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Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2230-2233页

作者： Yi Ching Esther Wan tsz chui sophia leung Dongbo Ding Xulun Sun Jiaxian Liu Lina Zhu Tze Zhen Evangeline Kang Du Yang Yuchen Zhang Jitian Zhang Chengmin Qian Michael Shing Yan Huen Qing Li Maggie Zi Ying Chow Zongli Zheng Junhong Han Ajay Goel Xin Wang Toyotaka Ishibashi Kui Ming Chan Department of Biomedical Sciences City University of Hong KongHong KongChina Key Laboratory of Biochip Technology Biotech and Health CentreShenzhen Research Institute of City University of Hong KongShenzhenChina Division of Life Science Hong Kong University of Science and TechnologyHong KongChina State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life SciencesPeking UniversityPekingChina School of Biomedical Sciences The University of Hong KongHong KongChina Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong KongChina State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan UniversitySichuanChina Department of Molecular Diagnostics and Experimental Therapeutics Beckman Research Institute at City of Hope Comprehensive Cancer CenterDuarteCAUSA

Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different *** H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 *** contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s).

关键词： Cancer clinical pediatric

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Structure and sequence analysis of influenza A virus nucleoprotein

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Science China(Life Sciences) 2009年第5期52卷 439-449页

作者： NG Andy Ka-leung SHAW Pang-chui Molecular Biotechnology Programme Department of Biochemistry and Centre for Protein Science and Crystallography The Chi-nese University of Hong Kong

Influenza A virus nucleoprotein (NP) forms homo-oligomers and multiple copies of NP wrap around genomic RNA, along with a trimeric polymerase making up ribonucleoprotein (RNP) complex. Sequence comparison of more than 2500 influenza A NP showed that this protein contains 30.1 % of polymorphic residues. NP is composed of a head and a body domain and a tail loop/ linker region. The head domain is more conserved than the body domain, as revealed from the structure-based sequence alignment. NP oligomerization is mediated by the insertion of the non-polymorphic and structurally conserved tail loop of one NP molecule to a groove of another NP. The different form of NP oligomers is due to the flexibility of the polymorphic linkers that join the tail loop to the rest of the protein. The RNA binding property of NP is known to involve the protruding element and the flexible basic loop between the head and body domains, both having high degree of primary sequence conservation. To bind RNA, NP may first capture the RNA by the flexible basic loop and then the RNA is clamped by the protruding element.

关键词： Influenza H5N1 nucleoprotein oligomerization RNA binding

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污水中新型冠状病毒监测技术的进展与启示

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科学通报 2024年第3期69卷 362-369页

作者：邓妤徐晓庆郑夏婉梁卓伟徐浩光李迎慧扈庆华杨敏黄霞唐宋张岚张彤香港大学土木工程系环境工程研究中心环境微生物组工程与技术实验室中国香港999077 香港大学李嘉诚医学院公共卫生学院中国香港999077 香港特别行政区政府环境保护署中国香港999077 深圳市疾病预防控制中心深圳518055 中国科学院生态环境研究中心北京100085 清华大学环境学院北京100084 中国疾病预防控制中心环境与健康相关产品安全所北京100021

污水流行病学的概念最早于2001年提出[1],最初是通过追踪污水中多种与人群健康和行为相关的化学与生物标记物,对使用毒品与非法药物的群体进行精准溯源[2],或是预警、跟踪和遏制传染病的暴发及其在社区中的传播[3].其中一个典型的应用... 详细信息

污水流行病学的概念最早于2001年提出[1],最初是通过追踪污水中多种与人群健康和行为相关的化学与生物标记物,对使用毒品与非法药物的群体进行精准溯源[2],或是预警、跟踪和遏制传染病的暴发及其在社区中的传播[3].其中一个典型的应用实例是2013年以色列在常规污水监测中发现了被认为已经根除的脊髓灰质炎病毒,随即据此展开大规模疫苗接种从而成功避免了小儿麻痹症在当地的再次暴发.

