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World Journal of Gastroenterology 2006年第7期12卷 1071-1077页

作者： Osamu Kanauchi Masanobu Fukuda Yoshiaki Matsumoto Shino Ishii toyokazu ozawa Makiko Shimizu Keiichi Mitsuyama Akira Andoh Kirin Brewery Co.Ltd. 10-1-2 Shinkawa Chuo-kuTokyo104-8288Japan College of Pharmacy Nihon University 7-7-1 Narashinodai FunabashiChiba 274-8555Japan Department of Clinical Pharmacology and Toxicology Showa Pharmaceutical University3-3165Higashi-TamagawagakuenMachidaTokyo194-8543Japan Kurume University School of Medicine 67 Asahi-machiKurumeFukuoka 830-0011Japan Shiga University of Medical Science TsukinowaSetaOtsuShiga520-2100Japan

瞄准：为了检验真细菌类高级轿车的效果，加(E。高级轿车和) 在结肠的上皮的房间线在试管内上，并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法：E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory... 详细信息

瞄准：为了检验真细菌类高级轿车的效果，加(E。高级轿车和) 在结肠的上皮的房间线在试管内上，并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法：E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory 效果。T84 房间上的高级轿车和代谢物被 IL-6 生产被 SUDH 活动，和反煽动性的效果评估。在象受体 4 一样的使用费(TLR4 ) 的 mRNA 的变化被实时 PCR 评估。大肠炎被用 2.0% 葡聚糖硫酸钠喂 BALB/C 老鼠导致。这些老鼠收到了任何一个 5% lyophilized E。高级轿车和(n = 7 ) 或控制节食(n = 7 ) 。在大肠炎正式就职，临床、组织学的分数，冒号长度，和盲肠的有机酸层次以后的七天是坚定的。结果：E。高级轿车和在 0.25， 1.0， 0.025 和 0.07 mmol/L 生产了丁酸盐，醋酸盐，丙酸盐，和 lactate，分别地在里面中等。在这集中，每酸没有生长在 T84 细胞上刺激活动；然而，当这些酸在上述层次一起被混合时，它比控制显示出显著地高的活动。除了 lactate，这些酸显著地在就 0.1 mmol/L 稀释了 IL-6 生产。在 TNF-alpha 刺激下面，另外，丁酸盐稀释了 TLR4 mRNA 的生产。有 E 的处理。高级轿车和显著地随盲肠的丁酸盐层次的增加稀释了大肠炎的临床、组织学的分数，与控制组相比。结论：E。高级轿车和能改善试验性的结肠的发炎。部分地， E 的代谢物。高级轿车和，丁酸盐，增加粘膜正直和表演经由 TLR4 的粘膜防卫系统的反煽动性的行动调整。

关键词：真菌实验研究肠炎微生物结肠炎

Numerical analysis on element creation by nuclear transmutation of fission products

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Nuclear Science and Techniques 2015年第1期26卷 113-120页

作者： Atsunori Terashima Masaki ozawa Department of Nuclear Engineering Graduate School of Science and EngineeringTokyo Institute of Technology Research Laboratory for Nuclear Reactors Tokyo Institute of Technology

A burnup calculation was performed to analyze the Apr`es ORIENT process, which aims to create highlyvaluable elements from fission products separated from spent nuclear fuels. The basic idea is to use nuclear transmutation induced by a neutron capture reaction followed by a β-decay, thus changing the atomic number Z of a target element in fission products by 1 unit. LWR(PWR) and FBR(MONJU) were considered as the transmutation devices. High rates of creation were obtained in some cases of platinum group metals(44Ru by FBR,46 Pd by LWR) and rare earth(64Gd by LWR,66 Dy by FBR). Therefore, systems based on LWR and FBR have their own advantages depending on target elements. Furthermore, it was found that creation rates of even Z(= Z + 1) elements from odd Z ones were higher than the opposite cases. This creation rate of an element was interpreted in terms of "average 1-group neutron capture cross section of the corresponding target element σc Z defined in this work. General trends of the creation rate of an even(odd) Z element from the corresponding odd(even) Z one were found to be proportional to the 0.78th(0.63th) power of σc Z, however with noticeable dispersion. The difference in the powers in the above analysis was explained by the difference in the number of stable isotopes caused by the even-odd effect of Z.

