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Inhibition of Ehrlich ascites carcinoma growth by melatonin:Studies with micro-CT

Oncology Research 2024年第1期32卷 175-185页

作者： SEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM SuNA ARIKAN SÖYLEMEZ ASLI OKAN OFLAMAZ SÜMEYYE uÇAR ŞÜKRÜATEŞ AMMAD AHMAD FAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(pund in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(purthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT Serine/Threonine Kinase(PKB/AKT)genes(puated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： Signaling pathway Apoptosis Real-time PCR AgNOR

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中国大陆科学钻探主孔0～4000m岩心的裂变径迹年龄测定

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岩石学报 2006年第7期22卷 1969-1974页

作者：刘顺生 u glasmacher 许志琴 u Weber G Wagner 中国科学院广州地球化学研究所 Max-Planck-Institut für Kernphysik D-69029 Heidelberg Geologisch-Palontologisches InstitutRuprecht-Karls Universitt HeidelbergD-69120 Heidelberg 中国地质科学院地质研究所 Max-Planck-Institut für Kernphysik D-69029 Heidelberg

对中国大陆科学钻探(CCSD)主孔0-4000的岩心样进行了裂变径迹年龄测定。在不同深度共测定了38个样品的磷灰石裂变径迹年龄,磷灰石的裂变径迹年龄数据分布在98．6～3．2Ma之间,年龄值的变化规律总体上是随钻孔深度的增加而逐渐减少,地表... 详细信息

对中国大陆科学钻探(CCSD)主孔0-4000的岩心样进行了裂变径迹年龄测定。在不同深度共测定了38个样品的磷灰石裂变径迹年龄,磷灰石的裂变径迹年龄数据分布在98．6～3．2Ma之间,年龄值的变化规律总体上是随钻孔深度的增加而逐渐减少,地表样的磷灰石裂变径迹年龄是87．1Ma,至3899m深处则为3．2Ma,基于磷灰石中裂变径迹的退火特征,反映出地壳温度随深度的增加而增加的规律。年龄值随深度的变化,也有若干波动,尤其是1550～2450m之间的这部分岩心,在年龄随深度变化的趋势上是不连续的,这部分岩体可以认为是一个重要的构造作用带。根据年龄．深度关系和约束径迹长度的分布特征,对超高压变质岩体的后期折返机制进行了探讨。

关键词：中国大陆科学钻探裂变径迹年龄测定超高压变质带

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Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera Champika Bandara Tithira Lakkana Shanika Jayasinghe David Woodbury Arun Dayanandan B.M.P.Singhakumara Xiangcheng Mi I.A.u.N.Gunatilleke C.V.S.Gunatilleke Mark SAshton Department of Science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental Science University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:No studies have documented long-term trends in aboveground biomass(AGB)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 Mg·ha^(-1).No differences exist among sites in AGB primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top five species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGB and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in MDF difficult over wide regions.

关键词： Western ghats Shorea spp. Southeast Asia Sri Lanka Tropical rain forest Wood specific gravity

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An unusual etiology of subarachnoid hemorrhage,basilar artery perforator aneurysms,in Macao:Three case reports and review of literature

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World Journal of Clinical Cases 2024年第20期12卷 4337-4347页

作者： Ieong-Chon Man Tam-Man Pan Kuok-Cheong u Department of Radiology Hospital Conde S.JanuárioMacao SAR 999078China

BACKGROuND Subarachnoid hemorrhage is a severe neurological condition that requires prompt and appropriate treatment to prevent *** are the most common cause of spontaneous subarachnoid ***,basilar artery perforator aneurysms(BAPAs)are a rare *** is no consensus on the optimal management of ruptured BAPAs in the acute *** SuMMARY We present a case series of 3 patients with ruptured BAPAs who were treated at our *** patients had a modified Fisher grade of I,and one had a grade of IV on initial *** aneurysms were detected by computed tomography angiography in two cases and conventional angiography in one *** 3 patients underwent endovascular treatment with Guglielmi detachable ***-treatment,the patients had good clinical outcomes,and follow-up brain computed tomography scans showed reduced subarachnoid hemorrhage without any new ***,one patient experienced a cerebral infarction 2 months later and eventually succumbed to the *** other 2 patients showed progressive recovery,and no aneurysm recurrence was observed at the 2-year *** Endovascular treatment may be a preferable approach for managing ruptured BAPAs compared with surgical intervention or conservative *** detection and prompt treatment is important to achieve favorable patient outcomes.

关键词： Basilar artery Intracranial aneurysm Endovascular treatment Subarachnoid hemorrhage Case report

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Hordedane diterpenoid phytoalexins restrict Fusarium graminearum infection but enhance Bipolaris sorokiniana colonization of barley roots

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Molecular Plant 2024年第8期17卷 1307-1327页

作者： Yaming Liu Dario Esposto Lisa K.Mahdi Andrea Porzel Pauline Stark Hidayat Hussain Anja Scherr-Henning Simon Isfort ulschan.Bathe Ivan F.Acosta Alga Zuccaro Gerd u.Balcke Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryHalleGermany Institute for Plant Sciences Cluster of Excellence on Plant Sciences(CEPLAS)Cologne BiocenterUniversity of CologneCologneGermany Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalleGermany Max Planck Institute for Plant Breeding Research CologneGermany Horticultural Sciences University of FloridaGainesvilleFLUSA.

