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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & Molecular Immunology 2024年第2期21卷 103-118页

作者： s.Cankat M.u.Demael L.swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of sARs-CoV-2,MERs-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation sARs-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

stability analysis and soliton solutions of the(1+1)-dimensional nonlinear chiral schrodinger equation in nuclear physics

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Communications in Theoretical Physics 2024年第9期76卷 1-15页

作者： Fazal Badshah Kalim u Tariq Ahmet Bekir s M Raza Kazmi Emad Az-Zo'bi school of Electrical and Information Engineering Hubei University of Automotive TechnologyShiyan 442002China Department of Mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey Department of Mathematics and statistics Faculty of ScienceMutah UniversityAlKarak 61710Jordan

The nonlinear schrodinger equation equation is one of the most important physical models used in optical fiber theory to explain the transmission of an optical *** field of chiral soliton propagation in nuclear physics is very interesting because of its numerous applications in communications and ultra-fast signal routing ***(1+1)-dimensional chiral dynamical structure that describes the soliton behaviour in data transmission is dealt with in this work using a variety of in-depth analytical *** work has applications in particle physics,ionised science,nuclear physics,optics,and other applied mathematical *** are able to develop a variety of solutions to demonstrate the behaviour of solitary wave structures,periodic soliton solutions,chiral soliton solutions,and bell-shaped soliton solutions with the use of applied ***,in order to verify the scientific calculations,the stability analysis for the observed solutions of the governing model is taken into *** addition,the3-dimensional,contour,and 2-dimensional visuals are supplied for a better understanding of the behaviour of the *** employed strategies are dependable,uncomplicated,and effective;yet have not been utilised with the governing model in the literature that is now *** resulting outcomes have impressive applications across a large number of study areas and computational physics phenomena representing real-world *** methods applied in this model are not utilized on the given models in previous literature so we can say that these describe the novelty of the work.

关键词： solitons the nonlinear schrodinger equation stability analysis chiral solitons exact solutions

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.s.Mahabaleshwar G.P.Vanitha L.M.Pérez Emad H.Aly I.Pop Department of studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

Inhibition of Ehrlich ascites carcinoma growth by melatonin:studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： sEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM suNA ARIKAN sÖYLEMEZ AsLI OKAN OFLAMAZ sÜMEYYE uÇAR ŞÜKRÜATEŞ AMMAD AHMAD FAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(psignificant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(purthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT serine/Threonine Kinase(PKB/AKT)genes(psis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： signaling pathway Apoptosis Real-time PCR AgNOR

symmetries,optimal system,exact and soliton solutions of(3+1)-dimensional Gardner-KP equation

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Journal of Ocean Engineering and science 2024年第2期9卷 178-190页

作者： Amjad Hussain Ashreen Anjum M.Junaid-u-Rehman Ilyas Khan Mariam A.sameh Amnah s.Al-Johani Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-MajmaahP.O Box 66Majmaah 11952Saudi Arabia Electrical Engineering Department Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo 11845Egypt Mathematics Department Faculty of ScienceUniversity of TabukTabukSaudi Arabia

In this research article,the(3+1)-dimensional nonlinear Gardner-Kadomtsov-Petviashvili(Gardner-KP)equation which depicts the nonlinear modulation of periodic waves,is analyzed through the Lie group-theoretic *** the Lie invariance condition,we find the symmetry *** pro-posed model yields eight-dimensional Lie ***,an optimal system of sub-algebras is com-puted,and similarity reductions are *** considered nonlinear partial differential equation is re-duced into ordinary differential equations(ODEs)by utilizing the similarity transformation method(sTM),which has the benefit of yielding a large number of accurate traveling wave *** ODEs are further solved to get closed-form solutions of the Gardner-KP equation in some cases,while in other cases,we use the new auxiliary equation method to get its soliton *** evolution profiles of the obtained solutions are examined graphically under the appropriate selection of arbitrary parameters.

关键词： Gardner-KP equation Lie symmetry analysis Optimal system New auxiliary equation method solitary wave solutions

A review of methane leakage from abandoned oil and gas wells:A case study in Lubbock,Texas,within the Permian Basin

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Energy Geoscience 2024年第3期5卷 1-12页

作者： stanley u.Opara Chinedu J.Okere Bob L.Herd Department of Petroleum Engineering Texas Tech UniversityTXUSA

In the pursuit of global net zero carbon emissions and climate change mitigation,ongoing research into sustainable energy sources and emission control is *** review examines methane leakage from abandoned oil and gas(AOG)wells,focusing particularly on Lubbock,a geographic area situated within the larger region known as the Permian Basin in West Texas,united *** objective is to assess the extent and environmental implications of methane leakage from these *** analysis integrates pertinent literature,governmental and industry data,and prior Lubbock *** affecting methane leakage,including well integrity,geological characteristics,and human activities,are *** research estimates 1781 drilled wells in Lubbock,forming a foundation for targeted assessments and monitoring due to historical drilling *** hierarchy of well statuses in Lubbock highlights the prevalence of“active oil wells,”trailed by“plugged and abandoned oil wells”and“inactive oil wells.”Methane leakage potential aligns with these well types,underscoring the importance of strategic monitoring and *** analysis notes a zenith in“drilled and completed”wells during *** our study's case analysis and literature review reiterate the critical significance of assessing and mitigating methane emissions from AOG wells,it's important to clarify that the research does not directly provide methane leakage ***,it contextualizes the issue's magnitude and emphasizes the well type and status analysis's role in targeted mitigation *** summary,our research deepens our understanding of methane leakage,aiding informed decision-making and policy formulation for environmental *** clarifying well type implications and historical drilling patterns,we aim to contribute to effective strategies in mitigating methane emissions from AOG wells.

关键词： Net zero carbon emissions Climate change mitigation Methane emission control Abandoned oil and gas(AOG)well Permian Basin

Hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

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Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： M.Grandin H.K.Connor s.Hoilijoki M.Battarbee Y.Pfau-Kempf u.Ganse K.Papadakis M.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NAsA Goddard space Flight Center GreenbeltMD20771USA space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** solar wind Magnetosphere Ionosphere Link Explorer(sMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their soft X-ray Imager(sXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by sMILE sXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the sMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation sMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves

Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： sisira Ediriweera Champika Bandara Tithira Lakkana shanika Jayasinghe David Woodbury Arun Dayanandan B.M.P.singhakumara Xiangcheng Mi I.A.u.N.Gunatilleke C.V.s.Gunatilleke Mark sAshton Department of science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest school Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental science University of Sri JayewardenepuraNugegodaSri Lanka state Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:No studies have documented long-term trends in aboveground biomass(AGB)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 Mg·ha^(-1).No differences exist among sites in AGB primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top five species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGB and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in MDF difficult over wide regions.

关键词： Western ghats shorea spp. southeast Asia sri Lanka Tropical rain forest Wood specific gravity

Polio eradication surveillance in sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando N.s.Madarasinghe C.Rangana N.Weerasinghe D.C.u.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rRTPCR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication