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Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats

Asian pacific Journal of Reproduction 2021年第4期10卷 168-175页

作者： Sevil kiremitli tunay kiremitli Umit Nayki Nesrin Yilmaz Can Turkler Kemal Dinc Renad Mammadov Gulce Naz Yazici Mine Gulaboglu Nihal Cetin Erzincan Binali Yildirim University Faculty of Medicine Department of Obstetrics and GynaecologyErzincanTurkey Erzincan Binali Yildirim University Faculty of Medicine Department of PharmacologyErzincanTurkey Erzincan Binali Yildirim University Faculty of Medicine Department of Histology and EmbryologyErzincanTurkey Ataturk University Faculty of Pharmacy Department of BiochemistryErzurumTurkey Selcuk University Faculty of Medicine Department of PharmacologyKonyaTurkey

Objective:To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in ***:A total of 18 female Wistar albino rats were randomly and equally divided into three groups:the sham group,the ovarian ischemia reperfusion group,and the 50 mg/kg taxifolin+ovarian ischemia reperfusion *** ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion *** and histopathologic examinations were performed on the extracted ***:Levels of malondialdehyde and cyclooxygenase-2 were increased,while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion ***,these values were reversed in the taxifolin+ovarian ischemia reperfusion ***,the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group,while they were within normal range in the taxifolin+ovarian ischemia reperfusion ***:Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury,and taxifolin may be useful for protecting ovarian tissue from such injury.

关键词： Antioxidants Ischemia-reperfusion Ovarian damage Rat Taxifolin Oxidative stress Ovarian torsion

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Effects of diode laser photocoagulation treatment on ocular biometric parameters in premature infants with retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 277-282页

作者： Damla Erginturk Acar Ugur Acar Zuhal Ozen tunay Aysegul Arman Anil Barak Minister of Health Ankara City Hospital Ankara 06800Turkey Selcuk University Faculty of Medicine Konya 42250Turkey RMIT University Mathematical SciencesLecturer in School of ScienceMelbourne 3001Australia

AIM:To investigate the effects of diode laser treatment on ocular biometric parameters in premature infants with retinopathy of prematurity(ROP).METHODS:Premature infants who received diode laser treatment for ROP(n=68)and premature infants with spontaneous regressed ROP without treatment(n=50)were performed longitudinal ocular biometric measurements including anterior chamber depth,lens thickness and axial length as follows:1 d prior to laser treatment,and 3,6,9,and 12 mo after the laser ***:The mean birth weight,gestational age and initial examination time values were 936.53±302.07 g,26.66±2.42 wk,36.26±2.73 wk in the treatment group and 959.78±260.08 g,27.28±2.10 wk,36.56±2.54 wk in the control *** was no statistically significant difference in these demographic characteristics of the *** chamber depth,lens thickness and axial length demonstrated statistically significant linear increases during the study period in the two groups(P<0.001 for each).There were no statistically significant differences between the two groups in terms of anterior chamber depth after laser *** of the lens thickness at 9 th and 12 th months(9 th month 3.70±0.22 vs 3.60±0.21 mm,P=0.017;12 th month 3.81±0.21 vs 3.69±0.22 mm,P=0.002)and the axial length at 12 th month(19.35±0.79 vs 19.13±0.54 mm,P=0.031)after laser treatment were statistically higher in the treatment ***:Diode laser retinal photocoagulation treatment in premature infants seems to increase the lens thickness and axial length.

