 210023China Yunnan Observatories Chinese Academy of SciencesKunming 650216.China

The 2.5 m wide-field and high-resolution solar telescope(WeHoST)is currently under developing for solar *** aims to achieve high-resolution observations over a super-wide field of view(FOV)of5′×5′,and a desired resolution of 0.3″.To meet the scientific requirements of WeHoST,the ground-layer adaptive optics(GLAO)with a specially designed wave front sensing system is as the primary *** introduce the GLAO configuration,particularly the wave front sensing *** analytic method,we simulate the performance of both classical AO and GLAO systems,optimize the wave front sensing system,and evaluate GLAO performance in terms of PSF uniformity and correction improvement across whole *** results indicate that,the classical AO will achieve diffraction-limited resolution;the suggested GLAO configuration will uniformly improve the seeing across the full 5′×5′FOV,reducing the FWHM across the axis FOV to less than0.3″(λ≥705 nm,r0≥11 cm),which is more than two times *** specially designed wave front sensor schedule offers new potential for WeHoST’s GLAO,particularly the multi-FOV GLAO and the flexibility to select the detected *** capabilities will significantly enhance the scientific output of the telescope.

关键词： instrumentation adaptive optics-instrumentation detectors-instrumentation high angular resolution-methods numerical-telescopes-Sun activity

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Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using 13C metabolic flux analysis

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Journal of Pharmaceutical Analysis 2024年第2期14卷 244-258页

作者： Baixi Shan Haoyan Zhou Congying Guo Xiaolu Liu Mingyu Wu rao Zhai Jun Chen State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing210009China Department of Pharmacognosy School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing210009China

Evidence indicates that metabolic reprogramming characterized by the changes in cellular metabolic patterns contributes to the pathogenesis of pulmonary fibrosis (PF). It is considered as a promising therapeutic target anti-PF. The well-documented against PF properties of Tanshinone IIA (Tan IIA) have been primarily attributed to its antioxidant and anti-inflammatory potency. Emerging evidence suggests that Tan IIA may target energy metabolism pathways, including glycolysis and tricarboxylic acid (TCA) cycle. However, the detailed and advanced mechanisms underlying the anti-PF activities remain obscure. In this study, we applied [u-13C]-glucose metabolic flux analysis (MFA) to examine metabolism flux disruption and modulation nodes of Tan IIA in PF. We identified that Tan IIA inhibited the glycolysis and TCA flux, thereby suppressing the production of transforming growth factor-β1 (TGF-β1)-dependent extracellular matrix and the differentiation and proliferation of myofibroblasts in vitro. We further revealed that Tan IIA inhibited the expression of key metabolic enzyme hexokinase 2 (HK2) by inhibiting phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor 1α (HIF-1α) pathway activities, which decreased the accumulation of abnormal metabolites. Notably, we demonstrated that Tan IIA inhibited ATP citrate lyase (ACLY) activity, which reduced the collagen synthesis pathway caused by cytosol citrate consumption. Further, these results were validated in a mouse model of bleomycin-induced PF. This study was novel in exploring the mechanism of the occurrence and development of Tan IIA in treating PF using 13C-MFA technology. It provided a novel understanding of the mechanism of Tan IIA against PF from the perspective of metabolic reprogramming.

关键词： Pulmonary fibrosis Tanshinone IIA 13C-metabolic flux analysis Metabolic reprogramming

Simulation Study on Constraining Gravitational Wave Propagation Speed by Gravitational Wave and Gamma-ray Burst Joint Observation on Binary Neutron Star Mergers

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Research in Astronomy and Astrophysics 2024年第8期24卷 44-53页

作者： Jin-Hui rao Shu-Xu Yi Lian Tao Qing-Wen Tang Department of Physics School of Physics and Materials ScienceNanchang University Institute of High Energy Physics Chinese Academy of Sciences

Theories of modified gravity suggest that the propagation speed of gravitational waves （GW） vgmay deviate from the speed of light c.A constraint can be placed on the difference between c and vgwith a simple method that uses the arrival time delay between GW and electromagnetic wave simultaneously emitted from a burst *** simulated the joint observation of GW and short gamma-ray burst signals from binary neutron star merger events in different observation campaigns,involving advanced LIGO （aLIGO） in design sensitivity and Einstein Telescope（ET） joint-detected with Fermi/*** a result,the relative precision of constraint on vgcan reach～10-17（aLIGO） and～10-18（ET）,which are one and two orders of magnitude better than that from GW170817,*** continue to obtain the bound of graviton mass mg≤7.1（3.2）×10-20eV with aLIGO （ET）.Applying the Standard-Model Extension test framework,the constraint on vgallows us to study the Lorentz violation in the nondispersive,nonbirefringent limit of the gravitational *** obtain the constraints of the dimensionless isotropic coefficients ■at mass dimension d=4,which are■for aLIGO and■for ET.

