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Effect of silica forms in rice husk ash on the properties of concrete

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 252-258页

作者： Le Anh-tuan Bui chun-tsun Chen Chao-lung Hwang Department of Construction Engineering Taiwan University of Science and Technology

The strength and durability properties of concrete with or without three types of rice husk ash （RHA）, namely, amorphous, partial crystalline, and crystalline RHA, were investigates. The three types of RHA were added into concrete at a 20% replacement level. Consequently, the pozzolanic reactivity of amorphous RHA was higher than that of partial crystalline and crystalline RHA. Concrete added with amorphous RHA showed excellent characteristics in its mechanical and durability properties. The results showed that the higher the amount of crystalline silica in RHA, the lower the concrete resistivity value became. When compared with each other, concretes with 20% of the ce- ment replaced with these types of RHA achieved similar ultrasonic pulse velocity values, but all were lower than that of the control concrete. The incorporation of these kinds of RHA significantly reduced chloride penetration. The results not only encourage the use of amorphous materials, they also support the application of crystalline or partial crystalline RHA as mineral and pozzolanic admixtures for cement.

关键词： rice husk ash silica concrete compressive strength durability waste management

Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho stacia tsun-tsun chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng Yiu-chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and Princess Margaret Hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

Comparison of systematic and combined biopsy for the detection of prostate cancer

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Asian Journal of Andrology 2024年第5期26卷 517-521页

作者： Jin-Lun Huang Da Huang tsun-tsun chun Chi Yao Yong-Le Zhan Xiao-Hao Ruan Terence chun-Ting Lai Chiu-Fung Tsang Karl-Ho Pang Ada Tsui-Lin Ng Dan-Feng Xu Brian Sze-Ho Ho Rong Na Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Division of Urology Department of SurgeryLKS Faculty of MedicineThe University of Hong KongHong KongChina Division of Urology Department of SurgeryQueen Mary HospitalHong KongChina

Systematic prostate biopsy has limitations,such as overdiagnosis of clinically insignificant prostate cancer and underdiagnosis of clinically significant prostate *** resonance imaging(MRI)-guided biopsy,a promising alternative,might improve diagnostic *** compare the cancer detection rates of systematic biopsy and combined biopsy(systematic biopsy plus MRI-targeted biopsy)in Asian men,we conducted a retrospective cohort study of men who underwent either systematic biopsy or combined biopsy at two medical centers(Queen Mary Hospital and Tung Wah Hospital,Hong Kong,China)from July 2015 to December *** statistics were calculated,and univariate and multivariate logistic regression analyses were *** primary and secondary outcomes were prostate cancer and clinically significant prostate cancer.A total of 1391 participants were *** overall prostate cancer detection rates did not significantly differ between the two groups(36.3%vs 36.6%,odds ratio[OR]=1.01,95%confidence interval[CI]:0.81-1.26,P=0.92).However,combined biopsy showed a significant advantage in detecting clinically significant prostate cancer(Gleason score≥3+4)in patients with a total serum prostate-specific antigen(tPSA)concentration of 2-10 ng ml−1(systematic vs combined:11.9%vs 17.5%,OR=1.58,95%CI:1.08-2.31,P=0.02).Specifically,in the transperineal biopsy subgroup,combined biopsy significantly outperformed systematic biopsy in the detection of clinically significant prostate cancer(systematic vs combined:12.6%vs 24.0%,OR=2.19,95%CI:1.21-3.97,P=0.01).These findings suggest that in patients with a tPSA concentration of 2-10 ng ml−1,MRI-targeted biopsy may be of greater predictive value than systematic biopsy in the detection of clinically significant prostate cancer.

关键词： clinically significant prostate cancer combined biopsy prostate cancer systematic biopsy transperineal biopsy

No Additional Cholesterol-Lowering Effect Observed in the Combined Treatment of Red Yeast Rice and Lactobacillus Casei in Hyperlipidemic Patients：A Double-Blind Randomized Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2017年第8期23卷 581-588页

作者： Chien-Ying Lee Min-Chien Yu Wu-tsun Perng chun-Che Lin Ming-Yung Lee Ya-Lan Chang Ya-Yun Lai Yi-Ching Lee Yu-Hsiang Kuan James Cheng-chung Wei Hung-Che Shih Institute of Medicine Chung Shan Medical University Taichung Taiwan 40201 China Department of Pharmacy Chung Shah Medical University Hospital Taichung Taiwan 40201 China Department of Pharmacology Chung Shan Medical University Taichung Taiwan 40201 China Department of Integrated Chinese and Western Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Recreation Sport & Health Promotion National Pingtung University of Science and Technology Taiwan 91201 China Division of Hepatogastroenterology Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Statistics and Informatics Science Providence University Taiwan 43301 China Department of Applied Cosmetology National Tainan Junior College of Nursing China Taiwan 700 Department of Internal Medicine Chung Shan Medical University HospitalGraduate Institute of Integrated Medicine China Medical University Taichung Taiwan 40201 China

