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Impact of Action Observation Therapy along with Usual Physiotherapy Intervention of Individual with Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第1期13卷 1-10页

作者： Zahid Bin Sultan Nahid Faruq Ahmed tuhin Ahammed Md Kutub Uddin Md Sirazul Islam S M Maruf Hossain Sajib Md Rafiqul Islam Department of Physiotherapy Saic College of Medical Science and Technology Mirpur Bangladesh Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Savar Bangladesh Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Mymensingh Bangladesh Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Mirpur Bangladesh Department of Physiotherapy State College of Health Sciences Dhaka Bangladesh

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairments in the initial stage, which lead to severe cognitive dysfunction in the later stage. Action observation therapy (AOT) is a multisensory cognitive rehabilitation technique where the patient initially observes the actions and then tries to perform. The study aimed to examine the impact of AOT along with usual physiotherapy interventions to reduce depression, improve cognition and balance of a patient with AD. A 67 years old patient with AD was selected for this study because the patient has been suffering from depression, dementia, and physical dysfunction along with some other health conditions like diabetes and hypertension. Before starting intervention, a baseline assessment was done through the Beck Depression Inventory (BDI) tool, the Mini-Cog Scale, and the Berg Balance Scale (BBS). The patient received 12 sessions of AOT along with usual physiotherapy interventions thrice a week for four weeks, which included 45 minutes of each session. After four weeks of intervention, the patient demonstrated significant improvement in depression, cognition, and balance, whereas the BDI score declined from moderate 21/63 to mild 15/63 level of depression. The Mini-Cog score improved from 2/5 to 4/5, and the BBS score increased from 18/56 to 37/56. It is concluded that AOT along with usual physiotherapy intervention helps to reduce depression, improve cognition and balance of people with AD.

关键词： Alzheimer’s Disease Action Observation Therapy Physiotherapy Intervention

Superior printed parts using history and augmented machine learning

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npj Computational Materials 2022年第1期8卷 1736-1745页

作者： Meng Jiang tuhin Mukherjee Yang Du Tarasankar DebRoy State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA

Machine learning algorithms are a natural fit for printing fully dense superior metallic parts since 3D printing embodies digital technology like no other manufacturing *** traditional machine learning needs a large volume of reliable historical data to optimize many printing variables,the algorithm is augmented with human intelligence derived from the rich knowledge base of metallurgy and physics-based *** augmentation improves the computational efficiency and makes the problem tractable by enabling the algorithm to use a small set of *** provide a verifiable quantitative index for achieving fully dense superior parts,facilitate material selection,uncover the hierarchy of important variables that affect the density,and present easy-to-use visual process *** findings can improve the quality consistency of 3D printed parts that now limit their greater industrial *** approach used here can be applied to solve other problems of 3D printing and beyond.

关键词： printing augmented consistency

Assessment of Hydrogen Embrittlement Susceptibility and Mechanism(s)in Quench and Tempered AISI 4135 Steel Using A Novel Fast Fracture Test in Bending

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Acta Metallurgica Sinica(English Letters) 2023年第7期36卷 1078-1094页

作者： tuhin Das Salim V.Brahimi Jun Song Stephen Yue Department of Materials Engineering McGill UniversityMontrealQC H3A OC5Canada Industrial Fasteners Institute ClevelandOH 44131USA

A newly proposed rapid fracture test in four-point bending was used to evaluate the effect of tempering on the hydrogen embrittlement(HE)susceptibility of an AISI 4135 steel,where it was tempered to four different strength(or hardness)*** was observed that HE susceptibility increases with the increase in *** was shown that there will be minimal impact of hydrogen(H)on the fracture of materials with hardness 37 HRC and below,even if they are completely saturated with *** the other hand,H will have similar detrimental effect on fracture properties of quench and tempered(Q and T)steels having hardness higher than 45 *** to brittle transition behavior was observed for a critical hardness(or strength)range as well as for a critical concentration level of ***,a critical H concentration was observed to exist for each of the strength *** was performed in addition to microstructural characterization using transmission electron microscopy(TEM).A very good correlation was observed between the fast fracture test results and *** fast fracture test was further compared with a conventional incremental step load(ISL)test for the evaluation of HE *** ISL test results and fracture surface characteristics corroborate very well with the observations from the fast fracture *** study successfully establishes the fast fracture test as a novel technique to study HE susceptibility and mechanism(s).