关键词： (stars:) gamma-ray burst: general gravitational waves stars: neutron

Phase transition of multi-component(TiZrVNb)C ceramics—Part I:Phase decomposition induced by carbon content

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Journal of Advanced Ceramics 2024年第5期13卷 679-688页

作者： Qingyi Kong rao Zhang Lei Chen Sijia Huo Wenyu Lu Yujin Wang Boxin Wei Yu Zhou Institute for Advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Key Laboratory of Advanced Structure‒Function Integrated Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150001China National Key Laboratory of Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

Phase decomposition can effectively enhance the mechanical properties of carbide ceramics and can overcome the difficulty of enhancing the mechanical properties of single-phase multicomponent carbide *** this work,a series of nonstoichiometric(TiZrVNb)Cx ceramics were prepared by spark plasma sintering(SPS)at different *** effects of the carbon content on the phase composition,microstructure evolution,and mechanical properties were investigated in *** decomposition occurred with decreasing carbon *** different solid solutions of(Ti,V)-rich and Zr-rich phases formed from the decomposition of equimolar single-phase solid solutions,namely,the Zr-poor phase and Zr-rich phase,*** distribution of Nb element is relatively *** semicoherent interfaces between the Zr-poor phase and the Zr-rich phase can harden and strengthen effectively under the synergistic effect of grain *** with phase decomposition structures have apparent advantages compared to single-phase high-entropy *** work provides an important train of thought for the microstructure tailoring and properties optimization of multi-component carbide ceramics.

关键词： multicomponent ceramics nontoichiometry microstructure evolution phase decomposition mechanical properties

Dimethylamine oxalate manipulating CsPbI_(3) perovskite film crystallization process for high efficiency carbon electrode based perovskite solar cells

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Journal of Energy Chemistry 2024年第6期93卷 221-228,I0006页

作者： Wenran Wang Xin Peng Jianxin Zhang Jiage Lin Rong Huang Guizhi Zhang Huishi Guo Zhenxiao Pan Xinhua Zhong Huashang rao Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642GuangdongChina College of Chemistry and Civil Engineering Shaoguan UniversityShaoguan 512005GuangdongChina Guangdong Provincial Key Laboratory of utilization and Conservation of Food and Medicinal Resources in Northern Region Shaoguan UniversityShaoguan 512005GuangdongChina

Crystallization process determines the quality of perovskite films and the performances of resultant perovskite solar cells(PSCs).Dimethylamine oxalate has been proven as a multifunctional modulator,and is explored as an efficient additive in manipulating the crystallization process of CsPbI_(3) perovskite *** one hand,oxalate serves as the precipitator that facilitates the nucleation process of *** larger size of intermediate is conductive to the larger size and smaller grain boundaries of resultant *** the other hand,in subsequent annealing process,the phase conversion and growth process of transient perovskite can be decelerated due to the strong interactions of oxalate with both dimethylamine cation(DMA^(+))and Pb^(2+).Due to the optimized crystallization kinetics,the morphology and quality of CsPbI_(3) perovskite films are comprehensively improved with lower defect concentrations,and charge recombination loss is effectively *** from the optimized crystal quality of perovskite films,the carbon electrode-based CsPbI_(3) PSCs exhibit a champion efficiency of 18.48%.This represents one of the highest levels among all hole transport layer-free inorganic perovskite solar cells.

关键词： Solar cells Perovskite CsPbI_(3) Carbon electrodes Oxalate

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A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： Ping Yu Tanwei Gu Yueyang rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou Guangdong Provincial Key Laboratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key Laboratory for Research and Evaluation of Drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in Prdx1-overexpression(Prdx1-OE)***,S14 also increases PRDX1 nuclear translocation and directly activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AuC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and uDPglycosyltransferase(uGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： Tian He Chao Yang Jing Wang Ji-Sheng Zhong Ai-Hua Li Ya-Jing Yin Li-Ling Luo Chun-Mei rao Nian-Fen Mao Qiang Guo Zan Zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROuND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)wasuggesting that the blood loss of most MD patients was less than 20%–30%,and only a few patients had a blood loss of>30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

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喜马拉雅稀有金属伟晶岩的铪超常富集

岩石学报 2024年第5期40卷 1510-1526页

作者：谢磊田恩农饶乐王汝成南京大学内生金属矿床成矿机制研究国家重点实验室南京大学地球科学与工程学院南京210023 河北地质大学河北省岩石矿物材料绿色开发重点实验室宝石与材料学院石家庄050031 河北省战略性关键矿产研究协同创新中心石家庄050031

