检索结果-南通市图书馆

Transfer of single dose of intravitreal injection of ranibizumab and bevacizumab into milk of sheep

International Journal of Ophthalmology(English edition) 2017年第7期10卷 1069-1075页

作者： tugba cakmak argun Ozlem Yalcin Tok Levent Tok Gulsen Yilmaz Fatma Meric Yilmaz Alime Gunes Mehmet argun Osman Butuner Department of Ophthalmology Hatay Dortyol State Hospital Faculty of Medicine Ophthalmology Suleyman Demirel University Ministry of Health Ankara HospitalBiochemistry Biochemistry Department Faculty of MedicineYildirim Beyazit University The Management of Veterinary Service

AIM： To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS： This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points. Serum and milk concentrations of bevacizumab and ranibizumab were measured using an enzyme-linked immunosorbent assay（ELISA） kit. The limit of determination was 0.9 ng/m L for bevacizumab and 0.62 ng/m L for ***： At 6h after intravitreal injections, bevacizumab concentration was above the limit of determination in the blood of all sheep. At 3wk, when the study was terminated, bevacizumab concentrations were high in 4 sheep. Even though bevacizumab concentrations in milk showed fluctuations, the drug transferred into the milk of all sheep at detectable concentrations. Ranibizumab drug concentrations in the blood and milk of sheep and those in the blood of lambs were below the limit of determination by the ELISA ***： This sheep model study demonstrate that intravitreal injection of ranibizumab, which did not transfer into the milk of sheep and suckling lambs, is safer than bevacizumab during lactation period.

关键词： bevacizumab ranibizumab lactation milk vascular endothelial growth factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment

引用

International Journal of Ophthalmology(English edition) 2015年第5期8卷 938-944页

作者： Ozlem Yalcin Tok Levent Tok Inci Meltem Atay tugba cakmak argun Nazire Demirci Alime Gunes Department of Ophthalmology Süleyman Demirel University Research and Education Hospital Department of Psychiatry Süleyman Demirel University Research and Education Hospital

AIMTo evaluate the clinical findings of toxic keratopathy associated with abuse of topical anesthetics and the treatment efficacy of amniotic membrane transplantation (AMT).METHODSFifteen eyes of 10 patients with abuse of topical anesthetics were included in this study. The data collected included patients' demographic information, initial best corrected visual acuity (BCVA), clinical findings, time to AMT, duration of epithelization, additional treatments, posttreatment BCVA, and the results of psychiatric *** patients were male, with the mean age of 37.9±5.4y. The patients had received 0.5% proparacaine hydrochloride due to pain resulting from foreign bodies, such as welding flash burns and car battery explosions, for a mean of 18.2±12.4d. The mean initial BCVA of the patients was 0.069±0.100. All patients had persistent epithelial defects, stromal infiltration, ring ulcer, and corneal edema. Initially, medical treatment was attempted in all cases. Because of severe pain, persistent epithelial defects and progressing stromal thinning did not improve with medical treatment, thus, the patients underwent AMT. The mean posttreatment BCVA of the patients was 0.33±0.27. All of them, except for two patients, showed improved visual acuity. One patient underwent evisceration for corneal melting and endophthalmitis in another center, and one patient underwent evisceration for severe pain of unknown origin. All 5 patients who consented to a psychiatric examination had depression, had personality disorder, and used *** appears to be an effective method for pain relief, rapid epithelial and stromal healing; however, visual prognosis is still poor despite medical and surgical interventions.

关键词： amniotic membrane transplantation ring stromal infiltration topical anesthetic abuse toxic keratopathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long term diazotrophic cultivation induces phycobiliprotein production in Anabaena variabilis IMU8

引用

BIOCELL 2019年第4期43卷 327-333页

作者： MOHAMMED FADHIL HADDAD tugba DAYIOGLU BARBAROS NALBANTOGLU TURGAY cakmak Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesIstanbul Medeniyet University34730IstanbulTurkey Department of Chemistry Faculty of Arts and SciencesYildiz Technical University34220IstanbulTurkey Mosul Technical Institute Northern Technical University41002MosulIraq

Cyanobacteria are considered as a sustainable feedstock for the production of biochemically active compounds such as phycobiliproteins(PBPs).In this study,the impact of nitrogen(N)and phosphorus(P)availability on PBP production of“N-free acclimated”Anabaena variabilis IMU8 was *** isolation and identification,the cyanobacterium has been maintained in N-free BG-11 medium for more than 20 *** experimentation,the strain was incubated in N-replete,N-depleted,N-P-depleted BG-11 ***-term diazotrophic cultivation of *** IMU8 resulted in elevated PBP productivity with a limited impact on *** compared to N-depleted ones,N supply stimulated a slight induction of growth and total saccharide production,but total protein content did not change while PBP production *** the other hand,N-P-depletion resulted in decreased growth rate along with reduced total protein and PBP production while rapid induction of total saccharide production was *** transform infrared spectroscopy results refer that membrane-bound oligosaccharides may have regulatory roles for PBP production in *** IMU8 during long term diazotrophic cultivation.

关键词： Cyanobacteria Nitrogen Phosphorus Phycobiliprotein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of early results of quick-chop phacoemulsification in the patients with high myopic cataract

引用

International Journal of Ophthalmology(English edition) 2014年第5期7卷 828-831页

作者： Ali Akal tugba Goncu Sevin Soker cakmak Isa Yuvaci Mustafa Atas Süleyman Demircan Omer Faruk Yilmaz Department of Ophthalmology School of MedicineHarran University Department of Ophthalmology Kayseri Training and Research Hospital

AIM:To assess the early surgical outcomes of quickchop phacoemulsification technique in patients with high ***:The data of patients with high myopia who underwent quick-chop phacoemulsification were reviewed retrospectively. There were 42 eyes of 31 patients. The axial length was more than 26 mm in all eyes. All eyes underwent quick-chop phacoemulsification surgery with the placement of an intraocular lens(IOL) in the capsular bag. Postoperative visits were performed at 1, 3d; 2wk,1mo. Early postoperative best corrected visual acuity(BCVA), preoperative and postoperative corneal endothelial cell density(ECD), central corneal thickness(CCT) and postoperative complications were *** sample t-test or Wilcoxon tests were used to compare data between preoperative and postoperative data.· RESULTS:There was no statistically significant difference between preoperative and postoperative ECD and CCT. Retinal detachment was developed in one eye at postoperative first day. There was an iris prolapsus from side port insicion.· CONCLUSION:Quick-chop phacoemulsification technique is a safe surgical technique. However we can encounter some complications in high myopic eyes due to histopathological differences. Both side port and clear corneal tunnel insicion size is crucial for preventing postoperative complications. If any persistent leakage is noticed, suture should be placed.

关键词： high myopia cataract quick-chop phacoemulsification intraocular lens

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：