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Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

Bone Research 2018年第2期6卷 177-188页

作者： Shan-Shan Rao Yin Hu Ping-Li Xie Jia Cao Zhen-Xing Wang Jiang-Hua Liu Hao Yin Jie Huang Yi-Juan Tan Juan Luo Ming-Jie Luo Si-Yuan Tang tuan-hui chen Ling-Qing Yuan Er-Yuan Liao Ran Xu Zheng-Zhao Liu Chun-Yuan chen hui Xie Movement System Injury and Repair Research Center Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Spine Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Forensic Science School of Basic Medical SciencesCentral South UniversityChangshaHunan 410013China Xiangya Nursing School Central South UniversityChangshaHunan 410013China Second Xiangya Hospital Central South UniversityChangshaHunan 410011China Hunan Key Laboratory of Organ Injury Aging and Regenerative MedicineChangshahunan 410008China Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China China Orthopedic Regenerative Medicine Group(CORMed) ChangshaHunanChina

Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout（omentin-1^-/-） mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α（TNF-α）, we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines.

关键词： TNF Omentin-1 prevents inflammation-induced osteoporosis downregulating pro-inflammatory cytokines RANKL

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Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

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Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-hui chen Ai-hui Tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate

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Generic Existence of Infinitely Many Non-contractible Closed Geodesics on Compact Space Forms

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1674-1684页

作者： hui Liu Yu chen Wang School of Mathematics and Statistics Wuhan UniversityWuhan430072P.R.China School of Mathematics Tianjin Normal UniversityTianjin300384P.R.China

Let M=S^(n)/Γand h be a nontrivial element of finite order p inπ_(1)(Μ),where the integers n,p≥2,Γis a finite abelian group which acts freely and isometrically on the n-sphere and therefore M is diffeomorphic to a compact space *** this paper,we prove that there are infinitely many non-contractible closed geodesics of class[h]on the compact space form with C^(r)-generic Finsler metrics,where 4≤r≤∞.The conclusion also holds for Cr-generic Riemannian metrics for 2≤r≤∞.The proof is based on the resonance identity of non-contractible closed geodesics on compact space forms.

关键词： Compact space forms non-contractible closed geodesics generic Finsler metrics resonance identity

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Estimation of tunnel axial orientation in the interlayered rock mass using a comprehensive algorithm

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2579-2590页

作者： hui Li Weizhong chen Xianjun Tan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The axial selection of tunnels constructed in the interlayered soft-hard rock mass affects the stability and safety during *** optimization is primarily based on experience or comparison and selection of alternative values under specific geological *** this work,an intelligent optimization framework has been proposed by combining numerical analysis,machine learning(ML)and optimization *** automatic and intelligent numerical analysis process was proposed and coded to reduce redundant manual *** conventional optimization algorithm was developed from two aspects and applied to the hyperparameters estimation of the support vector machine(SVM)model and the axial orientation optimization of the ***,the comprehensive framework was applied to a numerical case study,and the results were compared with those of other *** results of this study indicate that the determination coefficients between the predicted and the numerical stability evaluation indices(STIs)on the training and testing datasets are 0.998 and 0.997,*** a given geological condition,the STI that changes with the axial orientation shows the trend of first decreasing and then increasing,and the optimal tunnel axial orientation is estimated to be 87.This method provides an alternative and quick approach to the overall design of the tunnels.

关键词： Tunnel Building information modeling Design optimization Particle swarm optimization Support vector machine(SVM)

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Metal-organic-framework-derived copper-based catalyst for multicomponent C-S coupling reaction

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Chinese Journal of Chemical Engineering 2024年第6期70卷 1-8页

作者： Lixin chen hui Zhang Linxi Hou Xin Ge Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Department of Materials-Oriented Chemical Engineering School of Chemical EngineeringFuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China

Copper-based metal-organic frameworks(Cu-MOFs)are a promising multiphase catalyst for catalyzing C-S coupling reactions by virtue of their diverse structures and ***,the unpleasant odor and instability of the organosulfur,as well as the mass-transfer resistance that exists in multiphase catalysis,have often limited the catalytic application of Cu-MOFs in C-S coupling *** this paper,a Cu-MOFs catalyst modified by cetyltrimethylammonium bromide(CTAB)was designed to enhance mass transfer by increasing the adsorption of organic substrates using the long alkanes of ***,elemental sulfur was used to replace organosulfur to achieve a highly efficient and atom-economical multicomponent C-S coupling reaction.

