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Celiac disease:diagnostic criteria in progress

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Cellular & Molecular Immunology 2011年第2期8卷 96-102页

作者： u Volta V Villanacci Department of Clinical Medicine St Orsola-Malpighi University HospitalBolognaItaly Department of Pathology Spedali CiviliBresciaItaly

until a few years ago,celiac disease(CD)was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal ***,CD is regarded as an autoimmune disorder that is common in the general population(affecting 1 in 100 individuals),with possible onset at any age and with many possible *** identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal(constipation and recurrent abdominal pain)and extra-intestinal symptoms(anemia,raised transaminases,osteoporosis,recurrent miscarriages,aphthous stomatitis and associated autoimmune disorders),or it could be completely *** the last 20 years,the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests,such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide *** routine use of antibody markers has allowed researchers to discover a very high number of‘borderline’cases,characterized by positive serology and mild intestinal lesions or normal small intestine architecture,which can be classified as potential ***,it is evident that the‘old celiac disease’with flat mucosa is only a part of the spectrum of *** is possible that serology could identify CD in its early stages,before the appearance of severe intestinal *** cases with a positive serology but with mild or absent intestinal lesions,the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

关键词： celiac disease clinical presentation diagnostic criteria histology,genetics serology

Bubble coalescence in interacting system of DNA molecules

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International Journal of Biomathematics 2024年第4期17卷 195-216页

作者： u.A.Rozikov V.I.Romanouskiy Institute of Mathematics 9 Universitet Street100174 Tashkent uzbekistan AKFA university National Park StreetBarkamol MFY Mirzo-Ulugbek District111221 Tashkent uzbekistan National university of uzbekistan 4Universitet Street 100174 TashkentUzbekistan

We consider two models of interacting DNA molecules:First is(four parametric)bubble coalescence model in interacting DNAs(shortly:BCI-DNA).Second is(three parametric)bubble coalescence model in a condensed DNA molecules(shortly BCC-DNA).To study bubble coalescence thermodynamics of BCI-DNA and BCC-DNA models we use methods of statistical ***,we define Hamiltonian of each model and give their translation-invariant Gibbs measures(TIGMs).For the first model,we find parameters such that corresponding Hamiltonian has up to three TIGMs(three phases of system)biologically meaning existence of three states:“No bubble coalescence”,“Dominated soft zone”,“Bubble coalescence”.For the second model,we show that for any(admissible)parameters,this model has unique *** is a state where“No bubble coalescence”phasedominates.

关键词： DNA bubble configuration Cayley tree Gibbs measure Potts model

Growth of Ni Films Observed by Scanning Tunneling Microscopy and X-ray

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Chinese Physics Letters 1999年第5期16卷 370-372页

作者： WANG De-liang u.Geyer National Laboratory for Superconductivity Institute of PhysicsChinese Academy of SciencesBeijing 100080 I.Physikalisches Institut der universitaet Goettingen Bunsenstrasse 9D-37073 GoettingenGermany

Scanning tunneling microscopy was used to measure the mean lateral dimensions D of grains at the surface of Ni films with thicknesses ranging from 15 to *** same films were analyzed by x-ray diffraction to obtain the average linear dimensionsδof coherent scattering regions in the direction normal to the film plane(coherence depths).For thin Ni films condensed on single sapphire substrate at room temperature,these two lengths D andδare equal and increase with film *** for films thicker than 130nm,these two lengths have different constant values and D>δ.This is because the coherent scattering depth is not only limited by the grain sizes but also by various defects in the *** difference between the constant values of D andδdisappears for films after annealing for 30min at 423K in the ultra-high vacuum system.

关键词： dimensions coherent film

Correction of failure in antenna array using matrix pencil technique

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Chinese Physics B 2017年第6期26卷 491-498页

作者： S u Khan M K A Rahim Advanced RF & Microwave Research Group Department of Communication Engineering Faculty of Electrical Engineering Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia

In this paper a non-iterative technique is developed for the correction of faulty antenna array based on matrix pencil technique（MPT）. The failure of a sensor in antenna array can damage the radiation power pattern in terms of sidelobes level and nulls. In the developed technique, the radiation pattern of the array is sampled to form discrete power pattern information set. Then this information set can be arranged in the form of Hankel matrix（HM） and execute the singular value decomposition（SVD）. By removing nonprincipal values, we obtain an optimum lower rank estimation of HM. This lower rank matrix corresponds to the corrected pattern. Then the proposed technique is employed to recover the weight excitation and position allocations from the estimated matrix. Numerical simulations confirm the efficiency of the proposed technique, which is compared with the available techniques in terms of sidelobes level and nulls.