锆-铪(Zr-Hf)是重要的关键金属,锆石是最主要的Zr-Hf载体,因Zr-Hf相似的晶体化学特征形成了锆石-铪石完全固溶体系列,以晶体化学式中Hf/(Zr+Hf)原子比(Hf^(#))0.9为区间进行划分,包括锆石、铪质锆石、锆质铪石和铪石。而自然界形成锆铪... 详细信息

锆-铪(Zr-Hf)是重要的关键金属,锆石是最主要的Zr-Hf载体,因Zr-Hf相似的晶体化学特征形成了锆石-铪石完全固溶体系列,以晶体化学式中Hf/(Zr+Hf)原子比(Hf^(#))0.9为区间进行划分,包括锆石、铪质锆石、锆质铪石和铪石。而自然界形成锆铪分异从而达到铪超常富集的条件非常严苛,已报道的富铪锆石主要出现在高分异花岗岩和伟晶岩中,而铪质锆石和铪石尤其稀少,我国境内仅在阿尔泰可可托海1号脉LCT(Li-Cs-Ta)伟晶岩中发现了锆质铪石。本次研究在位于喜马拉雅造山带中部、吉隆岩体北部扎龙沟的锂电气石锂云母伟晶岩中发现了锆质铪石(Hf#最高达0.67)。依据矿物产状和成分,该伟晶岩中锆石-铪石被分为四类:核部多孔的斑状Zrn-1,为锆石和铪质锆石;成分均匀且具有暗色CL图像的Zrn-2最为常见,生长在Zrn-1外围或颗粒的核部,主要是铪质锆石;而Zrn-3和Zrn-4是具有铪质锆石-锆质铪石连续成分的边部,分别对应于富Y(最高4.9%Y_(2)O_(3))和低Y(u锆石结晶;岩浆晚期亚固相条件下流体作用之后锆石发生溶解再沉淀作用;以及助熔剂元素(Li-B-F等)富集和Li-F矿物(锂电气石、锂云母)大量结晶导致锆铪强烈分异,形成铪质锆石-锆质铪石边部,与岩浆-热液过渡阶段紧密相关。同时,扎龙沟绿柱石伟晶岩和锂辉石伟晶岩中发现了铪质锆石(Hf^(#)达0.27),扎龙沟电气石白云母花岗岩和吉隆沟的花岗岩-伟晶岩只含有锆石(Hf^(#)<0.04),这些显示了岩浆分异作用也是导致锆石中Hf含量的增加和Zr/Hf比值降低的重要因素。结合全球不同岩体中铪质锆石和锆质铪石形成过程,以及喜马拉雅不同岩体花岗岩-伟晶岩中的锆石成分,本次研究对喜马拉雅锆石-铪石系列的指示作用和超常富铪体系的研究进行了展望。

关键词：伟晶岩稀有金属锆铪分异岩浆-热液过渡

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重组大肠杆菌S3-2产羰基还原酶发酵工艺优化及动力学研究

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化学与生物工程 2024年第5期41卷 25-30,43页

作者：田俊龚大春饶振辉三峡大学生物与制药学院湖北宜昌443002 三峡大学附属第二人民医院湖北宜昌443099 安琪酵母股份有限公司湖北宜昌443003

以重组大肠杆菌S3-2为发酵菌株,通过单因素实验和正交实验对重组大肠杆菌S3-2产羰基还原酶的1 L发酵罐发酵工艺进行优化,并通过Logistic方程和Luedeking-Piret方程对重组大肠杆菌S3-2分批发酵产羰基还原酶的动力学过程进行模拟。结果表... 详细信息

以重组大肠杆菌S3-2为发酵菌株,通过单因素实验和正交实验对重组大肠杆菌S3-2产羰基还原酶的1 L发酵罐发酵工艺进行优化,并通过Logistic方程和Luedeking-Piret方程对重组大肠杆菌S3-2分批发酵产羰基还原酶的动力学过程进行模拟。结果表明,重组大肠杆菌S3-2的最佳发酵工艺为:IPTG在OD600值为1.0时诱导、IPTG终浓度为0.30 mmol·L^(-1)、种子液OD600值为3.0时接种、诱导温度为26℃,在此条件下,菌体细胞干重为1.586 g·L^(-1)、羰基还原酶酶活为0.712 u·mL^(-1);菌体生长、羰基还原酶酶活及甘油消耗的动力学模型的拟合度分别为0.9883、0.9917和0.9807,说明该模型对重组大肠杆菌S3-2的发酵动力学模型拟合良好,为后续中试放大研究提供了理论依据。

关键词：重组大肠杆菌S3-2 羰基还原酶发酵工艺优化正交实验动力学模型