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Changed clinical aspects of primary liver cancer in china during the past 30 years

Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 194-198页

作者： Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, china Liver Cancer Institute & zhongshan hospital, Fudan university, Shanghai 200032, china tumor hospital, zhongshan university, guangzhou 510000, china tumor hospital, guangxi medical universi- ty, nanning 530000, china Xiehe hospital, Fujian medical university, Fuzhou 350000, china Second Hos- pital, Chinese medical university, Shenyang 110000, china Huaxi hospital, Sichuan university, Chengdu 610041, china hospital Affiliated to Nantong medical university, Nantong 226000 , china Second hospital, Jiangxi medical university, Nanchang 330000 , china First hospital Affiliated to guangxi medical university, nanning 530000 , china People’s hospital of Hainan Province, Haikou 570000, china Liver Cancer Institute & zhongshan hospital Fudan University Shanghai 200032 China. bhyang@zshospital. net

BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in china. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of china were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, w

关键词： primary liver cancer diagnosis therapy survival rate

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Multiphase hepatic scans with multirow- detector helical CT in detection of hypervascular hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 204-208页

作者： Hong Zhao, Jin-Lin Yao, Ming-Jun Han, Kang-Rong Zhou and Fu-Hua Yan Zhuhai, chinaDepartment of Radiology , and Department of Surgery Fifth hospital, zhongshan universi- ty, Zhuhai 519000, china Department of Radiology, zhongshan Hospi- tal, Fudan university, Shanghai 200032, china Department of Radiology Fifth Hospital Zhongshan University Zhuhai 519000 China. zhaohongmd@***

BACKGROUND: Multirow-detector helical CT (MDCT) allows faster Z-axis coverage and improves longitudinal re- solution to scan the entire liver. This study was to evaluate the value of multiphase hepatic CT scans using MDCT in diagnosing hypervascular hepatocellular carcinoma (HCC). METHODS: Multiphase hepatic CT scans in 40 patients were carried out with a Marconi Mx8000 MDCT scanner. The scans of early arterial phase (EAP), late arterial phase (LAP) and portal venous phase (PVP) were started at 21, 34 and 85 seconds after injection of contrast medium, re- spectively. The number of detected lesions was calculated in each phase. The density of the liver and tumor was great- er than 1 cm for HCC, and the density of the liver and tumor in each phase was statistically calculated. RESULTS: A total of 61 lesions were found in the 40 pa- tients , and lesions greater than 1 cm were seen in 47 cases. The density differences between the liver and tumor were statistically significant (Pty in the EAP, LAP and the double arterial phases (DAP) was 32%, 87%, and 94%, respectively. Significant difference was found between the LAP plus PVP and the EAP plus PVP; but no significant difference was observed between the DAP plus PVP and the LAP plus PVP. CONCLUSIONS: The utility of MDCT scan in the liver has optimized the protocol of arterial phase scan. MDCT is possible to scan the entire liver in a real arterial phase and it is very valuable in the detection of small HCC.

关键词： hepatocellular carcinoma X-ray multirow-detector helical computed tomography

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Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 292-295页

作者： Xiao-Ling Jin, Shu-Sen Zheng, Bing-Sheng Wang and Hui-Li Chen Nanjing, china Department of General Surgery, Nanjing First Hospi- tal Affiliated to Nanjing medical university, Nanjing 210006, china Department of Hepatobiliary Surgery, First Affiliated hospital, Zhe- jiang university School of Medicine, Hangzhou 310003, china Department of General Surgery, zhongshan hospital, Fudan universi- ty, Shanghai 200032 , china and Key Laboratory of Glycocon- jugate Research, Ministry of Health, Department of Biochemistry, Fudan university School of Medicine, Shanghai 200032, china Department of General Surgery Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China. xiaoling_jin@***

BACKGROUND: The incidence of extrahepatic bile duct carcinoma (EBDC) has been increasing, especially in aged people, but the glycobiology of the tumor is not elucida- ted. In this study we investigated the expressions of three glycosyltransferases in 35 patients with EBDC and 35 pa- tients with benign biliary duct disease (BBDD) as well as their clinicopathological significance. METHOD: The patients were divided into several sub- groups by tumor differentiation, TNM stage, and invasion by the standards recommended by UICC. tumor samples were immediately frozen in liquid nitrogen after resection, followed by mRNA determination of enzymes in the tissue using a mRNA selective reverse trancriptase-polymerase chain reaction kit. The mRNA levels of different groups were semi-quantitatively compared. RESULTS: The mRNA levels of N-acetylglucosaminyltrans- ferase V (GnT-V) and a subtype of α2,3 sialyltransferases for N-glycans, ST3Gal- were elevated 7.75 and 5.39 times in EBDC as compared with BBDD, respectively, and they were correlated to several clinicopathological factors including tumor advancement, differentiation, metastasis, and invasiveness. The mRNA expression of another sialyl- transferase, ST6Gal- , was also 0.63-fold higher in EBDC than in BBDD, but not involved in the clinicopathological characteristics. CONCLUSION: The elevated expression of these three gly- cosyltransferases can be considered as an important molecu- lar event in the occurrence and progression of EBDC.