Objective：To observe the effect of combining red yeast rice and Lactobacillus casei（***）in lowering cholesterol in patients with primary hyperlipidemia,the later has also been shown to remove cholesterol in in vitro ***：A double-blind clinical trial was conducted to evaluate the cholesterol-lowering effect of the combination of red yeast rice and *** patients with primary hyperlipidemia were recruited and randomized equal y to either the treatment group（red yeast rice＋***）or the control group（red yeast rice＋placebo）.One red yeast rice capsule and two *** capsules were taken twice a *** treatment lasted for 8 weeks,with an extended follow-up period of 4 *** primary endpoint was a difference of serum low-density lipoprotein cholesterol（LDL-C）level at week ***：At week 8,the LDL-C serum level in both groups was lower than that at baseline,with a decrease of 33.85±26.66 mg/dL in the treatment group and 38.11±30.90 mg/dL in the control group;however,there was no statistical difference between the two groups（P〉0.05）.The total cholesterol was also lower than the baseline in both groups,yet without a statistical difference between the two *** only statistical y significant difference between the two groups was the average diastolic pressure at week 12,which dropped by 2.67 mm Hg in the treatment group and increased by 4.43 mm Hg in the placebo group（P〈0.05）.The antihypertensive activity may be associated with *** yeast rice can significantly reduce LDL-C,total cholesterol and ***：The combination of red yeast rice and *** did not have an additional effect on lipid profiles.

关键词： red yeast rice Lactobacillus casei,low-density lipoprotein cholesterol randomizedcontrolled trial

Rotablation in the treatment of high-risk patients with heavily calcified left-main coronary lesions

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Journal of Geriatric Cardiology 2013年第3期10卷 217-225页

作者： Meng-Hsiu Chiang Hung-Tao Yi Cheng-Rong Tsao Wei-chun Chang Chieh-Shou Su tsun-Jui Liu Kae-Woei Liang Chih-Tai Ting Wen-Lieng Lee Division of Cardiology Saint Mary’s Hospital 160 Zhongzheng South Road Luodong Yilan 26546 Taiwan China Cardiovascular Center Taichung Veterans General Hospital 160 Sec.3 Chung-Kang Road Taichung 407 Taiwan China Institute of Clinical Medicine National Yang Ming University Schoo lof Medicine 155 Sec.2 Linong Street Taipei 112 Taiwan China

Objective Heavily calcified left-main coronary diseases (LMCA) remain a formidable challenge for percutaneous interventions (PCI). This study was to investigate the safety and efficacy of using rotational atherectomy (RA) in treating such lesions in actual practice. Methods From February 2004 to March 2012, all consecutive patients who received RA for heavily-calcified LMCA lesions in our cath lab were en-rolled. The relevant clinical and angiographic characteristics at the time of index PCI, as well as the clinical follow-up outcomes, were re-trieved and analyzed. Results A total of 34 consecutive patients were recruited with a mean age 77.2 ± 10.2 years. There were 82.4%pre-sented with acute coronary syndrome and 11.8%with cardiogenic shock. Chronic renal disease and diabetes were seen in 64.7%and 52.9%, respectively. Triple-vessel coronary disease was found in 76.5%of them. The mean SYNTAX score was 50 ± 15 and EuroSCORE II scale 5.6 ± 4.8. The angiographic success rate was 100%with a procedural success rate of 91.2%. The mean number of burrs per patient was 1.7 ± 0.5. Crossing-over stenting was used in 64.7%. Most stents were drug-eluting (67.6%). Intra-aortic ballon pump was used in 20.6%of the procedures. Three patients died during hospitalization, all due to presenting cardiogenic shock. No major complication occurred. Among 31 hospital survivors, the major adverse cardiac events (MACE) rate was 16.1%, all due to target lesion revascularization or target vessel revas-cularization. Conclusions In high-surgical-risk elderly patients, plaque modification with RA in PCI of heavily-calcified LMCA could be safely accomplished with a minimal complication rate and low out-of-hospital MACE.

关键词： Heavily calcified Left main coronary Rotational atherectomy

Effectiveness of post-COVID-19 primary care attendance in improving survival in very old patients with multimorbidity:a territory-wide target trial emulation

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Family Medicine and Community Health 2024年第3期12卷 25-35页