关键词：脊髓灰质炎病毒生物标记物人群健康污水监测监测技术进展与启示暴发

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Crocodile blood supplementation protect svascular function in diabetic mice

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Food Production, Processing and Nutrition 2021年第1期3卷 283-295页

作者： chui Yiu Bamboo Chook Francis M.Chen Gary Tse Fung Ping leung Wing Tak Wong School of Life Sciences Faculty of ScienceThe Chinese University of Hong KongShatinNTHong Kong SAR State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina

Cardiovascular disease is a major cause of mortality in diabetic patients due to the heightened oxidative stress and pro-inflammatory state in vascular *** approaches targeting cardiovascular health for diabetic patients are urgently *** blood,an emerging dietary supplement,was suggested to have anti-oxidative and anti-inflammatory effects in vitro,which have yet to be proven in animal *** study thereby aimed to evaluate whether crocodile blood can protect vascular function in diabetic mice against oxidation and *** db/db mice and their counterparts db/m+mice were treated daily with crocodile blood soluble fraction(CBSF)or vehicle via oral gavage for 4 weeks before their aortae were harvested for endothelium-dependent relaxation(EDR)quantification using wire myograph,which is a well-established functional study for vascular function *** culture experiments culturing mouse aortae from C57BL/6 J mice with or without IL-1βand CBSF were done to evaluate the direct effect of CBSF on endothelial *** oxygen species(ROS)levels in mouse aortae were assessed by dihydroethidium(DHE)staining with inflammatory markers in endothelial cells quantified by quantitative polymerase chain reaction(qPCR).CBSF significantly improved deteriorated EDR in db/db diabetic mice through both diet supplementation and direct culture,with suppression of ROS level in mouse *** also maintained EDR and reduced ROS levels in mouse aortae against the presence of pro-inflammatory IL-1β.Under the pro-inflammatory state induced by IL-1β,gene expressions of inflammatory cytokines were downregulated,while the protective transcripts UCP2 and SIRT6 were upregulated in endothelial *** study suggests a novel beneficial effect of crocodile blood on vascular function in diabetic mice and that supplementation of diet with crocodile blood may act as a complementary approach to protect against vascular diseases through anti

关键词： Crocodile blood Diabetes mellitus Vascular endothelial function Anti-oxidative Anti-inflammatory

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Residues of Polychlorinated Biphenyls (PCBs) in Fish, Water and Sediment from Shing Mun River

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Biomedical and Environmental Sciences 1991年第4期4卷 399-408页

作者： V.W.D.chui T.C.CHAN S.Y.LAM-leung Department of Biology Hong Kong Baptist College 224 Waterloo Road Kowloon Hong KongDepartment of Biology Hong Kong Baptist College 224 Waterloo Road Kowloon Hong KongDepartment of Chemistry Hong Kong Baptist College 224 Waterloo Road Kowloon Hong Kong

The level and pattern of contamination by polychlorinated biphenyls (PCBs) were investigated in tilapia, Oreochromis mossambicus (Peters), sediment, and water from the Shing Mun River. The range of total PCBs was 12.9 ng/g to 181.6 ng/g wet weight in tilapia, 12.7 ng/g to 46.0 ng/g freeze-dried weight in sediment, and 3.8 ng/L to 13.6 ng/L in water. The effect of biomagnification was also observed, PCB concentrations increased from water to sediment to tilapia. PCB congeners occurred in such a way that lower chlorinated PCBs comprised a higher fraction of the total PCBs in water, sediment, and tilapia muscle, whereas higher chlorinated PCBs were more commonly found only in tilapia.

关键词： PCBs Residues of Polychlorinated Biphenyls Water and Sediment from Shing Mun River in Fish

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A WiFi-ZigBee Building Area Network Design of High Traffics AMI for Smart Grid

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Smart Grid and Renewable Energy 2012年第4期3卷 324-333页

作者： Hoi Yan Tung Kim Fung Tsang Hoi Ching Tung Veseline Rakocevic Kwok Tai chui Yat Wah leung 1Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of SEEM City University of Hong Kong Hong Kong China. School of Engineering & Mathematical Science City University London London UK