关键词：裂变产物元素数值分析嬗变快中子增殖反应堆轻水反应堆稳定同位素 LWR

Resourceability on nuclear fuel cycle by transmutation approach

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Science China Chemistry 2012年第9期55卷 1746-1751页

作者： ozawa Masaki SAITO Masaki Research Laboratory for Nuclear Reactors Tokyo Institute of Technology2-12-1-N1-1 OokayamaMeguro-kuTokyo 152-8550Japan

A resourceability on nuclear fuel cycle by transmutation of fission products in the spent fuel of nuclear reactors is discussed in this paper to investigate the feasibility of "creation and utilization" of Après ORIENT from Adv.-ORIENT cycle,in which chemical "separation and utilization" of nuclear rare metals(platinum group metals,Mo,Tc,rare earth,etc.) has been proposed since ***ès ORIENT research program was newly initiated in FY2011 for nuclear transmutation of fission products into stable or short-lived highly-valuable *** the resourceability of rare earth metals from fission products,non-radioactive Nd and Dy can be created from Pr and Tb,respectively,by ***,the Dy creation has a relatively high feasibility of about 10-20 %/y in creation rate.A proper moderation of neutrons in blanket of fast reactors may be required to provide a high creation rate of La from *** light platinum group metals,non-radioactive Ru can be created from Tc by transmutation,of which creation rate is about 4-5 %/y in blanket of fast *** created from Rh is almost non-radioactively depending on the isotope fraction of 107 *** creation from Ru is not feasible under the neutron irradiation of typical nuclear reactors.

关键词：核燃料循环嬗变非放射性同位素核裂变产物核反应堆铂族金属稀土金属中子照射

Three-Dimensional Visualization of Shock Cell Structure and Screech Tone Emission in Underexpanded Circular Jet

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Journal of Flow Control, Measurement & Visualization 2022年第1期10卷 1-11页

作者： Keita ozawa Takayuki Yamagata Nobuyuki Fujisawa Graduate School of Science and Technology Niigata University Niigata Japan Department of Mechanical Engineering Niigata University Niigata Japan Department of Mechanical Engineering Shinshu University Nagano Japan

The three-dimensional visualization of flow and screech-tone emission from an underexpanded circular jet is first investigated experimentally using high-speed cross-schlieren imaging and microphone measurements in the cross-sectional planes along the jet axis. This experimental technique allows the visualization of the shock-cell structure, directivity of sound intensity, and frequency spectrum in the cross-sectional planes of the screeching jet. The high-speed cross-schlieren observation of the screeching jet shows the occurrence of an asymmetrical shock-cell structure that is generated by the flapping mode in the screeching jet. This contributes to the generation of a screech tone propagating upstream along the jet axis and non-uniform sound intensities around the jet in circumferential direction. These observations by high-speed cross-schlieren imaging were validated by the microphone measurements.

关键词： Screech Tone Aeroacoustics Directivity Frequency Spectrum Underexpanded Circular Jet Schlieren Imaging

Deobfuscation,unpacking,and decoding of obfuscated malicious JavaScript for machine learning models detection performance improvement

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CAAI Transactions on Intelligence Technology 2020年第3期5卷 184-192页

作者： Samuel Ndichu Sangwook Kim Seiichi ozawa Graduate School of Engineering Kobe UniversityKobe CityJapan Center for Mathematical and Data Sciences Kobe UniversityKobe CityJapan

Obfuscation is rampant in both benign and malicious JavaScript(JS)*** generates an obscure and undetectable code that hinders comprehension and ***,accurate detection of JS codes that masquerade as innocuous scripts is *** existing deobfuscation methods assume that a specific tool can recover an original JS code *** a multi-layer obfuscation,general tools realize a formatted JS code,but some sections remain *** the detection of such codes,this study performs Deobfuscation,Unpacking,and Decoding(DUD-preprocessing)by function redefinition using a Virtual Machine(VM),a JS code editor,and a python int_to_str()function to facilitate feature learning by the FastText *** learned feature vectors are passed to a classifier model that judges the maliciousness of a JS *** performance evaluation,the authors use the Hynek Petrak’s dataset for obfuscated malicious JS codes and the SRILAB dataset and the Majestic Million service top 10,000 websites for obfuscated benign JS *** then compare the performance to other models on the detection of DUD-preprocessed obfuscated malicious JS *** experimental results show that the proposed approach enhances feature learning and provides improved accuracy in the detection of obfuscated malicious JS codes.

