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Biliary microbiome and gallstones: A silent friendship

World Journal of Gastrointestinal Surgery 2024年第11期16卷 3395-3399页

作者： tuhina banerjee Aakansha Giri Goswami Somprakas Basu Microbiology Institute of Medical SciencesBanaras Hindu UniversityUttar PradeshVaranasi 221005India Department of General Surgery All India Institute of Medical SciencesUttarakhandRishikesh 249203India

With increasing evidence,the biliary tract and the gallbladder mucosa are no longer considered sterile environments devoid of *** a profound biofilm of resident bacterial flora is associated with the mucosal *** bile too harbors a resident *** is when a dysbiotic process ensues,that this bac-terial flora either becomes opportunist or is replaced by a pathogenic one that has a strong ability to survive the challenges of the biliary *** once believed a metabolic problem,recent evidence indicates a complex intera-ction between different species of bacteria and gallbladder mucosa and bile which may culminate in calculus *** resident microbiota and its several enzymes dictate the type of gallstone by the mere interplay of the constituting type of bacteria in the biofilm,even without any evidence of *** is often mediated by either intestinal dysbiosis or less probably by oral *** gallstones,in turn,provide a haven for the resident microbiota in which they can form their own defined niche enriched with the biofilm that can resist the biliary defense mechanisms and survive the hostile biliary environment in the background of biliary stasis and local ***,this process of silent friendship is more complex than said,and further research is needed to define the relationship between the two.

关键词： Biliary microbiome Resident flora Dysbiosis Gallstones Β-glucuronidase

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Isolation and Characterization of Beneficial Microorganisms in Organic, Semi-Organic and Conventional Fertilizer Treated Agricultural Field Soil and Comparison of Bacterial Richness

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Journal of Agricultural Chemistry and Environment 2020年第4期9卷 223-239页

作者： Md. Mahfujur Rahman Laisa Ahmed Lisa Sunzid Ahmed Md. Nazim Uddin tuhina Hasan Sharmin Zaman Department of Microbiology Jagannath University Dhaka Bangladesh Department of Biochemistry and Molecular Biology Jagannath University Dhaka Bangladesh Centre for Advanced Research in Sciences (CARS) University of Dhaka Dhaka Bangladesh Horticulture Research Center Bangladesh Agriculture Research Institute (BARI) Gazipur Bangladesh

The effect of different farming systems on microbial communities in agricultural environment was investigated in the present study. Depending on the present farming trend, the microbial distribution in agricultural soils treated with organic, semi-organic and conventional fertilizers was analyzed. A total of 20 soil samples were collected from different types of agricultural fields of Bangladesh Agricultural Research Institute (BARI, Gazipur). Microorganisms playing beneficial roles in soil such as nitrogen fixation (e.g. Rhizobium sp., Azotobacter sp.), phosphate solubilization (e.g. Bacillus sp., Pseudomonas sp., Phosphobacteria) and auxin production (e.g. Pseudomonas sp., Serratia sp. and Bacillus sp.) were evaluated from each of the samples. The results revealed that agricultural fields treated with chemical fertilizers showed lower microbial count than that of organic fertilizer treated agricultural fields’ soil samples. In addition, organic fertilizers amended field soils have higher phytohormone (Auxin) activities, phosphate solubilization bacteria and other bacterial richness compared to chemical fertilizer applied field soil.

关键词： Chemical Fertilizer Organic Fertilizers Bacterial Richness and Bacterial Diversity

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IASP关节痛文献资料,《中国疼痛医学杂志》组织翻译第九篇:关节痛的流行病学

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中国疼痛医学杂志 2016年第6期22卷 481-481页

作者： tuhina Neogi 江颖颖赵华

肌肉骨骼痛,尤其是关节痛和后背痛是最为常见的慢性痛类型。引起关节痛最常见的原因是各种关节炎。患者往往寻求药物缓解关节痛,而关节痛是导致残疾的主要原因之一。根据美国健康访谈调查的数据,大约5 250万(22.7%)的成年人被医生诊断... 详细信息