关键词： Design Copper-based metal-organic frameworks (Cu-MOFs) Adsorption C-S coupling reaction Multiphase reaction

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Adaptive composite anti-disturbance control for heavy haul trains

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Transportation Safety and Environment 2024年第1期6卷 75-82页

作者： Longsheng chen hui Yang School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang 33013JiangxiChina School of Aircraft Engineering Nanchang Hangkong UniversityNanchang 330063JiangxiChina

In this paper,an adaptive composite anti-disturbance control of heavy haul trains(HHTs)is ***,the mechanical principle and characteristics of couplers are analysed and the longitudinal multi-particles nonlinear dynamic model of HHTs is established,which can satisfy that the forces of vehicles in different positions are ***,a radial basis function network(RBFNN)is employed to approximate the uncertainties of HHTs,and a nonlinear disturbance observer(NDO)is constructed to estimate the approximation error and external *** indicate and improve the approximation accuracy,a serial-parallel identification model of HHTs is constructed to generate a prediction error,and an adaptive composite anti-disturbance control scheme is developed,where the prediction error and tracking error are employed to update RBFNN weights and an auxiliary variable of ***,the feasibility and effectiveness of the proposed control scheme are demonstrated through the Lyapunov theory and simulation experiments.

关键词： heavy haul train(HHT) radial basis function neural network nonlinear disturbance observer(NDO) serial-parallel identification model composite anti-disturbance control

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Aircraft parameter estimation using a stacked long short-term memory network and Levenberg-Marquardt method

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Chinese Journal of Aeronautics 2024年第2期37卷 123-136页

作者： Zhe hui Yinan KONG Weigang YAO Gang chen School of Aerospace Science and Technology Xidian UniversityXi’an 710071China Computation Aerodynamics Institution China Aerodynamics Research and Development CenterMianyang 621000China Faculty of Computing Engineering and MediaDe Montfort UniversityLeicester LE19BHUnited Kingdom School of Aerospace Engineering Xi’an Jiaotong UniversityXi’an 710049China

To effectively estimate the unknown aerodynamic parameters from the aircraft’s flight data,this paper proposes a novel aerodynamic parameter estimation method incorporating a stacked Long Short-Term Memory(LSTM)network model and the Levenberg-Marquardt(LM)*** stacked LSTM network model was designed to realize the aircraft dynamics modeling by utilizing a frame of nonlinear functional mapping based entirely on the measured input-output data of the aircraft system without requiring explicit postulation of the *** LM method combines the already-trained LSTM network model to optimize the unknown aerodynamic *** proposed method is applied by using the real flight data,generated by ATTAS aircraft and a bio-inspired morphing Unmanned Aerial Vehicle(UAV).The investigation reveals that for the two different flight data,the designed stacked LSTM network structure can maintain the efficacy of the network prediction capability only by appropriately adjusting the dropout rates of its hidden layers without changing other network parameters(i.e.,the initial weights,initial biases,number of hidden cells,time-steps,learning rate,and number of training iterations).Besides,the proposed method’s effectiveness and potential are demonstrated by comparing the estimated results of the ATTAS aircraft or the bio-inspired morphing UAV with the corresponding reference values or wind-tunnel results.

关键词： Parameter estimation LSTM network model LM method Aerodynamic parameters Flight data Aircraft dynamics modeling Network prediction capability Network parameters

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Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

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Bone Research 2019年第3期7卷 296-309页

作者： Chun-Yuan chen Shan-Shan Rao Yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao Yin Jie Huang Yin Hu Zhong-Wei Luo Zheng-Zhao Liu Zhen-Xing Wang Jia Cao Yi-Wei Liu Hong-Ming Li Yang chen Wei Du Jiang-Hua Liu Yan Zhang tuan-hui chen Hao-Ming Liu Ben Wu Tao Yue Yi-Yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang hui Xie Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China Xiangya School of Nursing Central South University Changsha Hunan 410013 China Department of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Rehabilitation Xiangya Hospital Central South University Changsha Hunan 410008 China Hunan Key Laboratory of Organ Injury Aging and Regenerative Medicine Changsha Hunan 410008 China Hunan Key Laboratory of Bone Joint Degeneration and Injury Changsha Hunan 410008 China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan 410008 China

Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.

