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黄斑裂孔术后视功能及主观视力知觉研究

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 24-24页

作者： tranos p.g. ghazi-Nouri S.M.S. Rubin g.S. 王海燕

To evaluate the functional and anatomical results of macular hole surgery and to explore its effect on patients’Health-Related Quality Of Life (HR-QOL) and to investigate the associations between self-reported HR-QOL and conventional measures of visual function. Case series. The National Eye Institute 25-Item V isual Function Questionnaire (VFQ-25) and the 36-Item Short-Form Health Surve y (SF-36) were self-administered by 30 patients before and 4 months after macu lar hole surgery. preoperative, intraoperative, and postoperative clinical data were collected including visual acuity, contrast sensitivity, and metamorphopsia . Multi-item scales rating different aspects of HR-QOL were compared before an d after surgery, and their correlation with traditional methods of outcome evalu ation was analyzed. Macular hole closure was achieved in 26 patients (87%). Mea n LogMAR visual acuity improved by 6±10 letters for distance and 7 ±12 letters for near. Metamorphopsia was reduced by a mean of 35±70 squares on Amsler char t, and pelli-Robson contrast sensitivity decreased by a mean of -0.09 ±0.3 lo g units postoperatively. The VFQ-25 composite score as well as scale scores ass ociated with general vision, near vision, vision-related mental health, and rol e difficulties were significantly improved (p ght SF-36 health concepts, limitation i n usual role activities because of emotional problems was the only one that sign ificantly improved postoperatively. Both baseline and postoperative best-correc ted visual acuity significantly correlated with most of the VFQ subscale scores before and after surgery, respectively. In this case-se-ries, macular hole sur gery appears to have a beneficial effect on patients’subjective perception of v isual function. The use of vision-targeted health status questionnaires in conj unction with detailed clinical examination provides a more comprehensive overvie w of indivi

关键词：黄斑裂孔视功能视物变形手术干预对比敏感度简明健康调查表功能恢复情况临床数据眼科研究所系列分析

prediction of preferential fluid flow in porous structures based on topological network models: Algorithm and experimental validation

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Science China(Technological Sciences) 2018年第8期61卷 1217-1227页

作者： JU Yang LIU peng ZHANg DongShuang DONg JiaBin RANJITH p.g. CHANg Chun State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology State Key Laboratory for geomechanics and Deep Underground Engineering China University of Mining and Technology School of Mechanics and Civil Engineering China University of Mining & Technology School of Resources and Safety Engineering China University of Mining & Technology Institute of Mechanics Chinese Academy of Science Department of Civil Engineering Monash University

The understanding and prediction of preferential fluid flow in porous media have attracted considerable attention in various engineering fields because of the implications of such flows in leading to a non-equilibrium fluid flow in the subsurface. In this study, a novel algorithm is proposed to predict preferential flow paths based on the topologically equivalent network of a porous structure and the flow resistance of flow paths. The equivalent flow network was constructed using poiseuille's law and the maximal inscribed sphere algorithm. The flow resistance of each path was then determined based on Darcy's law. It was determined that fluid tends to follow paths with lower flow resistance. A computer program was developed and applied to an actual porous structure. To validate the algorithm and program, we tested and recorded two-dimensional(2 D) water flow using an ablated perspex sheet featuring the same porous structure investigated using the analytical calculations. The results show that the measured preferential flow paths are consistent with the predictions.

关键词： preferential flow porous structure topological networks flow resistance Darcy's law experimental validation

An SpH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed particle Hydrodynamics(SpH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the pM4Sand model implemented in a three-phase,single-layer SpH framework.A staggered discretisation scheme based on the stress particle SpH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SpH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SpH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SpH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle pM4Sand smoothed particle hydrodynamics(SpH)

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne Moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of pharmacology-physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Direct Evidence of Coal Swelling and Shrinkage with Injecting CO_(2) and N_(2) Using in-situ Synchrotron X-ray Microtomography

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Engineering 2022年第11期18卷 88-95页

作者： guanglei Zhang p.g.Ranjith Herbert E.Huppert Department of Earth Science and Engineering Imperial College LondonLondon SW72BPUK Deep Earth Energy Laboratory Department of Civil EngineeringMonash UniversityMelbourneVIC3800Australia Institute of Theoretical geophysics King’s CollegeCambridge CB21STUK

Deep coal seams are one of the world’s most widespread deposits for carbon dioxide(C02)disposal and are generally located near large point sources of CO_(2)*** injection of CO_(2)into coal seams has great potential to sequester CO_(2)while simultaneously enhancing coalbed methane(CO_(2)-ECBM)*** tests of CO_(2)-ECBM have been conducted in coal seams worldwide with favorable early ***,one of the main technical barriers in coal seams needs to be resolved:Injecting CO_(2)reduces coal permeability and well ***,using in situ synchrotron X-ray microtomography,we provide the first observational evidence that injecting nitrogen(N_(2))can reverse much of this lost permeability by reopening fractures that have closed due to coal swelling induced by CO_(2)*** findings support the notion that injecting minimally treated flue gas-a mixture of mainly N_(2) and CO_(2)-is an attractive alternative for ECBM recovery instead of pure CO_(2)injection in deep coal ***,flue gas produced by power plants could be directly injected after particulate removal,thus avoiding high CO_(2)-separation ***,the presence of N_(2)makes it possible to maintain a sufficiently high level of coal *** results suggest that flue-gas ECBM for deep coal seams may provide a promising path toward net-zero emissions from coal mines.

关键词： CCS CO_(2)-ECBM Carbon neutrality X-ray imaging Coal permeability

projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： Lawrence g.Brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup,we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Unlocking hyp.g.ycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hyp.g.ycemia-a critical complication linked to worsened brain function in diabetic subjects:Hyp.g.ycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hyp.g.ycemia,classified as level 1 hyp.g.ycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hyp.g.ycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hyp.g.ycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical