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Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： thanh-Nhan Nguyen-Pham Mi-Seon Lim truc Anh Thi Nguyen Youn-Kyung Lee Chun-Ji Jin Hyun Ju Lee Cheol Yi hong Jae-Sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

A WebGIS Solution for Estimation Landuse Affected by Salinity Intrusion: Case Study in Ben Tre Province, Vietnam

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Journal of Geographic Information System 2020年第3期12卷 188-201页

作者： Tran Thai Binh ho Lam Truong Do thanh Long Vietnam National Space Center VAST HCMC Vietnam

Ben Tre, located in the Mekong Delta, is one of the most places affected by climate change, especially in sea level rise and salinity intrusion. For the seven provinces bordering the East Sea, the need for monitoring water resources is critical. This paper represents an approach to build a web-based GIS to store, manage, analyze and visualize the data of saline intrusion phenomenon. The novelty focuses on automating the workflow for the generation and publication of time series saline intrusion maps on server side. The analysis results are provided on the web browser interface. This helps users access valuable information without having to install professional GIS software. Spatial distribution of saline intrusion and statistical results support government agencies in planning and decision making. This work is funded by Ben Tre Provincial People's Committee and Vietnam Academy of Science and Technology (VAST).

关键词： Geographic Information System WebGIS Salinity Intrusion Mekong Delta

A novel finite element formulation for static bending analysis of functionally graded porous sandwich plates

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1599-1620页

作者： Van Chinh NGUYEN Trung thanh TRAN Trung NGUYEN-ThoI Quoc-hoa PHAM Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiVietnam Laboratory for Applied and Industrial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh CityVietnam Faculty of Mechanical-Electrical and Computer Engineering Van Lang UniversityHo Chi Minh CityVietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

This article aims to propose a finite element formulation based on Quasi-3D theory for the static bending analysis of functionally graded porous(FGP)sandwich *** FGP sandwich plates consist of three layers including the bottom skin of homogeneous metal,the top skin of fully ceramic and the FGP core layer with uneven porosity distribution.A quadrilateral(Q4)element with nine degrees of freedom(DOFs)per node is derived and employed in analyzing the static bending response of the plate under uniform and/or sinusoidally distributed *** accuracy of the present finite element formulation is verified by comparing the obtained numerical results with the published results in the ***,some numerical examples are performed to examine the effects of the parameters including power-law index k and porosity coefficient on the static bending response of rectangular FGP sandwich *** addition,a problem with a complicated L-shape model is conducted to illustrate the superiority of the proposed finite element method.

关键词： sandwich plates functionally graded porous static bending Quasi-3D theory Q4 element

Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-truc Chu-Dao Kim-Tuyen Huynh-Dam Dang-Thuc Ngo-Luong Quang-Luan Le thanh-Thao Vo-Nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

The effectiveness of light emitting diode(LED)lamps in the offshore purse seine fishery in Vietnam

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Aquaculture and Fisheries 2023年第5期8卷 551-557页

作者： Nguyen Dang Nhat Do thanh Tien Truong Van Dan Nguyen Duy Quynh Tram Nguyen Quang Lich ho Dang Phuc Nguyen Ngoc Phuoc School of Engineering and Technology Hue University01 Dien Bien PhuHue City52000Viet Nam Faculty of Engineering and Food Technology University of Agriculture and ForestryHue University102 Phung HungHue City52000Viet Nam Faculty of Fisheries University of Agriculture and ForestryHue University102 Phung HungHue City52000Viet Nam Institute of Mathematics Vietnam Academy of Science and Technology18 Hoang Quoc VietCau Giay DistrictHanoi11300Viet Nam

Fishing with artificial light has become one of the most advanced,efficient,and common methods for the night-time purse seining in *** study evaluated the radiation spectrum,CIE chromaticity coordinates,correlated color temperature(CCT),catch rate,fuel consumption,and CO_(2)emissions when using Light emitting diode(LED)lamps(0.196 kW)in comparison with the use of metal halide(MH)lights(1 kW)in the offshore purse seine fishery in Quang Tri province,*** fishing efficiency of the purse seine fishing boats using LED lamps has increased 1.58 times in catch rate than MH lights,although the energy consumption of LED lamp is 4 times *** consumption of boats per trip using LED lamps was one third of that using MH *** use of LED reduced the radiation spectrum,especially the intense UV radiation which negatively affects the health of *** study also showed the potential of CO_(2)emission reduction up to 1.09 tons of CO_(2)per trip per boat from the use of LED lamps in the offshore purse seine fishing boats.

关键词： Light emitting diode(LED)lamp Metal halide(MH)light Offshore purse seine fishery Quang tri province Vietnam

Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy

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Cellular & Molecular Immunology 2012年第1期9卷 45-53页

作者： thanh-Nhan Nguyen-Pham Deok-Hwan Yang truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National University Hwasun HospitalJeollanamdoKorea Vaxcell-Bio Therapeutics JeollanamdoKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea

Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer *** require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 *** play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of *** investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions *** that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce *** cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte *** data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy.

关键词： cancer immunotherapy dendritic cells natural killer cells signal

Fuzzy MCDM for Improving the Performance of Agricultural Supply Chain

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Computers, Materials & Continua 2022年第11期73卷 4003-4015页

作者： Le Thi Diem My Chia-Nan Wang Nguyen Van thanh Department of Industrial Engineering and Management National Kaohsiung University of Science and TechnologyKaohsiung CityTaiwan Faculty of Commerce Van Lang UniversityHo Chi Minh CityVietnam

Fertilizer industry in Vietnam and globally have entered the saturation *** the growth rate slowing down,this poses challenges for the development impetus of the fertilizer industry in the next *** fact,over the past few decades,Vietnam’s crop industry has abused excessive investment in chemical fertilizers,with organic fertilizers are rarely used or not at all,limiting crop productivity,increasing pests and *** develop sustainable agriculture,Vietnam’s crop industry must limit the use of chemical fertilizers,increase the use of environmentally friendly organic and natural mineral fertilizers to produce clean agricultural products which is ***,it is necessary to consider and choose the right supplier to ensure the goal of sustainable *** Fuzzy Analytic Hierarchy Process(SF-AHP),and the combinative distance-based assessment(CODAS)are new Multicriteria Decision Making(MCDM)method which can be used to solve supplier selection *** paper uses an effective solution based on a combined the concept of triple bottom line(TBL),SF-AHP and CODAS approach to help agriculture companies that need to select the best fertilizer *** research can support supply chain managers to achieve supply chain systems that reduce not only sourcing costs,but also develop sustainable agriculture.

关键词： Fuzzy theory MCDM model fertilizer agricultural supply chain optimization

A truck Scheduling Problem for Multi-Crossdocking System with Metaheuristics

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Computers, Materials & Continua 2022年第9期72卷 5165-5178页

作者： Phan Nguyen Ky Phuc Nguyen Van thanh Duong Bao Tram International University-Vietnam National University Vietnam National UniversityHoChiMinh City70000Vietnam Faculty of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam

The cross-docking is a very important subject in logistics and supply chain *** to the definition,cross-docking is a process dealing with transhipping inventory,in which goods and products are unloaded from an inbound truck and process through a flow-center to be directly loaded onto an outbound ***-docking is favored due to its advantages in reducing the material handing cost,the needs to store the product in warehouse,as well decreasing the labor cost by eliminating packaging,storing,pick-location and order *** cross-docking,products can be consolidated and transported as a full load,reducing overall distribution *** this paper,we focus on a truck scheduling at the multidoor,multi-crossdocking network with inventory constraints and process capability *** this model,a truck can visit severals docks for loading or unloading many types *** situation is very common in *** study also developed an exact mathematical model using mixedinteger linear programming(MILP)with the objective of minimizing the makespan to obtaint the benchmark in small scale *** scale problems are solved through Simulated Annealing(SA)algorithm and Tabu Search(TS)*** of these algorithms will be compared to benchmarks obtained from solver as well as to each other.