Plant immunity is a multilayered process that includes recognition of patterns or effectors from pathogens to elicit defense *** include the induction of a cocktail of defense metabolites that typically restrict pathogen ***,we investigate the interaction between barley roots and the fungal pathogens Bipolaris sorokiniana(Bs)and Fusarium graminearum(Fg)at the metabolite *** identify hordedanes,a previously undescribed set of labdane-related diterpenoids with antimicrobial properties,as critical players in these *** of barley roots by Bs and Fg elicits hordedane synthesis from a 60o-kb gene *** reconstruction of the biosynthesis pathway in yeast and Nicotiana benthamiana produced several hordedanes,including one of the most functionally decorated products 19-β-hydroxy-hordetrienoic acid(19-OH-HTA).Barley mutants in the diterpene synthase genes of this cluster are unable to produce hordedanes but,unexpectedly,show reduced Bs *** contrast,colonization by Fusarium graminearum,another fungal pathogen of barley and wheat,is 4-fold higher in the mutants completely lacking ***,19-OH-HTA enhances both germination and growth of Bs,whereas it inhibits other pathogenic fungi,including *** of microscopy and transcriptomics data suggest that hordedanes delay the necrotrophic phase of *** together,these results show that adapted pathogens such as Bs can subvert plant metabolic defenses to facilitate root colonization.

关键词： barley Hordeum vulgare diterpenoid phytoalexins gene cluster pathogenic fungi Bipolaris sorokininiana Fusarium graminearum

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How the Flat Space Cosmology Model Correlates the Recombination CMB Temperature of 3000 K with a Redshift of 1100

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Journal of Modern Physics 2024年第2期15卷 174-178页

作者： Eugene Terry Tatum u. V. S. Seshavatharam Independent Researcher Bowling Green Kentucky USA I-SERVE Hitech City Hyderabad India

This paper shows how the Flat Space Cosmology model correlates the recom-bination epoch CMB temperature of 3000 K with a cosmological redshift of 1100. This proof is given in support of the recent publication that the Tatum and Seshavatharam Hubble temperature formulae can be derived using the Stephan-Boltzmann dispersion law. Thus, as explained herein, the era of high precision Planck scale quantum cosmology has arrived.

关键词： Hubble Constant Cosmic Microwave Background Quantum Cosmology Stephan-Boltzmann upsilon Coupling Constant Flat Space Cosmology ΛCDM Cosmology

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Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter

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Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo Kim Hyunju K.Connor Jaewoong Jung Brian M.Walsh David Sibeck Kip D.Kuntz Frederick S.Porter Catriana K.Paw u Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael Collier Space Research Institute Austrian Academy of Sciences8042 GrazAustria Geophysical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Administration(NASA)Goddard Space Flight Center GreenbeltMaryland 20771USA Astronomy Department University of Maryland College ParkCollege ParkMaryland 20742USA Center for Space Physics Boston UniversityBostonMassachusetts 02215USA Department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA Howard university WashingtonDC 20059USA

The Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind *** suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray *** this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is *** assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause *** create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson *** then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea *** the filte red images,we calculate RS and its accuracy for different LEXI locations,look directions,and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground *** method estimates RS with an accuracy of10 *** accuracy improves for greater solar wind densities and during southward interplanetary magnetic *** method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field ***,the technique will enable quantitative analysis of the magnetopause motion and help reveal the daysi

关键词： soft X-ray magnetopause reconnection low-pass filter LEXI SMILE

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论意思表示公告方式选择与生效的双层构造

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法学论坛 2024年第3期39卷 133-142页

作者：寇枫阳吉林大学法学院吉林长春130012

意思表示公告方式学说的单一化思维,产生了实践需求与理论无奈之张力。不同于私法上的其他公告,意思表示公告方式承载了私法自治工具的制度功能。意思表示生效时点的体系解释表明,公告方式适用于所有意思表示类型。因而参照《民事诉讼... 详细信息

意思表示公告方式学说的单一化思维,产生了实践需求与理论无奈之张力。不同于私法上的其他公告,意思表示公告方式承载了私法自治工具的制度功能。意思表示生效时点的体系解释表明,公告方式适用于所有意思表示类型。因而参照《民事诉讼法》公告送达制度的多数说,不符合《民法典》第139条的文义与体系。合理的解释方向是,在尊重公告方式选择自由的基础上,通过生效控制原理避免公告方式的滥用。我国公告实践发展出的禁止增加负担的效力控制标准,可合理分配选择自由之风险。在该风险分配模式下,公告方式的限制类型分为法定负担情形下的主体限制、意定负担情形下的媒介限制、单方增加负担情形下类推适用《诉讼时效司法解释》第8条第1款第4项的限制、无相对人与单方加利情形下的无限制。

关键词：意思表示公告方式公告送达方式自由效力控制风险分配

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The COVID-19 Pandemic: Present or Gone, Where Do Adolescents Stand?

