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Primary gastroduodenal tuberculosis presenting as gastric outlet obstruction:A case report and review of literature

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World Journal of Clinical Cases 2024年第8期12卷 1536-1543页

作者： Abdihamid Mohamed Ali Yahye Garad Mohamed Abdirahman Ahmed Mohamud Abdulkadir Nor Mohamed Mohamed Rage Ahmed Ismail Mohamud Abdullahi tuba Saydam Department of General Surgery Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research HospitalMogadishu 2526Somalia Department of Radiology Mogadishu Somali TurkeyTraining and Research HospitalMogadishu 2526Somalia Department of Pathology Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research HospitalMogadishu 2526Somalia

BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous *** disease is prevalent in low-income countries,posing a significant global health *** TB is one of the three *** disease can mimic other intra-abdominal conditions,leading to delayed diagnosis owing to the absence of specific *** gastric outlet obs-truction(GOO)remains a frequent complication,its incidence has declined with the advent of proton pump inhibitors and Helicobacter pylori eradication *** TB can cause upper gastrointestinal hemorrhage,obstruction,and malignancy-like *** SUMMARY A 23-year-old male presented with recurrent epigastric pain,distension,nausea,vomiting,and weight loss,prompting a referral to a gastroenterologist *** examination revealed distorted gastric mucosa and signs of chronic ***,treatment was interrupted,possibly owing to vomiting or comorbidities such as human immunodeficiency virus infection or *** surgical intervention revealed a dilated stomach and diffuse thickening of the duodenal *** revealed gastric wall effacement with *** Primary gastric TB is rare,frequently leading to *** its rarity,suspicions should be promptly raised when encountering relevant symptoms,often requiring surgical intervention for diagnosis and treatment.

关键词： Tuberculosis Gastrointestinal tuberculosis Gastric outlet obstruction Gastroduodenal tuberculosis Case report

Intrinsic Bio-Enhancer Entities of <i>Fagonia cretica</i>for Synthesis of Silver Nanoparticles Involves Anti-Urease, Anti-Oxidant and Anti-Tyosinase Activity

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Advances in Bioscience and Biotechnology 2019年第12期10卷 455-468页

作者： Aqsa Yousaf Ayesha Zafar Muhammad Ali Snober Mona Bukhary Yasmeen Manzoor tuba tariq Asma Saeed Muhammad Akram Faryal Bukhari Muhammad Abdullah Syeda Sadaf Zehra Shahbaz Gul Hassan Murtaza Hasan Department of Biochemistry and Biotechnology The Islamia University Bahawalpur Pakistan Department of Biological Sciences Gomal University Dera Ismail Khan Pakistan Department of Chemistry The Islamia University Bahawalpur Pakistan Cholistan Institute of Desert Studies (CIDS) The Islamia University Bahawalpur Pakistan Department of Botany The Islamia University Bahawalpur Pakistan College of Information Science and Engineering Zhongkai University of Agriculture and Engineering Guangzhou China

Objective: Evaluating the bio-reducing activity and various potential, annotates the biological entitties of Fagonia cretica. Method: By fractionating the crude extract with different ethanol-water fraction mixture. This substantiates the reduction potential for the biological synthesis of AgNPs, its antioxidant, anti-urease and anti-Tyrosinase activity. Results: UV-visible spectra confirm the bio-reducing potential for Ag NPs with the optimized 50% ethanol-water fraction mixture. Transmission electron microscopy (TEM) confirmed the round shaped AgNPs with an average size of 16 nm in optimized 50% fraction mixture. Further evaluating Ethanol-water fraction with 90% and 70% of plant extract showed more potentials for Anti-Tyrosinase and Anti-urease activity. Moreover, diluted 30% fraction exhibits two folds higher Anti-oxidant and Anti urease activity. Conclusion: Overall, this work showed that 50% Ethanol-water fraction has potentially active molecules (among all fractions) primarily involved in bio-reducing potential of Ag NPs and enzymatic assay while 90% mixture proved to be least active. This study suggested electing the optimum mixture fraction of 50% ethanol-water in order to screen the bioactive compounds and to inculcate their activity status for clinical trials.

关键词： Bioactivity Fagonia cretica Nanoparticles Enzymes Assay Bio Reducing Agent

Neural stem cells for Parkinson’s disease management:Challenges,nanobased support,and prospects

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World Journal of Stem Cells 2023年第7期15卷 687-700页

作者： tuba Oz Ajeet Kaushik Małgorzata Kujawska Department of Toxicology Poznan University of Medical SciencesPoznan 60-631Poland NanoBioTech Laboratory Health System EngineeringDepartment of Environmental EngineeringFlorida Polytechnic UniversityLakelandFL 33805United States School of Engineering University of Petroleum and Energy StudiesDehradun 248007India