关键词： truck scheduling multi-door multi-crossdocking network simulated annealing tabu search

Analysis of motorcycle microscopic characteristics at roundabouts under mixed traffic condition:A case study of Vietnam

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第4期8卷 605-619页

作者： Linh thanh Trinh Kazushi Sano Kiichiro Hatoyama Chathura Kovida De Silva Urban Transport Engineering and Planning Laboratory Department of Civil and Environmental EngineeringNagaoka University of TechnologyNiigata 940-2188Japan

Recently,the demand for comprehension of mixed traffic in developing countries,particularly at roundabouts,which are highly interactive road junctions,has ***,we analyzed mixed traffic at roundabouts,considering Vietnam as a case *** two main objectives of this study were to characterize the mixed traffic in Vietnam and to determine the microscopic characteristics of motorcycles at ***,efforts were made to clarify the two constitutions of mixed traffic(the performance rule and the presence of small-sized vehicles),and the term“motorcycle-oriented mixed traffic”was *** when satisfying the two fundamental constitutions,this traffic state has unique features,e.g.,only one type of non-lane-based vehicle(the motorcycle)and the predominance of motorcycles in the traffic composition(91.7%).Second,four microscopic characteristics of motorcycles were obtained from a large dataset:the motorcycles’continuous changes in speed,the relationship between the turning angle rate and the speed,the critical gap,and the following *** relationship between the turning angle rate and the speed was first formulated as a power *** critical gap of motorcycles was estimated as a small value(1.25 s)in the case *** following spaces varied with respect to the speed and had an oval *** smallest lateral and longitudinal dimensions were 1.5 and 1.74 m,*** all the findings are meaningful,they are restricted to the case study(ho Chi Minh City,Vietnam).

关键词： Mixed traffic Microscopic traffic characteristics Roundabout Turning angle rate Critical gap Following space

Fuzzy MCDM Model for Selection of Infectious Waste Management Contractors

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Computers, Materials & Continua 2022年第8期72卷 2191-2202页

作者： Nguyen Van thanh Nguyen hoang Hai Nguyen Thi Kim Lan Faculty of Commerce Van Lang UniversityHo Chi Minh CityVietnam International Education Institute Van Lang UniversityHo Chi Minh CityVietnam

Healthcare supply chains are under pressure to drive down costs because of digital business,shifting customer needs and new *** waste generated from medical facilities includes medical activities and daily-life activities of patients and their family *** to statistics of the Department of Health EnvironmentalManagement,Vietnam currently has more than 13,500 medical facilities,including hospitals from central to provincial and district levels and private hospitals and medical *** medicine generates about 590 tons of medical waste/day and is estimated to be about 800 tons/*** waste includes ordinary medical waste and hazardous medical waste;in which ordinary medical waste accounts for about 80%–90%,only about 10%–20%is hazardous medical waste including infectious waste and non-infectious hazardous *** is an environmental and occupational health issue that needs attention in developing countries like *** large amounts of medical waste to ensure environmental and personal hygiene,doing so inefficiently creates potential hazards to the environment and increases operating ***,hospitals lack objective criteria and methods to evaluate and select the most optimal infectious medical waste,relying instead on their own subjective assessment and prior ***,the author proposed a fuzzy multicriteria decision making(MCDM)model including Fuzzy Analytic hierarchy process(FAHP)and the Weighted Aggregated Sum-Product Assessment(WASPAS)for infectious medical waste contractors’selection in this *** proposed Fuzzy MCDM method is in-tended to provide a more efficient,accurate method in the selection of infectious medical waste contractors than subjective assessment methods,thus reduce potential risks to *** results of this study can be applied to evaluate and select contractors in other industries.

关键词： MCDM model fuzzy theory fuzzy AHP WASPAS medical waste contractors