关键词： Hydrogen embrittlement(HE) Mechanical testing Fracture mechanics Martensitic steel Hardness Dislocation density

Nanocellulose,a versatile platform:From the delivery of active molecules to tissue engineering applications

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Bioactive Materials 2022年第3期7卷 566-589页

作者： Tejal V.Patil Dinesh K.Patel Sayan Deb Dutta Keya Ganguly tuhin Subhra Santra Ki-Taek Lim Department of Biosystems Engineering Institute of Forest ScienceKangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea Deptarment of Engineering Design Indian Institute of TechnologyMadras600036India

Nanocellulose,a biopolymer,has received wide attention from researchers owing to its superior physicochemical properties,such as high mechanical strength,low density,biodegradability,and *** can be extracted from wide range of sources,including plants,bacteria,and *** on the extraction process and dimensions(diameter and length),they are categorized into three main types:cellulose nanocrystals(CNCs),cellulose nanofibrils(CNFs),and bacterial nanocellulose(BNC).CNCs are a highly crystalline and needle-like structure,whereas CNFs have both amorphous and crystalline regions in their *** is the purest form of *** nanocellulose properties can be tuned by chemical functionalization,which increases its applicability in biomedical *** review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules,such as drugs,proteins,and ***-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and *** applications of nanocellulose and its composites in tissue engineering have been ***,the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

关键词： Nanocellulose Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering

Conditions for void formation in friction stir welding from machine learning

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npj Computational Materials 2019年第1期5卷 554-561页

作者： Yang Du tuhin Mukherjee Tarasankar DebRoy Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Tianjin Key Laboratory of Advanced Joining Technology School of Materials Science and EngineeringTianjin UniversityTianjin 300350China

Friction stir welded joints often contain voids that are detrimental to their mechanical *** we investigate the conditions for void formation using a decision tree and a Bayesian neural *** types of input data sets including unprocessed welding parameters and computed variables using an analytical and a numerical model of friction stir welding were *** hundred and eight sets of independent experimental data on void formation for the friction stir welding of three aluminum alloys,AA2024,AA2219,and AA6061,were *** neural network-based analysis with welding parameters,specimen and tool geometries,and material properties as input predicted void formation with 83.3% *** the potential causative variables,i.e.,temperature,strain rate,torque,and maximum shear stress on the tool pin were computed from an approximate analytical model of friction stir welding,90 and 93.3%accuracies of prediction were obtained using the decision tree and the neural network,*** the same causative variables were computed from a rigorous numerical model,both the neural network and the decision tree predicted void formation with 96.6% *** these four causative variables,the temperature and maximum shear stress showed the maximum influence on void formation.

关键词： welding friction welded

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人胎盘提取液的抗炎和抗血小板聚集作用

Acta Pharmacologica Sinica 2003年第2期24卷 187-192页

作者： SUR Tapas Kumar BISWAS tuhin Kanti ALI Liaquat MUKHERJEE Biswapati SN Pradhan Centre for Neurosciences Dr BC Roy Postgraduate Institute of Basic Medical Sciences 244B Acharya J C Bose Road Calcutta 700020 India Research Division BIRDEM 122 Kazi Nazrul Islam Avenue Dhaka 1000 Bangladesh

AIM: To find the anti-inflammatory and anti-platelet aggregatory activity of human placental extract （HPE, Placentrex）.METHODS: The HPE was studied for anti-inflammatory effect in Wistar rats on carrageenin, serotonin （5-HT）,and prostaglandin E1（PGE1） induced edema in acute model and cotton pellet induced granuloma on sub-acute model. Anti-platelet aggregation was studied against protection of adinosine diphosphate （ADP）-induced aggregation of human platelet through in vitro study. RESULTS: HPE showed positive results both in acute and sub-acute models of inflammation. Highly significant （P<0.01） results were obtained against 5-HT induced acute inflammation and cotton pellet induced sub-acute inflammation in comparison with standard （diclofenac sodium） and control（normal saline） drugs. The anti-inflammatory property of HPE in animal model was well supported with clinical study of platelet aggregation. There was highly significant （P<0.01） inhibition of platelet aggregation with HPE at different doses against ADP. CONCLUSION: Our data suggest that human placental extract may be useful in suppressing inflammation and platelet aggregation.

关键词：胎盘提取物炎症角叉菜胶血小板聚集腺苷二磷酸

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人胎盘提取物对大鼠伤口愈合的作用(英文)

Acta Pharmacologica Sinica 2001年第12期22卷 59-62页

作者： BISWAS tuhin Kanti,AUDDY Biswajit,BHATTACHARYA Nitai P,BHATTACHARYA Subahshree,MUKHERJEE Biswapati SN Pradhan Centre for Neurosciences Dr BC Roy Postgraduate Institute of Basic Medical Sciences Calcutta 700020 SN Pradhan Centre for Neurosciences Dr BC Roy Postgraduate Institute of Basic Medical Sciences Calcutta 700020 Albert David limited Calcutta 700072 India Crystallography and Molecular Biology Division Saha Institute of Nuclear Physics Calcutta 700064 SN Pradhan Centre for Neurosciences Dr BC Roy Postgraduate Institute of Basic Medical Sciences Calcutta 700020

