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Comparative functional genomics identifies an iron-limited bottleneck in a Saccharomyces cerevisiae strain with a cytosolic-localized isobutanol pathway

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Synthetic and Systems biotechnology 2022年第2期7卷 738-749页

作者： Francesca V.Gambacorta Ellen R.Wagner tyler b.jacobson Mary Tremaine Laura K.Muehlbauer Mick A.McGee Justin J.baerwald Russell L.Wrobel John F.Wolters Mike Place Joshua J.Dietrich Dan Xie Jose Serate Shabda Gajbhiye Lisa Liu Maikayeng Vang-Smith Joshua J.Coon Yaoping Zhang Audrey P.Gasch Daniel Amador-Noguez Chris Todd Hittinger Trey K.Sato brian F.Pfleger DOE Great Lakes bioenergy Research Center University of Wisconsin-MadisonMadisonWIUSA Department of Chemical and biological Engineering University of Wisconsin-MadisonMadisonWIUSA Laboratory of Genetics Center for Genomic Science InnovationUniversity of Wisconsin-MadisonMadisonWIUSA Department of bacteriology University of Wisconsin-MadisonMadisonWIUSA Department of Chemistry University of Wisconsin-MadisonMadisonWIUSA Wisconsin Energy Institute J.F.Crow Institute for the Study of EvolutionUniversity of Wisconsin-MadisonMadisonWIUSA Department of biomolecular Chemistry University of Wisconsin-MadisonMadisonWIUSA

Metabolic engineering strategies have been successfully implemented to improve the production of isobutanol,a next-generation biofuel,in Saccharomyces ***,we explore how two of these strategies,pathway re-localization and redox cofactor-balancing,affect the performance and physiology of isobutanol producing *** equipped yeast with isobutanol cassettes which had either a mitochondrial or cytosolic localized isobutanol pathway and used either a redox-imbalanced(NADPH-dependent)or redox-balanced(NADH-dependent)ketol-acid reductoisomerase *** then conducted transcriptomic,proteomic and metabolomic analyses to elucidate molecular differences between the engineered *** localization had a large effect on isobutanol production with the strain expressing the mitochondrial-localized enzymes producing 3.8-fold more isobutanol than strains expressing the cytosolic ***-balancing did not improve isobutanol titers and instead the strain with the redox-imbalanced pathway produced 1.5-fold more isobutanol than the balanced version,albeit at low overall pathway *** genomic analyses suggested that the poor performances of the cytosolic pathway strains were in part due to a shortage in cytosolic Fe-S clusters,which are required cofactors for the dihydroxyacid dehydratase *** then demonstrated that this cofactor limitation may be partially recovered by disrupting iron homeostasis with a fra2 mutation,thereby increasing cellular iron *** resulting isobutanol titer of the fra2 null strain harboring a cytosolic-localized isobutanol pathway outperformed the strain with the mitochondrial-localized pathway by 1.3-fold,demonstrating that both localizations can support flux to isobutanol.

关键词： Saccharomyces cerevisiae Isobutanol Functional genomics analysis Pathway localization Fe incorporation

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网络新产品和升级产品的新闻发布

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个人电脑 1994年第2期 150-151页

作者： Vicki b.jacobson 魏红

新产品Metricom公司把无线引向大规模应用 Metricom公司在其新的无线广域网中,提供了一种无线服务,该无线服务声称比其它公司更快更便宜。Ricochet微蜂窝数据网(MCDN)允许固定站的用户和便携计算机用户以及个人数字助手(PDA)的用户在本... 详细信息

新产品Metricom公司把无线引向大规模应用 Metricom公司在其新的无线广域网中,提供了一种无线服务,该无线服务声称比其它公司更快更便宜。Ricochet微蜂窝数据网(MCDN)允许固定站的用户和便携计算机用户以及个人数字助手(PDA)的用户在本地或广域网上发送和接收图形文件或大数据文件。 Ricochet系统由用户无线调制解调器(其大小如同电视的遥控器)及被安装在大楼顶部或电话杆上的袖珍电台单元(其大小如同烤箱)组成。这些电台单元不同于传统无线网络,

关键词：无线服务新闻发布微蜂窝网络层升级产品图形文件数据文件计算机通信蜂窝通信数据传输速率

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Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

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Natural Products and bioprospecting 2022年第1期12卷 530-566页