关键词： extrahepatic bile duct carcinoma sialyltransferase N-acetylglucosaminyltransferase reverse trancriptase-polymerase chain reaction

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WAVELET CHARACTERIZATION OF WEIGHTED TRIEBEL-LIZORKIN SPACES

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Approximation Theory and Its Applications 2002年第4期18卷 76-92页

作者： Deng Donggao Xu Ming Yan Lixin (zhongshan university, china) Department of Mathematics Zhongshan University Guangzhou P. R. China

In this paper we use wavelets to characterize weighted Triebel-Lizorkin spaces. Our weights belong to the Muckenhoupt class A q and our weighted Triebel-Lizorkin spaces are weighted atomic Triebel-Lizorkin spaces.

关键词： WAVELET CHARACTERIZATION OF WEIGHTED TRIEBEL-LIZORKIN SPACES

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Delayed fluorescence spectroscopy and mechanism of the 730 nm component of chloroplast

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Optoelectronics Letters 2006年第2期2卷 158-162页

作者： WANG Cheng-long 1, XING Da2, FAN Duo-wang1, QIAN Long1, and LU Mai1 1. Key laboratory of Optoelectronic Technology and Intelligent Control,Education Ministry of china,Lanzhou Jiaotong universi- ty,Lanzhou 730070,china 2. Institute of Laser Life Science,South china Normal university,guangzhou 510631, china Lanzhou Jiaotong Univ Educ Minist China Key Lab Optoelect Technol & Intelligent Control Lanzhou 730070 Gansu Peoples R China South china Normal Univ Inst Laser Life Sci Guangzhou 510631 Guangdong Peoples R China

Charge recombination in reaction center (RC) of photosystem Ⅱ(PS Ⅱ)is regarded as the location of 685 nm delayed fluorescence (DF). The mechanism of 730 nm component appearing in the DF spectrum for chloroplast was studied by various spectral analysis methods. Experimental results of the DF spectrum at different chloroplast concentration show that the intensity of peaks at 685nm and 730 nm ascends with the chloroplast concentration increasing when the concentration is relatively low. When the concentration increases to the level of 7.8 μg/ml, a maximum intensity of the peak at 685 nm appears but the intensity of 730 nm peak still increases. The peak at 730 nm finally reaches a maximum intensity at the chloroplast concentration of 31.2 μg/ml while the intensity of the 685 nm peak has apparently fallen down. The results of absorption spectrum show that the ratios of A685 to A730 keep almost constant with the increasing of chloroplast concentration. Furthermore, the excitation spectrum for 730 nm fluorescence shows that the 685nm light has high excitation *** results indicate that the 730nm component of DF spectrum is the fluorescence of chlorophyll in PS Ⅰ RC excited by 685 nm DF. Meanwhile, this can be further verified by the invariability of DF spectrum at different delay time (1 second～9 seconds).

关键词： nm Delayed fluorescence spectroscopy and mechanism of the 730 nm component of chloroplast

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耳鼻咽喉部及头颈部非霍奇金淋巴瘤──附45例临床分析

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新医学 2002年第8期33卷 455-457页

作者：柴丽萍苏振忠雷文斌罗广裕中山大学附属第一医院耳鼻咽喉科 510080

目的:探讨耳鼻咽喉部及头颈部非霍奇金淋巴瘤(NHL)的临床特点、诊断及预后。方法:对45例耳鼻咽喉-头颈部NHL患者的临床资料作回顾性分析。结果:45例中T细胞淋巴瘤18例;B细胞淋巴瘤23例,未定型4例;其中10例曾被误诊。NHL的临床表现复杂,... 详细信息