关键词： diode laser photocoagulation laser treatment ocular biometric parameters retinopathy of prematurity

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(f, p)-Asymptotically Lacunary Equivalent Sequences with Respect to the Ideal I

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Journal of Applied Mathematics and Physics 2015年第9期3卷 1207-1217页

作者： tunay Bilgin Department of Mathematics Education Faculty Yuzuncu Yil University Van Turkey

In this study, we define (f, p)-Asymptotically Lacunary Equivalent Sequences with respect to the ideal I using a non-trivial ideal , a lacunary sequence , a strictly positive sequence , and a modulus function f, and o... 详细信息

关键词： Asymptotically Equivalence Ideal Convergence Lacunary Sequence Modulus Function Statistically Limit

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Comparison of non-cycloplegic photorefraction,cycloplegic photorefraction and cycloplegic retinoscopy in children

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 128-131页

作者： Ozdemir Ozdemir Zuhal Ozen tunay Ikbal Seza Petricli Damla Ergintürk Acar Muhammet Kazim Erol Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital Department of Ophthalmology Antalya Education and Research Hospital

AIM: To compare the results of noncycloplegic photorefraction, cycloplegic photorefraction and cycloplegic refraction in preschool and non-verbal ***: One hundred and ninety-six eyes of 98children(50 females, 48 males) were included in the study. Firstly, non-cycloplegic photorefraction was achieved with Plusoptix A09; secondly, cycloplegic photorefraction was carried out with Plusoptix A09 after10 min cyclopentolate. Finally, 30 min after instillation of twice cyclopentolate, cycloplegic refraction was obtained with autorefraction and/or standard retinoscopy. Spheric equivalent, spheric power, cylindric power and cylindrical axis measurements were statistically ***: The mean age was 28.8±18.5mo(range12-72mo). The differences in spherical equivalent, spheric power and cylindrical power measured by the three methods were found statistically significant(P 0.05).CONCLUSION: For the determination of refractive errors in children, the Plusoptix A09 measurements give incorrect results after instillation of ***, the cylindrical power measured by Plusoptix A09 with or without cycloplegia is higher. However, the non-cycloplegic Plusoptix A09 measures spheric equivalent and spheric power similar to cycloplegic refraction measurements in preschool and non-verbal children.

关键词： cyclopentolate cycloplegia photorefraction photoretinoscopy Plusoptix retinoscopy refraction

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Development of a Renewable Energy Based DC Excitation System in a Micro Hydro Power Plant

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Journal of Energy and Power Engineering 2016年第1期10卷 45-54页

作者： Mahmut Temel Ozdemir Gokay Bayrak Muhsin tunay Gencoglu Mehmet Cebeci Electrical and Electronics Engineering Department Faculty of Engineering Firat University Elazig 23100 Turkey Electrical and Electronics Engineering Department Faculty of Natural Sciences Architecture and Engineering Bursa TechnicalUniversity Bursa 16190 Turkey

MHPPs （micro hydro power plants） have become prominent in hydropower plants as a solution to provide the energy demands of the grid. In this study, a new hybrid renewable energy based DC excitation system for synchronous generator in the developed MHPP system is introduced. Proposed hybrid DC excitation system consists of solar ＆ hydrogen energy based power generating systems. Hybrid renewable energy based system is used for the excitation of the synchronous generator in the MHPP test system. The renewables are used as a secondary energy source to provide the excitation current to a synchronous generator that generates energy in MHPP. A PV （photovoltaic） array is used as the main source of excitation, and a FC （fuel cell） stack is used for DC excitation in the lack of sunshine. In the experimental setup, an electrical control card is developed, and a microcontroller is used to perform the proposed excitation system. All experimental results obtained from 5 kW rated power MHHP test system. Experimental results show that, the proposed method provides the continuous excitation current, and the operation of the synchronous generator is uninterrupted. The proposed method is also practical and easily implemented for MHPP systems.

关键词： Micro hydro power plant excitation system photovoltaic system fuel cell.