A WiFi-ZigBee hybrid BAN solution, namely WiZBAN, is proposed and implemented to cater for the development of high traffic AMI for smart grid application. It is important to highlight that the major challenge of WiZBAN is to handle the high density environment which results in heavy traffic loading and weak signal propagation. To overcome the captioned problem, Vertical Backbone Communication (VBC) and Horizontal Floor Communication (HFC) are defined for WiZBAN. The WiZBAN consists of WiZBAN Gateway (WiZGW), WiZBAN Meter Hub (WiZBAN) and WiZBAN In Home Display (WiZIHD) which caters for the smart grids services including smart metering and demand response. The WiZGW is the entrance of WiZBAN and connects WiZBAN to utilities. The WiZGW also teams up with WiZMH to enables VBC. On the other hand, WiZMH serves as the interception point of VBC and HFC. It interacts with smart meters and sets up the HFC together with WiZIHD to provide the user interface for end users. To shorten the transmission time, WiFi is adopted for VBC while ZigBee is applied to HCF to overcome the weak signal propagation. To investigate the performance of WiZBAN, a case study has been conducted based on an existing 23 floor residential building. From the measured and simulated results, the average round trip delay of demand response and smart metering are found to be 0.6 s and 9 s respectively.

关键词： Advance Metering Infrastructure Building Area Network WiFi ZigBee Delay

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Population-Based and Personalized Design of Total Knee Replacement Prosthesis for Additive Manufacturing Based on Chinese Anthropometric Data

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Engineering 2021年第3期7卷 386-394页

作者： C.S.chui K.S.leung J.Qin D.Shi P.Augat R.M.Y.Wong S.K.H.Chow X.Y.Huang C.Y.Chen Y.X.Lai P.S.H.Yung L.Qin W.H.Cheung Department of Orthcpaedics and Traumatology Faculty of MdicineThe Chinese University of Hong KongHong Kong 999077China Genter for Transiational Medicine Resarch and Development herzhet Institues of Advaned TechnologyChinese Academy of ScenesShenzhen 518055China Department of Orthopedirs and Traumatology Nanjing Drum Tower Hospital The Affiliated HospitalNanjing University Medial SchoolNanjing 210008China Institute for Biomechanics Berufgenos senschaftliche Unfallklinik MurnauMurnanu am Staffelsee 82418Cermany Instinute for Biomechanic Paracelsus Medical University SazburgSatzburg 5020Austria

At present,most total knee replacement(TKR)prostheses on the market are designed according to the sizes of ***,extensive studies have indicated that human anatomies differ among different ethnicities.A number of reports have indicated that Chinese TKR patients do not match with available *** this study,computed tomography(CT)images of 52 knees of Chinese men and women were used for anthropometric *** and geometric measurements were definedand used for correlation *** parameters from the measurement results were *** geometries of knees were measured as coordinates.A deformable three-dimensional(3D)knee modelbased on anatomical coordinates correlating with the identified key parameters was generated.A pros-thesis was then designed according to the analyzed *** matching analysis,bone resectionanalysis,and cadaveric trials were conducted and compared with commercial products to validate theproposed *** femoral component designed by this study resulted in the highest accuracy(rootmean square point-to-surface(RMS PS),(1.08±0.20)mm)and lowest amount of resected bone volume(27412mm^(3))in comparison with two commercial knee *** study suggests a new approachfor population-based patient-specific femoral prosthesis design With a single,easilty acquired dimen-sion-namely,epicondyle width(ECW)-as input,a patient-specific femoral prosthesis can be designed according to the analyzed measured data and manufactured by additive manufacturing(AM)***,the reconstructed femoral condylar surface was compared with the femoral condylar surfacein the original CT scanning data The average RMS PS distance of the reconstructed femoral condylar surface among all data was(1.10±0.18)mm,which is comparable to other statistical shape modeling methods using multiple radiographs as input *** is a need to develop an anthropometric-based knee prosthesis for the Chinese *** on

关键词： Additive manufacturing Population-based design Total knee replacement Knee prosthesis Anthropometric measurement

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Antenatal anxiety in the first trimester: Risk factors and effects on anxiety and depression in the third trimester and 6-week postpartum

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Open Journal of Psychiatry 2013年第3期3卷 301-310页

作者： chui Yi Chan Antoinette Marie Lee Siu Keung Lam Chin Peng Lee Kwok Yin leung Yee Woen Koh Catherine So Kum Tang Department of Obstetrics and Gynaecology LKS Faculty of Medicine The University of Hong Kong Hong Kong China Department of Obstetrics and Gynaecology Queen Elizabeth Hospital Hong Kong China Department of Psychiatry LKS Faculty of Medicine The University of Hong Kong Hong Kong China Department of Psychology National University of Singapore Singapore City Singapore

Objective: Anxiety is common among pregnant women. However, research attention in the area of reproductive mental health has mainly focused on postpartum depression in past decades. Given adverse outcomes of antenatal anxiety, there is an urgent need to fill the research gaps. The objectives of the present study were to determine the prevalence of antenatal anxiety symptoms and examine the risk factors and effects of anxiety symptoms in early pregnancy on anxiety and depressive symptoms in later pregnancy and early postpartum period. Methodology: A prospective longitudinal design with quantitative approach was adopted. A consecutive sample of 1470 Chinese pregnant women from hospitals in Hong Kong was invited to participate in the study and was assessed using standardized instruments on 3 time points including first and third trimesters of pregnancy and 6-week postpartum. Results: The results showed that 17.7% of pregnant women manifested anxiety symptoms in the first trimester of pregnancy. Single mothers, younger mothers, mothers who smoked before pregnancy and mothers who received low education level reported significantly higher levels of anxiety symptoms in the first trimester. Unwanted pregnancy, low self esteem, low marital satisfaction and perceived low social support were significant psychosocial risk factors for anxiety symptoms in the first trimester. Anxiety symptoms in the first trimester were independent predictors for anxiety symptoms in the third trimester ( QUOTE β = 0.26, t = 5.74, p < 0.001), however anxiety symptoms in the first trimester no longer significantly predicted anxiety and depressive symptoms in 6 weeks postpartum after adjusting for the effects of potential confounders. Discussions: The present study points to the need for greater research and clinical attention to antenatal anxiety given that antenatal anxiety is a prevalent problem and has serious impacts on maternal well-being. Such findings also contribute to the understanding of

关键词： Pregnancy Antenatal Anxiety Postpartum Anxiety and Depression

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Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

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Cancer Communications 2023年第8期43卷 951-955页

作者： Hoi-Hin Kwok Huiyu Li Jiashuang Yang Junyang Deng Nerissa chui-Mei Lee Timmy Wing-Kuk Au Alva Ko-Yung Sit Michael Kuan-Yew Hsin Stephanie Kwai-Yee Ma LydiaWai-Ting Cheung Luc Girard Junya Fujimoto Ignacio Ivan Wistuba Boning Gao John Dorrance Minna David Chi-leung Lam Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong SARP.R.China Nancy B.and Jake L.Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexasUSA Cardiothoracic Surgical Department Queen Mary HospitalHong Kong SARP.R.China School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARP.R.China Department of Translational Molecular Pathology Division of Pathology/Lab MedicineUniversity of Texas MD Anderson Cancer CenterHoustonTexasUSA

Dear Editor,Non-small cell lung carcinoma(NSCLC)accounts for more than 85%of all lung cancers[1].Lung adenocarcinomas(ADCs)arising from never-smokers have been frequently found to be associated with oncogenic driver mutations,including anaplastic lymphoma kinase(ALK)*** microtubule-associated protein-like 4(EML4)is the most common fusion partner of the ALK gene[2].Tyrosine kinase inhibitors(TKIs)are currently the first-line treatment for advanced EML4-ALKrearranged lung ADC.

关键词： lung adenocarcinoma Lung

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Icaritin Protects Cardiomyocytes from Oxidative Stress-induced Cell Injury Through Akt-Nrf2-HO-1 and Calcium Signaling Pathways

Icaritin Protects Cardiomyocytes from Oxidative Stress-induc...

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第十四届全国中药和天然药物学术研讨会

作者： Si Wan Lei Guozhen Cui Judy Yuet Wa Chan Sharon chui Wah Luk Ken Kwok Keung Chan Ronald Adolphus Li Liang Wang Gail B.Mahady George Pak Heng leung Simon Ming Yuen Lee University of Macau The University of Hong Kong University of Illinois at Chicago

＜正＞Icaritin,a prenylflavonoid isolated from Herbal Epimedii,is well known for its osteoplastic and anti-tumor ***,we aimed to investigate the protective effects of icaritin against oxidative stress-induced cell injury in H9c2 cardiomyocytes and human embryonic stem cells-derived cardiomyocytes（hESC-CMs）.We found that icaritin pretreatment significantly

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