目的:探讨耳鼻咽喉部及头颈部非霍奇金淋巴瘤(NHL)的临床特点、诊断及预后。方法:对45例耳鼻咽喉-头颈部NHL患者的临床资料作回顾性分析。结果:45例中T细胞淋巴瘤18例;B细胞淋巴瘤23例,未定型4例;其中10例曾被误诊。NHL的临床表现复杂,局部表现以发病部位的功能损害为主,有鼻塞、涕血、嗅觉下降、咽痛、咽异常感觉、颈部肿块、面瘫(双侧)、听力下降、腭部溃疡、头痛、抽搐、胸痛、腹痛等。发热、盗汗及体重下降为主要的全身症状。发病部位以鼻腔鼻窦居首位(40%),其次是扁桃体及颈部,分别占22%、16%。10例患者有3个或以上病灶。确诊主要靠病理检查或加免疫组织化学检查。本组3年、5年及10年的生存率分别为76%、51%及38%。T细胞淋巴瘤、有全身症状、临床分期高及恶性程度高者预后不良。结论:NHL的临床表现无固定特征,诊断应采用病理活组织检查及免疫组织化学检查相结合,其预后与病理类型、有无全身症状、临床分期、恶性程度等有关。

关键词：非霍奇金淋巴瘤耳鼻咽喉头颈部肿瘤诊断预后

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粒细胞集落刺激因子的免疫学测定方法的建立

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陕西医学检验 1998年第2期13卷 1-3页

作者：王晓光张亚莉王小宁温汉平陈凯解放军第157医院肿瘤科广州510510 第一军医大学分子免疫学研究所

由于hG-GF的重要作用以及rhG-CSF在临床上的广泛使用，有必要进一步了解正常人和某些疾病状态下病人外周血循环中G—CSF的浓度。利用两株针对不同抗原决定簇的单克隆抗体，建立了双抗夹心ELISA方法。方法特异性较好，检测灵敏度为340pg... 详细信息

由于hG-GF的重要作用以及rhG-CSF在临床上的广泛使用，有必要进一步了解正常人和某些疾病状态下病人外周血循环中G—CSF的浓度。利用两株针对不同抗原决定簇的单克隆抗体，建立了双抗夹心ELISA方法。方法特异性较好，检测灵敏度为340pg／ml。用该法检测了12例细菌感染病人，有11例病人G—GF检测阳性，阳性率91．6％；白血病病人血清G—GF阳性率25％～35．7％，正常血清则均为阴性。该方法克服了以往骨髓细胞集落形成法和G—GF依赖株测定法需时长、操作繁琐的缺点，为研究正常人和某些疾病状态下病人外周血G—CSF浓度的变化和G—CSF的药代动力学提供了一个简便、快速、特异性高的方法。

关键词：单克隆抗体 ELISA C-CSF

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灭活SARS病毒的免疫原性的实验研究

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现代免疫学 2004年第5期24卷 386-390页

作者：熊盛王一飞张庶民陆家海孟民杰张美英刘新建张传海刘石生李久香万卓越郑焕英鄢心革暨南大学生物医药研究开发基地广州510630 中国药品生物制品检定所北京100050 中山大学广州510275 第一军医大学广州510515 广东省疾病预防控制中心广州510300

研究灭活SARS病毒的免疫原性。SARS病毒F6 9株经甲醛灭活后 ,加入氢氧化铝佐剂 ,以 3种剂量接种BALB/c小鼠 ,定时采血 ,测定特异性抗体的滴度及其中和活性 ,同时用化学发光酶联免疫法测定抗血清与SARS病毒结构蛋白的反应特异性及其相对... 详细信息

研究灭活SARS病毒的免疫原性。SARS病毒F6 9株经甲醛灭活后 ,加入氢氧化铝佐剂 ,以 3种剂量接种BALB/c小鼠 ,定时采血 ,测定特异性抗体的滴度及其中和活性 ,同时用化学发光酶联免疫法测定抗血清与SARS病毒结构蛋白的反应特异性及其相对强度。结果发现 ,小鼠接种疫苗 4d后 ,血清中可检测到IgM抗体 ,直至 2 6d后逐渐下降 ;IgG抗体在初次免疫 8d后出现 ,4 7d时达最高峰 ,6 3d后进入稳定期 ;不同剂量组的抗体滴度具有明显剂效关系 ,低剂量组和中剂量组滴度峰值为 1∶192 0 0 ,高剂量组滴度峰值为 1∶384 0 0。中和实验结果表明 ,小鼠所产生的抗体具有中和病毒活性 ,在 6 3d时 ,低剂量组和中剂量组血清的中和效价为 1∶12 80 ,高剂量组血清的中和效价为 1∶5 12 0。抗体分类结果表明 ,小鼠抗血清中含有针对多种SARS病毒结构蛋白的特异性抗体 ,其中 ,针对N蛋白、S4蛋白和S2蛋白的抗体水平相对较高 ,而抗M抗体、抗 3CL抗体的水平相对较低。上述结果说明 ,SARS病毒F6 9株经甲醛灭活后 ,各主要结构蛋白仍保持较强免疫原性 ;免疫小鼠后 ,可以诱导产生高滴度的特异性混合抗体。

关键词： SARS病毒灭活 IgG 中和

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