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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

Magnetic Field Structure and Induced Electric Current Distribution on a Cylindrical Model： Application to Magnetic Nerve Stimulation

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Chinese Physics Letters 2009年第7期26卷 115-118页

作者： Taishi okita and Toshiyuki Takagi Institute of Fluid Science Tohoku University Aoba-ku Sendai 980–8577 Japan

We study the relation between the magnetic field structure and the induced electric-current distribution based on a cylindrical model composed of a uniform electrically conductive medium. When the time-varying magnetic fields are axisymmetrically applied in the axial direction of the model, the electric fields are induced around the central axis in accordance with Faradays law. We examine the eddy-current distributions generated by loop-coils with various geometries carrying an alternating electric current. It is shown that the radial structure of the induced fields can significantly be controlled by the loop coil geometry, which will be suitable for practical use especially in magnetic nerve stimulation on bioelectromagneties, if we appropriately p/ace the exciting coil with optimum geometry.

关键词： Mathematical physics Accelerators beams and electromagnetism Medical physics Biological physics

Analytical Solutions of Electromagnetic Fields from Current Dipole Moment on Spherical Conductor in a Low-Frequency Approximation

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Communications in Theoretical Physics 2010年第1期53卷 149-155页

作者： Taishi okita Toshiyuki Takagi Institute of Fluid Science Tohoku University

我们经分解为电流偶极子时刻的电磁的地导出答案，它被放在球形的同类的售票员的外表，并且沿着光线的方向被削尖。偶极子时刻在低频率 f = 被驾驶 1 kHz 和高频率 f = 1 GHz 政体。售票员的电的性质适当地在每频率被选择。电磁的地严... 详细信息

我们经分解为电流偶极子时刻的电磁的地导出答案，它被放在球形的同类的售票员的外表，并且沿着光线的方向被削尖。偶极子时刻在低频率 f = 被驾驶 1 kHz 和高频率 f = 1 GHz 政体。售票员的电的性质适当地在每频率被选择。电磁的地严厉地在球形的几何学，磁性的向量潜力被 BiotSavart 公式正直地在给在一个任意的点被提出，并且分级的潜力与 Legendre 多项式被扩展，考虑在售票员的球形的表面的适当边界条件。导致的电场数字地在低、高的 frequeny 刺激沿着几条路径被计算。在这个工作获得的前後一致的答案将具有在电磁的正式就职问题的一个宽区域的许多重要性。

关键词：偶极矩电磁场低频率导体球解析解逼近勒让德多项式电磁感应问题

NUMERICAL ANALYSIS OF THE INFLUENCE OF THE TIP CLEARANCE FLOWS ON THE UNSTEADY CAVITATING FLOWS IN A THREE- D IMENSIONAL INDUCER

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Journal of Hydrodynamics 2009年第1期21卷 34-40页

作者： okita K. UGAJIN H. MATSUMOTO Y. RIKEN Saitama 351-0198 Japan IHI Corporation Yokohama 235-8501 Japan Department of Mechanical Engineering The University of TokyoTokyo 113-8656 Japan

To clarify the influences of the tip clearance flows on the unsteady cavitating flow, the three-dimensional unsteady cavitating flows through both the two-dimensional cascades and the three-dimensional inducer with and without tip clearance are performed numerically. The governing equations for the compressible fluid flow with the DES turbulence model are employed with the assumption of the isentropic process of liquid phase. The evolution of cavities is represented as the source/sink of vapor phase. The basic equations in the curve linear coordinate are solved by the finite difference method. As the results of the three-dimensional cavitating flows through the two-dimensional cascades, the tip clearance flows from the pressure side to the suction side of the blade produces the tip vortex cavitation, which affects the sheet cavitation on the leading edge of the next blade and enhances the blockage effect near the casing than the flows without tip clearance. On the other hand, in the case of the three-dimensional inducer, the large backflow cavitation is observed around the inlet of the inducer, where the cavities are developed on the casing by the tip clearance flows. The large pressure gradient between the non-cavitating pressure side and the cavitating suction side enhances the tip clearance flows. The calculation considering the tip clearance reproduces the developed cavitation region similar to that of experimental visualizations. Additionally, the backflow cavitation rotates with the speed slower than the rotation speed of the inducer. Then, the rotation of backflow cavitation causes the periodic fluctuation of the outlet pressure greater than that of the inlet pressure.