Parkinson’s disease(PD),characterized by loss of nigrostriatal dopaminergic neurons,is one of the most predominant neurodegenerative diseases affecting the elderly population *** concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly *** stem cells(NSCs)have a few key features,including selfrenewal,proliferation,and multipotency,which make them a promising agent targeting *** is generally agreed that challenges for NSC-based therapy are present at every stage of the transplantation process,including preoperative cell preparation and quality control,perioperative procedures,and postoperative graft preservation,adherence,and overall therapy *** this review,we provided a comprehensive,careful,and critical discussion of experimental and clinical data alongside the pros and cons of NSC-based therapy in *** the state-of-the-art accomplishments of stem cell therapy,gene therapy,and nanotechnology,we shed light on the perspective of complementing the advantages of each process by developing nano-stem cell therapy,which is currently a research *** various obstacles and challenges remain,nano-stem cell therapy holds promise to cure PD,however,continuous improvement and development from the stage of laboratory experiments to the clinical application are necessary.

关键词： Parkinson’s disease Synuclein Neural stem cells Nanomaterials Nano-stem cell therapy

Technology-based psychosocial support for adolescent survivors of leukemia:An example intervention for nurse specialists

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Journal of Integrative Nursing 2022年第3期4卷 157-165页

作者： tuba ARPACİ Naime ALTAY Department of Nursing Faculty of Health SciencesKaramanoglu Mehmetbey UniversityKaramanTurkey Department of Nursing Faculty of Health SciencesGazi University AnkaraTurkey

Technology-based interventions are thought to be one of the innovative alternatives for improving the psychosocial health of adolescent *** article outlines an example of technology-based psychosocial intervention for adolescent survivors of *** technology-based psychosocial support intervention consists of five separate modules related to personal development,coping skills,and a healthy *** can be applied to adolescents(aged 12-18 years)who have completed leukemia treatment at least 2 years ago and are disease *** interventions are crucial to improving adolescent survivors’psychosocial well-being in long-term *** is thought that psychosocial interventions can be effective on survivors’self-efficacy,coping skills,and quality of life,and survivors will be satisfied with the *** the model of childhood cancer survivorship care,this intervention can be integrated into the follow-up program and guide pediatric oncology nurses in preparing support programs for adolescent survivors.

关键词： Adolescents leukemia long-term follow-up nursing psychosocial support survivors technology

On ideal convergence of double sequences in 2-fuzzy n-normed linear space

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Applied Mathematics(A Journal of Chinese Universities) 2022年第2期37卷 177-186页

作者： Vakeel A.Khan Sameera A.A.Abdullah Kamal M.A.S.Alshlool Umme tuba Nazneen Khan Department of Mathematics Aligarh Muslim UniversityAligarh 202002India Department of Mathematics Sultan Qaboos UniversityMuscatOman

The purpose of this paper is to define the notions of convergence, Cauchy st–convergence, st–Cauchy, I –convergence and I –Cauchy for double sequences in 2–fuzzy n–normed spaces with respect to α–n–norms and ... 详细信息

关键词： 2-fuzzy n-normed spaces -n-norm I-convergence I-Cauchy

Corrosion Behavior ofAg-doped TiO2 Coatings on Commercially Pure Tita- nium in Simulated Body Fluid Solution

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Journal of Bionic Engineering 2016年第3期13卷 397-405页

作者： tuba Yetim Department of Chemical Engineering Faculty of Engineering and Architecture Erzurum Technical University Erzurum 25100 Turkey

TiO2 films including different amounts of Ag obtained by sol-gel method on commercially pure titanium （CP-Ti） and the corrosion properties of Ag-doped TiO2 films were investigated by potentiodynamic polarisation and Electrochemical ImpedanceSpectroscopy （EIS） tests in Simulated Body Fluid （SBF） solution. The results were compared with untreated and un-doped samples. Surface characterizations before and after the corrosion tests were performed by the Scanning Electron Microscopy （SEM） and X-ray Diffraction （XRD） analysis. It was observed that Ag-doping for TiO2 films improved the corrosion resistance when compared with untreated and un-doped TiO2 film coated samples. The highest corrosion resistance was obtained from Ag-doped samples coated with a solution of 0.05 M Ag.

关键词： TiO2 coating Ag-doping corrosion CP-Titanium simulated body fluid

Thermodynamics of Stability Constant of Binary Complex of Nicotinamide with Mn^(++)

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Chinese Chemical Letters 2003年第11期14卷 1207-1210页

作者： tuba SISMANOGLU Istanbul University Engineering Faculty Department of Chemistry34850Avcilar-IstanbulTurkey

The stability constants of the binary complexes of Mn2+ with nicotinamide (NA) were determined from potentiometric pH titrations data at 15.0 , 25.0 and 35.0oC and I = 0.1,0.2,0.4 mol L-1 (NaClO4). The formation of binary 1:1 , 1:2 NA-Mn complexes at three different temperatures and the influence of three different ionic strength on their stability were reported. The thermodynamic parameters (DGof, DSof, DHof) for the complex formation reaction were estimated from stability constant at different temperatures.

关键词： Nicotinamide stability constant binary complexes.

Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene:A case report

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世界临床病例杂志 2023年第26期11卷 6176-6182页

作者： Ugur Musabak tuba Erdoğan Serdar Ceylaner EmreÖzbek Nuretdin Suna Binnaz HandanÖzdemir Department of Immunology and Allergy Baskent University School of MedicineAnkara 06490AnkaraTurkey Department of Medical Genetics Lokman Hekim UniversityAnkara 06000Turkey Department of Medical Genetics Intergen Genetic and Rare Disease Diagnosis and Reseach CenterAnkara 06000Turkey Department of Immunology-Allergy Etlik City HospitalAnkara 06490AnkaraTurkey Division of Gastroenterology Baskent University School of MedicineAnkara 06000Turkey Department of Pathology Baskent UniversityAnkara 06000Turkey

BACKGROUND Cytotoxic T Lymphocyte Antigen-4(CTLA4)deficiency is a genetic defect that causes a common variable immunodeficiency(CVID)clinical *** studies have reported an association between CTLA mutations or variants and various autoimmune *** therapy models,which have become increasingly popular in recent years,have been successful in treating CTLA4 *** this article,we discuss the clinical outcomes of abatacept treatment in a patient with CTLA4 and lipopolysaccharide-responsive beige-like anchor(LRBA)variants that was previously diagnosed with *** SUMMARY A 25-year-old female patient,who was visibly cachectic,visited our clinic over the course of five years,complaining of *** patient was diagnosed with ulcerative colitis in the centers she had visited previously,and various treatments were administered;however,clinical improvement could not be *** hypokalemia was detected during an *** serum immunoglobulin levels,CD19+B-cell percentage,and CD4/CD8 ratio were *** endoscopic examination revealed erosive gastritis,nodular duodenitis,and *** findings supported the presence of immune mediated *** the patient was examined carefully,she was diagnosed with CVID,and intravenous immunoglobulin treatment was *** and rectal therapeutic drugs including steroid therapy episodes were administered to treat the immune mediated *** follow-ups and treatment were performed due to the *** conducting genetic analyses,the CTLA4 and LRBA variants were identified and abatacept treatment was *** targeted therapy,the patient’s clinical and laboratory findings rapidly regressed,and there was an increase in *** The heterozygous CTLA4 variant identified in the patient has been previously shown to be associated with various autoimmune *** successful clinical outcome of abatacept treatment in this patien

关键词： Common variable immunodeficiency Abatacept CTLA4 antigen Case report

Actions of N-acetylcysteine,daptomycin,vancomycin,and linezolid on methicillin-resistant Staphylococcus aureus biofilms in the ventriculoperitoneal shunt infections:an experimental study

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Chinese Neurosurgical Journal 2022年第4期8卷 239-247页

作者： tuba Kuruoglu Gamze Altun Enis Kuruoglu Derya BayırlıTuran Mehmet EminÖnger Department of Infectious Diseases and Clinical Microbiology Medical FacultyOndokuz Mayıs UniversitySamsunTurkey Department of Histology and Embryology Medical FacultyOndokuz Mayıs University55139 SamsunTurkey Department of Neurosurgery Medical FacultyOndokuz Mayıs UniversitySamsunTurkey Department of Infectious Diseases and Clinical Microbiology School of MedicineYeni Yuzyil UniversityIstanbulTurkey Department of Neuroscience Health Science InstituteOndokuz Mayıs UniversitySamsunTurkey

Background:Shunt systems are used to provide cerebrospinal fluid drainage in the treatment of ***,antibiotic-impregnated shunt systems are used to prevent colonization in the ventriculoperitoneal ***-resistant Staphylococcus aureus(MRSA)is the most common causative microorganism of shunt *** aim of the study is to investigate effects of several substances on MRSA biofilms in the ventriculoperitoneal ***:The present study consists of mainly eight groups(each has two subgroups as antibiotic-impregnated and nonantibiotic-impregnated catheters).In addition,each group contains six molds using MRSA *** this study,daptomycin(DAPT)(2 mg/ml),vancomycin(VAN)(10 mg/ml),linezolid(LIN)(2 mg/ml),N-acetylcysteine(NAC)(6 mg/ml),and various combinations of these substances were used to evaluate the treatment against MRSA using scanning electron microscope(SEM)images and microbiological ***:The colony count in the antibiotic-impregnated samples significantly decreased compared to nonantibiotic-impregnated samples in the MRSA,MRSA+DAPT,and MRSA+LIN groups(p<0.01),***,the colony count in antibiotic-impregnated samples significantly increased compared to nonantibiotic-impregnated samples in NAC+DAPT and NAC+VAN groups(p<0.01),***:The results showed that the use of antibiotic-impregnated catheters has a significant impact on the prevention of infection whereas the combination of NAC and DAPT showed better antibiofilm and antibacterial effects than other combinations on the prevention and treatment of nonantibiotic-impregnated catheter infections.

关键词： Methicillin-resistant Biofilm Antibiotic-impregnated catheters Scanning electron microscope