AIM: To study wound healing activity of the humanplacental extract(HPE) in rats. METIHODS: Fullthickness wounds were inflicted on depilated dorsum ofCharles foster rats with 8 mm Acu-punch biopsy. TheHPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physicalcriteria, biochemical criteria, and histopathological studywith respect to untreated control, vehicle control (1. 5%benzyl alcohol), and framycetin topical treated ***: Significant lowering of wound size(P<0.05), wound index(P<0.05), and number of daysrequired for complete healing (P<0.01); significantgain in tensile strength(P<0.01); appreciable increaseof tissue DNA, total protein, and collagenesis wereobserved in HPE treated group. CONCLUSION:Human placental extract systematically helps collagenesisleading to potent healing of wounds.

关键词：胎盘提取物伤口愈合动物疾病模型半数致死量

In-Situ Hydrothermal Synthesis of Bi–Bi2O2CO3 Heterojunction Photocatalyst with Enhanced Visible Light Photocatalytic Activity

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Nano-Micro Letters 2017年第2期9卷 58-67页

作者： Prasenjit Kar tuhin Kumar Maji Ramesh Nandi Peter Lemmens Samir Kumar Pal Department of Chemical Biological and Macromolecular Sciences S.N.Bose National Centre for Basic SciencesBlock JDSector ⅢSaltLakeKolkata 700106India Institute for Condensed Matter Physics TU BraunschweigMendelssohnstraße 338106 BrunswickGermany Laboratory for Emerging Nanometrology TU BraunschweigBrunswickGermany

Bismuth containing nanomaterials recently received increasing attention with respect to environmental applications because of their low cost, high stability and nontoxicity. In this work, Bi–Bi_2O_2CO_3 heterojunctions were fabricated by in-situ decoration of Bi nanoparticles on Bi_2O_2CO_3 nanosheets via a simple hydrothermal synthesis approach. X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM) and high-resolution TEM(HRTEM) were used to confirm the morphology of the nanosheet-like heterostructure of the Bi–Bi_2O_2CO_3 composite. Detailed ultrafast electronic spectroscopy reveals that the in-situ decoration of Bi nanoparticles on Bi_2O_2CO_3 nanosheets exhibit a dramatically enhanced electron-hole pair separation rate, which results in an extraordinarily high photocatalytic activity for the degradation of a model organic dye, methylene blue(MB) under visible light illumination. Cycling experiments revealed a good photochemical stability of the Bi–Bi_2O_2CO_3 heterojunction under repeated irradiation. Photocurrent measurements further indicated that the heterojunction incredibly enhanced the charge generation and suppressed the charge recombination of photogenerated electron-hole pairs.

关键词： Bi nanoparticles Bi–Bi2O2CO3 nanosheets Heterojunction Hydrothermal method Charge separation Visible light photocatalytic activity

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Pollen Morphology of Indian Species of Saraca L.(Leguminosae)-A Threatened and Legendary Medicinal Tree

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Phyton-International Journal of Experimental Botany 2019年第3期88卷 295-315页

作者： Sujit Sil Tanmoy Mallick tuhin Pal Animesh Mondal Kalyan Kumar De Asok Ghosh Postgraduate Department of Botany Hooghly Muhammad Mohsin College(Estd.1836)Chinsurah712101HooghlyWest BengalIndia UGC-CAS Department of Botany Taxonomy of Angiosperms and Biosystematics LaboratoryUniversity of BurdwanGolapbagBurdwan713104West BengalIndia

The genus Saraca L.(Leguminosae)is a universal panacea in herbal *** present study investigates the comparative pollen morphology of four species of Saraca ***(Roxb.)de Wilde,***(Jack)Miq.,*** L.,and *** Cantley ex Prain growing in India to reveal differences of their pollen structures to aid taxonomic and evolutionary *** detailed morphology and surface structure of pollen grains were studied and described using light microscopy and scanning electron *** pollen grains of Saraca showed isopolar,para-syncolporate,tricolporate,with radially symmetric,prolate and prolate-spheroidal *** surface of pollen of *** is rugulate with large lirae but in ***,the surface is micro-rugulate to vermiculate with relatively thin lirae and that of *** is indistinct as the psilate surface with a frequent protuberance and fewer perforations were observed along with the gemmae like *** ornamentation helped to separate *** and *** thickness varies from 3-4μ*** of protuberance and exine thickness varies among individuals of the species spread over different *** work also provides a unique palynological identity and interrelationship of these four species based on cluster analysis taking 23 pollen characters with the help of statistical method like the plotting of ternary *** plots also helped to calculate the level of plasticity of each character in the intra-and inter-specific level.

关键词： Cluster analysis palynology SEM study surface ornamentation ternary graph