关键词： cavitation inducer tip clearance flow numerical analysis

Invasive ductal carcinoma of the pancreas showing exophytic growth

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 97-102页

作者： Yuichi Sanada Kazuhiro Yoshida Masaoki Itoh Riki okita Morihito Okada Department of Surgical Oncology Research Institution for Radiation Biology and MedicineHiroshima University

BACKGROUND:Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative *** aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth. METHODS:A 67-year-old woman presented with a mass of 5.0 cm in diameter in the pancreatic *** computed tomography revealed a well-demarcated, primarily solid mass with a central low-density area. Magnetic resonance cholangiopancreatography revealed neither encasement nor dilation of the main pancreatic *** incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the *** serum carcinoembryonic antigen(CEA)levels and abnormal FDG positron emmission tomography accumulation suggested that the tumor had malignant potential requiring a pancreatoduodenectomy. RESULTS:The head of the pancreas contained a well- circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50%adenocarcinoma,with mucinous carci- noma in the center and anaplastic carcinoma at the *** anaplastic carcinoma comprised pleo- morphic cells(PCs)and pleomorphic giant cells(PGCs). The PGCs phagocytozed mononuclear PCs and lymphocytes adjacent to the capsule without infiltrating the capsule *** revealed that the anaplastic carcinoma cells including PGCs were positive for the tumor antigen Mucin 1 and CEA but negative for vimentin. CONCLUSION:Our observations suggest anaplastic carcinoma components in the present tumor have a ductal origin and that the exophytic tumor growth is associated with the phagocytotic activity of PGCs.

关键词： pancreatic carcinoma anaplastic carcinoma mucinous carcinoma Mucin 1 carcinoembryonic antigen

Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer

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World Journal of Gastroenterology 2011年第44期17卷 4867-4874页

作者： Makoto Tayama Tomohisa Furuhata Yoshiko Inafuku Kenji okita Toshihiko Nishidate Toru Mizuguchi Yasutoshi Kimura Koichi Hirata the First Department of Surgery Sapporo Medical University

AIM:To characterize the implications of vascular endothelial growth factor(VEGF)-A in stromal cells and colorectal cancer and the expression of VEGF-A splice ***:VEGF-A expression in tumor and stromal cells from 165 consecutive patients with colorectal cancer was examined by *** association between VEGF-A expression status and clinicopathological factors was *** freshfrozen samples were obtained for laser capture microdissection to analyze the splice variants of ***:VEGF-A was expressed in 53.9% and 42.4% of tumor and stromal cells,***-A expression in tumor cells(t-VEGF-A) was associated with advanced clinical stage(stage 0,1/9;stage 1,2/16;stage 2,32/55;stage 3,38/66;stage 4,16/19,P < 0.0001).VEGF-A expression in stromal cells(s-VEGF-A) increased in the earlier clinical stage(stage 0,7/9;stage 1,6/16;stage 2,33/55;stage 3,22/66;stage 4,5/19;P = 0.004).Multivariate analyses for risk factors of recurrence showed that only s-VEGF-A expression was an independent risk factor for recurrence(relative risk 0.309,95% confidence interval 0.141-0.676,P = 0.0033).The five-year disease-free survival(DFS) rates of t-VEGF-A-positive and-negative cases were 51.4% and 62.9%,*** was no significant difference in t-VEGF-A expression *** five-year DFS rates of s-VEGF-A-positive and-negative cases were 73.8% and 39.9%,respectively.s-VEGFA-positive cases had significantly better survival than s-VEGF-A-negative cases(P = 0.0005).Splice variant analysis revealed that t-VEGF-A was mainly composed of VEGF165 and that s-VEGF-A included both VEGF165 and *** cases with no venous invasion(v0),the level of VEGF165b mRNA was significantly higher(v0 204.5 ± 122.7,v1 32.5 ± 36.7,v2 2.1 ± 1.7,P = 0.03).The microvessel density tended to be lower in cases with higher VEGF165b mRNA ***:s-VEGF-A appears be a good prognostic factor for colorectal cancer and includes VEGF165 and VEGF165b.

关键词：血管内皮生长因子基质细胞大肠癌激光捕获显微切割 mRNA水平免疫组化检测肿瘤细胞危险因素

Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第13期26卷 1463-1473页

作者： Satoyoshi Yamashita Akira Kato Toshitaka Akatsuka Takashi Sawada Tomohide Asai Noriyuki Koyama Kiwamu okita Department of Gastroenterology and Hepatology Japan Community Health Care Organization Shimonoseki Medical CenterShimonosekiYamaguchi 7500061Japan Department of Physiology Faculty of MedicineSaitama Medical UniversityIruma-gunSaitama 3500495Japan Research and Development Division Sekisui Medical Company LimitedRyugasakiIbaraki 3010852Japan Clinical Research Department Eidia Company LimitedChiyoda-kuTokyo 1010032Japan Eisai Company Limited Shinjuku-kuTokyo 1600812Japan Department of Internal Medicine Shunan Memorial HospitalKudamatsuYamaguchi 7440033Japan

