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The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian j.urnal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin troy Gianduzzo Boon Kua David Wong Louise McEwan j.mes Walters Rachel Esler Matthew j.Roberts Geoff Coughlina j.hn W.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Obj.ctive:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)ordered at Department of Urology,The Wesley Hospital,Brisbane,QLD,Australia for non-PCa related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/CT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concordant with the 18F-FDG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** was no statistically significant difference in the 18F-FDG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

GraphFlow+:Exploiting Conversation Flow in Conversational Machine Comprehension with Graph Neural Networks

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Machine Intelligence Research 2024年第2期21卷 272-282页

作者： j.ng Hu Lingfei Wu Yu Chen Po Hu Mohammed j.Zaki School of Computer Science Central China Normal UniversityWuhan 430079China Pinterest San Francisco 94016USA Meta Mountain View 94039USA Rensselaer Polytechnic Institute Troy 12180USA

The conversation machine comprehension(MC)task aims to answer questions in the multi-turn conversation for a single ***,recent approaches don’t exploit information from historical conversations effectively,which results in some references and ellipsis in the current question cannot be *** addition,these methods do not consider the rich semantic relationships between words when reasoning about the passage *** this paper,we propose a novel model GraphFlow+,which constructs a context graph for each conversation turn and uses a unique recurrent graph neural network(GNN)to model the temporal dependencies between the context graphs of each ***,we exploit three different ways to construct text graphs,including the dynamic graph,static graph,and hybrid graph that combines the *** experiments on CoQA,QuAC and DoQA show that the GraphFlow+model can outperform the state-of-the-art approaches.

关键词： Conversational machine comprehension(MC) reading comprehension question answering graph neural networks(GNNs) natural language processing(NLP)

Bioactive compounds in Hericium erinaceus and their biological properties:a review

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Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang Robert j.Linhardt Xingli Wang Anqiang Zhang College of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhej.ang Biosan Biotech Co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active components in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive compounds Biological activities Antioxidation Neuroprotection Immunoregulation

Australian children living with rare diseases:health service use and barriers to accessing care

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World j.urnal of Pediatrics 2023年第7期19卷 701-709页

作者： Suzy Teutsch Yvonne Zurynski Guy DEslick Marie Deverell j.hn Christodoulou Helen Leonard troy Dalkeith Sandra Lj.ohnson Elizabeth j.lliott Faculty of Medicine and Health Discipline of Child and Adolescent HealthThe University of SydneySydneyNSWAustraliaAustralian Australian Paediatric Surveillance Unit Kids ResearchSydney Children's Hospitals NetworkWestmeadNSWAustralia Australian Institute of Health Innovation Center for Healthcare Resilience and Implementation Scienceand NHMRC Partnership Centre in Health System SustainabilityMacquarie UniversitySydneyNSWAustraliaFaculty of Medicine and HealthDiscipline of Child and Adolescent HealthThe University of SydneySydneyNSWAustralia Government Department of Health Western Australia PerthWAAustralia Murdoch Children's Research Institute and Victorian Clinical Genetics Services Royal Children's HospitalParkvilleVICAustralia Department of Paediatrics The University of MelbourneParkvilleVICAustralia Telethon Kids Institute The University of Western AustraliaNedlandsWAAustralia Genetic Metabolic Disorders Service Sydney Children's Hospitals NetworkWestmeadNSWAustralia

Background Children with rare diseases experience challenges at home and school and frequently require multi-disciplinary *** aimed to determine health service utilization by Australian children with rare diseases and barriers to access-ing *** Parents completed an online survey on health professional and emergency department(ED)presentations,hospi-talization,and barriers to accessing *** barriers to service access included residential location(city,regional,remote)and child health-related functioning,determined using a validated,parent-completed measure-of-function *** Parents of 462 children with over 240 rare diseases completed the *** with the general population,these children were more likely to be hospitalized[odds ratio(OR)=17.25,95%confidence interval(CI)=15.50-19.20]and present to the ED(OR=4.15,95%CI=3.68-4.68)or a family physician(OR=4.14,95%CI=3.72-4.60).Child functional impairment was nil/mild(31%),moderate(48%)or severe(22%).Compared to children with nil/mild impair-ment,those with severe impairment were more likely to be hospitalized(OR=13.39,95%CI=7.65-23.44)and present to the ED(OR=11.16,95%CI=6.46-19.27).Most children(75%)lived in maj.r cities,but children from regional(OR=2.78,95%CI=1.72-4.55)and remote areas(OR=9.09,95%CI=3.03-25.00)experienced significantly more barriers to healthcare access than children from maj.r *** included distance to travel,out-of-pocket costs,and lack of specialist medical and other health *** Children with rare diseases,especially those with severe functional impairment have an enormous impact on health services,and better integrated multidisciplinary services with patient-centered care are *** must be improved for children living in rural and remote settings.