肌肉骨骼痛,尤其是关节痛和后背痛是最为常见的慢性痛类型。引起关节痛最常见的原因是各种关节炎。患者往往寻求药物缓解关节痛,而关节痛是导致残疾的主要原因之一。根据美国健康访谈调查的数据,大约5 250万(22.7%)的成年人被医生诊断患有关节炎。2 270万(9.8%)患关节炎并因关节炎导致活动受限。预计到2030年,大约6 700万,即四分之—的美国成年人将被医师诊断患有关节炎。据报道大约30%成年人在检查的30天内患有各种类型的关节痛,其中膝关节是最主要的疼痛部位。2007年,一项由欧洲委员会发起的欧洲民意调

关键词：关节痛 IASP 关节炎

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Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 556-563页

作者： Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless Department of Medicine Division of Gastroenterology and HepatologyJohns Hopkins University Guangdong provincial Key Laboratory of Colorectal and Pelvic Floor Diseases the Sixth Affiliated Hospital of Sun Yat-sen University Department of Gastroenterology the Sixth Affiliated Hospital of Sun Yat-sen University Department of Medicine Med Star Health Internal Medicine Department of Health and Sport Sciences Federal University of Acre Department of Medicine Faculty of Medicine and Health SciencesAn-Najah National University Ravindra Nath Tagore Medical College St Vincent Hospital Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health

AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United *** We performed a survey-based cross-sectional study of participants with CD recruited from China and the United *** compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential *** We recruited 49 participants from China and 145 from the United *** prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in *** involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two *** The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United *** the potential difference in etiology,surgery and ileal involvement were similar in the two *** the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.

关键词： Crohn’s disease Family history Disease outcome Inflammatory bowel disease Epidemiology genetics Environment Medication Surgery

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2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联盟的联合倡议

2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联...

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贵州省医学会风湿病学分会第四届学术年会

作者： Daniel Aletaha tuhina Neogi Alan J Silman Julia Funovits David T Felson Clifton O Bingham Ⅲ Neal S Birnbaum Gerd R Burmester Vivian P Bykerk Marc D Cohen Bernard Combe Karen H Costenbader Maxime Dougados Paul Emery Gianfranco Ferraccioli Johanna MW Hazes Kathryn Hobbs Tom WJ Huizinga Arthur Kavanaugh Jonathan Kay Tore K Kvien Timothy Laing Philip Mease Henri A Menard Larry W Moreland Raymond L Naden Theodore Pincus Josef S Smolen Ewa Stanislawska-Biernat Deborah Symmons Paul P Tak Katherine S Upchurch Jiri Vencovsky Frederick Wolfe Gillian Hawker 季兰岚邓雪蓉赵明田真张卓莉 Medical University of Vienna ViennaAustria Boston University School of Medicine BostonMassachusettsUSA

目的 :在早期类风湿关节炎(rheumatoid arthritis,RA)的诊断中,1987年美国风湿病学会(AmericanCollege of Rheumatology,ACR;旧称AmericanRheumatism Association,ARA)的诊断标准因为缺乏敏感度而受到质疑。本研究的目的是建立新的RA分类标准。方法 :由ACR和欧洲抗风湿病联盟(EuropeanLeague Against Rheumatism,EULAR)共同组成的工作小组,分三个阶段建立RA新的分类标准。研究的目标人群是初发的未分化关节炎患者,主要研究目的是寻找能够预测这些病人发展为RA的危险因素,并将RA疾病特点定义为持续性和/或侵蚀性关节炎。结果 :在新的分类标准中,确诊RA至少需要一个关节有明确的滑膜炎表现,除外其他可能导致滑膜炎症的疾病,同时以下四项评分的总分≥6分(最高10分):受累关节的数量和部位(0-5分)、血清学自身抗体异常(0-3分)、急性期反应物升高(0-1分)和症状持续时间(共分两级;0-1分)。结论 :既往诊断RA比较依赖骨破坏这一RA晚期表现,而新的分类标准着重于疾病早期表现而不是晚期特点,将疾病特点重新定义为持续性和/或侵蚀性滑膜炎。这一新标准的推出将再次强调了RA早期诊断的必要性以及早期有效治疗对于预防或减少不良后遗症的发生具有重要意义。

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