关键词： array correction low rank estimation matrix pencil technique singular value decomposition

Pulmonary Toxicity of a Formulated Preparation of Fenvalerate in Rats Subchronically Exposed by Nose Only Inhalation for 90 Days

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Biomedical and Environmental Sciences 2001年第4期14卷 333-340页

作者： u.MANI FAKRuLISLAM 等 InhalationToxicologyLaboratory IndustrialToxicologyResearchCentreM.G.MargP.Box.No.80M.G.MargLucknow－226001India DepartmentofMedicalElementolgoy＆Toxicology HamdardUniversityNewDelhi

Objective The pulmonary toxicity of a commercially available formulated preparation of Fenvalerate (Fen), a synthetic pyrethroid has been studied in rats following subchronic nose only inhalation exposure route. Method Adult male rats were exposed to Fen for 4h/day, 5 days a week for 90 days by using Flow Past Dynamic Nose only Inhalation Chamber. Results Fen exposed rats showed a significant increase in enzymatic activities of lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and γ-glutamyl transferase (γ-GT) which are considered as biochemical indicators of pulmonary damage. The concomitant histopathological examination of Fen exposed rats' lung revealed inflammatory changes viz., influx of mononuclear cells admixed with a few giant cells in alveolar lumen, hypetrophied bronchiolar and alveolar epithelial lining cells and presence of edematous fluid in alveolar lumen alongwith congested parenchymatous blood vessels. Conclusion These results for the first time indicate the pulmonary toxic effects of a commonly used formulated Fen preparation by using rat model and nose only inhalation as the route of exposure.

关键词： Animals Behavior, Animal Body Weight Inhalation Exposure Insecticides Lung Male Nitriles Nose Organ Size Pyrethrins Rats Rats, Wistar

Buckling analysis of planar linear uniform deployable structures consisting of scissor-like element in space under compression

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Science China(Technological Sciences) 2021年第3期64卷 493-507页

作者： LI Bo WANG SanMin TAN u-Xuan School of Mechanical and Precision Instrument Engineering Xi’an University of TechnologyXi’an 710048China Department of Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China

This paper comprehensively investigates the buckling load and the stability of a planar linear array deployable structure composed of scissor-like element(SLE)under *** present,the researches on deployable structure are mainly focused on configuration design and dynamics characteristics of the mechanisms,but less on structural *** fact,when the external load exceeds the structural critical load value,the deployable structure will be permanently deformed or even collapse directly and no longer have any bearing *** address this issue,a new stability model is derived using linear elastic analysis method and substructure method to evaluate the buckling characteristics of the deployable structure with n SLEs when it is carried out in space,which can accurately obtain the structural instability load and can be used quantitatively to optimize the structure for making it have the most stable *** addition,the effects of the number of elements,the length,material properties and flexibility of the bar,and the deployment degree on the buckling of the scissor deployable structure are investigated,and the results of the theoretical analysis are compared with simulation and analytical results,respectively,confirming that the proposed stability model not only is able to effectively predict the structural instability load but also determine which part of the deployable structure is *** can be concluded that the stability of the deployable structure gradually decreases with the increase of the number of elements or the bar *** the calculation process,the critical load of each sub-element should be considered,and the minimum value of the critical loads of all subunits can be regarded as the instability load of the whole structure.

