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A study on bonding and energetic aspect of the Fe-Si binary system

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Chinese Journal of Chemistry 1997年第6期15卷 492-503页

作者： chacon Garardo Department of Chemistry Northern Illinois UniversityDekalbeIL60115USA

We have studied the electronic, bonding and energetic characteristics of the Fe-Si binary system using the tight-bonding extended Huckel method. Among the Fe-Si binary compounds, FeSi has the most symmetric geometric arrangement in the crystal structure. It also possesses the largest cohesive energy per atom. This correlates to the fact that FeSi is the most stable congruently-melting compound in the bulk phase diagram. An estimate of interaction energies between different atoms is also given.

关键词： Fe-Si binary system bonding extended Huckel method

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' uTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Population dynamics of three lizard species from the genus Sceloporus:short-term changes in demographic parameters

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Integrative Zoology 2019年第6期14卷 542-560页

作者： Selene VARGAS-GARCÍA Víctor argaez Israel SOLANO-ZAVALETA J.Jaime ZÚÑIGA-VEGA Graduate Program in Biological Sciences National Autonomous University of MexicoUniversity CityMexico CityMéxico Department of Ecology and Natural Resources Faculty of SciencesNational Autonomous University of MexicoUniversity CityMexico CityMéxico.

Most demographic studies focus on numerical changes that occur within populations across ***,typically studies at an interannual scale do not provide information on the particular times of the year(particular months or seasons)when rates of survival,recruitment,or migration increase or decrease due to physiological,behavioral or ecological *** monthly or seasonal changes in demographic parameters may lead to substantial variations in population *** this study,we collected capture-mark-recapture data on 3 species of lizards of the genus Sceloporus(Sceloporus torquatus,Sceloporus grammicus and Sceloporus megalepidurus)found in ecologically similar habitats to examine potential changes in demographic rates among 3 different climatic seasons:rainy,cold-dry and warm-dry *** tested different hypotheses about the effect of these seasons on survival,recruitment of new adults,and temporary *** found that during the season with severe thermal constraints,the cold-dry season,survival of *** decreased *** also detected a considerable increase in the recruitment rate of *** during the rainy season,when these lizards are establishing territories and finding *** contrast,we found no evidence of intra-annual changes in the rate of temporary *** addition,we calculated abundance and population growth rates for each species and for each *** study represents a significant contribution to the understanding of intra-annual demographic variation in lizards.

关键词： abundance recruitment Sceloporus lizards survival temporary emigration

Review and update on the molecular basis of Leber congenital amaurosis

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World Journal of Clinical Cases 2015年第2期3卷 112-124页

作者： Oscar Francisco chacon-Camacho Juan Carlos Zenteno Genetics Department-Research unit Institute of Ophthalmology"Conde de Valenciana" Biochemistry Department Faculty of MedicineNational Autonomous University of Mexico

Inherited retinal diseases are uncommon pathologies and one of the most harmful causes of childhood and adult blindness. Leber congenital amaurosis(LCA) is the most severe kind of these diseases accounting for approximately 5% of the whole retinal dystrophies and 20% of the children that study on blind schools. Clinical ophthalmologic findings including severe vision loss, nystagmus and ERG abnormalities should be suspected through the first year of life in this group of patients. Phenotypic variability is found when LCA patients have a full ophthalmologic examination. However, a correct diagnosis may be carried out; the determination of ophthalmologic clues as light sensibility, night blindness, fundus pigmentation, among other, join with electroretinographics findings, optical coherence tomography, and new technologies as molecular gene testing may help to reach to a precise diagnosis. Several retinal clinical features in LCA may suggest a genetic or gene particular defect; thus genetic-molecular tools could directly corroborate the clinical diagnosis. Currently, approximately 20 genes have been associated to LCA. In this review, historical perspective, clinical ophthalmological findings, new molecular-genetics technologies, possible phenotype-genotypes correlations, and gene therapy for some LCA genes are described.

关键词： Gene therapy Leber congenital amaurosis Retinal dystrophies Childhood blindness

Particle-in-Cell with Monte CarloCollisions Gun Code Simulations of a Surface-Conversion H^(−)Ion Source

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Communications in Computational Physics 2008年第8期4卷 659-674页

作者： E.chacon-Golcher K.J.Bowers Los Alamos National Laboratory Los AlamosNM 87545USA Los Alamos National Laboratory Guest Scientist currently at D.E.Shaw&CompanyNew YorkNY 10036USA.

We present an extended update on the status of a particle-in-cellwithMonte Carlo collisions(PIC-MCC)gun code developed at LosAlamos for the study of surfaceconverter H−ion *** programis fully *** of the program’s features include:solution of arbitrary electrostatic and magnetostatic fields in an axisymmetric(r,z)geometry to describe the self-consistent time evolution of a plasma;simulation of a multi-species(e^(−),H^(+),H^(+)_(2),H^(+)_(3),H^(−))plasma discharge from a neutral hydrogen gas and filament-originated seed electrons;full 2-dimensional(r,z)3-velocity(v_(r),v_(z),vφ)dynamics for all species;detailed collision physics between charged particles and neutrals and the ability to represent multiple smooth(not stair-stepped)electrodes of arbitrary shape and voltage whose surfaces may be secondary-particle emitters(H^(−)and e^(−)).The status of this development is discussed in terms of its physics content and current implementation details.