作者： Cuiling Wei Vincent Ka chun Yan Camille Maringe Wenxin Tian Rachel Yui Ki Chu Wenlong Liu Boyan Liu Yuqi Hu Lingyue Zhou Celine Sze Ling Chui Xue Li Eric Yuk Fai Wan Ching Lung Cheung Esther Wai Yin Chan William Chi Wai Wong Ian Chi Kei Wong Francisco Tsz tsun Lai Centre for Safe Medication Practice and Research Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Health Services Research and Policy Faculty of Public Health and PolicyLondon School of Hygiene and Tropical MedicineLondonUK School of Nursing Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong School of Public Health Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Laboratory of Data Discovery for Health(D24H) Hong KongHong Kong Advanced Data Analytics for Medical Science(ADAMS)Limited Hong KongHong Kong Department of Medicine School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Family Medicine and Primary Care School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Pharmacy The University of Hong Kong-Shenzhen HospitalShenzhenPeople's Republic of China Aston Pharmacy School Aston UniversityBirminghamUK School of Pharmacy Macao University of Science and TechnologyTaipaMacao

Objectives Older individuals with multimorbidity are at an elevated risk of infection and complications from *** of post-COVID-19 interventions or care models in reducing subsequent adverse outcomes in these individuals have rarely been *** study aims to examine the effectiveness of attending general outpatient within 30 days after discharge from COVID-19 on 1-year survival among older adults aged 85 years or above with *** Retrospective cohort study emulating a randomised target trial using electronic health *** We used data from the Hospital Authority and the Department of Health in Hong Kong,which provided comprehensive electronic health records,COVID-19 confirmed case data,population-based vaccination records and other individual characteristics for the *** Adults aged 85 years or above with multimorbidity who were discharged after hospitalisation for COVID-19 between January 2020 and August *** Attending a general outpatient within 30 days of last COVID-19 discharge defined the exposure,compared to no outpatient *** outcome measures Primary outcome was all-cause mortality within one *** outcomes included mortality from respiratory,cardiovascular and cancer *** A total of 6183 eligible COVID-19 survivors were included in the *** all-cause mortality rate following COVID-19 hospitalisation was lower in the general outpatient visit group(17.1 deaths per 100 person-year)compared with non-visit group(42.8 deaths per 100 person-year).After adjustment,primary care consultations within 30 days after discharge were associated with a significantly greater 1-year survival(difference in 1-year survival:11.2%,95%CI 8.1%to 14.4%).We also observed significantly better survival from respiratory diseases in the general outpatient visit group(difference in 1-year survival:6.3%,95%CI 3.5%to 8.9%).In a sensitivity analysis for different grace period lengths

关键词： morbidity visit records

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

重温吴文俊先生关于现代画家对古代数学家造像问题的教诲——庆祝吴文俊先生90华诞

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内蒙古师范大学学报（自然科学汉文版） 2009年第5期38卷 491-495页

作者：郭书春中国科学院自然科学史研究所北京100010

重温了吴文俊院士关于严肃的学术著作,不应使用现代画家对古代数学家造像的教诲.批评了某些画家对祖冲之的画像和1980年前后蒋兆和对刘徽的画像,指出刘徽作《九章算术注》时当30岁上下,将他画成耄耋老人违背了历史事实和魏晋时代精神.... 详细信息

重温了吴文俊院士关于严肃的学术著作,不应使用现代画家对古代数学家造像的教诲.批评了某些画家对祖冲之的画像和1980年前后蒋兆和对刘徽的画像,指出刘徽作《九章算术注》时当30岁上下,将他画成耄耋老人违背了历史事实和魏晋时代精神.分析了蒋兆和画刘徽像的时代背景.

关键词：吴文俊祖冲之刘徽造像

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基于图神经网络的最大化代数连通度算法

计算机系统应用 2024年第3期33卷 146-157页

作者：夏春燕侯新民中国科学技术大学大数据学院合肥230026 中国科学技术大学数学科学学院合肥230026 中国科学院吴文俊数学重点实验室合肥230026 合肥国家实验室合肥230088

随着智能体数量的增加,多智能体系统中潜在的通信链路数量呈指数级增长.过多冗余链路的存在给系统带来了大量的能源浪费和维护成本,而盲目地去除链路又会降低系统的稳定性和安全性.代数连通度是衡量图连通性的重要指标之一.然而,传统的... 详细信息

随着智能体数量的增加,多智能体系统中潜在的通信链路数量呈指数级增长.过多冗余链路的存在给系统带来了大量的能源浪费和维护成本,而盲目地去除链路又会降低系统的稳定性和安全性.代数连通度是衡量图连通性的重要指标之一.然而,传统的半正定规划(SDP)方法和启发式算法在求解大规模场景下的最大化代数连通度问题时非常耗时.在本文中,我们提出了一种监督式的图神经网络模型来优化多智能体系统的代数连通度.我们将传统的SDP方法应用于小规模任务场景中,得到足够丰富的训练样本和标签.在此基础上,我们训练了一个图神经网络模型,该模型可用于更大规模的任务场景中.实验结果表明,当需要去除15条边时,我们的模型的平均性能达到了传统SDP方法的98.39%.此外,我们的模型计算时间极其有限,可以推广到实时场景中去.

关键词：多智能体系统代数连通度图神经网络半正定规划舍入技术控制研究机器学习