关键词： deployable structure stability analysis buckling load sub structure linear array simulation

Estimation of Rheological Properties of RAP Binder

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Journal of Wuhan university of Technology(Materials Science) 2010年第5期25卷 866-870页

作者：马涛 HuSSAIN u Bahia School of Transportation Southeast University Nanjing 210096 China Department of Civil and Environmental Engineering University of Wisconsin-Madison 2205 Engineering Hall Madison WI 53706 USA

The low-temperature rheological properties of binders in the recycled asphalt pavement （RAP） material without the damaging effects of solvent extractions were analyzed. The developed procedure is based on testing of bitumen-RAP mortars produced by mixing the fresh （virgin） binder with RAP material smaller than # 8 sieve. Different mortars were prepared, containing RAP material passing the #8 sieve and 15% by weight of fresh binder. Low temperature properties of these mortars were investigated by using the bending beam rheometer （BBR） test procedure that is specially modified for testing of the RAP mortars. The modification involved the development of a new kind of mold and different testing parameters. The RAP material used in the experimental study were both extracted from real reclaimed pavement and prepared in the laboratory, by aging binder through repeated PAV cycles. The results indicate the new procedure can capture the effect of aged properties of bitumen in the RAP and can be used to estimate the PG low temperature grade of the blended binder. Although data is limited in size, the modification of the BBR appears to be simple and provide repeatable data.

关键词： RAP binder rheological properties aging bending beam rheometer

Generalized Weighted Morrey Estimates for Marcinkiewicz Integrals with Rough Kernel Associated with Schrodinger Operator and Their Commutators

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 77-98页

作者： Ferit GuRBuZ Faculty of Education Department of Mathematics EducationHakkari UniversityHakkari 30000Turkey

Let L =-△+V(x) be a Schrodinger operator, where △ is the Laplacian on R^n,while nonnegative potential V(x) belonging to the reverse Holder class. The aim of this paper is to give generalized weighted Morrey estimates for the boundedness of Marcinkiewicz integrals with rough kernel associated with Schrodinger operator and their ***, the boundedness of the commutator operators formed by BMO functions and Marcinkiewicz integrals with rough kernel associated with Schrodinger operators is discussed on the generalized weighted Morrey spaces. As its special cases, the corresponding results of Marcinkiewicz integrals with rough kernel associated with Schrodinger operator and their commutators have been deduced, respectively. Also, Marcinkiewicz integral operators, rough Hardy-Littlewood(H-L for short) maximal operators, Bochner-Riesz means and parametric Marcinkiewicz integral operators which satisfy the conditions of our main results can be considered as some examples.

关键词： Marcinkiewicz operator Rough kernel Schrodinger operator generalized weighted Morrey space Commutator BMO

Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic

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Bioactive Materials 2023年第1期19卷 127-138页

作者： V.P.Galván-chacon D.de Melo Pereira S.Vermeulen H.Yuan J.Li P.Habibovic MERLN Institute for Technology Inspired Regenerative Medicine Maastricht Universitythe Netherlands Kuros Biosciences BV 3723 MBBilthoventhe Netherlands

Calcium phosphates(CaP)are widely used synthetic bone graft substitutes,having bioactivity that is regulated by a set of intertwined physico-chemical and structural *** some CaPs have shown to be as effective in regenerating large bone defects as autologous bone,there is still the need to understand the role of individual material properties in CaP ***,we aimed to decouple the effects of chemical composition and surface-microstructure of a beta-tricalcium phosphate(TCP)ceramic,with proven osteoinductive potential,on human mesenchymal stromal cells(hMSCs)*** this end,we replicated the surface structure of the TCP ceramic into polylactic acid without inorganic additives,or containing the chemical constituents of the ceramic,i.e.,a calcium salt,a phosphate salt,or TCP *** microstructure of the different materials was characterized by confocal laser *** were cultured on the materials,and the expression of a set of osteogenic genes was *** cell culture medium was collected and the levels of calcium and phosphate ions were quantified by inductively-coupled plasma mass *** results revealed that none of the tested combinations of properties in polymer/composite replicas was as potent in supporting the osteogenic differentiation of hMSCs as the original ***,we observed some effects of the surface structure in the absence of inorganics,as well as combined effects of surface structure and the added salts,in particular calcium,on osteogenic *** approach presented here can be used to study the role of independent properties in other CaP-based biomaterials.

关键词： Calcium phosphate Microstructure Chemical composition Mesenchymal stromal cells Osteogenic differentiation