关键词： JavaScript editor python

Successful treatment with laparoscopic surgery and sequential multikinase inhibitor therapy for hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 260-267页

作者： Yutaka Endo Motohide Shimazu Tadayuki Sakuragawa Yusuke Uchi Motonori Edanami Ken Sunamura Soji ozawa Naokazu Chiba Shigeyuki Kawachi Department of Surgery Tama Kyuryo HospitalTokyo 1940297Japan Department of Digestive and Transplantation Surgery Tokyo Medical University Hachioji Medical CenterTokyo 1930998Japan

BACKGROUND Hepatocellular carcinoma(HCC)with massive portal vein tumor thrombosis(PVTT)and distant metastasis is considered ***,due to recent developments in systemic chemotherapy,successful cases of conversion therapy for unresectable diseases have been ***,we report a successful multidisciplinary approach for treatment of multi-visceral recurrence with sequential multikinase inhibitor and laparoscopic *** SUMMARY A 63-year-old woman with chronic hepatitis B virus infection was diagnosed with ***,she underwent two rounds of laparoscopic partial hepatectomy,laparoscopic left adrenalectomy,and transcatheter arterial chemoembolization plus sorafenib for *** years after initial hepatectomy,she presented with a 43-mm mass in the spleen and tumor thrombus involving the main portal vein trunk with *** liver function was Child-Pugh B(8),and protein induced by vitamin K absence or antagonist II(PIVKA II)levels were elevated up to 46.291 mAU/*** initial treatment with regorafenib for three months was unsuccessful,the patient was administered *** months post-treatment,there was no contrast enhancement of PVTT or splenic *** was discontinued due to severe ***,splenic metastasis became viable,and PIVKA II ***,hand-assisted laparoscopic splenectomy was *** experienced no clinical recurrence 14 mo after *** Conversion surgery after successful multikinase inhibitor treatment might be considered an effective treatment option for advanced HCC.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein Venous thrombosis Splenic neoplasms Case report

Optogenetic Control of Phosphatidylinositol (3,4,5)-Triphosphate Production by Light-Sensitive Cryptochrome Proteins on the Plasma Membrane

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Chinese Journal of Chemistry 2021年第5期39卷 1240-1246页

作者： Lingzhi Yang Takeaki ozawa Haifeng Dong Xueji Zhang School of Pharmaceutical Sciences Health Science CenterShenzhen UniversityShenzhenGuangdong 518060China Deportment of Chemistry School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhenGuangdong 518060China

Phosphatidylinositol(3,4,5)-triphosphate(PIP3),acting as a fundamental second messenger,is emerging as a promising biomarker for disease diagnosis and ***,the real time analysis of phosphoinositide in living cells remains a key challenge owing to the low basal abundance and its fast metabolic ***,we design an optogenetic system that uses light sensitive protein-protein interaction between Arabidopsis cryptochrome 2(CRY2)and CIB1 to spatiotemporally visualize the PIP3 production with sub-second *** this system,a CIBN is anchored on the plasma membrane,whereas a CRY2 fused with a constitutively active PI3-kinase(acPI3K)would be driven from the cytosol to the membrane by the blue-light-activated CRY2-CIB1 interaction upon light *** PIP3 production is visualized via a fused fluorescent protein by the translocation of a Pleckstrin Homology(PH)domain(GRP1)from the cytosol to the plasma membrane with high *** demonstrated the fast dynamics and reversibility of the optogenetic system initiated PIP3 synthesis on the plasma ***,the real-time cell movements were also observed upon localized light *** established optogenetic method provides a novel spatiotemporal strategy for specific PIP3 visualization,which is beneficial to improve the understanding of PIP3 functions.