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Advances in Infectious Diseases 2024年第2期14卷 374-386页

作者： Ifueko Enadeghe Ayebo Sadoh Emmanuel u. Eyo-Ita Phillip O. Abiodun Department of Child Health University of Benin Teaching Hospital Benin City Nigeria Institute of Child Health University of Benin Benin City Nigeria

Introduction: The initial global response to the SARS-CoV-2 pandemic focused on adults as adolescents mainly had subclinical infections. Adolescents, however, could transmit the virus and hence be a risk to the elderly, young children and immunocompromised. Adolescents are also at risk of long-term complications. This study sought to determine the prevalence of antibodies to SARS-CoV-2 among adolescents in Southern Nigeria, and to determine the association between SARS-CoV-2 seropositivity and age, gender, socioeconomic class, school type and nutritional status. Methods: This descriptive cross-sectional study was carried out in Edo state of southern Nigeria. We recruited 270 in-school adolescents aged 10 - 19 years. A WHO-adapted, pre-tested questionnaire was used to obtain data on participant history and risk factors. The questionnaire was interviewer-administered. Adolescents whose parents gave consent were recruited through a multi-stage randomized sampling method. Capillary blood for the assay was collected and analysed using a lateral-flow immunoassay device. The primary outcome was serostatus of the study. The positive predictors of serostatus were finally determined using a multiple logistics regression model. Statistical significance was set at p Results: The seroprevalence of SARS-CoV-2 was 45.9%. IgM antibodies were found in 5.6% of participants. Older adolescents had higher seropositivity rates than younger adolescents (2 = 8.101, p = 0.017). There was no association between gender and seropositivity. Adolescents in public schools were more likely to be seropositive than those in private schools (2 = 25.242, p = 0.001). A higher seroprevalence was noticed among study participants in the lower socioeconomic class (x2 = 6.928, p = 0.031), and those in overcrowded classes. (2 = 79.303, p = 0.001). Conclusion: This study showed a high seroprevalence of SARS-CoV-2 among in-school adolescents. Behavioural change communication on SARS-CoV-2, vaccination of adole

关键词： Pandemic Adolescents Seroprevalence COVID-19

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Generation of Eco-Friendly and Disease-Resistant Channel Catfish(Ictalurus punctatus)Harboring the Alligator Cathelicidin Gene via CRISPR/Cas9 Engineering

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Engineering 2024年第8期39卷 273-286页

作者： Jinhai Wang Baofeng Su De Xing Timothy J.Bruce Shangjia Li Logan Bern Mei Shang Andrew Johnson Rhoda Mae C.Simora Michael Coogan Darshika u.Hettiarachchi Wenwen Wang Tasnuba Hasin Jacob Al-Armanazi Cuiyu Lu Rex A.Dunham School of Fisheries Aquacultureand Aquatic SciencesAuburn UniversityAuburnAL 36849USA

As a precise and versatile tool for genome manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)platform holds promise for modifying fish traits of *** the aim of reducing transgene introgression and controlling reproduction,upscaled disease resistance and reproductive intervention in catfish species have been studied to lower the potential environmental risks of the introgression of escapees as transgenic *** advantage of the CRISPR/Cas9-mediated system,we succeeded in integrating the cathelicidin gene(As-Cath)from an alligator(Alligator sinensis)into the target luteinizing hormone(lh)locus of channel catfish(Ictalurus punctatus)using two delivery systems assisted by double-stranded DNA(dsDNA)and single-stranded oligodeoxynucleotides(ssODNs),*** this study,high knock in(KI)efficiency(22.38%,64/286)but low ontarget events was achieved using the ssODN strategy,whereas adopting a dsDNA as the donor template led to an efficient on-target KI(10.80%,23/213).The on-target KI of As-Cath was instrumental in establishing the lh knockout(LH^(–)_As-Cath^(+))catfish line,which displayed heightened disease resistance and reduced fecundity compared with the wild-type(WT)sibling ***,administration of human chorionic gonadotropin(HCG)and luteinizing hormone-releasing hormone analogue(LHRHa)can restore the reproduction of the transgenic fish ***,we replaced the lh gene with an alligator cathelicidin transgene and then administered hormone therapy to move towards complete reproductive control of diseaseresistant transgenic catfish in an environmentally responsible *** strategy not only effectively improves consumer-valued traits but also guards against unwanted introgression,providing a breakthrough in aquaculture genetics to confine fish reproduction and prevent the establishment of transgenic or domestic genotypes in the natural environment.

关键词： Genome editing ssODN dsDNA Antimicrobial peptide Reproductive confinement Aquaculture

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