关键词： Access Health functioning Health service use Rare diseases

Recent advances in the diagnostic evaluation of pancreatic cystic lesions

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World j.urnal of Gastroenterology 2022年第6期28卷 624-634页

作者： Devarshi R Ardeshna troy Cao Brandon Rodgers Chidiebere Onongaya Dan j.nes Wei Chen Eugene j.Koay Somashekar G Krishna Department of Internal Medicine Ohio State University Wexner Medical CenterColumbusOH 43210United States College of Medicine Ohio State UniversityColumbusOH 43210United States j.mes Molecular Laboratory Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Pathology Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of GI Radiation Oncology The University of Texas MD AndersonHoustonTX77030United States Division of Gastroenterology Department of Internal MedicineOhio State University Wexner Medical CenterColumbusOH 43210United States

Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general *** has become crucial to identify these PCLs and subsequently risk stratify them to guide *** the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such ***,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying ***,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for *** sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive *** cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of *** ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying *** most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future.

关键词： Pancreatic cystic lesion Intraductal papillary mucinous neoplasms Mucinous cystic neoplasm Microforceps biopsy Radiomics Confocal laser endomicroscopy

Physical contributors to glenohumeral internal rotation deficit in high school baseball players

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j.urnal of Sport and Health Science 2015年第3期4卷 299-306页

作者： Elizabeth E. Hibberd Casey E. Shutt Sakiko Oyama j. troy Blackburn j.seph B. Myers Department of Health Science The University of Alabama Tuscaloosa AL 35487-0311 USA U.S. Army-Baylor University San Antonio TX 78234-6100 USA Department of Health and Kinesiology University of Texas at San Antonio San Antonio TX 78249 USA Department of Exercise and Sport Science Neuromuscular Research Laboratory University of North Carolina at Chapel Hill Chapel Hill NC 27599-8700 USA Department of Exercise and Sport Science Sports Medicine Research Laboratories University of North Carolina at Chapel Hill Chapel Hill NC 27599-8700 USA

背景对棒球运动员而言,盂肱关节内旋能力降低(GIRD)是导致肩部和肘部损伤的一个危险因素。尽管这为推荐拉伸提供证据基础,但内旋活动范围(ROM)临床测试无法区分GIRD是由于肌肉韧带还是骨成分因素导致。因此正确理解导致GIRD的原因,对采... 详细信息

背景对棒球运动员而言,盂肱关节内旋能力降低(GIRD)是导致肩部和肘部损伤的一个危险因素。尽管这为推荐拉伸提供证据基础,但内旋活动范围(ROM)临床测试无法区分GIRD是由于肌肉韧带还是骨成分因素导致。因此正确理解导致GIRD的原因,对采取针对性干预措施有重要意义。本研究假设骨成分是导致其内旋能力降低的主要因素,其次是肌肉僵硬和后囊膜厚度。方法以156位棒球运动员为对象,评估其内旋ROM,肌肉僵硬(小圆肌、冈下肌与三角肌后束)程度,后囊膜厚度和肱骨后移程度。每个变量都计算了左右侧的差异。将变量输入多元线性回归分析以确定GIRD的重要预测因素。结果:该回归模型只在肱骨后移作为重要预测因素(β=-0 243,t_(156)=-4 9,p<0 01)时存在显著性差异(R^2=0 134,F(1,1 56)=24 0,p<0 01)。不同侧肱骨后移的变化与GIRD有关。结论:肱骨后移在导致GIRD的原因中占13 3%。而浅表肌肉和囊膜僵硬不能作为GIRD的预测因素。在本研究中未评估的因素,如更深层肌肉的僵硬程度、囊膜GIRD或韧带松弛以及神经肌肉调节能力迟缓也可能导致GIRD。肱骨后移是导致GIRD的最大的因素,需要确认其原因。骨成分在GIRD中仅占13 3%,揭示了在这项研究中并未解决软组织因素对该问题的影响。需要进一步确认这些因素,以便完善其评估证据及干预方案,从而降低棒球运动员的受伤风险度。

