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Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.M.Liyanage Thilina u.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets inhibitors

All-optical image denoising using a diffractive visual processor

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Light(Science & Applications) 2024年第3期13卷 429-445页

作者： Çağatay işıl Tianyi Gan Fazil Onuralp Ardic Koray Mentesoglu Jagrit Digani Huseyin Karaca Hanlong Chen Jingxi Li Deniz Mengu Mona Jarrahi Kaan Akşit Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems institute(CNSi) University of CaliforniaLos AngelesCA 90095USA university College London Department of Computer ScienceLondonUnited Kingdom

image denoising,one of the essential inverse problems,targets to remove noise/artifacts from input *** general,digital image denoising algorithms,executed on computers,present latency due to several iterations implemented in,e.g.,graphics processing units(GPus).While deep learning-enabled methods can operate non-iteratively,they also introduce latency and impose a significant computational burden,leading to increased power ***,we introduce an analog diffractive image denoiser to all-optically and non-iteratively clean various forms of noise and artifacts from input images–implemented at the speed of light propagation within a thin diffractive visual processor that axially spansis the wavelength of *** all-optical image denoiser comprises passive transmissive layers optimized using deep learning to physically scatter the optical modes that represent various noise features,causing them to miss the output image Field-of-View(FoV)while retaining the object features of *** results show that these diffractive denoisers can efficiently remove salt and pepper noise and image rendering-related spatial artifacts from input phase or intensity images while achieving an output power efficiency of~30–40%.We experimentally demonstrated the effectiveness of this analog denoiser architecture using a 3D-printed diffractive visual processor operating at the terahertz *** to their speed,power-efficiency,and minimal computational overhead,all-optical diffractive denoisers can be transformative for various image display and projection systems,including,e.g.,holographic displays.

关键词： remove rendering holographic

integrated Approaches of Mechanical Barrier, insecticide and Botanicals against Mango Mealybug (Drosicha mangiferae)

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Advances in Entomology 2024年第3期12卷 195-202页

作者： N. Akhter M. Z. Alam M. A. Rahaman M. R. u. Miah i. H. Mian M. A. Latif Department of Entomology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Entomology Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh Department of Plant Pathology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Plant Pathology Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh

An experiment was conducted to test the efficacy of a mechanical barrier around the tree trunk with one spray of Cypermethrin @ 1 ml/l and turmeric powder extract @ 15 g/500ml of water applied in integrated approaches against mango mealybug on mango tree. There were 7 treatments including a control. The treatments were Mechanical barrier, Cypermethrin spray @ 1 ml/l, Turmeric powder spray @ 15 g/500ml of water, Cypermethrin spray + Turmeric spray, Cypermethrin spray + Mechanical barrier, Turmeric + Mechanical barrier and untreated control. Three-year-old mango plants grafted from a 5-year-old mango tree (Variety Amropali) and planted in pots were used in the experiment. The treatment, Cypermethrin spray + Mechanical barrier gave the highest reduction of mango mealybug population 87.06% to 93.90% followed by Turmeric spray + Mechanical barrier and showed 81.13% to 86.04% and Mechanical barrier alone showed 81.13% to 84.59% population reduction. Turmeric powder extract showed only (8.42% to 23.77%) population reduction of mango mealybug which was lowest compared to other treatments.

关键词： Mango Mealybug integrated Management

inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YiLMAZ ZÜLEYHA DOĞANYiĞiT MERT OCAK EVRiM SuNA ARiKAN SÖYLEMEZ ASLi OKAN OFLAMAZ SÜMEYYE uÇAR ŞÜKRÜATEŞ AMMAD AHMAD FAROOQi Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(iHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the iHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(pignificant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(purthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(Pi3K),AKT Serine/Threonine Kinase(PKB/AKT)genes(pis was evaluated with Annexin V in an in vitro study with different doses of melatonin;it was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

An unusual etiology of subarachnoid hemorrhage,basilar artery perforator aneurysms,in Macao:Three case reports and review of literature

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World Journal of Clinical Cases 2024年第20期12卷 4337-4347页

作者： ieong-Chon Man Tam-Man Pan Kuok-Cheong u Department of Radiology Hospital Conde S.JanuárioMacao SAR 999078China

BACKGROuND Subarachnoid hemorrhage is a severe neurological condition that requires prompt and appropriate treatment to prevent *** are the most common cause of spontaneous subarachnoid ***,basilar artery perforator aneurysms(BAPAs)are a rare *** is no consensus on the optimal management of ruptured BAPAs in the acute *** SuMMARY We present a case series of 3 patients with ruptured BAPAs who were treated at our *** patients had a modified Fisher grade of i,and one had a grade of iV on initial *** aneurysms were detected by computed tomography angiography in two cases and conventional angiography in one *** 3 patients underwent endovascular treatment with Guglielmi detachable ***-treatment,the patients had good clinical outcomes,and follow-up brain computed tomography scans showed reduced subarachnoid hemorrhage without any new ***,one patient experienced a cerebral infarction 2 months later and eventually succumbed to the *** other 2 patients showed progressive recovery,and no aneurysm recurrence was observed at the 2-year *** Endovascular treatment may be a preferable approach for managing ruptured BAPAs compared with surgical intervention or conservative *** detection and prompt treatment is important to achieve favorable patient outcomes.

