Actions of N-acetylcysteine,daptomycin,vancomycin,and linezolid on methicillin-resistant Staphylococcus aureus biofilms in the ventriculoperitoneal shunt infections:an experimental study

作     者：Tuba Kuruoglu Gamze Altun Enis Kuruoglu Derya BayırlıTuran Mehmet EminÖnger 

作者机构：Department of Infectious Diseases and Clinical MicrobiologyMedical FacultyOndokuz Mayıs UniversitySamsunTurkey Department of Histology and EmbryologyMedical FacultyOndokuz Mayıs University55139 SamsunTurkey Department of NeurosurgeryMedical FacultyOndokuz Mayıs UniversitySamsunTurkey Department of Infectious Diseases and Clinical MicrobiologySchool of MedicineYeni Yuzyil UniversityIstanbulTurkey Department of NeuroscienceHealth Science InstituteOndokuz Mayıs UniversitySamsunTurkey 

出 版 物：《Chinese Neurosurgical Journal》 (中华神经外科杂志（英文）)

年 卷 期：2022年第8卷第4期

页      面：239-247页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100204[医学-神经病学] 10[医学] 

主　　题：Methicillin-resistant Biofilm Antibiotic-impregnated catheters Scanning electron microscope 

摘      要：Background:Shunt systems are used to provide cerebrospinal fluid drainage in the treatment of ***,antibiotic-impregnated shunt systems are used to prevent colonization in the ventriculoperitoneal ***-resistant Staphylococcus aureus(MRSA)is the most common causative microorganism of shunt *** aim of the study is to investigate effects of several substances on MRSA biofilms in the ventriculoperitoneal ***:The present study consists of mainly eight groups(each has two subgroups as antibiotic-impregnated and nonantibiotic-impregnated catheters).In addition,each group contains six molds using MRSA *** this study,daptomycin(DAPT)(2 mg/ml),vancomycin(VAN)(10 mg/ml),linezolid(LIN)(2 mg/ml),N-acetylcysteine(NAC)(6 mg/ml),and various combinations of these substances were used to evaluate the treatment against MRSA using scanning electron microscope(SEM)images and microbiological ***:The colony count in the antibiotic-impregnated samples significantly decreased compared to nonantibiotic-impregnated samples in the MRSA,MRSA+DAPT,and MRSA+LIN groups(p0.01),***,the colony count in antibiotic-impregnated samples significantly increased compared to nonantibiotic-impregnated samples in NAC+DAPT and NAC+VAN groups(p0.01),***:The results showed that the use of antibiotic-impregnated catheters has a significant impact on the prevention of infection whereas the combination of NAC and DAPT showed better antibiofilm and antibacterial effects than other combinations on the prevention and treatment of nonantibiotic-impregnated catheter infections.