关键词： Negative hydrogen ion source simulation particle-in-cell with Monte Carlo collisions low temperature plasma simulation

Face Recognition from Incomplete Measurements via <i>l<sub>1</sub></i>-Optimization

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American Journal of Computational Mathematics 2012年第4期2卷 287-294页

作者： Miguel argaez Reinaldo Sanchez Carlos Ramirez Department of Mathematical Sciences The University of Texas at El Paso El Paso USA Program in Computational Science The University of Texas at El Paso El Paso USA

In this work, we consider a homotopic principle for solving large-scale and dense l1underdetermined problems and its applications in image processing and classification. We solve the face recognition problem where the input image contains corrupted and/or lost pixels. The approach involves two steps: first, the incomplete or corrupted image is subject to an inpainting process, and secondly, the restored image is used to carry out the classification or recognition task. Addressing these two steps involves solving large scale l1minimization problems. To that end, we propose to solve a sequence of linear equality constrained multiquadric problems that depends on a regularization parameter that converges to zero. The procedure generates a central path that converges to a point on the solution set of the l1underdetermined problem. In order to solve each subproblem, a conjugate gradient algorithm is formulated. When noise is present in the model, inexact directions are taken so that an approximate solution is computed faster. This prevents the ill conditioning produced when the conjugate gradient is required to iterate until a zero residual is attained.

关键词： Sparse Representation l1Minimization Face Recognition Sparse Recovery Interior Point Methods Sparse Regularization

Nanoparticle type effects on flexural, interfacial and vibration properties of GFRE composites

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Chinese Journal of Aeronautics 2016年第2期29卷 520-533页

作者： u.A.Khashaba Mechanical Engineering Department Faculty of Engineering King Abdulaziz University

Damping improvement in composite structures via introducing nanofillers generally has remarkable negative effects on the other mechanical properties. Therefore, in the present work, SiC and A1203 nanoparticles＇ infusion effects on the flexural, interracial and vibration properties of epoxy matrix and glass fiber reinforced epoxy （GFR/E） laminates were investigated. unidirectional （uD-GFR/E） and quasi-isotropic （QI-GFR/E） laminates with [0/± 45/90]s and [90/±45/0]s stack- ing sequences were hybridized by the optimum nanoparticles percentages. Results from off-axis flexural strengths of uD-GFR/E demonstrate good fiber/nanophased-matrix interracial bonding. The interlaminar shear stress between the adjacent layers with different orientations/strains of duc- tile QI-GFR/SiC/E laminates results in decreasing the flexural strengths respectively by 24.3% and 9.1% for [0/±45/90]s and [90/± 45/0]s stacking sequences and increasing the dissipated interfacial friction energy and thus the damping by 105.7% and 26.1%. The damping of QI-GFR/E, QI-GFR/SiC/E and QI-GFR/AI203/E laminates with [90/± 45/0]s stacking sequence was increased by 111.4%, 29.7% and 32.9% respectively compared to [0/± 45/90]s stacking sequence.

关键词： Flexural properties GFRE composites Interracial bonding Nanoparticles Non-destructive vibrationtechnique

Self-Organizing Maps in Seismic Image Segmentation

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Computer Technology and Application 2012年第9期3卷 624-629页

作者： Carlos Ramirez Miguel argaez Pablo Guiilen Gladys Gonzalez Program in Computational Science The University of Texas at El Paso El Paso Texas 79968 United States Geophysics Research and Development Repsol USA the Woodlands Texas 77380 United States

unsupervised neural networks such as the Kohonen Self-Organizing Maps （SOM） have been widely used for searching natural clusters in multidimensional and massive data. One example where the data available for analysis can be extremely large is seismic interpretation for hydrocarbon exploration. In order to assist the interpreter in identifying characteristics of interest confined in the seismic data, the authors present a set of data attributes that can be used to train a SOM in such a way that zones of interest can be automatically identified or segmented, reducing time in the interpretation process. The authors show how to associate SOM to 2D color maps to visually identify the clustering structure of the input seismic data, and apply the proposed technique to a 2D synthetic seismic dataset of salt structures.

关键词： Self-organizing maps image segmentation seismic attributes.

General investigation for longitudinal wave propagation under magnetic field effect via nonlocal elasticity

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Applied Mathematics and Mechanics(English Edition) 2015年第10期36卷 1305-1318页

作者： u.GVEN Department of Mechanical Engineering Yildiz Technical University

In this paper, the propagation of longitudinal stress waves under a longitu- dinal magnetic field is addressed using a unified nonlocal elasticity model with two scale coefficients. The analysis of wave motion is mainly based on the Love rod model. The effect of shear is also taken into account in the framework of Bishop＇s correction. This analysis shows that the classical theory is not sufficient for this subject. However, this unified nonlocal elasticity model solely used in the present study reflects in a manner fairly realistic for the effect of the longitudinal magnetic field on the longitudinal wave propagation.

关键词： Rayleigh-Bishop rod nonlocal elasticity magnetic field wave propagation