关键词： Basilar artery intracranial aneurysm Endovascular treatment Subarachnoid hemorrhage Case report

Hordedane diterpenoid phytoalexins restrict Fusarium graminearum infection but enhance Bipolaris sorokiniana colonization of barley roots

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Molecular Plant 2024年第8期17卷 1307-1327页

作者： Yaming Liu Dario Esposto Lisa K.Mahdi Andrea Porzel Pauline Stark Hidayat Hussain Anja Scherr-Henning Simon isfort ulschan.Bathe ivan F.Acosta Alga Zuccaro Gerd u.Balcke Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryHalleGermany institute for Plant Sciences Cluster of Excellence on Plant Sciences(CEPLAS)Cologne BiocenterUniversity of CologneCologneGermany Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalleGermany Max Planck institute for Plant Breeding Research CologneGermany Horticultural Sciences University of FloridaGainesvilleFLUSA.

Plant immunity is a multilayered process that includes recognition of patterns or effectors from pathogens to elicit defense *** include the induction of a cocktail of defense metabolites that typically restrict pathogen ***,we investigate the interaction between barley roots and the fungal pathogens Bipolaris sorokiniana(Bs)and Fusarium graminearum(Fg)at the metabolite *** identify hordedanes,a previously undescribed set of labdane-related diterpenoids with antimicrobial properties,as critical players in these *** of barley roots by Bs and Fg elicits hordedane synthesis from a 60o-kb gene *** reconstruction of the biosynthesis pathway in yeast and Nicotiana benthamiana produced several hordedanes,including one of the most functionally decorated products 19-β-hydroxy-hordetrienoic acid(19-OH-HTA).Barley mutants in the diterpene synthase genes of this cluster are unable to produce hordedanes but,unexpectedly,show reduced Bs *** contrast,colonization by Fusarium graminearum,another fungal pathogen of barley and wheat,is 4-fold higher in the mutants completely lacking ***,19-OH-HTA enhances both germination and growth of Bs,whereas it inhibits other pathogenic fungi,including *** of microscopy and transcriptomics data suggest that hordedanes delay the necrotrophic phase of *** together,these results show that adapted pathogens such as Bs can subvert plant metabolic defenses to facilitate root colonization.

关键词： barley Hordeum vulgare diterpenoid phytoalexins gene cluster pathogenic fungi Bipolaris sorokininiana Fusarium graminearum

How the Flat Space Cosmology Model Correlates the Recombination CMB Temperature of 3000 K with a Redshift of 1100

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Journal of Modern Physics 2024年第2期15卷 174-178页

作者： Eugene Terry Tatum u. V. S. Seshavatharam independent Researcher Bowling Green Kentucky USA i-SERVE Hitech City Hyderabad India

This paper shows how the Flat Space Cosmology model correlates the recom-bination epoch CMB temperature of 3000 K with a cosmological redshift of 1100. This proof is given in support of the recent publication that the Tatum and Seshavatharam Hubble temperature formulae can be derived using the Stephan-Boltzmann dispersion law. Thus, as explained herein, the era of high precision Planck scale quantum cosmology has arrived.

关键词： Hubble Constant Cosmic Microwave Background Quantum Cosmology Stephan-Boltzmann upsilon Coupling Constant Flat Space Cosmology ΛCDM Cosmology

Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter

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Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo Kim Hyunju K.Connor Jaewoong Jung Brian M.Walsh David Sibeck Kip D.Kuntz Frederick S.Porter Catriana K.Paw u Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael Collier Space Research institute Austrian Academy of Sciences8042 GrazAustria Geophysical institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Administration(NASA)Goddard Space Flight Center GreenbeltMaryland 20771USA Astronomy Department University of Maryland College ParkCollege ParkMaryland 20742USA Center for Space Physics Boston UniversityBostonMassachusetts 02215USA Department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA Howard university WashingtonDC 20059USA

The Lunar Environment heliospheric X-ray imager(LEXi)and Solar wind Magnetosphere ionosphere Link Explorer(SMiLE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind *** suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray *** this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is *** assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause *** create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson *** then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea *** the filte red images,we calculate RS and its accuracy for different LEXi locations,look directions,and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground *** method estimates RS with an accuracy ofind density exceeds>10 *** accuracy improves for greater solar wind densities and during southward interplanetary magnetic *** method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field ***,the technique will enable quantitative analysis of the magnetopause motion and help reveal the daysi

关键词： soft X-ray magnetopause reconnection low-pass filter LEXi SMiLE

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论意思表示公告方式选择与生效的双层构造

法学论坛 2024年第3期39卷 133-142页

作者：寇枫阳吉林大学法学院吉林长春130012

意思表示公告方式学说的单一化思维,产生了实践需求与理论无奈之张力。不同于私法上的其他公告,意思表示公告方式承载了私法自治工具的制度功能。意思表示生效时点的体系解释表明,公告方式适用于所有意思表示类型。因而参照《民事诉讼... 详细信息

意思表示公告方式学说的单一化思维,产生了实践需求与理论无奈之张力。不同于私法上的其他公告,意思表示公告方式承载了私法自治工具的制度功能。意思表示生效时点的体系解释表明,公告方式适用于所有意思表示类型。因而参照《民事诉讼法》公告送达制度的多数说,不符合《民法典》第139条的文义与体系。合理的解释方向是,在尊重公告方式选择自由的基础上,通过生效控制原理避免公告方式的滥用。我国公告实践发展出的禁止增加负担的效力控制标准,可合理分配选择自由之风险。在该风险分配模式下,公告方式的限制类型分为法定负担情形下的主体限制、意定负担情形下的媒介限制、单方增加负担情形下类推适用《诉讼时效司法解释》第8条第1款第4项的限制、无相对人与单方加利情形下的无限制。

关键词：意思表示公告方式公告送达方式自由效力控制风险分配