关键词： stem cells USCs bone loss

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Complex interactions among insect viruses-insect vector-arboviruses

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Insect Science 2024年第3期31卷 683-693页

作者： hui Wang Qian chen Taiyun Wei State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Vector-borne Virus Research CenterFujian Agriculture and ForestryUniversityFuzhouChina

Insects are the host or vector of diverse viruses including those that infect vertebrates,plants,and *** viruses reside inside their insect hosts and are vertically transmitted from parent to *** insect virus-host relationship is intricate,as these viruses can impact various aspects of insect biology,such as development,reproduction,sex ratios,and ***-borne viruses(arboviruses)that cause substantial global health or agricultural problems can also be vertically transmitted to insect vector *** infections with insect viruses and arboviruses are common in *** coinfections involve complex interactions,including synergism,dependence,and *** studies have shed light on the influence of insect viruses on the competence of insect vectors for *** this review,we focus on the biological effects of insect viruses on the transmission of arboviruses by *** also discuss the potential mechanisms by which insect viruses affect the ability of hosts to transmit arboviruses,as well as potential strategies for disease control through manipulation of insect *** of the interactions among insect vectors,insect viruses and arboviruses will provide new opportunities for development of innovative strategies to control arbovirus transmission.

关键词： arbovirus insect biology insect vectors insect virus interaction transmission

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Preventing formation of intermetallic compounds in ultrasonic-assisted Sn soldering of Mg/Al alloys through pre-plating a Ni coating layer on the Mg substrate

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Journal of Magnesium and Alloys 2024年第2期12卷 726-741页

作者： Yingzong Liu Yuanxing Li hui chen Zongtao Zhu Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031PR China

Magnesium and aluminum alloys are widely used in various industries because of their excellent properties,and their reliable connection may increase application of *** compounds(IMCs)affect the joint performance of Mg/*** this study,AZ31 Mg alloy with/without a nickel(Ni)coating layer and 6061 Al alloy were joined by ultrasonic-assisted soldering with Sn-3.0Ag-0.5Cu(SAC)*** effects of the Ni coating layer on the microstructure and mechanical properties of Mg/Al joints were systematically *** Ni coating layer had a significant effect on formation of the Mg_(2)Sn IMC and the mechanical properties of Mg/Al *** blocky Mg_(2)Sn IMC formed in the Mg/SAC/Al joints without a Ni coating *** content of the Mg_(2)Sn IMC increased with increasing soldering temperature,but the joint strength *** joint without a Ni coating layer fractured at the blocky Mg_(2)Sn IMC in the solder,and the maximum shear strength was 32.2 *** pre-plating Ni on the Mg substrate,formation of the blocky Mg_(2)Sn IMC was inhibited in the soldering temperature range 240–280℃and the joint strength ***,when the soldering temperature increased to 310℃,the blocky Mg_(2)Sn IMC precipitated again in the *** electron microscopy showed that some nano-sized Mg_(2)Sn IMC and the(Cu,Ni)_(6)Sn_(5)phase formed in the Mg(Ni)/SAC/Al joint soldered at 280℃,indicating that the Ni coating layer could no longer prevent diffusion of Mg into the solder when the soldering temperature was higher than 280℃.The maximum shear strength of the Mg(Ni)/SAC/Al joint was 58.2 MPa for a soldering temperature of 280℃,which was 80.7%higher than that of the Mg/SAC/Al joint,and the joint was broken at the Mg(Ni)/SAC ***-plating Ni is a feasible way to inhibit formation of IMCs when joining dissimilar metals.

关键词： Ultrasonic-assisted soldering Mg_(2)Sn Ni coating layer Shear strength

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