作者： Sheena E.b.tyler Luke D.K.tyler John Ray Research Field Station CheshireUK School of Natural Sciences Bangor UniversityGwyneddUK

Alzheimer’s disease(AD)is progressive and ultimately fatal,with current drugs failing to reverse and cure *** study aimed to find plant species which may provide therapeutic bioactivities targeted to causal agents proposed to be driving AD.A novel toolkit methodology was employed,whereby clinical symptoms were translated into categories recognized in *** categories were applied to find plant species with therapeutic effects,mined from ethnomedical *** locations were mapped to assess how this data is at *** were found of therapeutic relevance to 15 hypothesised causal bases for AD.107 species with an ethnological report of memory improvement demonstrated therapeutic activity for all these 15 causal *** majority of the surveys were found to reside within biodiversity hotspots(centres of high biodiversity under threat),with loss of traditional knowledge the most common *** findings suggest that the documented plants provide a large resource of AD thera-peutic *** demonstrating bioactivities targeted to these causal bases,such plants may have the capacity to reduce or reverse AD,with promise as drug leads to target multiple AD ***,there is a need to preserve ethnomedical knowledge,and the habitats on which this knowledge depends.

关键词： Medicinal plants Alzheimer’s Causal basis Ethnomedicine Traditional knowledge

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Emerging role of microRNAs in lipid metabolism

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Acta Pharmaceutica Sinica b 2015年第2期5卷 145-150页

作者： Zhihong Yang tyler Cappello Li Wang Department of Physiology and Neurobiology and the Institute for Systems Genomics University of Connecticut Veterans Affairs Connecticut Healthcare System Department of Internal Medicine Section of Digestive Diseases Yale University

micro RNAs(mi RNAs or mi Rs) are small non-coding RNAs that are involved in posttranscriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that mi RNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of mi RNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of mi RNAs expression. We emphasized on several representative mi RNAs that are functionally involved into lipid metabolism, including mi R-33/33 n, mi R122, mi R27a/b, mi R378/378 n, mi R-34 a and mi *** the function of mi RNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease.

关键词： Lipid metabolism microRNAs Nuclear receptors

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The Moduli Space in the Gauged Linear Sigma Model

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Chinese Annals of Mathematics,Series b 2017年第4期38卷 913-936页

作者： Huijun FAN tyler JARVIS Yongbin RUAN School of Mathematical Sciences Peking University Beijing 100871 China. Department of Mathematics Brigham Young University Provo UT 84602 USA. Department of Mathematics University of Michigan Ann Arbor MI 48105 USA.

This is a survey article for the mathematical theory of Witten's Gauged Linear Sigma Model, as developed recently by the authors. Instead of developing the theory in the most general setting, in this paper the authors... 详细信息

关键词： Landau-Ginzburg Calabi-Yau Gromov-Witten GLSM Moduli Phase Variation of geometric invariant theory Symplectic reduction

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Analysis of genetic diversity in banana cultivars(Musa cvs.) from the South of Oman using AFLP markers and classification by phylogenetic,hierarchical clustering and principal component analyses

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2010年第5期11卷 332-341页

作者： Umezuruike Linus OPARA Dan jacobson Nadiya Abubakar AL-SAADY Department of Horticultural Science Faculty of AgricSciencesUniversity of Stellenbosch Department of Viticulture and Oenology Institute of Wine BiotechnologyFaculty of AgricSciencesUniversity of Stellenbosch Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos University

banana is an important crop grown in Oman and there is a dearth of information on its genetic diversity to assist in crop breeding and improvement *** study employed amplified fragment length polymorphism(AFLP) to investigate the genetic variation in local banana cultivars from the southern region of *** 12 primer combinations,a total of 1094 bands were scored,of which 1012 were ***-two unique markers were identified,which revealed the distinct separation of the seven *** results obtained show that AFLP can be used to differentiate the banana *** classification by phylogenetic,hierarchical clustering and principal component analyses showed significant differences between the clusters found with molecular markers and those clusters created by previous studies using morphological *** on the analytical results,a consensus dendrogram of the banana cultivars is presented.