BACKGROUND The prognosis of hepatocellular carcinoma(HCC)patients remains poor despite advances in treatment modalities and *** is important to identify useful markers for the early detection of HCC in *** antigen(PNA),originally reported in a rat carcinogenesis model,is increased in the tissues and serum of HCC *** To determine the diagnostic value of PNA for discriminating HCC and to characterize PNA-positive *** Patients with hepatitis C virus(HCV)-related hepatic disorders were prospectively enrolled in this study,which included patients with hepatitis,with cirrhosis,and with HCC.A novel enzyme-linked immunosorbent assay was developed to measure serum PNA concentrations in *** Serum PNA concentrations were measured in 89 controls and 141 patients with HCV infections(50 hepatitis,44 cirrhosis,and 47 HCC).Compared with control and non-HCC patients,PNA was increased in *** receiver operating characteristic curve analysis,the sensitivity of PNA was similar to the HCC markers des-γ-carboxy-prothrombin(DCP)andα-fetoprotein(AFP),but the specificity of PNA was *** was no correlation between PNA and AFP and a significant but weak correlation between PNA and DCP in HCC ***,the correlations with biochemical markers were completely different for PNA,AFP,and DCP;glutamyl transpeptidase was highly correlated with PNA,but not with AFP or DCP,and was significantly higher in PNA-high patients than in PNA-low patients with HCV-related *** PNA may have the potential to diagnose a novel type of HCC in which glutamyl transpeptidase is positively expressed but AFP or DCP is weakly or negatively expressed.

关键词： Serum preneoplastic antigen Hepatitis C virus Hepatocellular carcinoma Des-γ-carboxy-prothrombin α-Fetoprotein Sensitivity Specificity

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基于快慢相位振荡器耦合系统的呼吸网络模型

基于快慢相位振荡器耦合系统的呼吸网络模型

作者： okita TAKAYUKI 上海交通大学

学位级别：硕士

本文提出了一种快和慢相位振荡器相结合的耦合系统。通过该耦合系统的数值模拟,直接观察到两步跃迁到准周期运动的现象,并结合Ott-Antonsen ansatz方程导出低维方程的序参数。通过比较耦合系统的模拟结果和简化后的低维方程,来检查ansat... 详细信息

本文提出了一种快和慢相位振荡器相结合的耦合系统。通过该耦合系统的数值模拟,直接观察到两步跃迁到准周期运动的现象,并结合Ott-Antonsen ansatz方程导出低维方程的序参数。通过比较耦合系统的模拟结果和简化后的低维方程,来检查ansatz方程的适用性。在基础上,本文深入研究并得出几个有趣的结论,这其中快和慢相位振荡器之间的相互作用发挥了关键性作用。由于与慢相位振荡器在某个参数范围内的兴奋性相互作用,快相位振荡器呈现间歇性的出现。而慢相位振荡器由于与快相位振荡器的相互作用,出现了振荡器死亡现象。其主要原因在于使用快相位振荡器的时间平均法而建立的简单相位方程中,出现鞍结点分支的结果。最后,我们展示了在慢相位和快相位振荡器之间的1:m阶的宏观同步现象。

关键词：数值计算计算机模拟呼吸无意识昼夜节律神经元星形胶质细胞振荡器相互作用同步建模

Comparison between Fast Fourier Transform and Autoregressive Model on Analysis of Autonomic Nervous Function after Food Intake in Women

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Health 2016年第6期8卷 567-574页

作者： Kumiko Ohara Yoshimitsu okita Katsuyasu Kouda Harunobu Nakamura Graduate School of Human Development and Environment Kobe University Kobe Japan Japan Society for the Promotion of Science Tokyo Japan Graduate School of Engineering Shizuoka University Hamamatsu Japan Department of Public Health Kinki University Faculty of Medicine Osaka-Sayama Japan

Purpose: Heart rate variability (HRV) is acknowledged as a useful tool to estimate autonomic function. Fast Fourier transform (FFT) and autoregressive model (AR) are used for power spectral analysis of HRV. However, there is little evidence of agreement between FFT and AR in relation to HRV following food intake in females. In the present study, we applied both FFT and AR after food intake during the follicular and luteal phases, and compared raw low-frequency (LF) and high- frequency (HF) powers, and LF/HF ratio obtained with the two power-spectral analytical methods. Methods: All subjects participated in two sessions: follicular phase session and luteal phase session. In each session, R-R intervals were continuously recorded before and after meals, and power spectral analysis of heart rate variability was performed. We analyzed low-frequency power (LF: 0.04 - 0.15 Hz) and high-frequency power (HF: 0.15 - 0.40 Hz) by using FFT and AR. LF and HF power were computed for each 30 sec, 1 min, 2.5 min, and 5 min of the 5-min R-R data before meal intake and at 20, 40, 60 and 80 min after meal intake. The LF/HF ratio was calculated as an index of sympathovagal balance. Results: In the present study, after 30 sec and 1 min of segment analysis, there was little interchangeability between AR and FFT in LF, HF, and LF/HF ratio in both follicular and luteal phases. In 2.5 min or 5 min of segment analysis, there was interchangeability between FFT and AR in LF and HF, but not in the LF/HF ratio in both follicular and luteal phases. Additionally, FFT underestimated HRV compared with AR, and the extent of underestimation increased with increasing AR value. Conclusion: FFT underestimated HRV compared with AR, and FFT correlated poorly with AR when the analysis segment was shortened.

关键词： Heart Rate Variability Power Spectral Analysis Food Intake Females Menstrual Cycle