关键词：肩关节运动员棒球物理因素高中多元线性回归危险因素运动范围

Improvement in Radicular Symptoms but Continued Facet Arthropathy and Axial Back Pain Following Rupture of a Facet j.int Synovial Cyst

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Neuroscience & Medicine 2018年第1期9卷 46-52页

作者： Bryan j. Kratz troy Buck Daniel Cramer Department of Pain Management Loyola University Medical Center Maywood IL USA

Lumbar synovial cysts are benign fluid collections thought to form in a background of facet j.int degeneration, allowing for fluid to leak from the j.int capsule and form cysts in the synovium. Although often asymptomatic, patients with symptomatic synovial cysts will present with low back pain and possibly an associated radiculopathy. Clinicians can consider conservative management, epidural steroid inj.ction, surgical intervention, or facet j.int block with aspiration and rupture. This case describes a 59-year-old male facilities manager with intermittent low back pain for one year with worsening right-sided radicular symptoms secondary to a lumbar facet j.int synovial cyst in the context of severe facet arthropathy and microinstability. The patient’s low back pain and radicular symptoms were refractory to conservative treatment. Imaging demonstrated a lumbar synovial cyst and subsequent management included transforaminal epidural steroid inj.ction and facet j.int block with cyst aspiration and rupture. The patient’s radicular pain resolved but axial lumbar pain returned after 3 weeks of relief. Follow-up imaging demonstrated decreased cyst size with fluid accumulation and j.int space widening. Although the cyst was successfully decompressed with resolution of radicular pain, the underlying facet arthropathy remains contributing to persistent axial low back pain and potential for continued degenerative changes including cyst recurrence.

关键词： Facet j.int Synovial Cyst Lumbar Synovial Cyst Radicular Pain Cyst Rupture Low Back Pain Non-Surgical Management

Designing Hardware for the Boundary Condition Round Robin Challenge

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Sound & Vibration 2018年第1期52卷 9-12页

作者： David E.Soine Richard j.j.nes j.lie M.Harvie troy j.Skousen Tyler F.Schoenherr Kansas City National Security Campus* 14520 Botts RoadKansas CityMissouriUSA Sandia National Laboratories P.O.Box 5800-MS 0840AlbuquerqueNM 87185

Qualification of products to their vibration and shock requirements in a laboratory setting consists of two basic *** first is the quantification of the product’s mechanical environment in the *** second is the process of testing the product in the laboratory to ensure it is robust enough to survive the field *** latter part is the subj.ct of the“Boundary Condition for Component Qualification”challenge *** paper describes the challenges in determining the appropriate boundary conditions and input stimulus required to qualify the *** paper also describes the step sand analyses that were taken to design a set of hardware that demonstrates the issue and can be used by round robin challenge participants to investigate the problem.

关键词： field. Boundary Robin

Cost-effectiveness analysis comparing robotic sacrocolpopexy to a vaginal mesh hysteropexy for treatment of uterovaginal prolapse

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Open j.urnal of Obstetrics and Gynecology 2013年第8期3卷 613-620页

作者： Patrick j. Culligan Charbel Salamon Christa Lewis troy D. Abell Atlantic Health System Division of Urogynecology and Reconstructive Pelvic Surgery Morristown USA

Obj.ctive: To compare costs and QoL associated with 2 minimally invasive operations to treat uterovaginal prolapse. Study Design: A decision analytic cost-effectiveness model comparing vaginal mesh hysteropexy to robotic-assisted sacrocolpopexy. Costs were derived from a hospital perspective. QoL estimates focused on: recurrent prolapse;erosion;infection;transfusion;cystotomy;chronic pain;lower urinary tract symptoms;and mortality. Actual procedural costs at our institution were calculated. Costs and quality adj.sted life years were examined over 1 year. Results: The costs ($21,853) and QALYs (0.9645) for robotic sacrocolpopexy produced a CE Ratio of $22,657 per QALY. The costs ($14,890) and QALYs (0.9309) for vaginal mesh produced a CE Ratio of $15,995 per QALY. The incremental cost per QALYs for robotic surgery was $207,232. Sensitivity analysis on all utilities, cost estimates, and complication estimates didn’t cross any thresholds. Conclusion: Vaginal mesh was more cost-effective than robotic sacrocolpopexy even when the cost of the robot was not factored.

关键词： Cost-Effectiveness Robotic-Sacrocolpopexy Uterovaginal Prolapse Vaginal-Mesh