关键词： Musa Genetic diversity Amplified fragment length polymorphism(AFLP) Phylogenetics Principal component analysis(PCA) Hierarchical clustering analysis(HCA) Oman

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电动汽车悬架运动学优化方法

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同济大学学报（自然科学版） 2022年第S01期50卷 1-9页

作者： Y HUANG J KÖPLER A WAGNER J NEUbECK b.jacobson 查尔默斯理工大学瑞典哥德堡41296 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

电池电动汽车(bEV)的主要挑战之一是续航里程是否足够,因此在任何最近的车辆概念中,最大化的电池体积是合乎需要的。悬架作为最大的电动汽车子系统之一,对这一点有着重要的影响。本研究目的是使用自动化方法进行悬架开发,主要是引入一... 详细信息

电池电动汽车(bEV)的主要挑战之一是续航里程是否足够,因此在任何最近的车辆概念中,最大化的电池体积是合乎需要的。悬架作为最大的电动汽车子系统之一,对这一点有着重要的影响。本研究目的是使用自动化方法进行悬架开发,主要是引入一种新的可转向后悬架概念与电力推进系统,即从配备内燃机(ICE)的传统汽车开始,开发一种悬架,以满足纯电动汽车的新装配要求,同时保持有关驾驶动力学的典型要求。悬架概念是为具有大电池尺寸的高级汽车而优化的,此外还考虑了先进的主动系统,如空气弹簧和大转向角的主动后轮转向。该概念还提出了一种具有良好调整运动学性能的封装解决方案,符合原始设备制造商的调整理念。为解决由此产生的高复杂性,使用了新开发的方法,即运动学优化是用一种创新的方法完成的,该方法根据给定的要求自动提出新的硬点。在设计中,使用简化模型来表示复杂零件的形状,因此可以从包装的角度自动判断运动学概念是否可行。结果表明,新的悬架概念可以处理具有挑战性的装配问题和复杂的运动学要求。

关键词：电动汽车(bEV) 开发过程运动学包装

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A TAXONOMY OF JAVAN HOMINID MANDIbLES

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人类学学报 1992年第4期11卷 292-299页

作者： Donald E.tyler Idaho 83843 U.S.A Moscow Dept. of Anthropology University of Idaho

The hominid mandibular remains from the Pleistocene of Java have been controversial since the discovery of Kedung brubus (Mandible A) in 1890. Now, with several specimens, are they one species, or a mixture of species? What species of hominoid do these fossils represent?What was the fate of these hominoids? Were some replaced by a later hominid, or are they all representative of a single population? These mandibles are now called Kedung brubus, and Sangiran 1 (Mandible b), 5 ("The Mandible of 1939") 6 (Meganthropus A), 8 (Meganthropus b),

关键词： In A TAXONOMY OF JAVAN HOMINID MANDIbLES than

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The “Iterated Weakest Link” Model of Adaptive Security Investment

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Journal of Information Security 2016年第2期7卷 81-102页

作者： Rainer böhme tyler Moore Department of Computer Science Universitat Innsbruck Innsbruck Austria Tandy School of Computer Science University of Tulsa Oklahoma USA

We devise a model for security investment that reflects dynamic interaction between a defender, who faces uncertainty, and an attacker, who repeatedly targets the weakest link. Using the model, we derive and compare optimal security investment over multiple periods, exploring the delicate balance between proactive and reactive security investment. We show how the best strategy depends on the defender’s knowledge about prospective attacks and the recoverability of costs when upgrading defenses reactively. Our model explains why security under-investment is sometimes rational even when effective defenses are available and can be deployed independently of other parties’ choices. Finally, we connect the model to real-world security problems by examining two case studies where empirical data are available: computers compromised for use in online crime and payment card security.

关键词： Optimal Security Investment under Uncertainty Return on Security Investment

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Witten's D_4 Integrable Hierarchies Conjecture

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Chinese Annals of Mathematics,Series b 2016年第2期37卷 175-192页

作者： Huijun FAN Amanda FRANCIS tyler JARVIS Evan MERRELL Yongbin RUAN School of Mathematical Sciences Peking University Department of Mathematics Brigham Young University Department of Mathematics University of Michigan Ann Arbor the Yangtz Center of Mathematics at Sichuan University

The authors prove that the total descendant potential functions of the theory of Fan-Jarvis-Ruan-Witten for D4 with symmetry group J and for D4T with symmetry group Gmax, respectively, are both tau-functions of the D4 Kac-Wakimoto/Drinfeld-Sokolov hierarchy. This completes the proof, begun in the article by Fan-Jarvis-Ruan（2013）, of the Witten Integrable Hierarchies Conjecture for all simple（ADE） singularities.

关键词： Quantum cohomology Frobenius manifolds Singularity theory Integrable hierarchies

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