关键词： Protein-protein interactions Protein engineering Fluorescent probes Optogenetic control Phosphatidylinosito (3,4,5)-triphosphate

Additive Manufacturing of Metal Micro-ring and Tube by Laser-Assisted Electrophoretic Deposition with Laguerre-Gaussian Beam

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Nanomanufacturing and Metrology 2021年第4期4卷 271-277页

作者： Kenta Nakazawa Syunya ozawa Futoshi Iwata Graduate School of Integrated Science and Technology Shizuoka University3-5-1 Johoku.Naka-kuHamamatsu 432-8561.Japan Graduate School of Medical Photonics Shizuoka University3-5-1 JohokuNaka-kuHamamatsu 432-8011Japan Research Institute of Electronics Shizuoka University3-5-1 JohokuNaka-kuHamamatsu 432-8011Japan

We report a method for laser-assisted electrophoretic deposition using a Laguerre-Gaussian beam for maskless patterning of metal rings and *** are structures of utmost importance,particularly in photonic *** nanoparticles,which are gathered in a colloidal solution by a laser trapping technique,are deposited on a substrate via *** deposition pattern is dependent on the focused spot shape during laser *** intensity distribution of the Laguerre-Gaussian beam is *** with different inner diameters can be fabricated by varying the topological charge of the Laguerre-Gaussian *** equivalent inner diameters of the deposited rings with topological charges of 1,3,and 5 were 0.30,0.78,and 1.45μm,*** inner diameter of the deposited ring with a topological charge of 1 was smaller than the wavelength of the laser beam(532 nm).A tube was also fabricated with a topological charge of 3 by vertical displacement of the deposition *** deposition technology developed here using Laguerre-Gaussian beam will contribute to advancements in the fabrication of photonic and nano-fluidic devices.

关键词： Additive manufacturing Laguerre-Gaussian beam Laser trapping Maskless fabrication Electrophoretic deposition

Van Vleck paramagnetism of europium oxyhydroxide

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Journal of Rare Earths 2015年第2期33卷 177-181页

作者： Hiroaki Samata Naoki Wada Tadashi C.ozawa Graduate School of Maritime Sciences Kobe University FukaeminamiHigashinada Kobe Hyogo 658-0022 Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceNamiki Tsukuba Ibaraki 305-0044 Japan

Europium oxyhydroxide crystals were synthesized by the flux method. The as-grown crystals were transparent and had a plate-like shape with natural flat surfaces. The powder XRD data were refined by assuming a monoclinic structure of the space group P21/m and lattice parameters of a=0.4346 nm, b=0.3744 nm, c=0.6107 nm, and β=108.62°. The magnetic susceptibility of the EuOOH crystals exhibited typical Van Vleck temperature-independent paramagnetism below 120 K. The calculated susceptibility, based on Van Vleck＇s theory, agreed with the experimental data to some extent, with the coupling constant λ=458±10 K. The experimental results were in close agreement with the results calculated using a modified formula with λ=505±2 K and a constant term C=4.6×10^-4 emu/（mol·Oe）.

关键词： europium oxyhydroxide magnetic measurement Van Vleck paramagnetism rare earths

Efficient high harmonics generation by enhancement cavity driven with a post-compressed FCPA laser at 10 MHz

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High Power Laser Science and Engineering 2018年第2期6卷 45-50页

作者： Zhigang Zhao Akira ozawa Makoto Kuwata-Gonokami Yohei Kobayashi The Institute for Solid State Physics The University of Tokyo Department of Physics Graduate School of Science The University of Tokyo

Efficient high harmonics generation(HHG) was demonstrated at 10 MHz repetition rate with an external femtosecond enhancement cavity, seeded by a ～70 fs post-compressed 10 MHz fiber chirped pulse amplifier(FCPA) laser. Operation lasting over 30 min with 0.1 m W outcoupled power at 149 nm was demonstrated. It was found that shorter pulse was beneficial for alleviating the nonlinear plasma effect and improving the efficiency of HHG. Low finesse cavity can relax the plasma nonlinearity clamped intra-cavity power and improve the cavity-locking stability. The pulse duration is expected to be below 100 fs for both 1040 nm and 149 nm outputs, making it ideal for applications such as time-resolved photoemission spectroscopy.

关键词： enhancement cavity high harmonics generation ultrafast fiber lasers