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Influence of preoperative coronary collateral circulation on in-hospital mortality in patients undergoing coronary artery bypass graft surgery with intra-aortic balloon pump support

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Chinese Medical Journal 2014年第17期127卷 3077-3081页

作者： Hasan Gungor Cemil Zencir Abraham Samuel Babu Cagdas Akgullu Ufuk Eryilmaz All Zorlu Mithat Selvi Sevil Onay tunay Kurtoglu Department of Cardiology Adnan Menderes University Aydin Turkey Department of Physiotherapy School of Allied Health Sciences Manipal University Karnataka India Department of Cardiology Cumhuriyet University Sivas Turkey Department of Cardiovascular Surgery Adnan Menderes University Aydin Turkey

Background Outcomes in patients requiring coronary artery bypass graft （CABG） surgery have been improved with devices such as the intra-aortic balloon pump （IABP）.Good coronary collateral circulation （CCC） has been shown to reduce mortality in patients with coronary artery disease （CAD）.We aimed to investigate whether poor preoperative CCC grade is a predictor of in-hospital mortality in CABG surgery requiring IABP *** Fifty-five consecutive patients who were undergoing isolated first time on-pump CABG surgery with IABP support were enrolled into this study and CCC of those patients was *** Twenty-seven patients had poor CCC and 28 patients had good ***-hospital mortality rate in poor CCC group was significantly higher than good CCC group （14 （50％） vs.4 （13％）,P=0.013）.Preoperative hemoglobin level （OR：0.752; 95％ CI,0.571-0.991,P=0.043）,chronic obstructive pulmonary disease （OR：6.731; 95％ CI,1.159-39.085,P=0.034） and poor CCC grade （OR：5.750; 95％ CI,1.575-20.986,P=0.008） were associated with post-CABG in-hospital *** CCC grade （OR：4.853; 95％ CI,1.124-20.952,P=0.034） and preoperative hemoglobin level （OR：0.624; 95％ CI,0.476-0.954,P=0.026） were independent predictors of in-hospital mortality after *** Preoperative poor CCC and hemoglobin are predictors of in-hospital mortality after CABG with IABP support.

关键词： coronary collateral circulation coronary artery bypass graft surgery intra-aortic balloon pump in-hospital mortality

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Nanostructured hybrid materials for bone-tooth unit regeneration

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Open Journal of Regenerative Medicine 2013年第3期2卷 47-52页

作者： Sabine Kuchler-Bopp Thibault Becavin tunay Kokten Florence Fioretti Etienne Deveaux Nadia Benkirane-Jessel Laetitia Keller Institut National de la Santeet de la Recherche Medicale(INSERM) UMR 1109Osteoarticular and Dental RegenerativeNanomedicineFacultede MedecineStrasbourgFrance Universitede Strasbourg Facultede Chirurgie Dentaire1 Place de l’HopitalStrasbourgFrance 3.UniversitéLille Nord de FranceFacultede Chirurgie DentaireLilleFrance

As a part of regenerative medicine, biomaterials are largely used in this field of nanotechnology and tissue engineering research. We have recently developed a new scaffold using electrospun nanofibers of Poly (ε-caprolactone), PCL which is able to mimic the collagen extracellular matrix of cells. The aim of this study was to engineer a biological and implantable structure leading the regeneration of the tooth-bone unit. For this aim, we have cultured mouse osteoblasts embedded in a collagen gel on the nanofibrous membrane and coupled this structure with an embryonic dental germ before implantation. To follow bone and tooth regeneration, we have performed RT-PCR, histology and immunofluorescence analysis. We showed here that this leaving implantable structure represents an accurate strategy for bone-tooth unit regeneration. We report here the first demonstration of bone-tooth unit regeneration by using a strategy based on a synthetic nanostructured membrane. This electrospun membrane is manufactured by using an FDA approved polymer, PCL and functionalized with osteoblasts before incorporation of the tooth germs at ED14 (the first lower molars) to generate bone-tooth unit in vivo after implantation in mice. Our technology represents an excellent platform on which other sophisticated products could be based.

关键词： Bone Nanostructured Material Osteoblast Tissue Engineering Tooth

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A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study

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Health 2013年第7期5卷 30-40页

作者： Yesim Gokce Kutsal Nurten Eskiyurt Jale Irdesel Vesile Sepici Hatice Ugurlu Yesim Kirazli Fusun Ardic Mirko Korsic Tonko Vlak Mane Grlickov Snezana Markovic Temelkova Miroslav Lazarov Nada Pilipovic Vera Popovic Aleksandar Dimic Branka Kovacev Dorina Ruci Argjend Tafaj Elma Kucukalic-Selimovic Dijana Avdic Hajrija Seleskovic Snjezana Pejicic Bulent Butun Gulseren Akyuz Lale Cerrahoglu Omer Faruk Sendur Peyman Yalcin Sema Oncel Merih Saridogan tunay Sarpel Mehmet Tosun Kazim Senel Savas Gursoy Ferhan Canturk Huseyin Demir Blazenka Miskic Dalibor Krpan Franjo Skreb Simeon Grazio Zeljka Crncevic-Orlic Fatih Ozdener Hakan Oncel Clinic for Orthopaedic Surgery Clinical Centre Vodnjansk Skopje Macedonia Clinic of Endocrinology Diabetes and Metabolic Disorders Skopje Macedonia Clinic of Rheumatology Clinical Centre Skopje Macedonia Clinical Center of Vojvodina Novi Sad Serbia Clinical Center Banja Luka Bosnia and Herzegovina Clinical Hospital Centre Split Croatia Department of PMR Cerrahpasa School of Medicine Istanbul University Istanbul Turkey Department of PMR Clinical Hospital Center Rijeka Rijeka Croatia Department of PMR Dr. Josip Bencevic General Hospital Slavonski Brod Croatia Department of PMR Istanbul School of Medicine Istanbul University Istanbul Turkey Department of PMR Polyclinic for Internal Medicine Zagreb Croatia Department of PMR School of Medicine Adnan Menderes University Aydin Turkey Department of PMR School of Medicine Akdeniz University Ankara Turkey Department of PMR School of Medicine Ankara University Ankara Turkey Department of PMR School of Medicine Ataturk University Erzurum Turkey Department of PMR School of Medicine Celal Bayar University Manisa Turkey Department of PMR School of Medicine Cukurova University Adana Turkey Department of PMR School of Medicine Dokuz Eylul University Izmir Turkey Department of PMR School of Medicine Ege University Izmir Turkey Department of PMR School of Medicine Erciyes University Kayseri Turkey Department of PMR School of Medicine Gazi University Ankara Turkey Department of PMR School of Medicine Gaziantep University Gaziantep Turkey Department of PMR School of Medicine Hacettepe University Ankara Turkey Department of PMR School of Medicine Karadeniz Technical University Trabzon Turkey Department of PMR School of Medicine Marmara University Istanbul Turkey Department of PMR School of Medicine Ondokuz Mayis University Samsun Turkey Department of PMR School of Medicine Pamukkale University Denizli Turkey Department of PMR School of Medicine Selcuk University Konya Turkey Department

A candidate identification questionnaire (CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a prospective, open-label, multicenter international study in patients with postmenopausal osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate for at least 3 months. Patients completed a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM) at baseline for 6 months. Scores were converted to composite satisfaction scores (CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in the treatment phase and comprised the intent-to-treat (ITT) population, and 630 completed the study. In the ITT population, 68.1% patients answered “yes” to one or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of life and overall satisfaction domains (p scores for the side effects domains were significant (p < 0.001) in the CIQ “yes” group, but not for the degree of bother (decrease in mean of 0.1 points, p = 0.50) or duration (no change, p = 0.84) of non-gastrointestinal side effects. Of 638 patients who completed the preference questionnaire, 93.0% of patients preferred the once-monthly dosing schedule and 563 patients (90.7%) found it more convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%), and upper abdominal pain (0.9%). Patients are likely to prefer treatment with monthly ibandronate to a weekly or monthly bisphosphonate irrespective of their stated preference before switching treatment.

关键词： Bisphosphonate Compliance Ibandronate Postmenopausal Osteoporosis

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